LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Stasiak, Andrzej"
  2. AU="Ward, B.F.L."
  3. AU="Wu, Sizhu"
  4. AU="Maria-Magdalena Titirici"
  5. AU="Papapoulos, Socrates"
  6. AU="Valdivia, Anddre Osmar"
  7. AU="Graham, Miranda"
  8. AU="Lisitsyn, Nikolai A"

Suchergebnis

Treffer 1 - 10 von insgesamt 133

Suchoptionen

  1. Artikel ; Online: The influence of the Crown of Polish Mountains on the attitudes of its ascensionists

    Hyt Ewa / Stasiak Andrzej

    Miscellanea Geographica: Regional Studies on Development, Vol 27, Iss 1, Pp 26-

    2023  Band 39

    Abstract: The aim of this article is to identify the changes in the (intra- and interpersonal) attitudes of experienced travellers after climbing the highest peaks of the 28 mountain ranges in Poland. The survey was conducted on 617 members of the Club of the ... ...

    Abstract The aim of this article is to identify the changes in the (intra- and interpersonal) attitudes of experienced travellers after climbing the highest peaks of the 28 mountain ranges in Poland. The survey was conducted on 617 members of the Club of the Ascensionists of the Crown of Polish Mountains. The respondents provided subjective evaluations of the changes in their attitudes (in nine proposed areas) that resulted from regular mountain hikes. The obtained results demonstrated a significant improvement in the practical skills related to mountain climbing, which was greater than the change in attitudes to other people and the physical condition of the respondents. The most significant changes concerned knowledge of Polish mountains, ability to plan trips, and persistence in pursuing goals. Statistically significant differences were also found between the ages, genders, and frequency of trips (in particular in reference.
    Schlagwörter mountain tourism ; tourists’ attitudes ; personal and interpersonal change ; change through travel ; the crown of polish mountains ; Geography (General) ; G1-922
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: AlphaFold Blindness to Topological Barriers Affects Its Ability to Correctly Predict Proteins' Topology.

    Dabrowski-Tumanski, Pawel / Stasiak, Andrzej

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 22

    Abstract: AlphaFold is a groundbreaking deep learning tool for protein structure prediction. It achieved remarkable accuracy in modeling many 3D structures while taking as the user input only the known amino acid sequence of proteins in question. Intriguingly ... ...

    Abstract AlphaFold is a groundbreaking deep learning tool for protein structure prediction. It achieved remarkable accuracy in modeling many 3D structures while taking as the user input only the known amino acid sequence of proteins in question. Intriguingly though, in the early steps of each individual structure prediction procedure, AlphaFold does not respect topological barriers that, in real proteins, result from the reciprocal impermeability of polypeptide chains. This study aims to investigate how this failure to respect topological barriers affects AlphaFold predictions with respect to the topology of protein chains. We focus on such classes of proteins that, during their natural folding, reproducibly form the same knot type on their linear polypeptide chain, as revealed by their crystallographic analysis. We use partially artificial test constructs in which the mutual non-permeability of polypeptide chains should not permit the formation of complex composite knots during natural protein folding. We find that despite the formal impossibility that the protein folding process could produce such knots, AlphaFold predicts these proteins to form complex composite knots. Our study underscores the necessity for cautious interpretation and further validation of topological features in protein structures predicted by AlphaFold.
    Mesh-Begriff(e) Protein Conformation ; Models, Molecular ; Proteins/chemistry ; Protein Folding ; Peptides
    Chemische Substanzen Proteins ; Peptides
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28227462
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: How to Effectively Build the Image of an Emerging Destination

    Skowronek Ewa / Brzeziñska-Wójcik Teresa / Stasiak Andrzej

    Quaestiones Geographicae, Vol 42, Iss 4, Pp 143-

    2023  Band 156

    Abstract: Only a few studies have focused on building the image of emerging destinations. The region’s image is influenced by its tourist attractiveness (image-related perception) and the knowledge about its tourist attributes (recognition). To build the image of ... ...

