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  1. Article: Diagnostic Accuracy of Multiplex Polymerase Chain Reaction in Early Onset Neonatal Sepsis.

    Stein, Anja / Soukup, Daniel / Rath, Peter-Michael / Felderhoff-Müser, Ursula

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 11

    Abstract: Early onset neonatal sepsis is a significant contributor to neonatal morbidity and mortality. Although blood cultures remain the diagnostic gold standard, they detect pathogens in only a minority of suspected cases. This study compared the accuracy of ... ...

    Abstract Early onset neonatal sepsis is a significant contributor to neonatal morbidity and mortality. Although blood cultures remain the diagnostic gold standard, they detect pathogens in only a minority of suspected cases. This study compared the accuracy of blood cultures with a rapid multiplex PCR test. Newborns at risk of neonatal sepsis were prospectively screened as recommended per national guidelines. Evaluations included laboratory parameters (CrP, IL6, differential blood count), blood culture, and a molecular multiplex PCR test (ROCHE LightCycler SeptiFast
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10111809
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  2. Article ; Online: Incidence of brain injuries in a large cohort of very preterm and extremely preterm infants at term-equivalent age: results of a single tertiary neonatal care center over 10 years.

    Drommelschmidt, Karla / Mayrhofer, Thomas / Hüning, Britta / Stein, Anja / Foldyna, Borek / Schweiger, Bernd / Felderhoff-Müser, Ursula / Sirin, Selma

    European radiology

    2024  

    Abstract: Objectives: Cerebral magnetic resonance imaging (cMRI) at term-equivalent age (TEA) can detect brain injury (BI) associated with adverse neurological outcomes in preterm infants. This study aimed to assess BI incidences in a large, consecutive cohort of ...

    Abstract Objectives: Cerebral magnetic resonance imaging (cMRI) at term-equivalent age (TEA) can detect brain injury (BI) associated with adverse neurological outcomes in preterm infants. This study aimed to assess BI incidences in a large, consecutive cohort of preterm infants born < 32 weeks of gestation, the comparison between very (VPT, ≥ 28 + 0 to < 32 + 0 weeks of gestation) and extremely preterm infants (EPT, < 28 + 0 weeks of gestation) and across weeks of gestation.
    Methods: We retrospectively analyzed cMRIs at TEA of VPT and EPT infants born at a large tertiary center (2009-2018). We recorded and compared the incidences of BI, severe BI, intraventricular hemorrhage (IVH), periventricular hemorrhagic infarction (PVHI), cerebellar hemorrhage (CBH), cystic periventricular leukomalacia (cPVL), and punctate white matter lesions (PWML) between VPTs, EPTs, and across weeks of gestation.
    Results: We included 507 preterm infants (VPT, 335/507 (66.1%); EPT, 172/507 (33.9%); mean gestational age (GA), 28 + 2 weeks (SD 2 + 2 weeks); male, 52.1%). BIs were found in 48.3% of the preterm infants (severe BI, 12.0%) and increased with decreasing GA. IVH, PVHI, CBH, cPVL, and PWML were seen in 16.8%, 0.8%, 10.5%, 3.4%, and 18.1%, respectively. EPT vs. VPT infants suffered more frequently from BI (59.3% vs. 42.7%, p < 0.001), severe BI (18.6% vs. 8.7%, p = 0.001), IVH (31.9% vs. 9.0%, p < 0.001), and CBH (18.0% vs. 6.6%, p < 0.001).
    Conclusion: Brain injuries are common cMRI findings among preterm infants with a higher incidence of EPT compared to VPT infants. These results may serve as reference values for clinical management and research.
    Clinical relevance statement: Our results with regard to gestational age might provide valuable clinical insights, serving as a key reference for parental advice, structured follow-up planning, and enhancing research and management within the Neonatal Intensive Care Unit.
    Key points: • Brain injury is a common cMRI finding in preterm infants seen in 48.3% individuals. • Extremely preterm compared to very preterm infants have higher brain injury incidences driven by brain injuries such as intraventricular and cerebellar hemorrhage. • Reference incidence values are crucial for parental advice and structured follow-up planning.
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10592-z
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  3. Article ; Conference proceedings: Einfluss der kumulativen Coffeindosis auf das neurologische Outcome bei Frühgeborenen < 32 Schwangerschaftswochen

    Grote, Kristin / Stein, Anja / Dewan, Monia Vanessa / Hüning, Britta Maria / Felderhoff-Müser, Ursula

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769378
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  4. Book ; Thesis: Zur Epidemiologie von Helicobacter pylori an einem Patientenkollektiv in einer internistisch-gastroenterologischen Praxis unter besonderer Berücksichtigung der Nationalität

    Brunke, Anja

    1997  

    Author's details vorgelegt von Anja Brunke
    Language German
    Size 118 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Diss., 1999
    HBZ-ID HT010910021
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    99 E 2462 order for loan Magazin

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  5. Article: Postpartal Affective and Endocrine Differences Between Parents of Preterm and Full-Term Infants.

