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  1. Article ; Online: Medicaid Costs and Utilization of Collaborative Versus Colocation Care for Patients With Depression.

    Chung, Henry / Patel, Urvashi / Stein, Dana / Collado, Kayla / Blackmore, Michelle

    Psychiatric services (Washington, D.C.)

    2023  Volume 74, Issue 11, Page(s) 1132–1136

    Abstract: Objective: The authors examined cost and utilization metrics for racially diverse Medicaid primary care patients with depression receiving care through either a collaborative care model (CoCM) of integration or the standard colocation model.: Methods!# ...

    Abstract Objective: The authors examined cost and utilization metrics for racially diverse Medicaid primary care patients with depression receiving care through either a collaborative care model (CoCM) of integration or the standard colocation model.
    Methods: Data from a retrospective cohort of Medicaid patients screening positive for clinically significant depression during January 2016-December 2017 were analyzed to assess health care costs and selected utilization measures. Seven primary care clinics providing CoCM were compared with 16 clinics providing colocated behavioral health care. Data for the first year and second year after a patient received an initial Patient Health Questionnaire-9 score ≥10 were analyzed.
    Results: In the first year, compared with patients receiving colocated care (N=3,061), CoCM patients (N=4,315) had significantly lower odds of emergency department (ED) visits (OR=0.95) and medical specialty office visits (OR=0.92), with slightly higher odds of primary care provider (PCP) visits (OR=1.03) and behavioral health office visits (OR=1.03). In year 2, CoCM patients (N=2,623) had significantly lower odds of inpatient medical admissions (OR=0.87), ED visits (OR=0.84), medical specialty office visits (OR=0.89), and PCP visits (OR=0.94) than the colocated care patients (N=1,838). The two groups did not significantly differ in total cost in both years.
    Conclusions: Access to CoCM treatment in primary care for racially diverse Medicaid patients with depression was associated with more positive health care utilization outcomes than for those accessing colocated treatment. As organizations continue to seek opportunities to integrate behavioral health care into primary care, consideration of health care costs and utilization may be helpful in the selection and implementation of integration models.
    MeSH term(s) United States ; Humans ; Retrospective Studies ; Medicaid ; Depression/therapy ; Health Care Costs ; Patient Acceptance of Health Care ; Emergency Service, Hospital
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20220604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Collaborative Care for Low-Income Patients From Racial-Ethnic Minority Groups in Primary Care: Engagement and Clinical Outcomes.

    Blackmore, Michelle A / Patel, Urvashi B / Stein, Dana / Carleton, Kelly E / Ricketts, Sarah M / Ansari, Asif M / Chung, Henry

    Psychiatric services (Washington, D.C.)

    2022  Volume 73, Issue 8, Page(s) 842–848

    Abstract: Objective: To assess model impact and opportunities for improvement, this study examined collaborative care model (CoCM) engagement and clinical outcomes among low-income patients from racial-ethnic minority groups with depression and anxiety.: ... ...

    Abstract Objective: To assess model impact and opportunities for improvement, this study examined collaborative care model (CoCM) engagement and clinical outcomes among low-income patients from racial-ethnic minority groups with depression and anxiety.
    Methods: Starting in 2015, the CoCM was implemented in seven primary care practices of an urban academic medical center serving patients from racial-ethnic minority backgrounds, predominantly Medicaid beneficiaries. Eligible individuals scored positive for depressive or anxiety symptoms (or both) on the Patient Health Questionnaire-2 (PHQ-2) and PHQ-9 and the Generalized Anxiety Disorder Scale-2 (GAD-2) and GAD-7 during systematic screening in primary care settings. Screening rates and yield, patient characteristics, and CoCM engagement and outcomes were examined. Clinical improvement was measured by the difference in PHQ-9 and GAD-7 scores at baseline and at 10-to-14-week follow-up.
    Results: High rates of screening (87%, N=88,236 of 101,091) and identification of individuals with depression or anxiety (13%, N=11,886) were observed, and 58% of 3,957 patients who engaged in minimally adequate CoCM treatment had significant clinical improvement. Nevertheless, only 56% of eligible patients engaged in the model, and 25% of those individuals did not return for at least one follow-up appointment. Being female with clinically significant comorbid anxiety and depressive symptoms and having Medicaid or commercial insurance increased the likelihood of CoCM engagement.
    Conclusions: CoCM can help engage vulnerable patients in behavioral health care and improve clinical symptoms. However, significant opportunity exists to advance the model's impact in treating depressive and anxiety disorders and decreasing health disparities by addressing engagement barriers.
    MeSH term(s) Depression/therapy ; Ethnic and Racial Minorities ; Ethnicity ; Female ; Humans ; Male ; Minority Groups ; Patient Health Questionnaire ; Primary Health Care
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.202000924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhancing the scalability of the collaborative care model for depression using mobile technology.

