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Article ; Online: Complete resection of pulmonary artery hemangioma on the beating heart.

Atta, Sameh / Verdichizzo, Danilo / Taberham, Rhona / Stavroulias, Dionisios / Kourliouros, Antonios

2021 Volume 36, Issue 8, Page(s) 2931–2932

Abstract: Cardiac hemangiomas are rare entities and very few cases have been reported where they originate from the main arteries of the heart. We present a case of hemangioma arising from the main pulmonary artery, which was completely resected with clear margins ...

Abstract	Cardiac hemangiomas are rare entities and very few cases have been reported where they originate from the main arteries of the heart. We present a case of hemangioma arising from the main pulmonary artery, which was completely resected with clear margins on the beating heart.
MeSH term(s)	Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Hemangioma/diagnostic imaging ; Hemangioma/surgery ; Hemangioma, Capillary ; Humans ; Margins of Excision ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery
Language	English
Publishing date	2021-03-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.15518
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Article ; Online: Should all patients receive extended thromboprophylaxis after resection of primary lung cancer?

Kho, Jason / Mitchell, Jenny / Curry, Nicola / Di Chiara, Francesco / Stavroulias, Dionisios / Belcher, Elizabeth

The Journal of thoracic and cardiovascular surgery

2022 Volume 164, Issue 6, Page(s) 1603–1611.e1

Abstract: Objective: The optimal duration of thromboprophylaxis in patients undergoing resection of primary lung cancer is not known. We investigated the incidence of pulmonary emboli and venous thromboembolism in patients undergoing early-stage lung cancer ... ...

Abstract	Objective: The optimal duration of thromboprophylaxis in patients undergoing resection of primary lung cancer is not known. We investigated the incidence of pulmonary emboli and venous thromboembolism in patients undergoing early-stage lung cancer resection and the impact of change from short duration to extended thromboprophylaxis. Methods: We reviewed the outcomes of consecutive patients who underwent resection of early-stage primary lung cancer following a change in protocol from inpatient-only to extended thromboprophylaxis to 28 days. Propensity-score matching of control (routine inpatient pharmacologic thromboprophylaxis) and treatment group (extended pharmacologic thromboprophylaxis) was performed. Adjustment for covariates based on the Caprini risk assessment model was undertaken. Thromboembolic outcomes were compared between the 2 groups. Results: Seven hundred fifty consecutive patients underwent resection of primary lung cancer at Oxford University Hospitals NHS Foundation Trust between January 2013 and December 2018. Six hundred patients were included for analysis and propensity-score matching resulted in 253 matched pairs. Extended prophylaxis was associated with a significant reduction in pulmonary emboli (10 of 253 patients [4%] vs 1 of 253 patients [0.4%], P = .01). One patient (0.4%) developed a bleeding complication within the treatment cohort. Multivariable logistic regression model demonstrated that extended thromboprophylaxis was independently associated with a reduction in postoperative pulmonary emboli. Conclusions: Patients undergoing lung cancer resection surgery are at moderate-to-high risk of postoperative thromboembolic disease. Extended dalteparin for 28 days is safe and is associated with reduced incidence of pulmonary embolus in patients undergoing resection of early-stage primary lung cancer.
MeSH term(s)	Humans ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Anticoagulants/adverse effects ; Drug Administration Schedule ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/etiology ; Pulmonary Embolism/prevention & control ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Postoperative Complications/etiology ; Lung Neoplasms/surgery ; Lung Neoplasms/complications
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2022.06.016
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Article ; Online: Optimal resection rate for lung cancer in the UK: how high should we go?

Belcher, Elizabeth / Mitchell, Jenny / Stavroulias, Dionisios / Di Chiara, Francesco / Rahman, Najib

BMJ open respiratory research

2021 Volume 8, Issue 1

Abstract: Background: The optimal resection rate for institutions managing early-stage primary lung cancer is not known. Whether the prognosis of patients who do not proceed to operation is determined by their comorbidities for which they were deemed at ... ...

