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Article ; Online: Delayed PET/CT of Pericardial Synovial Sarcoma.

Stefanelli, Antonella / Savelli, Giordano / Bonacina, Mattia / Zaniboni, Alberto

2021 Volume 46, Issue 9, Page(s) e451–e453

Abstract: Abstract: Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside ... ...

Abstract	Abstract: Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside the right atrium, and then a PET/CT scan was performed. Standard images were inconclusive whether delayed images showed an FDG-avid pericardial lesion that was surgically removed with histological diagnosis of a poorly differentiated biphasic synovial sarcoma. When considering mediastinal or pericardial mass, a delayed PET/CT may improve lesion-to-background contrast by reducing blood pool activity.
MeSH term(s)	Heart Neoplasms/diagnostic imaging ; Humans ; Mediastinal Neoplasms ; Pericardial Effusion ; Positron Emission Tomography Computed Tomography ; Sarcoma, Synovial/diagnostic imaging
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003603
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Zs.A 1276: Show issues

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Article ; Online: Re: Clinical and molecular features of treatment-related neuroendocrine prostate cancer.

Savelli, Giordano / Zaniboni, Alberto / Stefanelli, Antonella

International journal of urology : official journal of the Japanese Urological Association

2018 Volume 26, Issue 1, Page(s) 142

MeSH term(s)	Humans ; Male ; Neoplasms, Second Primary ; Prostatic Neoplasms
Language	English
Publishing date	2018-10-24
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13832
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 278: Show issues

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Article ; Online: 18F-Fluorocholine Uptake by a Head and Neck Meningeal Inflammatory Pseudotumor.

Savelli, Giordano / Morassi, Mauro / Cobelli, Milena / Stefanelli, Antonella / Zaniboni, Alberto

Clinical nuclear medicine

2019 Volume 44, Issue 8, Page(s) 657–659

Abstract: F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an ... ...

Abstract	F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an opportunity to study different diseases, on the other hand, this condition brings with it the source of error in the evaluation of the images. Here we present the case of a meningeal inflammatory pseudotumor evidenced by F-FCH.
MeSH term(s)	Choline/analogs & derivatives ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Male ; Meninges/diagnostic imaging ; Meninges/pathology ; Middle Aged ; Neck/diagnostic imaging ; Neck/pathology ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2019-07-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002635
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Article ; Online: A standardized dual-phase 18F-DOPA PET/CT protocol in the detection of medullary thyroid cancer.

Treglia, Giorgio / Stefanelli, Antonella / Castaldi, Paola / Rufini, Vittoria

Nuclear medicine communications

2013 Volume 34, Issue 2, Page(s) 185–186

MeSH term(s)	Carcinoma, Medullary/diagnostic imaging ; Female ; Humans ; Male ; Multimodal Imaging/methods ; Positron-Emission Tomography ; Thyroid Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2013-02
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0b013e32835afb67
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Zs.A 1577: Show issues

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Article ; Online: (123)I-MIBG Scintigraphy as a Powerful Tool to Plan an Implantable Cardioverter Defibrillator and to Assess Cardiac Resynchronization Therapy in Heart Failure Patients.

Stefanelli, Antonella / Treglia, Giorgio / Giordano, Alessandro

International journal of molecular imaging

2012 Volume 2012, Page(s) 690468

Abstract: Iodine-123-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is a nuclear medicine technique which describes the functional status of the cardiac sympathetic nervous system. It is well known that an autonomic dysfunction is present in heart failure ... ...

Abstract	Iodine-123-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is a nuclear medicine technique which describes the functional status of the cardiac sympathetic nervous system. It is well known that an autonomic dysfunction is present in heart failure setting as a neuronal uptake of norepinephrine is impaired in the failing myocardium. Reduction in sympathetic nervous function in the heart, measured by reduced myocardial uptake of (123)I-MIBG, is an indicator of poor prognosis for heart failure patients. The aim of this paper was to investigate the role of (123)I-MIBG scintigraphy in evaluating the need of implantable cardioverter defibrillator (ICD) and the response to cardiac resynchronization therapy (CRT) in heart failure patients. For this purpose scientific literature data on these topics were reviewed. Based on literature data, (123)I-MIBG scintigraphy seems to be a useful tool to assess which patients may benefit most from an ICD implantation to reduce the risk of ventricular arrhythmia or sudden cardiac death. Furthermore, (123)I-MIBG scintigraphy seems to predict which patients will response to CRT with an improvement in left ventricular function.
Language	English
Publishing date	2012-09-26
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2595407-6
ISSN	2090-1720 ; 2090-1712
ISSN (online)	2090-1720
ISSN	2090-1712
DOI	10.1155/2012/690468
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Article ; Online: Transposition of the great arteries: a myocardial perfusion PET-CT study.

