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Article: Possible Advantages of Minimal-Invasive Approaches in Rectal Cancer Surgery: A Nationwide Analysis.

Horvath, Philipp / Steidle, Christoph / Yurttas, Can / Baur, Isabella / Königsrainer, Alfred / Königsrainer, Ingmar

2023 Volume 12, Issue 14

Abstract: 1) Background: Laparoscopic resection for colon and rectal cancer was introduced in the early 1990s; the aim of this analysis was to show possible advantages of minimal-invasive approaches in rectal cancer surgery. (2) Methods: From 2016 to 2020, all ... ...

Abstract	(1) Background: Laparoscopic resection for colon and rectal cancer was introduced in the early 1990s; the aim of this analysis was to show possible advantages of minimal-invasive approaches in rectal cancer surgery. (2) Methods: From 2016 to 2020, all patients undergoing open, laparoscopic or robotic-assisted rectal cancer surgery in Germany were retrospectively analyzed regarding sex distribution, conversion rates and in-hospital mortality rates according to nationwide hospital billing data based on diagnosis-related groups (DRGs). (3) Results: In total, 68,112 patients were analyzed, and most commonly, low anterior rectal resections with primary anastomosis (
Language	English
Publishing date	2023-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144765
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Article: Current Medical Care Situation of Patients in Germany Undergoing Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).

Horvath, Philipp / Yurttas, Can / Baur, Isabella / Steidle, Christoph / Reymond, Marc André / Girotti, Paolo Nicola Camillo / Königsrainer, Alfred / Königsrainer, Ingmar

Cancers

2022 Volume 14, Issue 6

Abstract: Objective: Tailored approaches in gastrointestinal oncology have been more frequently introduced in past years and for patients with peritoneal metastases. This article attempts to overview the current strategies in surgical gastrointestinal oncology, ... ...

Abstract	Objective: Tailored approaches in gastrointestinal oncology have been more frequently introduced in past years and for patients with peritoneal metastases. This article attempts to overview the current strategies in surgical gastrointestinal oncology, with a focus on gastrointestinal peritoneal metastases. Methods: In 2019, all patients undergoing PIPAC therapy in Germany were retrospectively analyzed regarding morbidity and in-hospital mortality rates. Furthermore, patients with chemotherapy-refractory peritoneal metastases from gastric cancer undergoing PIPAC-therapy at our institution were analyzed. Results: In 2019, 534 patients received PIPAC treatment in german hospitals. The in-hospital mortality rate was 0%. In total, 36 patients suffered from postoperative complications (8%). From April 2016 to September 2021, a total of 44 patients underwent 93 PIPAC applications at our institution. The non-access-rate was 0%. The median PRGS was two (range, 1-4). Eleven patients (44%) showed histologically stable disease, whereas six patients (24%) showed histological regression. Median survival, calculated from the date of the first PIPAC application, was 181 days (range, 43-636 days). Conclusions: PIPAC is a safe and feasible procedure with a low in-hospital morbidity and mortality. Furthermore, PIPAC in the palliative and chemorefractory setting and is an appealing approach for patient management in the future.
Language	English
Publishing date	2022-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14061443
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Article ; Online: Evaluating the diagnostic value of zoom endoscopic surveillance compared to routine biopsy after intestinal transplantation.

Wichmann, Dörte / Nadalin, Silvio / Schweizer, Ulrich / Solaß, Wiebke / Steidle, Christoph / Stüker, Dietmar / Lange, Jessica / Werner, Christoph R / Königsrainer, Alfred / Quante, Markus

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2022 Volume 54, Issue 3, Page(s) 385–390

Abstract: Background: After intestinal transplantation, close allograft monitoring especially during the early postoperative period is crucial since the intestine is a highly immunogenic organ. Current protocols are based on endoscopic and histologic examination ... ...