Abstract	Background: The optimal resection rate for institutions managing early-stage primary lung cancer is not known. Whether the prognosis of patients who do not proceed to operation is determined by their comorbidities for which they were deemed at prohibitively high-operative risk, or disease progression, is uncertain. We investigated the outcomes of patients with early-stage lung cancer who were considered for surgical management. Methods: We reviewed the outcomes of consecutive patients who were considered for resection of early-stage primary lung cancer at Oxford University Hospitals National Health Service Foundation Trust between 2012 and 2017. Results: Between 29 November 2012 and 31 March 2017, 467 consecutive patients underwent resection with curative intent for primary lung cancer (operative group), while 81 patients were deemed resectable but either inoperable or did not wish to proceed to operation (non-operative group). Reason for not proceeding to resection was cardiovascular in 16 patients (19.8%), respiratory in 21 (25.9%), cardiorespiratory in 11 (13.6%), performance status in 8 (9.9%) and patient choice in 25 (30.9%) patients. Sixty-six patients (81.5%) received an alternative radical treatment. Median follow-up was 169 weeks (IQR 119-246 weeks) in the operative group and 118 weeks (IQR 74-167 weeks) in the non-operative group. Median survival of patients with early-stage lung cancer who did not proceed to operation was 2.5 years; median survival of patients undergoing lung cancer resection was undefined (p<0.0001). Lung cancer was documented as directly or indirectly leading to or contributing to death in 40 patients (76.9%). In 11 patients, the cause of death was due to comorbidities (21.2%). Conclusions: Patients turned down for operation in a high-resection rate UK unit have limited survival due to lung cancer progression. We conclude that 'optimal' resection rates may not have been reached in the UK even in high-resection rate centres.
MeSH term(s)	Humans ; Lung ; Lung Neoplasms/epidemiology ; Lung Neoplasms/surgery ; Prognosis ; State Medicine ; United Kingdom/epidemiology
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2020-000771
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Article ; Online: The Musculoskeletal Manifestations of Marfan Syndrome: Diagnosis, Impact, and Management.

Pollock, Lily / Ridout, Ashley / Teh, James / Nnadi, Colin / Stavroulias, Dionisios / Pitcher, Alex / Blair, Edward / Wordsworth, Paul / Vincent, Tonia L

Current rheumatology reports

2021 Volume 23, Issue 11, Page(s) 81

Abstract: Purpose of review: Marfan syndrome (MFS) is an autosomal dominant heritable disorder of fibrillin-1 (FBN1) with predominantly ocular, cardiovascular, and musculoskeletal manifestations that has a population prevalence of approximately 1 in 5-10,000 ( ... ...

Abstract	Purpose of review: Marfan syndrome (MFS) is an autosomal dominant heritable disorder of fibrillin-1 (FBN1) with predominantly ocular, cardiovascular, and musculoskeletal manifestations that has a population prevalence of approximately 1 in 5-10,000 (Chiu et al. Mayo Clin Proc. 89(1):34-42, 146, Dietz 3, Loeys et al. J Med Genet. 47(7):476-85, 4). Recent findings: The vascular complications of MFS still pose the greatest threat, but effective management options, such as regular cardiac monitoring and elective surgical intervention, have reduced the risk of life-threatening cardiovascular events, such as aortic dissection. Although cardiovascular morbidity and mortality remains high, these improvements in cardiovascular management have extended the life expectancy of those with MFS by perhaps 30-50 years from an estimated mean of 32 years in 1972 (Dietz 3, Gott et al. Eur J Cardio-thoracic Surg. 10(3):149-58, 147, Murdoch et al. N Engl J Med. 286(15):804-8, 148). The musculoskeletal manifestations of MFS, which to date have received less attention, can also have a significant impact on the quality of life and are likely to become more important as the age of the Marfan syndrome population increases (Hasan et al. Int J Clin Pract. 61(8):1308-1320, 127). In addition, musculoskeletal manifestations are often critically important in the diagnosis of MFS. Here, we review the main clinically relevant and diagnostically useful musculoskeletal features of MFS, which together contribute to the "systemic features score" (referred to hereafter as systemic score), part of the revised Ghent nosology for MFS. We discuss current treatment strategies and highlight the need for a multidisciplinary approach to diagnosis and management. Finally, we review new pharmacological approaches that may be disease modifying and could help to improve the outcome for individuals with this syndrome.
MeSH term(s)	Cardiovascular Diseases ; Humans ; Marfan Syndrome/diagnosis ; Marfan Syndrome/therapy ; Quality of Life
Language	English
Publishing date	2021-11-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-021-01045-3
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Article ; Online: Thymoma infiltrating an anomalous pulmonary vein.

Elzain, Osama / Petrou, Mario / Keiralla, Amar / Stavroulias, Dionisios

Interactive cardiovascular and thoracic surgery

2016 Volume 22, Issue 4, Page(s) 496

MeSH term(s)	Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Pulmonary Veins/abnormalities ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/pathology ; Pulmonary Veins/surgery ; Reconstructive Surgical Procedures ; Thymectomy ; Thymoma/diagnostic imaging ; Thymoma/pathology ; Thymoma/surgery ; Thymus Neoplasms/diagnostic imaging ; Thymus Neoplasms/pathology ; Thymus Neoplasms/surgery ; Tomography, X-Ray Computed ; Vascular Surgical Procedures
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivv364
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Article ; Online: Treatment solution by Elzain et al.

