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  1. AU="Steger, Klaus"
  2. AU=Tremaine W J
  3. AU="Pitha, Paula M"
  4. AU="Carmen Ruiz de Almodóvar"
  5. AU="Qiu, Xudong"
  6. AU="Groh, M"
  7. AU="Defres, S"
  8. AU="Khurana, Navneet"
  9. AU="Yanshan Yang"
  10. AU=Brouillet Emmanuel AU=Brouillet Emmanuel
  11. AU="Rajput, Sandeep"
  12. AU="Mansfield, Shawn D"
  13. AU="Isolan, Cecilia"
  14. AU="Li, Yiran"
  15. AU="Kang, Weechang"
  16. AU="Landoni, Elisa"
  17. AU=McCubbin Keith I AU=McCubbin Keith I
  18. AU="Jessica Bijsterbosch"
  19. AU="Dela Cruz, Charles S."
  20. AU="Yoo, Jennifer"
  21. AU="Berger, Miriam B"
  22. AU="Carlson, Jeffrey R"

Suchergebnis

Treffer 1 - 10 von insgesamt 98

Suchoptionen

  1. Buch ; Dissertation / Habilitation: Die Regulation der Genexpression von Kernproteinen während der Spermiogenese des Mannes

    Steger, Klaus

    1999  

    Verfasserangabe vorgelegt von: Klaus Steger
    Sprache Deutsch
    Umfang Getr. Zählung, Ill., graph. Darst., 30 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Gießen, Univ., Habil.-Schr., [2000]
    Anmerkung Enth. 3 Sonderabdr. aus verschiedenen Zeitschr.
    HBZ-ID HT012936765
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2001 E 472 bestellbar zur Nutzung im Lesesaal Magazin

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  2. Buch: Regulation of sertoli cell and germ cell differentation

    Brehm, Ralph / Steger, Klaus

    (Advances in anatomy, embryology and cell biology ; 181)

    2005  

    Verfasserangabe R. Brehm ; K. Steger
    Serientitel Advances in anatomy, embryology and cell biology ; 181
    Überordnung
    Schlagwörter Mann ; Sterilität ; Hodenkrebs ; Sertoli-Zelle ; Zelldifferenzierung ; Gamet ; Spermatogenese
    Schlagwörter Spermiogenese ; Spermienbildung ; Zelle ; Fortpflanzungszelle ; Geschlechtszelle ; Keimzelle ; Germ cell ; Stützzelle ; Maligner Hodentumor ; Infertilität ; Unfruchtbarkeit ; Erwachsener Mann ; Männlicher Erwachsener ; Männer
    Sprache Englisch
    Umfang X, 97 S. : Ill.
    Verlag Springer
    Erscheinungsort Berlin u.a.
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT014499231
    ISBN 3-540-25750-0 ; 978-3-540-25750-9
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    Zs A 6 -181- nicht ausleihbar Zeitschriften-Lesesaal

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  3. Buch ; Dissertation / Habilitation: Untersuchungen zur Immunsuppression mit Tacrolimus in Kombination mit monoklonalen Antikörpern gegen Aktivierungsantigene nach orthotoper Rattenlebertransplantation

    Steger, Klaus Ulrich

    1999  

    Verfasserangabe vorgelegt von Klaus Ulrich Steger
    Sprache Deutsch
    Umfang 67 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Würzburg, Univ., Diss., 1999
    HBZ-ID HT011213265
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2000 D 397 bestellbar zur Ausleihe Magazin

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  4. Buch ; Dissertation / Habilitation: Zirkadiane Rhythmik des Serumeisenspiegels

    Steger, Klaus

    1989  

    Umfang 71 Bl. : graph. Darst.
    Erscheinungsland XA-DDDE
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Leipzig, Univ., Diss., 1989
    HBZ-ID HT003419276
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    89 E 2818 bestellbar zur Ausleihe Magazin

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  5. Artikel ; Online: Sperm nuclear protamines: A checkpoint to control sperm chromatin quality.

    Steger, Klaus / Balhorn, Rod

    Anatomia, histologia, embryologia

    2018  Band 47, Heft 4, Seite(n) 273–279

    Abstract: Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. Their replacement of histones and binding to DNA is followed by chromatin hypercondensation that protects DNA from negative influences by environmental factors. ... ...

