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Article ; Online: Prognostic value of cardiac magnetic resonance parameters and biomarkers following myocardial infarction; 10-year follow-up of the Eplerenone Remodelling in Myocardial Infarction without Heart Failure trial.

Weir, Robin A P / Clements, Suzanne / Steedman, Tracey / Dargie, Henry J / McMurray, John J V

2022 Volume 24, Issue 2, Page(s) 393–395

MeSH term(s)	Biomarkers ; Eplerenone/therapeutic use ; Follow-Up Studies ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Magnetic Resonance Spectroscopy ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Myocardial Infarction ; Prognosis ; Spironolactone/therapeutic use
Chemical Substances	Biomarkers ; Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232) ; Eplerenone (6995V82D0B)
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Letter
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2402
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Zs.A 5299: Show issues

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Article: Dobutamine stress MRI in pulmonary hypertension: relationships between stress pulmonary artery relative area change, RV performance, and 10-year survival.

Blyth, Kevin G / Bellofiore, Alessandro / Jayasekera, Geeshath / Foster, John E / Steedman, Tracey / Chesler, Naomi C / Peacock, Andrew J

Pulmonary circulation

2017 Volume 7, Issue 2, Page(s) 465–475

Abstract: In pulmonary hypertension (PH), right ventricular (RV) performance determines survival. Pulmonary artery (PA) stiffening is an important biomechanical event in PH and also predicts survival based on the PA relative area change (RAC) measured at rest ... ...

Abstract	In pulmonary hypertension (PH), right ventricular (RV) performance determines survival. Pulmonary artery (PA) stiffening is an important biomechanical event in PH and also predicts survival based on the PA relative area change (RAC) measured at rest using magnetic resonance imaging (MRI). In this exploratory study, we sought to generate novel hypotheses regarding the influence of stress RAC on PH prognosis and the interaction between PA stiffening, RV performance and survival. Fifteen PH patients underwent dobutamine stress-MRI (ds-MRI) and right heart catheterization. RAC
Language	English
Publishing date	2017-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2638089-4
ISSN	2045-8940 ; 2045-8932
ISSN (online)	2045-8940
ISSN	2045-8932
DOI	10.1177/2045893217704838
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Article ; Online: Relief of Fontan obstruction demonstrated non-invasively by cardiac magnetic resonance imaging.

Weir, Robin A P / Steedman, Tracey / Hillis, W Stewart / Swan, Lorna

International journal of cardiology

2008 Volume 127, Issue 3, Page(s) e167–9

Abstract: Greater numbers of children with congenital heart disease are surviving to adulthood. The non-invasive assessment and surveillance of these patients, still based primarily on transthoracic echocardiography, has been significantly enhanced by the advent, ... ...

Abstract	Greater numbers of children with congenital heart disease are surviving to adulthood. The non-invasive assessment and surveillance of these patients, still based primarily on transthoracic echocardiography, has been significantly enhanced by the advent, and more widespread use of, cardiac magnetic resonance imaging. We report on the influence of cardiac magnetic resonance imaging in the initial evaluation of, and response to treatment in, a patient who had developed an obstruction within her Fontan circuit.
MeSH term(s)	Adult ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Female ; Fontan Procedure/adverse effects ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/surgery ; Humans ; Magnetic Resonance Imaging/methods ; Monitoring, Intraoperative/methods
Language	English
Publishing date	2008-07-21
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2007.04.124
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Zs.A 1673: Show issues

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Article ; Online: Association between proteinuria and left ventricular mass index: a cardiac MRI study in patients with chronic kidney disease.

McQuarrie, Emily P / Patel, Rajan K / Mark, Patrick B / Delles, Christian / Connell, John / Dargie, Henry J / Steedman, Tracey / Jardine, Alan G

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2011 Volume 26, Issue 3, Page(s) 933–938

Abstract: Background: Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. We hypothesized that the level of proteinuria would correlate with left ventricular mass, providing a potential link between elevated protein ... ...