Elzain, Osama / Petrou, Mario / Keiralla, Amar / Stavroulias, Dionisios

Interactive cardiovascular and thoracic surgery

2016 Volume 22, Issue 4, Page(s) 497

MeSH term(s)	Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Pulmonary Veins/abnormalities ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/pathology ; Pulmonary Veins/surgery ; Reconstructive Surgical Procedures ; Thymectomy ; Thymoma/diagnostic imaging ; Thymoma/pathology ; Thymoma/surgery ; Thymus Neoplasms/diagnostic imaging ; Thymus Neoplasms/pathology ; Thymus Neoplasms/surgery ; Tomography, X-Ray Computed ; Vascular Surgical Procedures
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivv383
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Article: Secondary pneumothorax in end-stage lung disease complicated by noninvasive ventilation and a persistent air leak.

McCracken, David J / Bedawi, Eihab O / Hassan, Maged / Stavroulias, Dionisios / Rahman, Najib M

Breathe (Sheffield, England)

2019 Volume 14, Issue 4, Page(s) e119–e122

Abstract: Pneumothorax is a well-recognised complication of end-stage COPD, but the management is often complex and may be complicated by other sequelae of advanced respiratory disease including the requirement for ... ...

Abstract	Pneumothorax is a well-recognised complication of end-stage COPD, but the management is often complex and may be complicated by other sequelae of advanced respiratory disease including the requirement for NIV
Language	English
Publishing date	2019-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2562899-9
ISSN	2073-4735 ; 1810-6838
ISSN (online)	2073-4735
ISSN	1810-6838
DOI	10.1183/20734735.027318
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Article ; Online: Late presentation of congenital H-type tracheoesophageal fistula in an immunocompromised patient.

Stavroulias, Dionisios / Ampollini, Luca / Carbognani, Paolo / Rusca, Michele

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2011 Volume 40, Issue 2, Page(s) e98–100

Abstract: Congenital tracheoesophageal fistulas without esophageal atresia - H-type tracheoesophageal fistula - accounts for approximately 4% of esophageal malformations. This term refers to a connection at an oblique course between the posterior wall of the ... ...

Abstract	Congenital tracheoesophageal fistulas without esophageal atresia - H-type tracheoesophageal fistula - accounts for approximately 4% of esophageal malformations. This term refers to a connection at an oblique course between the posterior wall of the trachea and the anterior wall of the esophagus, presenting as an 'H' form. Typically, the diagnosis is made before the third year of life; however, some reports have been made of late presentation in adults who present chronic cough and frequent respiratory infections. Traditionally, surgery has been considered as the best treatment, depending on the level of the fistula. We present the case of an immunocompromised patient who was diagnosed as having a congenital tracheoesophageal fistula of the upper third of the trachea.
MeSH term(s)	Bronchoscopy ; Delayed Diagnosis ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/immunology ; Tomography, X-Ray Computed ; Tracheoesophageal Fistula/complications ; Tracheoesophageal Fistula/congenital ; Tracheoesophageal Fistula/diagnosis ; Tracheoesophageal Fistula/surgery
Language	English
Publishing date	2011-08
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1016/j.ejcts.2011.03.026
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Article ; Online: Post-pneumonectomy cavity: is there still a cavity?

Stavroulias, Dionisios / Ampollini, Luca / Carbognani, Paolo / Rusca, Michele

The Annals of thoracic surgery

2010 Volume 89, Issue 1, Page(s) 312

MeSH term(s)	Aged, 80 and over ; Diagnosis, Differential ; Follow-Up Studies ; Hernia/diagnostic imaging ; Hernia/etiology ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/etiology ; Lung Neoplasms/surgery ; Male ; Pneumonectomy/adverse effects ; Postoperative Complications ; Radiography
Language	English
Publishing date	2010-01
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2009.02.086
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Article ; Online: Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial-MIST-3.

Bedawi, Eihab O / Stavroulias, Dionisios / Hedley, Emma / Blyth, Kevin G / Kirk, Alan / De Fonseka, Duneesha / Edwards, John G / Internullo, Eveline / Corcoran, John P / Marchbank, Adrian / Panchal, Rakesh / Caruana, Edward / Kadwani, Owais / Okiror, Lawrence / Saba, Tarek / Purohit, Manoj / Mercer, Rachel M / Taberham, Rhona / Kanellakis, Nikolaos /

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 12, Page(s) 1305–1315

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Thoracic Surgery, Video-Assisted/adverse effects ; Feasibility Studies ; Communicable Diseases/etiology ; Pleural Diseases ; Sepsis/drug therapy ; Sepsis/surgery ; Sepsis/etiology ; Enzyme Therapy
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Multicenter Study ; Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202305-0854OC
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