    Abstract Only a few studies have focused on building the image of emerging destinations. The region’s image is influenced by its tourist attractiveness (image-related perception) and the knowledge about its tourist attributes (recognition). To build the image of emerging destinations, the attributes of attractiveness should be identified. In this study, such an attempt was made for Lublin Province. A diagnostic survey and statistical methods were used to assess the perception of its attractiveness and the recognition of the attractiveness attributes by visitors. Lublin Province has no tourism image, and its attractiveness attributes are identified only vaguely. The landscape is the only attribute on which the image of this destination can be built.
    Schlagwörter destination image ; emergent destinations ; building image ; campaign efficiency ; lublin province ; poland ; Geography (General) ; G1-922
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Model of DNA topology simplification has come full (supercoiled) circle after two decades of research: Comment on "Disentangling DNA molecules" by Alexander Vologodskii.

    Stasiak, Andrzej

    Physics of life reviews

    2016  Band 18, Seite(n) 154–157

    Mesh-Begriff(e) DNA ; DNA, Superhelical ; Nucleic Acid Conformation
    Chemische Substanzen DNA, Superhelical ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2016.06.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Presence control of DNA repair controllers.

    Stasiak, Andrzej

    Cell cycle (Georgetown, Tex.)

    2015  Band 14, Heft 14, Seite(n) 2199

    Mesh-Begriff(e) Animals ; Cell Cycle/physiology ; Cell Cycle Proteins/physiology ; Homologous Recombination/physiology ; Humans
    Chemische Substanzen Cell Cycle Proteins
    Sprache Englisch
    Erscheinungsdatum 2015-06-01
    Erscheinungsland United States
    Dokumenttyp News ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2015.1056618
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5881: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Buch ; Dissertation / Habilitation: Chemonucleolyse mit Kollagenase

    Stasiak, Andrzej

    1990  

    Verfasserangabe vorgelegt von Andrzej Stasiak
    Umfang 56 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Düsseldorf, Univ., Diss., 1990
    HBZ-ID HT003868321
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    91 D 4198 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Culinary Heritage as an Opportunity to Make Lubelskie Voivodeship’s Tourist Offer More Attractive (E Poland)

    Skowronek Ewa / Brzezińska-Wójcik Teresa / Stasiak Andrzej

    Quaestiones Geographicae, Vol 38, Iss 1, Pp 85-

    2019  Band 95

    Abstract: Lubelskie voivodeship has been standing out from other Polish administrative regions because of its agricultural function that has been shaped for centuries. Food and agricultural products originating in this region are seen as healthy, ecological and ... ...

    Abstract Lubelskie voivodeship has been standing out from other Polish administrative regions because of its agricultural function that has been shaped for centuries. Food and agricultural products originating in this region are seen as healthy, ecological and tradition-based. These resources have been noticed and used by the local government for building the regional brand and for promoting it. The main aim of this paper was to present the level of Polish people’s familiarity with lubelskie culinary heritage. Research findings obtained by means of the preliminary study and the diagnostic poll prove initiatives that have been undertaken to be effective. Inhabitants of other voivodeships do recognise lubelskie voivodeship and its culinary tradition, furthermore, a great majority know regional products from lubelskie. A development of tourism based on such a heritage is therefore an opportunity to make lubelskie voivodeship’s tourist offer more attractive. The offer may also become an important component for creating the brand.
    Schlagwörter tourism ; culinary heritage ; regional products ; perception of the lubelskie voivodeship ; eastern poland ; Geography (General) ; G1-922
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel: Chromatin Is Frequently Unknotted at the Megabase Scale

    Goundaroulis, Dimos / Lieberman, Aiden Erez / Stasiak, Andrzej

    Biophysical Journal. 2020 May 5, v. 118, no. 9

    2020  

    Abstract: Knots in the human genome would greatly impact diverse cellular processes ranging from transcription to gene regulation. To date, it has not been possible to directly examine the genome in vivo for the presence of knots. Recently, methods for serial ... ...

    Abstract Knots in the human genome would greatly impact diverse cellular processes ranging from transcription to gene regulation. To date, it has not been possible to directly examine the genome in vivo for the presence of knots. Recently, methods for serial fluorescent in situ hybridization have made it possible to measure the three-dimensional position of dozens of consecutive genomic loci in vivo. However, the determination of whether genomic trajectories are knotted remains challenging because small errors in the localization of a single locus can transform an unknotted trajectory into a highly knotted trajectory and vice versa. Here, we use stochastic closure analysis to determine if a genomic trajectory is knotted in the setting of experimental noise. We analyze 4727 deposited genomic trajectories of a 2-Mb-long chromatin interval from human chromosome 21. For 243 of these trajectories, their knottedness could be reliably determined despite the possibility of localization errors. Strikingly, in each of these 243 cases, the trajectory was unknotted. We note a potential source of bias insofar as knotted contours may be more difficult to reliably resolve. Nevertheless, our data are consistent with a model in which, at the scales probed, the human genome is often free of knots.
    Schlagwörter chromatin ; fluorescence ; genes ; genomics ; humans ; hybridization ; loci ; models
    Sprache Englisch
    Erscheinungsverlauf 2020-0505
    Umfang p. 2268-2279.
    Erscheinungsort Elsevier BV
    Dokumenttyp Artikel
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2019.11.002
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 4' 66/63: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel ; Online: Chromatin Is Frequently Unknotted at the Megabase Scale.