Abstract	Background: Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. We hypothesized that the level of proteinuria would correlate with left ventricular mass, providing a potential link between elevated protein excretion, left ventricular hypertrophy (LVH) and the increased mortality seen in patients with CKD. In order to do this, we assessed the determinants of left ventricular mass, measured using cardiac magnetic resonance (CMR) imaging, in patients with CKD. Methods: Patients attending the renal clinic with CKD stages 2-4 and diabetic nephropathy (n = 26) and IgA nephropathy (n = 23) were recruited. They underwent detailed demographic, biochemical and vascular phenotyping and CMR imaging. Proteinuria was measured using spot protein:creatinine ratio (PCR). Left ventricular mass index (LVMI) was calculated from short-axis cine imaging using Argus software and adjusted for body surface area. Results: Log-PCR correlated significantly with LVMI, as did waist circumference, pulse pressure and systolic blood pressure. LVMI was higher in men. When these variables were entered into a linear regression model, log-PCR (P = 0.006) and systolic blood pressure (P < 0.001) independently predicted LVMI. Renal function was not associated with LVMI. Conclusions: Using volume-independent CMR imaging, we have demonstrated that the level of urinary protein excretion is independently and significantly associated with left ventricular mass in patients with CKD. This relationship was independent of blood pressure. This finding provides a novel link between CKD and increased cardiovascular risk.
MeSH term(s)	Adult ; Aged ; Blood Pressure ; Cohort Studies ; Creatinine/blood ; Cross-Sectional Studies ; Diabetic Nephropathies/physiopathology ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertrophy, Left Ventricular/diagnosis ; Hypertrophy, Left Ventricular/etiology ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/surgery ; Kidney Function Tests ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Proteinuria/diagnosis ; Proteinuria/etiology ; Risk Factors
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2011-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfq418
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Plasma TIMP-4 predicts left ventricular remodeling after acute myocardial infarction.

Weir, Robin A P / Clements, Suzanne / Steedman, Tracey / Dargie, Henry J / McMurray, John J V / Squire, Iain B / Ng, Leong L

Journal of cardiac failure

2011 Volume 17, Issue 6, Page(s) 465–471

Abstract: Background: Alterations in the balance between matrix metalloproteinases and their endogenous tissue inhibitors (TIMPs) are associated with left ventricular (LV) remodeling after acute myocardial infarction (AMI). No relationships have been identified ... ...

Abstract	Background: Alterations in the balance between matrix metalloproteinases and their endogenous tissue inhibitors (TIMPs) are associated with left ventricular (LV) remodeling after acute myocardial infarction (AMI). No relationships have been identified between TIMPs and serial postinfarction change in LV function. Methods and results: Plasma concentrations of TIMP-1, -2, -4 were measured at baseline (mean 46 h) and at 24 weeks in 100 patients (age 58.9 ± 12 years, 77% male) admitted with AMI and LV dysfunction, with cardiac magnetic resonance imaging at each time point. TIMP-1 concentration was reduced, whereas TIMP-2 and -4 concentrations were elevated at baseline compared with a reference control population. TIMP-1 decreased and TIMP-2 increased significantly over time; there was an incremental trend in TIMP-4 concentration. Baseline TIMP-4 correlated with change in LV end-systolic volume index (∆LVESVI; r = 0.24; P = .023) and change in LV end-diastolic volume index (∆LVEDVI; r = 0.25; P = .015). ∆TIMP-4 also correlated with ∆LVESVI and with ∆LVEDVI, as did ∆TIMP-2. On multivariable analysis, baseline TIMP-4 concentration was an independent predictor of ∆LVESVI. Conclusions: Plasma TIMP-4 concentration, measured early after AMI, may assist in the prediction of LV remodeling and therefore in the assessment of prognosis. Further study of the role of the TIMPs in the pathophysiology of postinfarction remodeling is warranted.
MeSH term(s)	Aged ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/physiopathology ; Predictive Value of Tests ; Systole ; Tissue Inhibitor of Metalloproteinase-1/blood ; Tissue Inhibitor of Metalloproteinase-2/blood ; Tissue Inhibitor of Metalloproteinases/blood ; Ventricular Dysfunction, Left/blood ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling ; Tissue Inhibitor of Metalloproteinase-4
Chemical Substances	TIMP1 protein, human ; TIMP2 protein, human ; Tissue Inhibitor of Metalloproteinase-1 ; Tissue Inhibitor of Metalloproteinases ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0)
Language	English
Publishing date	2011-03-25
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2011.02.002
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Zs.A 4340: Show issues

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Article ; Online: Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction.

Weir, Robin A P / Tsorlalis, Ioannis K / Steedman, Tracey / Dargie, Henry J / Fraser, Robert / McMurray, John J V / Connell, John M C

European journal of heart failure

2011 Volume 13, Issue 12, Page(s) 1305–1313

Abstract: Aims: Mineralocorticoid receptor (MR) antagonists improve cardiovascular outcomes in patients with heart failure complicating acute myocardial infarction (AMI) and in chronic heart failure. It is unclear whether these beneficial effects are due solely ... ...