    Abstract Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. Their replacement of histones and binding to DNA is followed by chromatin hypercondensation that protects DNA from negative influences by environmental factors. Mammalian sperm contain two types of protamines: PRM1 and PRM2. While the proportion of the two protamines is highly variable between different species, abnormal ratios within a species are known to be associated with male subfertility. Therefore, it is more than likely that correct protamine expression represents a kind of chromatin checkpoint during sperm development rendering protamines as suitable biomarkers for the estimation of sperm quality. This review presents an overview of our current knowledge on protamines comparing gene and protein structures between different mammalian species with particular consideration given to man, mouse and stallion. At last, recent insights into the possible role of inherited sperm histones for early embryo development are provided.
    Mesh-Begriff(e) Animals ; Biological Evolution ; Chromatin/physiology ; Fertility/genetics ; Gene Expression ; Horses ; Humans ; Male ; Mice ; Protamines/chemistry ; Protamines/classification ; Protamines/genetics ; Spermatozoa/chemistry
    Chemische Substanzen Chromatin ; Protamines
    Sprache Englisch
    Erscheinungsdatum 2018-05-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/ahe.12361
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  6. Artikel: Sperm nuclear protamines: A checkpoint to control sperm chromatin quality

    Steger, Klaus / Rod Balhorn

    Anatomia, histologia, embryologia. 2018 Aug., v. 47, no. 4

    2018  

    Abstract: Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. Their replacement of histones and binding to DNA is followed by chromatin hypercondensation that protects DNA from negative influences by environmental factors. ... ...

    Abstract Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. Their replacement of histones and binding to DNA is followed by chromatin hypercondensation that protects DNA from negative influences by environmental factors. Mammalian sperm contain two types of protamines: PRM1 and PRM2. While the proportion of the two protamines is highly variable between different species, abnormal ratios within a species are known to be associated with male subfertility. Therefore, it is more than likely that correct protamine expression represents a kind of chromatin checkpoint during sperm development rendering protamines as suitable biomarkers for the estimation of sperm quality. This review presents an overview of our current knowledge on protamines comparing gene and protein structures between different mammalian species with particular consideration given to man, mouse and stallion. At last, recent insights into the possible role of inherited sperm histones for early embryo development are provided.
    Schlagwörter biomarkers ; chromatin ; DNA ; embryogenesis ; environmental factors ; genes ; haploidy ; histones ; male fertility ; mice ; protamines ; protein structure ; sperm quality ; stallions
    Sprache Englisch
    Erscheinungsverlauf 2018-08
    Umfang p. 273-279.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung REVIEW
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/ahe.12361
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  7. Artikel ; Online: The Role of the LINC Complex in Sperm Development and Function.

    Kmonickova, Vera / Frolikova, Michaela / Steger, Klaus / Komrskova, Katerina

    International journal of molecular sciences

    2020  Band 21, Heft 23

    Abstract: The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology ... ...

    Abstract The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic structures. While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. A further complex present in spermatozoa is involved in head-to-tail coupling. An intact LINC complex is crucial for the production of fertile sperm, as mutations in genes encoding for complex proteins are known to be associated with male subfertility in both mice and men. The present review provides a comprehensive overview on our current knowledge of LINC complex subtypes present in germ cells and its central role for male reproduction. Future studies on distinct LINC complex components are an absolute requirement to improve the diagnosis of idiopathic male factor infertility and the outcome of assisted reproduction.
    Mesh-Begriff(e) Animals ; Cell Nucleus/metabolism ; Humans ; Infertility, Male/metabolism ; Infertility, Male/pathology ; Male ; Models, Biological ; Multiprotein Complexes/metabolism ; Spermatozoa/metabolism
    Chemische Substanzen Multiprotein Complexes
    Sprache Englisch
    Erscheinungsdatum 2020-11-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21239058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health.

    Schagdarsurengin, Undraga / Steger, Klaus

    Nature reviews. Urology

    2016  Band 13, Heft 10, Seite(n) 584–595

    Abstract: Epigenetic inheritance and its underlying molecular mechanisms are among the most intriguing areas of current biological and medical research. To date, studies have shown that both female and male germline development follow distinct paths of epigenetic ... ...

    Abstract Epigenetic inheritance and its underlying molecular mechanisms are among the most intriguing areas of current biological and medical research. To date, studies have shown that both female and male germline development follow distinct paths of epigenetic events and both oocyte and sperm possess their own unique epigenomes. Fertilizing male and female germ cells deliver not only their haploid genomes but also their epigenomes, which contain the code for preimplantation and postimplantation reprogramming and embryonal development. For example, in spermatozoa, DNA methylation profile, DNA-associated proteins, protamine 1:protamine 2 ratio, nucleosome distribution pattern, histone modifications and other properties make up a unique epigenetic landscape. However, epigenetic factors and mechanisms possess certain plasticity and are affected by environmental conditions. Paternal and maternal lifestyle, including physical activity, nutrition and exposure to hazardous substances, can alter the epigenome and, moreover, can affect the health of their children. In male reproductive health, data are emerging on epigenetically mediated effects of a man's diet on sperm quality, for example through phytochemicals, minerals and vitamins, and nutritional support for subfertile men is already being used. In addition, studies in animal models and human epidemiological data point toward a transgenerational effect of the paternally contributed sperm epigenome on offspring health.
    Mesh-Begriff(e) Diet ; Epigenesis, Genetic ; Fertility ; Humans ; Male ; Spermatozoa
    Sprache Englisch
    Erscheinungsdatum 2016-08-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/nrurol.2016.157
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Comparison of ART outcomes in men with altered mRNA protamine 1/protamine 2 ratio undergoing intracytoplasmic sperm injection with ejaculated and testicular spermatozoa.