    Carleton, Kelly E / Patel, Urvashi B / Stein, Dana / Mou, David / Mallow, Alissa / Blackmore, Michelle A

    Translational behavioral medicine

    2020  Volume 10, Issue 3, Page(s) 573–579

    Abstract: The collaborative care model (CoCM) has substantial support for improving behavioral health care in primary care. However, large-scale CoCM adoption relies on addressing operational and financial implementation challenges across health care settings with ...

    Abstract The collaborative care model (CoCM) has substantial support for improving behavioral health care in primary care. However, large-scale CoCM adoption relies on addressing operational and financial implementation challenges across health care settings with varying resources. An academic medical center serving socioeconomically and racially diverse patients implemented the CoCM in seven practices. A smartphone application was introduced to facilitate CoCM care management during depression treatment (app-augmented CoCM). App features included secure texting, goal/appointment reminders, symptom monitoring, and health education material. A nonrandomized convenience patient sample (N = 807) was enrolled in app-augmented CoCM and compared with patients in standard CoCM (N = 3,975). Data were collected on clinical contact frequency, engagement, and clinical outcomes. App-augmented CoCM patients received more health care team contacts (7.9 vs. 4.9, p < .001) and shorter time to follow up compared with the standard CoCM sample (mean = 11 vs. 19 days, p < .001). App-augmented CoCM patients had clinical outcomes similar to the standard CoCM group (47% vs. 46% with ≥50% depression improvement or score <10), despite app-augmented patients having more prior depression treatment episodes. Further, the app-augmented group with greater app engagement demonstrated increased behavioral health appointment compliance, including more completed appointments and fewer no shows, and greater depression symptom improvement than those with less app engagement. App-augmented CoCM may improve patient engagement in treatment and provide opportunities to implement key CoCM elements without overburdening practice resources. CoCM sustainability and scalability in primary care may be enhanced by using this technology.
    MeSH term(s) Depression/therapy ; Humans ; Mobile Applications ; Patient Care Team ; Primary Health Care ; Technology
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586893-7
    ISSN 1613-9860 ; 1869-6716
    ISSN (online) 1613-9860
    ISSN 1869-6716
    DOI 10.1093/tbm/ibz146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mutation Profile of SARS-CoV-2 Genome Sequences Originating from Eight Israeli Patient Isolates.

    Zaide, Galia / Cohen-Gihon, Inbar / Israeli, Ofir / Stein, Dana / Shifman, Ohad / Weiss, Shay / Simon, Irit / Laskar, Orly / Beth-Din, Adi / Zvi, Anat

    Microbiology resource announcements

    2021  Volume 10, Issue 1

    Abstract: We report the genome sequences and the identification of genetic variations in eight clinical samples of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Samples were collected from nasopharyngeal swabs of symptomatic and asymptomatic ... ...

    Abstract We report the genome sequences and the identification of genetic variations in eight clinical samples of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Samples were collected from nasopharyngeal swabs of symptomatic and asymptomatic individuals from five care homes for elderly and infirm persons in Israel. The sequences obtained are valuable, as they carry a newly reported nonsynonymous substitution located within the nucleoprotein open reading frame.
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01387-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparison of Collaborative Care and Colocation Treatment for Patients With Clinically Significant Depression Symptoms in Primary Care.

    Blackmore, Michelle A / Carleton, Kelly E / Ricketts, Sarah M / Patel, Urvashi B / Stein, Dana / Mallow, Alissa / Deluca, Joseph P / Chung, Henry

    Psychiatric services (Washington, D.C.)

    2018  Volume 69, Issue 11, Page(s) 1184–1187

    Abstract: Objective: The study compared clinical outcomes of depression treatment in primary care with a colocation model versus a collaborative care model (CoCM).: Methods: Patients (N=240) with Patient Health Questionnaire-9 (PHQ-9) scores of ≥10 treated for ...

    Abstract Objective: The study compared clinical outcomes of depression treatment in primary care with a colocation model versus a collaborative care model (CoCM).
    Methods: Patients (N=240) with Patient Health Questionnaire-9 (PHQ-9) scores of ≥10 treated for clinically significant depression symptoms in primary care sites implementing the CoCM or a colocation model were compared. PHQ-9 scores were collected at baseline and 12 weeks.
    Results: From baseline to follow-up, reductions in PHQ-9 scores were 33% for the CoCM sites and 14% for the colocation sites, with an unadjusted mean difference in scores of 2.81 (p=.001).
    Conclusions: More patients treated in sites that used the CoCM experienced a significantly greater reduction in depression symptoms, compared with patients in sites with the colocation model. As greater adoption of integration models in primary care occurs, it will be important to consider potential implications of these results for promoting adoption of CoCM elements. Further replication of these findings is warranted.
    MeSH term(s) Adult ; Aged ; Delivery of Health Care, Integrated/methods ; Depressive Disorder/therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Mental Health Services ; Middle Aged ; Outcome and Process Assessment (Health Care) ; Patient Health Questionnaire ; Primary Health Care/methods ; Severity of Illness Index
    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.201700569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluating the efficacy of RT-qPCR SARS-CoV-2 direct approaches in comparison to RNA extraction.