Abstract	Aims: Mineralocorticoid receptor (MR) antagonists improve cardiovascular outcomes in patients with heart failure complicating acute myocardial infarction (AMI) and in chronic heart failure. It is unclear whether these beneficial effects are due solely to aldosterone blockade, as MR has a similar affinity for cortisol. We examined the relationships between plasma and urinary steroid hormones and left ventricular (LV) remodelling in patients with LV dysfunction following AMI. Methods and results: Plasma concentrations of renin, aldosterone, and N-terminal pro-brain natriuretic peptide (NT-proBNP), and 24 h urinary excretion rates of tetrahydroaldosterone (THAldo) and total cortisol metabolites were measured in 93 patients at a mean of 46 h following AMI prior to contrast-enhanced cardiac magnetic resonance (ceCMR). Patients were then randomized to 24 weeks of placebo or eplerenone therapy in addition to standard treatment, after which ceCMR was repeated. In placebo-treated patients, aldosterone, NT-proBNP, and excretion rates of THAldo and total cortisol metabolites were univariate predictors of remodelling (i.e. change in LV end-systolic volume index); aldosterone (P = 0.040) and total cortisol metabolite excretion (P = 0.038) remained independent predictors on multivariate analysis. None of the measured biomarkers predicted remodelling in the presence of eplerenone. Plasma and urinary aldosterone measures, and urinary cortisol metabolites, were not only related to larger infarct volumes and greater infarct remodelling over time, but were also higher in patients with microvascular obstruction on baseline ceCMR. Conclusion: Aldosterone and cortisol are associated with medium-term LV remodelling when measured early after AMI. The beneficial effects of MR antagonism may relate to blockade of both aldosterone- and cortisol-induced MR activation.
MeSH term(s)	Aldosterone/metabolism ; Biomarkers/blood ; Biomarkers/urine ; Double-Blind Method ; Echocardiography ; Electrocardiography ; Eplerenone ; Female ; Follow-Up Studies ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Humans ; Hydrocortisone/metabolism ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Myocardial Infarction/complications ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Prospective Studies ; Spironolactone/analogs & derivatives ; Spironolactone/therapeutic use ; Time Factors ; Treatment Outcome ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/prevention & control ; Ventricular Remodeling/drug effects
Chemical Substances	Biomarkers ; Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232) ; Aldosterone (4964P6T9RB) ; Eplerenone (6995V82D0B) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2011-09-22
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1093/eurjhf/hfr129
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Article ; Online: 2020 The detection of myocardial scar by ceMRI in patients with TnI positive chest pain and minimal angiographic coronary artery disease

Flapan Andrew / Elliott Alex / Foster John / Steedman Tracey / Groenning Bjoern / Martin Thomas N / Dargie Henry

Journal of Cardiovascular Magnetic Resonance, Vol 10, Iss Suppl 1, p A

2008 Volume 289

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microvolt T-wave alternans in end-stage renal disease patients--associations with uremic cardiomyopathy.

Patel, Rajan K / Mark, Patrick B / Halliday, Crawford / Steedman, Tracey / Dargie, Henry J / Cobbe, Stuart M / Jardine, Alan G

Clinical journal of the American Society of Nephrology : CJASN

2010 Volume 6, Issue 3, Page(s) 519–527

Abstract: Background and objectives: Premature cardiovascular (CV) events, especially sudden cardiac death, are common in ESRD patients and associated with uremic cardiomyopathy. Identification of high-risk patients is difficult. Microvolt T-wave alternans (MTWA) ...

Abstract	Background and objectives: Premature cardiovascular (CV) events, especially sudden cardiac death, are common in ESRD patients and associated with uremic cardiomyopathy. Identification of high-risk patients is difficult. Microvolt T-wave alternans (MTWA) is a noninvasive method of detecting variability in electrocardiogram (ECG) T-wave morphology and is a promising technique for identifying patients at high risk of ventricular tachyarrhythmias. MTWA results of ESRD and hypertensive left ventricular hypertrophy (LVH) patients were assessed to determine the prevalence of abnormal results and associations with uremic cardiomyopathy. Design, setting, participants, & measurements: In this single-center observational study, 200 ESRD and 30 LVH patients underwent assessment including CV history, ECG, cardiac magnetic resonance imaging, and an MTWA exercise test. MTWA results were classified as "negative" or "abnormal" on the basis of previously published reports. Results: An abnormal MTWA result was more common in ESRD compared with LVH patients (57.5% versus 26.7%, respectively; P = 0.002). In ESRD patients, MTWA was significantly associated with uremic cardiomyopathy, clinical history of atherosclerosis (coronary, cerebral, peripheral) and diabetes mellitus, older age, and hemodialysis therapy. Independent associations with an abnormal MTWA result were older age, macrovascular disease, increased left ventricle (LV) mass, and LV dilation. Conclusions: Features of uremic cardiomyopathy are associated with an abnormal MTWA result.
MeSH term(s)	Adult ; Aged ; Cardiomyopathies/diagnosis ; Cardiomyopathies/etiology ; Cardiomyopathies/mortality ; Cardiomyopathies/physiopathology ; Chi-Square Distribution ; Coronary Angiography ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Female ; Heart Conduction System/physiopathology ; Humans ; Hypertrophy, Left Ventricular/complications ; Hypertrophy, Left Ventricular/diagnosis ; Hypertrophy, Left Ventricular/mortality ; Hypertrophy, Left Ventricular/physiopathology ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/physiopathology ; Logistic Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Scotland ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/mortality ; Tachycardia, Ventricular/physiopathology ; Uremia/diagnosis ; Uremia/etiology ; Uremia/mortality ; Uremia/physiopathology
Language	English
Publishing date	2010-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.06370710
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Zs.A 6584: Show issues