Abstract	Background: After intestinal transplantation, close allograft monitoring especially during the early postoperative period is crucial since the intestine is a highly immunogenic organ. Current protocols are based on endoscopic and histologic examination with the latter one being linked to the risk of bleeding and perforation. Aims: Evaluation of the diagnostic value of endoscopy utilizing magnification to predict acute cellular rejection compared to routine allograft biopsies. Methods: Fourteen patients underwent the protocol with longitudinal zoom endoscopic and histological graft monitoring during the first year after transplantation. The intestinal mucosa was analyzed during endoscopy utilizing the SASAKI score while a minimum of two biopsies were taken during each examination. A new graduation of severity for acute cellular rejection based on the findings of the SASAKI score is established. Results: Endoscopic findings of 385 examinations and more than 1000 intestinal allograft biopsies were analyzed. A total of 7 acute cellular rejection episodes in 6/14 patients occurred. Allograft endoscopy was able to diagnose ACR with a sensitivity of 76% and a specificity of 82%. Conclusions: Our results will be critical for refining protocols for allograft monitoring after intestinal transplantation thus paving the way towards less invasive measures.
MeSH term(s)	Adult ; Biopsy ; Endoscopy, Gastrointestinal/methods ; Female ; Graft Rejection/diagnosis ; Humans ; Intestinal Mucosa/pathology ; Intestinal Mucosa/surgery ; Intestines/transplantation ; Male ; Middle Aged ; Postoperative Complications/diagnosis ; Predictive Value of Tests
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Evaluation Study ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2021.12.019
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Book ; Online: Kummunale Bewegungsförderung bei Menschen mit socialer Benachteiliging

Semrau, J. / Steidle, C. / Wolff, A. / Amann, K. / Mulderij, L.S. / Wolters, F. / Wagemakers, A. / Verkooijen, K.T.

Workshop during conference

2019

Keywords	Life Science
Language	German
Publishing country	nl
Document type	Book ; Online
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Article ; Online: Hip Revision Arthroplasty of Periprosthetic Fractures Vancouver B2 and B3 with a Modular Revision Stem: Short-Term Results and Review of Literature.

Schreiner, Anna Janine / Steidle, Christoph / Schmidutz, Florian / Gonser, Christoph / Hemmann, Philipp / Stöckle, Ulrich / Ochs, Gunnar

Zeitschrift fur Orthopadie und Unfallchirurgie

2020 Volume 160, Issue 1, Page(s) 40–48

Abstract: Background: Periprosthetic fractures Vancouver type B2/B3 after total hip arthroplasty (THA) is a challenging entity with increasing numbers. Limited data are available for this type of fracture treated with modular stems. Therefore, this study ... ...

Title translation	Hüftrevisionsendoprothetik bei periprothetischen Frakturen Typ Vancouver B2 und B3 mit einem modularen Revisionsschaft: Kurzfristige Resultate und ein Literaturüberblick.
Abstract	Background: Periprosthetic fractures Vancouver type B2/B3 after total hip arthroplasty (THA) is a challenging entity with increasing numbers. Limited data are available for this type of fracture treated with modular stems. Therefore, this study evaluated the outcome of Vancouver type B2/B3 fractures treated with a modular hip revision stem using a subproximal/distal anchorage and compared it to the current literature. Materials and methods: A consecutive series of periprosthetic Vancouver type B2/B3 fractures treated with a modular revision stem was retrospectively (2013 - 2016) evaluated. Assessment included the clinical (HHS, pain, ROM) as well as the radiological outcome (subsidence, loosening, facture healing). In adddition, the surgical technique is described in detail and results are compared with the current literature. Results: A total of 18 patients (female/male 12/6) with Vancouver B2/B3 (n = 12/6) fractures with a mean age of 75.5 (60 - 89) years were included. The revision stem was inserted via a modified transgluteal approach (n = 16) or classical transfemoral approach (n = 2). The mean follow-up was 18.5 months, with a mean Harris Hip Score of 72.5 ± 18.7 (35.0 - 99.0) points. The fracture healing rate was 94.4% (n = 17) with osseous integration according to Engh in all cases. Dislocations of the greater trochanter were recorded in seven patients (38.9%). According to Beals and Towers, all results were rated excellent or good. No implant-related failure or relevant subsidence during this time was observed. Major complications were observed in five patients with two periprosthetic joint infections and two cases of major revision surgery. Conclusion: This study assessing Vancouver B2/3 fractures shows reproducible, good, short-term results in terms of subsidence and clinical functional outcome by the use of a modular revision stem. The transfemoral approach together with the modular stem allows for a stable fixation and good fracture healing. However, our data and review of the literature also documents the difficulties and higher complication rate associated with Vancouver B2/3 fractures.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Periprosthetic Fractures/etiology ; Periprosthetic Fractures/surgery ; Reoperation ; Retrospective Studies
Language	English
Publishing date	2020-08-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2280747-0
ISSN	1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
ISSN (online)	1864-6743 ; 1438-941X
ISSN	1864-6697 ; 0044-3220
DOI	10.1055/a-1209-4002
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Article ; Online: SARS-CoV-2 in Solid Organ Transplant Recipients: A Structured Review of 2020.

