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  1. Article ; Online: In immunocompromised patients, Epstein-Barr virus lymphadenitis can mimic angioimmunoblastic T-cell lymphoma morphologically, immunophenotypically, and genetically: a case report and review of the literature.

    Steciuk, Mark R / Massengill, Susan / Banks, Peter M

    Human pathology

    2012  Volume 43, Issue 1, Page(s) 127–133

    Abstract: The development of lymphomas and solid malignancies in association with immunosuppression is a well-documented occurrence in the medical literature. We report the case of a young man who developed progressive diffuse lymphadenopathy with associated ... ...

    Abstract The development of lymphomas and solid malignancies in association with immunosuppression is a well-documented occurrence in the medical literature. We report the case of a young man who developed progressive diffuse lymphadenopathy with associated extremely high levels of serum Epstein-Barr virus in the setting of chronic immunosuppressive treatment of glomerulonephritis. Excisional biopsy of a right inguinal node revealed a sclerosing process with the morphologic appearance of angioimmunoblastic T-cell lymphoma with a CD3(+), CD4(+) immunophenotype. In situ hybridization of Epstein-Barr virus-encoded RNA was positive. Molecular probe studies demonstrated a clonal T-cell population. Upon reduction of immunosuppression, the patient's lymphadenopathy and Epstein-Barr virus titer have resolved without recurrence over 2 years time. This case demonstrates that a benign Epstein-Barr virus-associated process can mimic angioimmunoblastic T-cell lymphoma and should be considered particularly in the setting of immunosuppression, emphasizing the need for close communication with the treating physician in the interpretation of lymph node biopsies.
    MeSH term(s) Adolescent ; Diagnosis, Differential ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Glomerulonephritis/drug therapy ; Glomerulonephritis/immunology ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunoblastic Lymphadenopathy/diagnosis ; Immunoblastic Lymphadenopathy/immunology ; Immunoblastic Lymphadenopathy/virology ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Lymph Nodes/drug effects ; Lymph Nodes/pathology ; Lymphadenitis/diagnosis ; Lymphadenitis/immunology ; Lymphadenitis/virology ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/immunology ; Lymphoma, T-Cell/virology ; Male ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/immunology ; Tacrolimus/therapeutic use ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2011.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 722: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Implementing a personalized medicine cancer program in a community cancer system.

    Dressler, Lynn G / Bell, Gillian C / Schuetze, David P / Steciuk, Mark R / Binns, Oliver A / Raab, Rachel E / Abernathy, Pearl M / Wilson, Carolyn M / Kunutsor, Sedope E / Loveless, Marika C / Ahearne, Paul M / Messino, Michael J

    Personalized medicine

    2019  Volume 16, Issue 3, Page(s) 221–232

    MeSH term(s) Community Networks/standards ; Genomics ; Humans ; Neoplasms/genetics ; Pharmacogenetics ; Practice Guidelines as Topic ; Precision Medicine/methods
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299146-3
    ISSN 1744-828X ; 1741-0541
    ISSN (online) 1744-828X
    ISSN 1741-0541
    DOI 10.2217/pme-2018-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 73: Show issues

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  3. Article ; Online: A case of acute promyelocytic leukemia without RARα rearrangement and apparently normal cytogenetics.

    Vaklavas, Christos / Steciuk, Mark R / Ren, Yongsheng / Baird, Melissa F / Mikhail, Fady M / Foran, James M

    Clinical lymphoma, myeloma & leukemia

    2011  Volume 11, Issue 6, Page(s) 521–524

    MeSH term(s) Cytogenetics ; Female ; Gene Rearrangement ; Humans ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/pathology ; Middle Aged ; Receptors, Retinoic Acid/genetics ; Retinoic Acid Receptor alpha
    Chemical Substances RARA protein, human ; Receptors, Retinoic Acid ; Retinoic Acid Receptor alpha
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2011.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5903: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer

    Grunda Jessica M / Steg Adam D / He Qinghua / Steciuk Mark R / Byan-Parker Suzanne / Johnson Martin R / Grizzle William E

    BMC Research Notes, Vol 5, Iss 1, p

    2012  Volume 248

    Abstract: Abstract Background Recent studies suggest that the poorer breast cancer outcome observed in African-American women (AAW) may, in part, result from underlying molecular factors. The purpose of this study was to investigate gene expression differences ... ...