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Article ; Online: Comparison of serial measurements of infarct size and left ventricular ejection fraction by contrast-enhanced cardiac magnetic resonance imaging and electrocardiographic QRS scoring in reperfused anterior ST-elevation myocardial infarction.

Weir, Robin A P / Martin, Thomas N / Murphy, Charles Aengus / Petrie, Colin J / Clements, Suzanne / Steedman, Tracey / Dargie, Henry J / Wagner, Galen S

Journal of electrocardiology

2010 Volume 43, Issue 3, Page(s) 230–236

Abstract: Background: Left ventricular ejection fraction (LVEF) is a powerful prognostic marker after acute myocardial infarction and is dependent on infarct magnitude. Contrast-enhanced cardiac magnetic resonance (ceCMR) represents the current criterion standard ...

Abstract	Background: Left ventricular ejection fraction (LVEF) is a powerful prognostic marker after acute myocardial infarction and is dependent on infarct magnitude. Contrast-enhanced cardiac magnetic resonance (ceCMR) represents the current criterion standard means of LVEF and infarct size measurement. Infarct size and LVEF can be estimated from the 12-lead electrocardiogram (ECG) using the Selvester QRS score. We examined for the first time the relationship between serial measures of LVEF and infarct size by ceCMR and ECG in patients with reperfused anterior ST-elevation myocardial infarction (STEMI) and depressed LVEF. Methods: Thirty-four patients (mean +/- SD age, 59 +/- 11.8 years; 70.6% male) underwent ceCMR and simultaneous ECG at mean 93 hours after admission and at 12 and 24 weeks. The QRS score was calculated on each ECG, from which infarct size and LVEF were estimated and compared with the equivalent ceCMR measurements. Results: Infarct size on ceCMR was higher than that by QRS score at each time-point (P < .001) with modest correlation (r = 0.56-0.78, P < .001). Left ventricular ejection fraction was consistently significantly higher on CMR than on ECG, with weak correlation (r = 0.37-0.51, P < .05). We derived a novel equation relating QRS score to CMR-measured LVEF in the subacute phase of infarction: LVEF = 61 - (1.7 x QRS score) (%). Conclusions: In patients with reperfused anterior ST-elevation myocardial infarction and depressed LVEF, ceCMR is moderately correlated with the QRS in the serial measurement of infarct size and LVEF. Infarct size (measured by ceCMR) and LVEF are consistently higher than those calculated on the QRS score in the acute and subacute phases of infarction.
MeSH term(s)	Contrast Media ; Electrocardiography/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Myocardial Reperfusion ; Reproducibility of Results ; Sensitivity and Specificity ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/prevention & control
Chemical Substances	Contrast Media
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2010.01.003
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Article ; Online: Response to Letter Regarding Article, “Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction”.

Weir, Robin A P / Petrie, Colin J / Murphy, C Aengus / Clements, Suzanne / Steedman, Tracey / Miller, Ashley M / McInnes, Iain B / Squire, Iain B / Ng, Leong L / Dargie, Henry J / McMurray, John J V

Circulation. Heart failure

2013 Volume 6, Issue 4, Page(s) e58

MeSH term(s)	Female ; Galectin 3/blood ; Humans ; Male ; Mineralocorticoid Receptor Antagonists/pharmacology ; Myocardial Infarction/blood ; Myocardial Infarction/mortality ; Spironolactone/analogs & derivatives ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling/physiology
Chemical Substances	Galectin 3 ; Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232)
Language	English
Publishing date	2013-06-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/circheartfailure.113.000382
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