Quante, Markus / Brake, Linda / Tolios, Alexander / Della Penna, Andrea / Steidle, Christoph / Gruendl, Magdalena / Grishina, Anna / Haeberle, Helene / Guthoff, Martina / Tullius, Stefan G / Königsrainer, Alfred / Nadalin, Silvio / Löffler, Markus W

Transplantation proceedings

2021 Volume 53, Issue 8, Page(s) 2421–2434

Abstract: Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging health systems all over the world. Particularly high-risk groups show considerable mortality rates after infection. In 2020, a huge number of case ... ...

Abstract	Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging health systems all over the world. Particularly high-risk groups show considerable mortality rates after infection. In 2020, a huge number of case reports, case series, and consecutively various systematic reviews have been published reporting on morbidity and mortality risk connected with SARS-CoV-2 in solid organ transplant (SOT) recipients. However, this vast array of publications resulted in an increasing complexity of the field, overwhelming even for the expert reader. Methods: We performed a structured literature review comprising electronic databases, transplant journals, and literature from previous systematic reviews covering the entire year 2020. From 164 included articles, we identified 3451 cases of SARS-CoV-2-infected SOT recipients. Results: Infections resulted in a hospitalization rate of 84% and 24% intensive care unit admissions in the included patients. Whereas 53.6% of patients were reported to have recovered, cross-sectional overall mortality reported after coronavirus disease 2019 (COVID-19) was at 21.1%. Synoptic data concerning immunosuppressive medication attested to the reduction or withdrawal of antimetabolites (81.9%) and calcineurin inhibitors (48.9%) as a frequent adjustment. In contrast, steroids were reported to be increased in 46.8% of SOT recipients. Conclusions: COVID-19 in SOT recipients is associated with high morbidity and mortality worldwide. Conforming with current guidelines, modifications of immunosuppressive therapies mostly comprised a reduction or withdrawal of antimetabolites and calcineurin inhibitors, while frequently maintaining or even increasing steroids. Here, we provide an accessible overview to the topic and synoptic estimates of expectable outcomes regarding in-hospital mortality of SOT recipients with COVID-19.
MeSH term(s)	COVID-19/epidemiology ; Cross-Sectional Studies ; Humans ; Organ Transplantation ; Pandemics ; SARS-CoV-2 ; Transplant Recipients
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2021.08.019
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Article ; Online: Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone.

Shabsigh, R / Kaufman, J M / Steidle, C / Padma-Nathan, H

The Journal of urology

2008 Volume 179, Issue 5 Suppl, Page(s) S97–S102

Abstract: Purpose: We compare the efficacy of testosterone gel (T-gel) versus placebo as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone.: Materials and methods: A randomized, placebo ... ...

Abstract	Purpose: We compare the efficacy of testosterone gel (T-gel) versus placebo as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. Materials and methods: A randomized, placebo controlled, double-blind, parallel group, multicenter study was performed. A total of 75 hypogonadal men (18 to 80 years old, morning serum total testosterone 400 ng/dl or less) with confirmed lack of response to sildenafil monotherapy were randomized (1:1) to receive a daily dose of 1% T-gel or 5 gm placebo gel as adjunctive therapy to 100 mg sildenafil during a 12-week period. Subjects were evaluated for sexual function, primarily based on the International Index of Erectile Function (IIEF), quality of life and serum testosterone levels at baseline and weeks 4, 8 and 12. Results: Testosterone treated subjects had greater improvement in erectile function compared to those who received placebo, reaching statistical significance at week 4 (4.4 vs 2.1, p = 0.029, 95.1% CI 0.3, 4.7). Similar trends were observed for improvements in orgasmic function, overall satisfaction, total IIEF score and percentage of IIEF responders. T-gel significantly (p < or = 0.004) increased total and free testosterone levels throughout the study, although no significant correlations were made between testosterone levels and the IIEF at end point. Conclusions: T-gel taken with sildenafil may be beneficial in improving erectile function in hypogonadal men with erectile dysfunction who are unresponsive to sildenafil alone.
Language	English
Publishing date	2008-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2008.03.145
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Article: [No title information]