    Abstract Abstract Background Recent studies suggest that the poorer breast cancer outcome observed in African-American women (AAW) may, in part, result from underlying molecular factors. The purpose of this study was to investigate gene expression differences between Caucasian-American women (CAW) and AAW that may contribute to this poorer prognosis. Methods The expression of 84 genes involved in breast carcinoma prognosis, response to therapy, estrogen signaling, and tumor aggressiveness was assessed in age- and stage-matched CAW and AAW paraffin-embedded breast cancer specimens. The Wilcoxon–Mann–Whitney Test was used to identify genes with a significant difference in expression between CAW and AAW. To determine if the differentially expressed genes could segregate between the CAW and AAW, we performed semi-supervised principal component analysis (SSPCA). Results Twenty genes were differentially expressed between AAW and CAW. SSPCA incorporating these 20 genes segregated AAW and CAW into two distinct groups. AAW were significantly (p < 0.05) more likely to display aberrations in G 1 /S cell-cycle regulatory genes, decreased expression of cell-adhesion genes, and low to no expression of ESR1, PGR, ERBB2 and estrogen pathway targets. Conclusions The gene expression differences identified between AAW and CAW may contribute to more aggressive disease, resistance to therapy, enhanced metastatic potential and poor clinical outcome. These findings support the hypothesis that breast cancer specimens collected from AAW display distinct gene expression differences compared to similar tissues obtained from CAW. Additional population-based studies are necessary to determine if these gene expression variations contribute to the highly aggressive and treatment-resistant breast cancer phenotype frequently observed in AAW.
    Keywords Breast cancer ; Gene expression ; Race ; Estrogen signaling ; Cell cycle ; Cell migration ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 616 ; 610
    Language English
    Publishing date 2012-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer.

    Grunda, Jessica M / Steg, Adam D / He, Qinghua / Steciuk, Mark R / Byan-Parker, Suzanne / Johnson, Martin R / Grizzle, William E

    BMC research notes

    2012  Volume 5, Page(s) 248

    Abstract: Background: Recent studies suggest that the poorer breast cancer outcome observed in African-American women (AAW) may, in part, result from underlying molecular factors. The purpose of this study was to investigate gene expression differences between ... ...

    Abstract Background: Recent studies suggest that the poorer breast cancer outcome observed in African-American women (AAW) may, in part, result from underlying molecular factors. The purpose of this study was to investigate gene expression differences between Caucasian-American women (CAW) and AAW that may contribute to this poorer prognosis.
    Methods: The expression of 84 genes involved in breast carcinoma prognosis, response to therapy, estrogen signaling, and tumor aggressiveness was assessed in age- and stage-matched CAW and AAW paraffin-embedded breast cancer specimens. The Wilcoxon-Mann-Whitney Test was used to identify genes with a significant difference in expression between CAW and AAW. To determine if the differentially expressed genes could segregate between the CAW and AAW, we performed semi-supervised principal component analysis (SSPCA).
    Results: Twenty genes were differentially expressed between AAW and CAW. SSPCA incorporating these 20 genes segregated AAW and CAW into two distinct groups. AAW were significantly (p < 0.05) more likely to display aberrations in G(1)/S cell-cycle regulatory genes, decreased expression of cell-adhesion genes, and low to no expression of ESR1, PGR, ERBB2 and estrogen pathway targets.
    Conclusions: The gene expression differences identified between AAW and CAW may contribute to more aggressive disease, resistance to therapy, enhanced metastatic potential and poor clinical outcome. These findings support the hypothesis that breast cancer specimens collected from AAW display distinct gene expression differences compared to similar tissues obtained from CAW. Additional population-based studies are necessary to determine if these gene expression variations contribute to the highly aggressive and treatment-resistant breast cancer phenotype frequently observed in AAW.
    MeSH term(s) African Americans/genetics ; Age Factors ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biopsy ; Breast Neoplasms/chemistry ; Breast Neoplasms/ethnology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma, Ductal, Breast/chemistry ; Carcinoma, Ductal, Breast/ethnology ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/therapy ; Chi-Square Distribution ; European Continental Ancestry Group/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; Multivariate Analysis ; Neoplasm Staging ; Phenotype ; Principal Component Analysis ; Prognosis ; Risk Assessment ; Risk Factors
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2012-05-22
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/1756-0500-5-248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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