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  1. Book: Understanding the Origin and Global Spread of Covid-19

    Wickramasinghe, Nalin Chandra / Gorczynski, Reginald M / Steele, Edward J

    2022  

    Language English
    Size 304 p.
    Publisher World Scientific Publishing
    Document type Book
    Note PDA Manuell_17
    ISBN 9789811259074 ; 9811259070
    Database PDA

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  2. Book: Cosmic genetic evolution

    Steele, Edward J.

    (Advances in genetics ; volume 106)

    2020  

    Author's details edited by Edward J. Steele, N. Chandra Wickramasinghe
    Series title Advances in genetics ; volume 106
    Collection
    Language English
    Size xviii, 143 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT020641223
    ISBN 978-0-12-821518-0 ; 0-12-821518-6
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Introduction-Panspermia, 2020.

    Steele, Edward J

    Advances in genetics

    2020  Volume 106, Page(s) 1–4

    Abstract: This current volume is, in many ways, a 2020 update to the important 1999-2000 compendium by Sir Fred Hoyle and Professor N. Chandra Wickramasinghe's "Astronomical Origins of life: Steps towards Panspermia." The emerging new paradigm of biology that ... ...

    Abstract This current volume is, in many ways, a 2020 update to the important 1999-2000 compendium by Sir Fred Hoyle and Professor N. Chandra Wickramasinghe's "Astronomical Origins of life: Steps towards Panspermia." The emerging new paradigm of biology that connects life on Earth with the wider cosmos is covered in considerable depth showing that terrestrial biological evolution is best understood as a cosmically derived habitat and an interconnected genetic system. The various chapters here discuss all aspects of this interconnectedness, particularly relevant now in this time of the coronavirus pandemic (COVID-19) as the human race reacts to the many microbes and viral pathogens that arrive regularly from space.
    MeSH term(s) Betacoronavirus/physiology ; Biological Evolution ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Disease/etiology ; Ecosystem ; Environment ; Exobiology ; Extraterrestrial Environment ; Host-Pathogen Interactions/physiology ; Humans ; Models, Biological ; Origin of Life ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 148-x
    ISSN 0065-2660
    ISSN 0065-2660
    DOI 10.1016/bs.adgen.2020.04.001
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  4. Article ; Online: Somatic mutation patterns at Ig and Non-Ig Loci.

    Steele, Edward J / Franklin, Andrew / Lindley, Robyn A

    DNA repair

    2023  Volume 133, Page(s) 103607

    Abstract: The reverse transcriptase (RT) model of immunoglobulin (Ig) somatic hypermutation (SHM) has received insufficient scientific attention. This is understandable given that DNA deamination mediated by activation-induced deaminase (AID), the initiating step ... ...

    Abstract The reverse transcriptase (RT) model of immunoglobulin (Ig) somatic hypermutation (SHM) has received insufficient scientific attention. This is understandable given that DNA deamination mediated by activation-induced deaminase (AID), the initiating step of Ig SHM, has dominated experiments since 2002. We summarise some key history of the RT Ig SHM model dating to 1987. For example, it is now established that DNA polymerase η, the sole DNA repair polymerase involved in post-replication short-patch repair, is an efficient cellular RT. This implies that it is potentially able to initiate target site reverse transcription by RNA-directed DNA repair at AID-induced lesions. Recently, DNA polymerase θ has also been shown to be an efficient cellular RT. Since DNA polymerase θ plays no significant role in Ig SHM, it could serve a similar RNA-dependent DNA polymerase role as DNA polymerase η at non-Ig loci in the putative RNA-templated nucleotide excision repair of bulky adducts and other mutagenic lesions on the transcribed strand. A major yet still poorly recognised consequence of the proposed RT process in Ig SHM is the generation of significant and characteristic strand-biased mutation signatures at both deoxyadenosine/deoxythymidine and deoxyguanosine/deoxycytidine base pairs. In this historical perspective, we highlight how diagnostic strand-biased mutation signatures are detected in vivo during SHM at both Ig loci in germinal centre B lymphocytes and non-Ig loci in cancer genomes. These strand-biased signatures have been significantly obscured by technical issues created by improper use of the polymerase chain reaction technique. A heightened awareness of this fact should contribute to better data interpretation and somatic mutation pattern recognition both at Ig and non-Ig loci.
    MeSH term(s) DNA/genetics ; DNA Repair ; Mutation ; RNA ; Somatic Hypermutation, Immunoglobulin ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism
    Chemical Substances DNA (9007-49-2) ; RNA (63231-63-0) ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2023-11-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2023.103607
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  5. Article: Introduction-Panspermia, 2020

    Steele, Edward J

    Adv Genet

    Abstract: This current volume is, in many ways, a 2020 update to the important 1999-2000 compendium by Sir Fred Hoyle and Professor N. Chandra Wickramasinghe's "Astronomical Origins of life: Steps towards Panspermia." The emerging new paradigm of biology that ... ...

    Abstract This current volume is, in many ways, a 2020 update to the important 1999-2000 compendium by Sir Fred Hoyle and Professor N. Chandra Wickramasinghe's "Astronomical Origins of life: Steps towards Panspermia." The emerging new paradigm of biology that connects life on Earth with the wider cosmos is covered in considerable depth showing that terrestrial biological evolution is best understood as a cosmically derived habitat and an interconnected genetic system. The various chapters here discuss all aspects of this interconnectedness, particularly relevant now in this time of the coronavirus pandemic (COVID-19) as the human race reacts to the many microbes and viral pathogens that arrive regularly from space.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #634816
    Database COVID19

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  6. Article ; Online: Analysis of SARS-CoV-2 haplotypes and genomic sequences during 2020 in Victoria, Australia, in the context of putative deficits in innate immune deaminase anti-viral responses.

