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  1. Article ; Online: Matrix Metalloproteinase 2 Is Crucial for Hypertension- and Hyperglycemia-Induced Kidney Injury Independent of Blood Pressure.

    Liu, Ruisheng / Staruschenko, Alexander

    Journal of cardiovascular pharmacology

    2023  Volume 82, Issue 6, Page(s) 438–439

    MeSH term(s) Humans ; Blood Pressure ; Matrix Metalloproteinase 2 ; Hypertension/drug therapy ; Kidney ; Hyperglycemia/complications
    Chemical Substances Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1471: Show issues Location:
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  2. Article ; Online: TRPC6 in diabetic kidney disease: good guy or bad guy?

    Staruschenko, Alexander

    Kidney international

    2019  Volume 95, Issue 2, Page(s) 256–258

    Abstract: An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes ... ...

    Abstract An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial and detrimental effects on glomeruli function.
    MeSH term(s) Animals ; Diabetic Nephropathies ; Insulin Resistance ; Mice ; Mice, Knockout ; TRPC Cation Channels ; TRPC6 Cation Channel
    Chemical Substances TRPC Cation Channels ; TRPC6 Cation Channel ; Trpc6 protein, mouse
    Language English
    Publishing date 2019-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.10.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  3. Article ; Online: Lysine and salt-sensitive hypertension.

    Dissanayake, Lashodya V / Palygin, Oleg / Staruschenko, Alexander

    Current opinion in nephrology and hypertension

    2024  

    Abstract: Purpose of review: Salt-sensitive (SS) hypertension and its associated kidney damage have been extensively studied, yet proper therapeutic strategies are lacking. The interest in altering the metabolome to affect renal and cardiovascular disease has ... ...

    Abstract Purpose of review: Salt-sensitive (SS) hypertension and its associated kidney damage have been extensively studied, yet proper therapeutic strategies are lacking. The interest in altering the metabolome to affect renal and cardiovascular disease has been emerging. Here, we discuss the effect and potential mechanism behind the protective effect of lysine, an essential amino acid, on the progression of SS hypertension.
    Recent findings: We have recently demonstrated that administering lysine in an SS rodent model can control the progression of hypertension. Both the animal and pilot human studies showed that lysine can efficiently inhibit tubular reabsorption of albumin and protect the kidneys from further damage. In addition, we conducted multilevel omics studies that showed increased lysine conjugation and excretion, leading to the depletion of harmful metabolites and an increase in useful ones.
    Summary: Lysine's twofold action involves both mechanically flushing protein from proximal tubules to shield the kidneys and initiating metabolic adaptations in the kidneys. This results in a net positive impact on SS hypertension. While further research is necessary to apply the current findings in clinical settings, this study offers some evidence suggesting that lysine supplementation holds promise as a therapeutic approach for hypertensive kidney disease.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  4. Article ; Online: Beneficial Effects of High Potassium: Contribution of Renal Basolateral K

    Staruschenko, Alexander

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 71, Issue 6, Page(s) 1015–1022

    MeSH term(s) Blood Pressure/physiology ; Diet/methods ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Hypertension/prevention & control ; Kidney/metabolism ; Potassium/metabolism ; Potassium Channels/metabolism ; Potassium, Dietary/pharmacology
    Chemical Substances Potassium Channels ; Potassium, Dietary ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2018-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.118.10267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  5. Article ; Online: Calcium signalling and transport in the kidney.

    Staruschenko, Alexander / Alexander, R Todd / Caplan, Michael J / Ilatovskaya, Daria V

    Nature reviews. Nephrology

    2024  

    Abstract: The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly controlled to maintain calcium homeostasis, which is required to facilitate ... ...