    Sarasa, Jonás / Enciso, María / García, Laura / Leza, Andrea / Steger, Klaus / Aizpurua, Jon

    Asian journal of andrology

    2021  Band 22, Heft 6, Seite(n) 623–628

    Abstract: Assisted reproductive technologies involving the use of spermatozoa and eggs for in vitro fertilization (IVF) have come as the solution for many infertile couples to become parents. However, in some cases, the use of ejaculated spermatozoa delivers poor ... ...

    Abstract Assisted reproductive technologies involving the use of spermatozoa and eggs for in vitro fertilization (IVF) have come as the solution for many infertile couples to become parents. However, in some cases, the use of ejaculated spermatozoa delivers poor IVF performance. Some studies have suggested the use of testicular spermatozoa in severe male infertility cases, but no guidelines regarding their utilization are currently available. In the present study, we found the mRNA protamine 1/protamine 2 (P1/P2) ratio to be a valuable biomarker of poor sperm function that could be used as a diagnostic key for the identification of cases that would benefit from the use of testicular spermatozoa. A total of 23 couples undergoing egg donation cycles with at least one previous cycle failure were studied. All couples underwent two consecutive intracytoplasmic sperm injection (ICSI) cycles with either ejaculated or testicular spermatozoa (TESA). The sperm mRNA P1/P2 ratio, fertilization rate, blastocyst rate, and pregnancy and live birth rate were compared. Results showed improved ICSI and clinical outcomes in cycles with testicular spermatozoa in men with altered mRNA P1/P2 ratios. TESA cycles presented significantly higher rates of fertilization (mean ± standard deviation: 76.1% ± 15.1% vs 65.5% ± 18.8%), blastocyst formation (55.0% ± 20.3% vs 30.8% ± 23.8%), and good morphological quality blastocyst (28.9% ± 22.9% vs 13.5% ± 17.9%) and also improvements on pregnancy (60.9% vs 0%) and healthy birth rates (56.5% vs 0%) than EJACULATE cycles. The results described here suggest that in patients with previous IVF/ICSI failures and aberrant mRNA protamine ratios, the use of testicular spermatozoa may be a good alternative to improve clinical outcomes.
    Mesh-Begriff(e) Adult ; Humans ; Male ; Middle Aged ; Protamines/metabolism ; RNA, Messenger/metabolism ; Reproductive Techniques, Assisted ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Sperm Retrieval ; Spermatozoa/physiology ; Treatment Outcome
    Chemische Substanzen PRM1 protein, human ; Protamines ; RNA, Messenger ; protamine 2
    Sprache Englisch
    Erscheinungsdatum 2021-01-04
    Erscheinungsland China
    Dokumenttyp Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja.aja_146_19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Effect of Khat (Catha edulis Forsk) extract on testicular maturation in pre‐pubertal and pubertal rats: A morphological and biochemical study

    Abou‐Elhamd, Alaa S / Sumayli, Saud / Steger, Klaus / Ali, Asaad Khaled Mohamed / Zayed, Ahmed E

    Anatomia, histologia, embryologia. 2021 Mar., v. 50, no. 2

    2021  

    Abstract: The present study aimed at analysing the effect of Khat plant extract on rat testicular development. Thirty‐two weaned male albino rats (4 weeks old) were divided into four groups consisting of eight animals each. While control animals received normal ... ...

    Abstract The present study aimed at analysing the effect of Khat plant extract on rat testicular development. Thirty‐two weaned male albino rats (4 weeks old) were divided into four groups consisting of eight animals each. While control animals received normal saline, rats of groups I, II and III received 100, 200 and 300 mg Khat extract per kg body weight dissolved in distilled water by oral gavage daily for 8 weeks, respectively. Blood samples were collected in separate heparinized tubes by cardiac puncture from each rat and processed for measuring plasma levels of reproductive hormones LH, FSH, testosterone and prolactin. Five‐µm sections were stained with haematoxylin and eosin and examined by light microscope. Some sections were immunostained for protamine‐1 representing a biomarker for intact sperm differentiation. The present study clearly demonstrated that Khat extract has a pronounced effect on testicular maturation of developing albino rats at both the morphological and functional levels. Khat‐treated groups revealed a significantly low serum testosterone level and severe impairment of spermatogenesis when compared with control animals. The current findings also verified, for the first time, that the final stages of sperm maturation (spermiogenesis) were strongly impaired after administration of Khat extract to experimental rats particularly at a higher dose (300 mg/kg body weight). This was proved by the very weak, if any, expression of protamine‐1 in the maturing spermatids in Khat‐treated rats.
    Schlagwörter Catha edulis ; albino ; biomarkers ; blood serum ; body weight ; eosin ; light microscopes ; males ; plant extracts ; prolactin ; puberty ; rats ; spermatids ; spermatozoa ; spermiogenesis ; testes ; testicular development ; testosterone
    Sprache Englisch
    Erscheinungsverlauf 2021-03
    Umfang p. 271-283.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-light ; JOURNAL ARTICLE
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/ahe.12626
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