    Lindley, Robyn A / Steele, Edward J

    Scandinavian journal of immunology

    2021  Volume 94, Issue 5, Page(s) e13100

    Abstract: The SARS-CoV-2 epidemic infections in Australia during 2020 were small in number in epidemiological terms and are well described. The SARS-CoV-2 genomic sequence data of many infected patients have been largely curated in a number of publicly available ... ...

    Abstract The SARS-CoV-2 epidemic infections in Australia during 2020 were small in number in epidemiological terms and are well described. The SARS-CoV-2 genomic sequence data of many infected patients have been largely curated in a number of publicly available databases, including the corresponding epidemiological data made available by the Victorian Department of Health and Human Services. We have critically analysed the available SARS-CoV-2 haplotypes and genomic sequences in the context of putative deficits in innate immune APOBEC and ADAR deaminase anti-viral responses. It is now known that immune impaired elderly co-morbid patients display clear deficits in interferon type 1 (α/β) and III (λ) stimulated innate immune gene cascades, of which APOBEC and ADAR induced expression are part. These deficiencies may help explain some of the clear genetic patterns in SARS-CoV-2 genomes isolated in Victoria, Australia, during the 2nd Wave (June-September, 2020). We tested the hypothesis that predicted lowered innate immune APOBEC and ADAR anti-viral deaminase responses in a significant proportion of elderly patients would be consistent with/reflected in a low level of observed mutagenesis in many isolated SARS-CoV-2 genomes. Our findings are consistent with this expectation. The analysis also supports the conclusions of the Victorian government's Department of Health that essentially one variant or haplotype infected Victorian aged care facilities where the great majority (79%) of all 820 SARS-CoV-2 associated deaths occurred. The implications of our data analysis for other localized epidemics and efficient coronavirus vaccine design and delivery are discussed.
    MeSH term(s) APOBEC Deaminases/genetics ; APOBEC Deaminases/metabolism ; Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Age Factors ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Female ; Gene Regulatory Networks ; Haplotypes ; Humans ; Immunity, Innate ; Immunologic Deficiency Syndromes ; Interferon Type I/genetics ; Male ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; SARS-CoV-2/physiology ; Victoria/epidemiology
    Chemical Substances COVID-19 Vaccines ; Interferon Type I ; RNA-Binding Proteins ; ADAR protein, human (EC 3.5.4.37) ; Adenosine Deaminase (EC 3.5.4.4) ; APOBEC Deaminases (EC 3.5.4.5)
    Language English
    Publishing date 2021-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13100
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  7. Article: RNA-directed DNA repair and antibody somatic hypermutation.

    Franklin, Andrew / Steele, Edward J

    Trends in genetics : TIG

    2021  Volume 38, Issue 5, Page(s) 426–436

    Abstract: Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. Deamination of C to deoxyuridine (U) by activation-induced deaminase (AID) explains how mutation at C/G pairs is ... ...

    Abstract Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. Deamination of C to deoxyuridine (U) by activation-induced deaminase (AID) explains how mutation at C/G pairs is potentiated. Mutation at A/T pairs is triggered during the initial stages of repair of AID-generated U lesions and occurs through an as yet unknown mechanism in which polymerase η has a major role. Recent evidence confirms that human polymerase η can act as a reverse transcriptase. Here, we compare the popular suggestion of mutation at A/T pairs through nucleotide mispairing (owing to polymerase error) during short-patch repair synthesis with the alternative proposal of mutation at A/T pairs through RNA editing and RNA-directed DNA repair.
    MeSH term(s) Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; DNA/genetics ; DNA Repair/genetics ; DNA-Directed DNA Polymerase/genetics ; Humans ; Mutation ; RNA/genetics ; Somatic Hypermutation, Immunoglobulin/genetics
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2021-11-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2021.10.005
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  8. Book: Positive T-cell selection in the thymus

    Steele, Edward J.

    (Immunological reviews ; 135)

    1993  

    Author's details [E. J. Steele ...]
    Series title Immunological reviews ; 135
    Collection
    Keywords T-Lymphocytes / physiology ; Thymus Gland / physiology ; T-Lymphocytes / immunology ; Thymus Gland / immunology
    Language English
    Size 242 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT005036708
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -135- verfügbar in Königswinter Königswinter

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  9. Article: Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory.

    Steele, Edward J

    Frontiers in immunology

    2017  Volume 8, Page(s) 1611

    Abstract: The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet's Clonal Selection Theory, the evidence is briefly reviewed and ... ...

    Abstract The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet's Clonal Selection Theory, the evidence is briefly reviewed and updated.
    Language English
    Publishing date 2017-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01611
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  10. Book: Somatic hypermutation in V-regions

    Steele, Edward J.

    1991  

    Author's details ed. Edward J. Steele
    Keywords Antibody Diversity ; Immunoglobulin Variable Region ; Mutation ; B-Lymphozyt ; Immunglobuline ; Gen ; Somatische Mutation ; Immunreaktion
    Subject Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr ; Erbanlage ; Erbeinheit ; Erbfaktor ; Gamma-Globuline ; Ig ; Immunoglobuline ; Immunglobulin vom Menschen ; Beriglotin ; B-Zelle
    Size 185 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003810301
    ISBN 0-8493-5348-3 ; 978-0-8493-5348-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 2719 order for loan Magazin

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