    Abstract The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly controlled to maintain calcium homeostasis, which is required to facilitate optimal bone mineralization, preserve serum calcium levels within a narrow range, and support intracellular signalling mechanisms. The maintenance of these functions is attributed to a delicate balance achieved by various calcium channels, transporters, and calcium-binding proteins in renal cells. Perturbation of this balance due to deficiency or dysfunction of calcium channels and calcium-binding proteins can lead to severe complications. For example, polycystic kidney disease is linked to aberrant calcium transport and signalling. Furthermore, dysregulation of calcium levels can promote the formation of kidney stones. This Review provides an updated description of the key aspects of calcium handling in the kidney, focusing on the function of various calcium channels and the physiological stimuli that control these channels or are communicated through them. A discussion of the role of calcium as an intracellular second messenger and the pathophysiology of renal calcium dysregulation, as well as a summary of gaps in knowledge and future prospects, are also included.
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-024-00835-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  6. Article ; Online: Hypertension and Diabetes Mellitus: The Chicken and Egg Problem.

    Staruschenko, Alexander

    Hypertension (Dallas, Tex. : 1979)

    2017  Volume 69, Issue 5, Page(s) 787–788

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.117.08671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  7. Article ; Online: Call for papers: podocyte physiology and pathophysiology.

    Koehler, Sybille / Miner, Jeffrey H / Staruschenko, Alexander

    American journal of physiology. Renal physiology

    2023  Volume 324, Issue 5, Page(s) F505–F510

    MeSH term(s) Podocytes ; Kidney Glomerulus
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00045.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  8. Article ; Online: Opioids and the Kidney: A Compendium.

    Didik, Steven / Golosova, Daria / Xu, Biyang / Staruschenko, Alexander

    Kidney360

    2023  Volume 4, Issue 12, Page(s) 1816–1823

    Abstract: Opioids are a class of medications used in pain management. Unfortunately, long-term use, overprescription, and illicit opioid use have led to one of the greatest threats to mankind: the opioid crisis. Accompanying the classical analgesic properties of ... ...

    Abstract Opioids are a class of medications used in pain management. Unfortunately, long-term use, overprescription, and illicit opioid use have led to one of the greatest threats to mankind: the opioid crisis. Accompanying the classical analgesic properties of opioids, opioids produce a myriad of effects including euphoria, immunosuppression, respiratory depression, and organ damage. It is essential to ascertain the physiological role of the opioid/opioid receptor axis to gain an in-depth understanding of the effects of opioid use. This knowledge will aid in the development of novel therapeutic interventions to combat the increasing mortality rate because of opioid misuse. This review describes the current knowledge of opioids, including the opioid epidemic and opioid/opioid receptor physiology. Furthermore, this review intricately relates opioid use to kidney damage, navigates kidney structure and physiology, and proposes potential ways to prevent opioid-induced kidney damage.
    MeSH term(s) Humans ; Analgesics, Opioid/adverse effects ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/complications ; Opioid-Related Disorders/drug therapy ; Opioid Epidemic ; Receptors, Opioid ; Kidney
    Chemical Substances Analgesics, Opioid ; Receptors, Opioid
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Kir5.1 channels: potential role in epilepsy and seizure disorders.

    Staruschenko, Alexander / Hodges, Matthew R / Palygin, Oleg

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 3, Page(s) C706–C717

    Abstract: Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by ... ...

    Abstract Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the
    MeSH term(s) Animals ; Epilepsy/genetics ; Epilepsy/metabolism ; Humans ; Kidney/metabolism ; Mammals/metabolism ; Mice ; Potassium/metabolism ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Rats ; Kir5.1 Channel
    Chemical Substances KCNJ16 protein, human ; Kcnj16 protein, mouse ; Potassium Channels, Inwardly Rectifying ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00235.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: O'Brien Kidney Research Centers.

    Staruschenko, Alexander / Brooks, Heddwen L

    American journal of physiology. Renal physiology

    2020  Volume 319, Issue 6, Page(s) F1042

    MeSH term(s) Animals ; Cooperative Behavior ; Financing, Government ; Humans ; Interdisciplinary Communication ; Kidney Diseases/diagnosis ; Kidney Diseases/physiopathology ; Kidney Diseases/therapy ; National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)/economics ; Nephrology/economics ; Research Support as Topic ; Translational Research, Biomedical/economics ; United States
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00580.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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