Leccisotti, Lucia / Bruno, Isabella / Stefanelli, Antonella / Caldarella, Carmelo / Giordano, Alessandro

Clinical nuclear medicine

2013 Volume 38, Issue 12, Page(s) e467–70

Abstract: We report the case of a 20-year-old woman with surgically corrected transposition of the great arteries, pulmonary valve defects, and absence of left coronary ostium at a previous cardiac catheterization. Because of worsening dyspnea, she underwent ... ...

Abstract	We report the case of a 20-year-old woman with surgically corrected transposition of the great arteries, pulmonary valve defects, and absence of left coronary ostium at a previous cardiac catheterization. Because of worsening dyspnea, she underwent myocardial perfusion PET/CT study with 13N-ammonia at rest and during pharmacological stress, which showed extensive ischemia in the left coronary territory and signs of severe left ventricle dysfunction. Quantitative PET data showed impaired regional coronary flow reserve (<2.0) in the left coronary territory, thus allowing a precise and reliable evaluation of the myocardial perfusion defect because of the absence of left coronary ostium.
MeSH term(s)	Female ; Humans ; Multimodal Imaging ; Myocardial Perfusion Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed ; Transposition of Great Vessels/diagnostic imaging ; Transposition of Great Vessels/surgery ; Young Adult
Language	English
Publishing date	2013-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0b013e3182816486
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Article ; Online: Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance.

Biasucci, Luigi Marzio / Biasillo, Gina / Stefanelli, Antonella

Clinical chemistry and laboratory medicine

2010 Volume 48, Issue 12, Page(s) 1685–1691

Abstract: Statins are one of the most important medications in cardio-vascular diseases since they block cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A reductase and thus reduce low density lipoprotein concentrations. In the last ... ...

Abstract	Statins are one of the most important medications in cardio-vascular diseases since they block cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A reductase and thus reduce low density lipoprotein concentrations. In the last years, numerous pleiotropic properties of statins have been described, beyond their well-known lipid lowering function. In particular, they are able to modulate inflammation, which plays a pivotal role in the atherosclerotic process. Several trials have shown a direct correlation between statin therapy and lower C-reactive protein concentrations. Moreover, a large body of pathophysiological studies has demonstrated that statins lower cytokine concentrations and inhibit recruitment, migration and cell adhesion to endothelium by attenuating chemokine production. They also inhibit inflammatory pathways regulated by proteins as Ras and Rho, and increase nitric oxide production which exerts a protective effect on endothelium. In addition to reducing inflammation in coronary atherosclerosis, statins also have beneficial effects in chronic inflammatory and autoimmune diseases, such as psoriasis, and they could induce clinical improvement. Statins seem to exert benefits even in settings of infection. These results suggest that initiating and monitoring statin therapy on the basis of inflammatory markers, in particular C-reactive protein, may improve cardiovascular prevention and treatment.
MeSH term(s)	Biomarkers/analysis ; C-Reactive Protein ; Cholesterol/biosynthesis ; Coronary Artery Disease/prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Inflammation/diagnosis ; Inflammation/drug therapy
Chemical Substances	Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; C-Reactive Protein (9007-41-4) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2010-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/CCLM.2010.277
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Zs.A 121: Show issues

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Article ; Online: The Accessory Spleen Is an Important Pitfall of 68Ga-DOTANOC PET/CT in the Workup for Pancreatic Neuroendocrine Neoplasm.