    Goundaroulis, Dimos / Lieberman Aiden, Erez / Stasiak, Andrzej

    Biophysical journal

    2019  Band 118, Heft 9, Seite(n) 2268–2279

    Abstract: Knots in the human genome would greatly impact diverse cellular processes ranging from transcription to gene regulation. To date, it has not been possible to directly examine the genome in vivo for the presence of knots. Recently, methods for serial ... ...

    Abstract Knots in the human genome would greatly impact diverse cellular processes ranging from transcription to gene regulation. To date, it has not been possible to directly examine the genome in vivo for the presence of knots. Recently, methods for serial fluorescent in situ hybridization have made it possible to measure the three-dimensional position of dozens of consecutive genomic loci in vivo. However, the determination of whether genomic trajectories are knotted remains challenging because small errors in the localization of a single locus can transform an unknotted trajectory into a highly knotted trajectory and vice versa. Here, we use stochastic closure analysis to determine if a genomic trajectory is knotted in the setting of experimental noise. We analyze 4727 deposited genomic trajectories of a 2-Mb-long chromatin interval from human chromosome 21. For 243 of these trajectories, their knottedness could be reliably determined despite the possibility of localization errors. Strikingly, in each of these 243 cases, the trajectory was unknotted. We note a potential source of bias insofar as knotted contours may be more difficult to reliably resolve. Nevertheless, our data are consistent with a model in which, at the scales probed, the human genome is often free of knots.
    Mesh-Begriff(e) Chromatin/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Models, Molecular
    Chemische Substanzen Chromatin
    Sprache Englisch
    Erscheinungsdatum 2019-11-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2019.11.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 235: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 2: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel ; Online: Knoto-ID: a tool to study the entanglement of open protein chains using the concept of knotoids

    Dorier, Julien / Goundaroulis, Dimos / Benedetti, Fabrizio / Stasiak, Andrzej

    Bioinformatics. 2018 Oct. 01, v. 34, no. 19, p. 3402-3404

    2018  , Seite(n) 3402–3404

    Abstract: The backbone of most proteins forms an open curve. To study their entanglement, a common strategy consists in searching for the presence of knots in their backbones using topological invariants. However, this approach requires to close the curve into a ... ...

    Abstract The backbone of most proteins forms an open curve. To study their entanglement, a common strategy consists in searching for the presence of knots in their backbones using topological invariants. However, this approach requires to close the curve into a loop, which alters the geometry of curve. Knoto-ID allows evaluating the entanglement of open curves without the need to close them, using the recent concept of knotoids which is a generalization of the classical knot theory to open curves. Knoto-ID can analyse the global topology of the full chain as well as the local topology by exhaustively studying all subchains or only determining the knotted core. Knoto-ID permits to localize topologically non-trivial protein folds that are not detected by informatics tools detecting knotted protein folds. Knoto-ID is written in C++ and includes R (www.R-project.org) scripts to generate plots of projections maps, fingerprint matrices and disk matrices. Knoto-ID is distributed under the GNU General Public License (GPL), version 2 or any later version and is available at https://github.com/sib-swiss/Knoto-ID. A binary distribution for Mac OS X, Linux and Windows with detailed user guide and examples can be obtained from https://www.vital-it.ch/software/Knoto-ID.
    Schlagwörter bioinformatics ; geometry ; mathematical theory ; topology
    Sprache Englisch
    Erscheinungsverlauf 2018-1001
    Umfang p. 3402-3404
    Erscheinungsort Oxford University Press
    Dokumenttyp Artikel ; Online
    ZDB-ID 1468345-3
    ISSN 1367-4811 ; 1460-2059
    ISSN 1367-4811 ; 1460-2059
    DOI 10.1093/bioinformatics/bty365
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang