LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Single proton LET characterization with the Timepix detector and artificial intelligence for advanced proton therapy treatment planning.

    Stasica, Paulina / Nguyen, Hanh / Granja, Carlos / Kopeć, Renata / Marek, Lukas / Oancea, Cristina / Raczyński, Łukasz / Rucinski, Antoni / Rydygier, Marzena / Schubert, Keith / Schulte, Reinhard / Gajewski, Jan

    Physics in medicine and biology

    2023  Volume 68, Issue 10

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Proton Therapy/methods ; Protons ; Artificial Intelligence ; Linear Energy Transfer ; Radiotherapy Dosage ; Monte Carlo Method ; Radiometry
    Chemical Substances Protons
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acc9f8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Feasibility of the J-PET to monitor the range of therapeutic proton beams.

    Baran, Jakub / Borys, Damian / Brzeziński, Karol / Gajewski, Jan / Silarski, Michał / Chug, Neha / Coussat, Aurélien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya V / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopeć, Renata / Korcyl, Grzegorz / Kozik, Tomasz /
    Krzemień, Wojciech / Kumar, Deepak / Lomax, Antony J / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Paweł / Panek, Dominik / Parzych, Szymon / Perez Del Rio, Elena / Raczyński, Lech / Simbarashe, Moyo / Sharma, Sushil / Shivani / Shopa, Roman Y / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa Ł / Tayefi, Keyvan / Tayefi, Faranak / Weber, Damien C / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Paweł / Ruciński, Antoni

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2024  Volume 118, Page(s) 103301

    Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring.: Methods: The Monte Carlo simulation studies with GATE and PET image ... ...

    Abstract Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring.
    Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment.
    Results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10
    MeSH term(s) Protons ; Feasibility Studies ; Positron-Emission Tomography ; Proton Therapy/methods ; Phantoms, Imaging ; Monte Carlo Method
    Chemical Substances Protons
    Language English
    Publishing date 2024-01-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2024.103301
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study.

    Brzezinski, Karol Wiktor / Baran, Jakub / Borys, Damian / Gajewski, Jan / Chug, Neha / Coussat, Aurelien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya Valsan / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopec, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /
    Kumar, Deepak / Lomax, Antony John / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Pawel / Panek, Dominik / Parzych, Szymon / Perez Del Rio, Elena / Raczyński, Lech / Sharma, Sushil / Shivani, Shivani / Shopa, Roman Y / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa L / Tayefi Ardebili, Keyvan / Tayefi, Faranak / Weber, Damien Charles / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Pawel / Rucinski, Antoni

    Physics in medicine and biology

    2023  

    Abstract: Objective: The Jagiellonian PET (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range ... ...

    Abstract Objective: The Jagiellonian PET (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach: Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualised in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results: Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r^2 = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance: The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. .
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acdd4c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: ProTheRaMon - a GATE simulation framework for proton therapy range monitoring using PET imaging.

    Borys, Damian / Baran, Jakub / Brzezinski, Karol W / Gajewski, Jan / Chug, Neha / Coussat, Aurelien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya Valsan / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopec, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /
    Kumar, Deepak / Lomax, Antony John / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Pawel / Panek, Dominik / Parzych, Szymon / Del Río, Elena Pérez / Raczyński, Lech / Sharma, Sushil / Shivani, Shivani / Shopa, Roman Y / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa / Tayefi Ardebili, Keyvan / Tayefi, Faranak / Weber, Damien Charles / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Pawel / Rucinski, Antoni

    Physics in medicine and biology

    2022  

    Abstract: Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon ... ...

    Abstract Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland.
    Approach: The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design.
    Main results: ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized.
    Significance: We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github.
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac944c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: Feasibility of the J-PET to monitor range of therapeutic proton beams

    Baran, Jakub / Borys, Damian / Brzeziński, Karol / Gajewski, Jan / Silarski, Michał / Chug, Neha / Coussat, Aurélien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya V. / Kacprzak, Aleksander Gajos Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopeć, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /
    Kumar, Deepak / Lomax, Antony J. / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Paweł / Panek, Dominik / Parzych, Szymon / del Rio, Elena Perez / Raczyński, Lech / Simbarashe, Moyo / Sharma, Sushil / Shivani / Shopa, Roman Y. / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa Ł. / Tayefi, Keyvan / Tayefi, Faranak / Weber, Damien C. / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Pawel / Rucinski, Antoni

    2023  

    Abstract: Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image ... ...

    Abstract Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment. Main results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10$^{-5}$ coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for the future clinical application. Experimental tests are needed to confirm these findings.

    Comment: 19 pages, 7 pages
    Keywords Physics - Medical Physics
    Subject code 621
    Publishing date 2023-02-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top