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  1. Book: Pediatric infectious diseases

    Noel, Gary J. / Stavola, Joseph J. / Schauf, Victoria

    a comprehensive guide to the subspecialty

    1997  

    Author's details Gary J. Noel ; Joseph J. Stavola ; Victoria Schauf
    Keywords Communicable Diseases / in infancy & childhood / outlines ; Communicable Diseases / examination questions
    Language English
    Size XIV, 361 S. : Ill., graph. Darst., Kt.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008085139
    ISBN 0-8018-5563-2 ; 0-8018-5564-0 ; 978-0-8018-5563-4 ; 978-0-8018-5564-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 831 order for loan Magazin

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  2. Book: Pediatric infectious diseases

    Noel, Gary J / Stavola, Joseph J / Schauf, Victoria

    a comprehensive guide to the subspecialty

    1997  

    Author's details Gary J. Noel, Joseph J. Stavola, Victoria Schauf
    MeSH term(s) Communicable Diseases ; Child ; Infant
    Language English
    Size xiv, 361 p. :, ill.
    Publisher Johns Hopkins University Press
    Publishing place Baltimore
    Document type Book
    ISBN 9780801855634 ; 0801855632 ; 9780801855641 ; 0801855640
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: ASSESSMENT OF CORD BLOOD IL-6 LEVELS AS AN INDICATOR OF NEONATAL SEPSIS

    Perenyi, Agnes / Johann-Liang, Rosemary / Stavola, Joseph J.

    American Journal of Perinatology

    1999  Volume 16, Issue 10, Page(s) 525–530

    Abstract: Based on the recognition that interleukin-6 (IL-6) is produced early in infection, IL-6 determinations have been used to identify infants with early onset bacterial sepsis. This study intended to assess the value of IL-6 in maternal, cord and infant ... ...

    Abstract Based on the recognition that interleukin-6 (IL-6) is produced early in infection, IL-6 determinations have been used to identify infants with early onset bacterial sepsis. This study intended to assess the value of IL-6 in maternal, cord and infant peripheral blood as an index of sepsis, and examine the relationships of its values in mother and infants. The population consisted of 17 mother/infant pairs at high risk for neonatal infection. Eight of these infants had clinical signs of possible sepsis. Cord blood IL-6 levels in infants of mothers considered to be noninfected were lower than those born to women with chorioamnionitis. There was also a positive correlation between maternal and cord blood IL-6 values. There were no differences in maternal blood IL-6, whether they had infections or not. Also, peripheral infant blood obtained after birth did not differentiate between those born to women with or without chorioamnionitis, nor did it correlate with maternal blood IL-6 levels. Clinical symptoms of the infants did not correlate with either cord or peripheral blood IL-6 values. Although maternal prepartum treatment with antibiotics and/or steroids may influence their own and their infants' blood IL-6 levels, there is insufficient evidence to consider low infant blood IL-6 level a reliable predictor to rule out early newborn sepsis.
    Keywords Interleukin-6 (IL-6) ; neonatal sepsis ; bacterial sepsis
    Language English
    Publishing date 1999-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-1999-7282
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article: Antiviral activity of single-dose PRO 140, a CCR5 monoclonal antibody, in HIV-infected adults.

    Jacobson, Jeffrey M / Saag, Michael S / Thompson, Melanie A / Fischl, Margaret A / Liporace, Ralph / Reichman, Richard C / Redfield, Robert R / Fichtenbaum, Carl J / Zingman, Barry S / Patel, Mahesh C / Murga, Jose D / Pemrick, Suzanne M / D'Ambrosio, Paul / Michael, Marti / Kroger, Hans / Ly, Hieu / Rotshteyn, Yakov / Buice, Robert / Morris, Stephen A /
    Stavola, Joseph J / Maddon, Paul J / Kremer, Alton B / Olson, William C

    The Journal of infectious diseases

    2008  Volume 198, Issue 9, Page(s) 1345–1352

    Abstract: Background: The current goal of human immunodeficiency virus type 1 (HIV-1) therapy is to maximally suppress viral replication. Securing this goal requires new drugs and treatment classes. The chemokine receptor CCR5 provides an entry portal for HIV-1, ... ...

    Abstract Background: The current goal of human immunodeficiency virus type 1 (HIV-1) therapy is to maximally suppress viral replication. Securing this goal requires new drugs and treatment classes. The chemokine receptor CCR5 provides an entry portal for HIV-1, and PRO 140 is a humanized monoclonal antibody that binds to CCR5 and potently inhibits CCR5-tropic (R5) HIV-1 in vitro.
    Methods: A randomized, double-blind, placebo-controlled, dose-escalating study was conducted in 39 individuals with HIV-1 RNA levels or =5000 copies/mL, CD4(+) cell counts > or =250 cells/microL, no antiretroviral therapy for 3 months, and only R5 HIV-1 detectable. Cohorts were randomized 3:10 to receive placebo or doses of PRO 140 of 0.5, 2, or 5 mg/kg. Subjects were monitored for 58 days for safety, antiviral effects, and serum concentrations of PRO 140.
    Results: PRO 140 was generally well tolerated and demonstrated potent, rapid, prolonged, and dose-dependent antiviral activity. Mean reductions in HIV-1 RNA level of 0.58 log(10), 1.20 log(10) (P= .0002) and 1.83 log(10) (P= .0001) were observed for the 0.5-, 2-, and 5-mg/kg dose groups, respectively. Reductions in mean viral load of > or =10-fold were observed within 4 days and persisted for 2-3 weeks after treatment.
    Conclusions: This trial established clear proof of concept for PRO 140 as a potent antiretroviral agent with extended activity after a single dose.
    Trial registration: ISRCTN Register: ISRCTN45537485 .
    MeSH term(s) Anti-HIV Agents/blood ; Anti-HIV Agents/pharmacology ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal, Humanized ; Area Under Curve ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Resistance, Viral ; Female ; HIV Antibodies/blood ; HIV Antibodies/pharmacology ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Lymphocyte Count ; Lymphocytes/immunology ; Male ; RNA, Viral/blood ; Receptors, CCR5 ; Time Factors
    Chemical Substances Anti-HIV Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; HIV Antibodies ; PRO-140 monoclonal antibody ; RNA, Viral ; Receptors, CCR5
    Language English
    Publishing date 2008-11-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1086/592169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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