    Weigl, Tobias / Schneider, Nora / Stein, Anja / Felderhoff-Müser, Ursula / Schedlowski, Manfred / Engler, Harald

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 251

    Abstract: Background: During the postpartum period, new parents frequently experience emotional stress and exhibit symptoms of depression and anxiety, accompanied by substantial endocrine changes. However, evidence predominantly exists from parents of full-term ... ...

    Abstract Background: During the postpartum period, new parents frequently experience emotional stress and exhibit symptoms of depression and anxiety, accompanied by substantial endocrine changes. However, evidence predominantly exists from parents of full-term infants, while data on parents of preterm infants are scarce. In this exploratory, cross-sectional study, we compared psychological well-being and endocrine parameters in parents of very preterm and term born infants.
    Methods: Mothers (N = 28) and fathers (N = 30) of full-term infants as well as mothers (N = 18) and fathers (N = 21) of very or extreme preterm infants (< 32
    Results: New mothers and fathers of very preterm infants exhibited higher scores of depression, anxiety and stress than parents of term infants. Besides, mothers of very preterm infants showed lower levels of estradiol, progesterone, and prolactin, as well as a heightened post-awakening cortisol response compared to mothers of term infants. Furthermore, in mothers of preterm infants we found significant negative associations between serum prolactin levels and BDI and STAI scores, respectively.
    Conclusions: Parents of very preterm infants suffered from a higher burden of psychological distress than parents of full-term infants. The affective symptoms in preterm mothers were accompanied by altered endocrine profiles that, at least to some extent, may contribute to the psychological changes. The profound psychological and physiological disturbances in mothers of preterm infants may have an impact on long-term mental health and early pharmacological and psychological interventions may help to ameliorate postpartum affective symptoms.
    Language English
    Publishing date 2020-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00251
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  6. Article: Early Prediction of Mortality after Birth Asphyxia with the nSOFA.

    Dathe, Anne-Kathrin / Stein, Anja / Bruns, Nora / Craciun, Elena-Diana / Tuda, Laura / Bialas, Johanna / Brasseler, Maire / Felderhoff-Mueser, Ursula / Huening, Britta M

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: 1) Birth asphyxia is a major cause of delivery room resuscitation. Subsequent organ failure and hypoxic-ischemic encephalopathy (HIE) account for 25% of all early postnatal deaths. The neonatal sequential organ failure assessment (nSOFA) considers ... ...

    Abstract (1) Birth asphyxia is a major cause of delivery room resuscitation. Subsequent organ failure and hypoxic-ischemic encephalopathy (HIE) account for 25% of all early postnatal deaths. The neonatal sequential organ failure assessment (nSOFA) considers platelet count and respiratory and cardiovascular dysfunction in neonates with sepsis. To evaluate whether nSOFA is also a useful predictor for in-hospital mortality in neonates (≥36 + 0 weeks of gestation (GA)) following asphyxia with HIE and therapeutic hypothermia (TH), (2) nSOFA was documented at ≤6 h of life. (3) A total of 65 infants fulfilled inclusion criteria for TH. All but one infant received cardiopulmonary resuscitation and/or respiratory support at birth. nSOFA was lower in survivors (median 0 [IQR 0-2];
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134322
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  7. Article ; Conference proceedings: Inzidenz pathologischer MRT-Befunde bei Frühgeborenen unter 32 Schwangerschaftswochen: Ergebnisse einer unizentrischen Studie über 10 Jahre

    Drommelschmidt, Karla / Mayrhofer, Thomas / Stein, Anja / Hüning, Britta Maria / Foldyna, Borek / Schweiger, Bernd / Felderhoff-Müser, Ursula / Sirin, Selma

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769209
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  8. Article: Reticular abdominal hyperpigmentation.

    Stein, Anja

    American family physician

    2004  Volume 70, Issue 10, Page(s) 1969–1970

    MeSH term(s) Abdominal Pain/etiology ; Abdominal Pain/therapy ; Adolescent ; Erythema/etiology ; Erythema/pathology ; Hot Temperature/adverse effects ; Humans ; Male ; Peritoneal Dialysis/adverse effects
    Language English
    Publishing date 2004-11-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412694-4
    ISSN 0002-838X ; 0572-3612
    ISSN 0002-838X ; 0572-3612
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  9. Article: Association of Routinely Measured Proinflammatory Biomarkers With Abnormal MRI Findings in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.

    Ruhfus, Maria / Giannakis, Stamatios / Markus, Mona / Stein, Anja / Hoehn, Thomas / Felderhoff-Mueser, Ursula / Sabir, Hemmen

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 624652

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.624652
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  10. Article ; Online: Correction: Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy.

    Lieberwirth, Johann Kaspar / Joset, Pascal / Heinze, Anja / Hentschel, Julia / Stein, Anja / Iannaccone, Antonella / Steindl, Katharina / Kuechler, Alma / Jamra, Rami Abou

    European journal of human genetics : EJHG

    2021  Volume 29, Issue 5, Page(s) 887

    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-021-00843-8
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