Rufini, Vittoria / Inzani, Frediano / Stefanelli, Antonella / Castaldi, Paola / Perotti, Germano / Cinquino, Annarita / Indovina, Luca / Rindi, Guido

Pancreas

2017 Volume 46, Issue 2, Page(s) 157–163

Abstract: Objective: The aim of the study was to assess the value and potential pitfalls of Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN).: Methods: Consecutive ... ...

Abstract	Objective: The aim of the study was to assess the value and potential pitfalls of Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). Methods: Consecutive patients referred for Ga-DOTANOC PET/CT for suspected pNEN between May 1, 2011, and October 31, 2014, were retrospectively assessed. Scan data were compared with cytological/histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. Results: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. Conclusions: Intrapancreatic accessory spleen is an important pitfall in Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken.
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000000728
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Zs.A 2160: Show issues

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Article ; Online: Procalcitonin and acute coronary syndromes: a new biomarker for an old disease.

Biasucci, Luigi M / Biasillo, Gina / Stefanelli, Antonella

Internal and emergency medicine

2009 Volume 4, Issue 5, Page(s) 363–365

MeSH term(s)	Acute Coronary Syndrome/diagnosis ; Biomarkers/blood ; Calcitonin/blood ; Calcitonin Gene-Related Peptide ; Humans ; Protein Precursors/blood
Chemical Substances	Biomarkers ; CALCA protein, human ; Protein Precursors ; Calcitonin (9007-12-9) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2009-07-29
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-009-0295-7
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Zs.A 6673: Show issues

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Article ; Online: Neuroendocrine differentiation in castration resistant prostate cancer. Nuclear medicine radiopharmaceuticals and imaging techniques: A narrative review.

Usmani, Sharjeel / Orevi, Marina / Stefanelli, Antonella / Zaniboni, Alberto / Gofrit, Ofer Nathan / Bnà, Claudio / Illuminati, Sonia / Lojacono, Giulia / Noventa, Silvia / Savelli, Giordano

Critical reviews in oncology/hematology

2019 Volume 138, Page(s) 29–37

Abstract: Background: Androgen Deprivation Therapy (ADT) is the primary treatment for patients suffering from relapsing or advanced prostate cancer (PC). Hormone therapy generally guarantees adequate clinical control of the disease for some years, even in those ... ...

Abstract	Background: Androgen Deprivation Therapy (ADT) is the primary treatment for patients suffering from relapsing or advanced prostate cancer (PC). Hormone therapy generally guarantees adequate clinical control of the disease for some years, even in those patients affected by widespread skeletal and soft tissue metastases. Despite ADT, however, most patients treated with hormones eventually progress to castration-resistant prostate cancer (CRPC), for which there are no effective treatments. This clinical reality is an open challenge to the oncologist because of those neoplasms which elaborate neuroendocrine differentiation (NED). Methods: An online search of current and past literature on NED in CRPC was performed. Relevant articles dealing with the biological and pathological basis of NED, with nuclear medicine imaging in CRPC and somatostatin treatment in NED were analyzed. Evidence from the literature: NED may arise in prostate cancer patients in the late stages of ADT. The onset of NED offers prognostic insight because it reflects a dramatic increase in the aggressive nature of the neoplasm. Several genetic, molecular, cytological and immunohistochemical markers are associated with this transformation. Among these, overexpression of somatostatin receptors, seen through Nuclear Medicine testing, is one of the most studied. Conclusions: Preliminary studies show that the overexpression of somatostatin receptors related to NED in CRPC may easily be studied in vivo with PET/CT. This finding offers a potentially useful objective for targeted therapy in CRPC. If the overexpression of SSTRs is shown to afflict a significant segment of patients with CRPC, this will open further study of possible therapeutic options based on this marker.
MeSH term(s)	Biomarkers, Tumor/analysis ; Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Neuroendocrine/pathology ; Humans ; Male ; Nuclear Medicine/methods ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms, Castration-Resistant/diagnostic imaging ; Prostatic Neoplasms, Castration-Resistant/pathology ; Radiopharmaceuticals ; Receptors, Somatostatin/analysis
Chemical Substances	Biomarkers, Tumor ; Radiopharmaceuticals ; Receptors, Somatostatin
Language	English
Publishing date	2019-03-30
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2019.03.005
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