Schreiner, Anna Janine / Steidle, Christoph / Schmidutz, Florian / Gonser, Christoph / Hemmann, Philipp / Stöckle, Ulrich / Ochs, Gunnar

Zeitschrift für Orthopädie und Unfallchirurgie

2020 Volume 160, Issue 01, Page(s) 40–48

Abstract: Background: Periprosthetic fractures Vancouver type B2/B3 after total hip ... arthroplasty (THA) is a challenging entity with increasing numbers. Limited data ... are available for this type of fracture treated with modular stems. Therefore, ...

Abstract	Background: Periprosthetic fractures Vancouver type B2/B3 after total hip arthroplasty (THA) is a challenging entity with increasing numbers. Limited data are available for this type of fracture treated with modular stems. Therefore, this study evaluated the outcome of Vancouver type B2/B3 fractures treated with a modular hip revision stem using a subproximal/distal anchorage and compared it to the current literature. Materials and Methods: A consecutive series of periprosthetic Vancouver type B2/B3 fractures treated with a modular revision stem was retrospectively (2013 – 2016) evaluated. Assessment included the clinical (HHS, pain, ROM) as well as the radiological outcome (subsidence, loosening, facture healing). In adddition, the surgical technique is described in detail and results are compared with the current literature. Results: A total of 18 patients (female/male 12/6) with Vancouver B2/B3 (n = 12/6) fractures with a mean age of 75.5 (60 – 89) years were included. The revision stem was inserted via a modified transgluteal approach (n = 16) or classical transfemoral approach (n = 2). The mean follow-up was 18.5 months, with a mean Harris Hip Score of 72.5 ± 18.7 (35.0 – 99.0) points. The fracture healing rate was 94.4% (n = 17) with osseous integration according to Engh in all cases. Dislocations of the greater trochanter were recorded in seven patients (38.9%). According to Beals and Towers, all results were rated excellent or good. No implant-related failure or relevant subsidence during this time was observed. Major complications were observed in five patients with two periprosthetic joint infections and two cases of major revision surgery. Conclusion: This study assessing Vancouver B2/3 fractures shows reproducible, good, short-term results in terms of subsidence and clinical functional outcome by the use of a modular revision stem. The transfemoral approach together with the modular stem allows for a stable fixation and good fracture healing. However, our data and review of the literature also documents the difficulties and higher complication rate associated with Vancouver B2/3 fractures.
Keywords	periprosthetic fractures ; Vancouver B2 B3 ; hip arthroplasty ; revision arthroplasty ; modular stem ; periprothetische Frakturen ; Vancouver B2 B3 ; Hüftendoprothetik ; Revisionsendoprothetik ; modularer Schaft
Language	English
Publishing date	2020-08-03
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2280747-0
ISSN	1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
ISSN (online)	1864-6743 ; 1438-941X
ISSN	1864-6697 ; 0044-3220
DOI	10.1055/a-1209-4002
Database	Thieme publisher's database

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Article: Präferenzen von beruflich Pflegenden zu neuen Berufsbezeichnungen im Sinne des geplanten Pflegeberufegesetzes

Reuschenbach, Bernd / Daufratshofer, Lisa / Demmelhuber, Carolin / Steidle, Cordula / Paul, Lisa

Pflegewissenschaft

2016 Volume 18, Issue 11/12, Page(s) 597

Language	German
Document type	Article
ZDB-ID	2407183-3
ISSN	1662-3029 ; 1422-8629
Database	Current Contents Medicine

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Article ; Online: Neoadjuvant androgen deprivation therapy for prostate volume reduction, lower urinary tract symptom relief and quality of life improvement in men with intermediate- to high-risk prostate cancer: a randomised non-inferiority trial of degarelix versus goserelin plus bicalutamide.

Mason, M / Maldonado Pijoan, X / Steidle, C / Guerif, S / Wiegel, T / van der Meulen, E / Bergqvist, P B F / Khoo, V

Clinical oncology (Royal College of Radiologists (Great Britain))

2012 Volume 25, Issue 3, Page(s) 190–196

Abstract: Aims: The treatment of intermediate- to high-risk prostate cancer with radical radiotherapy is usually in combination with neoadjuvant androgen deprivation therapy. The aim of the present trial was to investigate whether degarelix achieves comparable ... ...

Abstract	Aims: The treatment of intermediate- to high-risk prostate cancer with radical radiotherapy is usually in combination with neoadjuvant androgen deprivation therapy. The aim of the present trial was to investigate whether degarelix achieves comparable efficacy with that of goserelin plus bicalutamide as neoadjuvant therapy before radiotherapy. Materials and methods: The study was a randomised, parallel-arm, active-controlled, open-label trial in 244 men with a UICC prostate cancer TNM category T2b-T4, N0, M0, Gleason score ≥7, or prostate-specific antigen ≥10 ng/ml and a total prostate volume >30 ml, who were scheduled to undergo radical radiotherapy and in whom neoadjuvant androgen deprivation therapy was indicated. Eligible patients received treatment with either monthly degarelix (240/80 mg) or goserelin (3.6 mg) for 12 weeks, the latter patients also receiving bicalutamide (50 mg) for 17 days initially. The primary efficacy measure was the mean percentage reduction in total prostate volume from baseline at week 12 measured by transrectal ultrasound. The severity and relief of lower urinary tract symptoms were assessed by the International Prostate Symptom Score questionnaire. Quality of life was assessed by the eighth question of the International Prostate Symptom Score. About 50% of the patients had moderate to severe lower urinary tract symptoms at baseline. Results: The total prostate volume decreased significantly from baseline to week 12 in both treatment groups, reaching -36.0 ± 14.5% in degarelix-treated patients and -35.3 ± 16.7% in goserelin-treated patients (adjusted difference: -0.3%; 95% confidence interval: -4.74; 4.14%). At the end of the therapy, more degarelix- than goserelin-treated patients reported International Prostate Symptom Score decreases of ≥3 points (37% versus 27%, P = 0.21). In addition, in patients with a baseline International Prostate Symptom Score of ≥13, the magnitude of the decrease was larger in degarelix- (n = 53) versus goserelin-treated patients (n = 17) (6.04 versus 3.41, P = 0.06). Conclusions: The efficacy of degarelix in terms of prostate shrinkage is non-inferior to that of goserelin plus bicalutamide. The added benefits of degarelix in terms of more pronounced lower urinary tract symptom relief in symptomatic patients could be the reflection of differences in the direct effects on extra-pituitary receptors in the lower urinary tract [Clinicaltrials.gov ID: NCT00833248].
MeSH term(s)	Aged ; Androgen Antagonists/adverse effects ; Androgen Antagonists/therapeutic use ; Anilides/administration & dosage ; Anilides/adverse effects ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Goserelin/administration & dosage ; Goserelin/adverse effects ; Humans ; Kallikreins/blood ; Male ; Neoadjuvant Therapy ; Nitriles/administration & dosage ; Nitriles/adverse effects ; Oligopeptides/adverse effects ; Oligopeptides/therapeutic use ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Quality of Life ; Risk Factors ; Testosterone/blood ; Tosyl Compounds/administration & dosage ; Tosyl Compounds/adverse effects
Chemical Substances	Androgen Antagonists ; Anilides ; Antineoplastic Agents, Hormonal ; Nitriles ; Oligopeptides ; Tosyl Compounds ; acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide ; Goserelin (0F65R8P09N) ; Testosterone (3XMK78S47O) ; bicalutamide (A0Z3NAU9DP) ; KLK3 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2012-12-17
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2012.09.010
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