    Israeli, Ofir / Beth-Din, Adi / Paran, Nir / Stein, Dana / Lazar, Shirley / Weiss, Shay / Milrot, Elad / Atiya-Nasagi, Yafit / Yitzhaki, Shmuel / Laskar, Orly / Schuster, Ofir

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 99, Page(s) 352–354

    Abstract: The genetic identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is based on viral RNA extraction prior to RT-qPCR assay. However, recent studies have supported the elimination of the extraction step. This study was performed to ...

    Abstract The genetic identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is based on viral RNA extraction prior to RT-qPCR assay. However, recent studies have supported the elimination of the extraction step. This study was performed to assess the necessity for the RNA extraction, by comparing the efficacy of RT-qPCR in several direct approaches versus the gold standard RNA extraction, in the detection of SARS-CoV-2 in laboratory samples, as well as in clinical oro-nasopharyngeal SARS-CoV-2 swabs. The findings showed an advantage for the extraction procedure; however a direct no-buffer approach might be an alternative, since it identified more than 60% of positive clinical specimens.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; COVID-19 ; Chlorocebus aethiops ; Coronavirus Infections/diagnosis ; Feasibility Studies ; Humans ; Nasal Cavity/virology ; Pandemics ; Pneumonia, Viral/diagnosis ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2 ; Vero Cells
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country Canada
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Coding-Complete Genome Sequences of Two SARS-CoV-2 Isolates from Early Manifestations of COVID-19 in Israel.

    Cohen-Gihon, Inbar / Israeli, Ofir / Shifman, Ohad / Stein, Dana / Achdout, Hagit / Weiss, Shay / Mandelboim, Michal / Erster, Oran / Regev-Yochay, Gili / Segal, Gad / Yitzhaki, Shmuel / Shapira, Shmuel C / Beth-Din, Adi / Zvi, Anat

    Microbiology resource announcements

    2020  Volume 9, Issue 28

    Abstract: We announce the genome sequences of two strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated in Israel, one imported by a traveler who returned from Japan and the second strain collected from a patient infected by a traveler ... ...

    Abstract We announce the genome sequences of two strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated in Israel, one imported by a traveler who returned from Japan and the second strain collected from a patient infected by a traveler returning from Italy. The sequences obtained are valuable as early manifestations for future follow-up of the local spread of the virus in Israel.
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00677-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits.

    Rosner, Amir / Steiner, Michal / Melamed, Sharon / Politi, Boaz / Vitner, Einat / Tamir, Hadas / Achdout, Hagit / Cherry, Lilach / Avraham, Roy / Yahalom-Ronen, Yfat / Levy, Haim / Beth-Din, Adi / Stein, Dana / Mechaly, Adva / Fisher, Morly / Fatelevich, Ella / Weiss, Shay / Kronfeld, Noam / Madar-Shapiro, Liora /
    Nyska, Abraham / Yitzhaki, Shmuel / Paran, Nir / Israely, Tomer / Marcus, Hadar / Madar-Balakirski, Noa

    Archives of toxicology

    2022  Volume 96, Issue 8, Page(s) 2329–2339

    Abstract: ... ...

    Abstract BriLife
    MeSH term(s) Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Rabbits ; SARS-CoV-2 ; Tissue Distribution
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-022-03302-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identification and genetic characterization of a novel Orthobunyavirus species by a straightforward high-throughput sequencing-based approach.

    Shifman, Ohad / Cohen-Gihon, Inbar / Beth-Din, Adi / Zvi, Anat / Laskar, Orly / Paran, Nir / Epstein, Eyal / Stein, Dana / Dorozko, Marina / Wolf, Dana / Yitzhaki, Shmuel / Shapira, Shmuel C / Melamed, Sharon / Israeli, Ofir

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 3398

    Abstract: Identification and characterization of novel unknown viruses is of great importance. The introduction of high-throughput sequencing (HTS)-based methods has paved the way for genomics-based detection of pathogens without any prior assumptions about the ... ...

    Abstract Identification and characterization of novel unknown viruses is of great importance. The introduction of high-throughput sequencing (HTS)-based methods has paved the way for genomics-based detection of pathogens without any prior assumptions about the characteristics of the organisms. However, the use of HTS for the characterization of viral pathogens from clinical samples remains limited. Here, we report the identification of a novel Orthobunyavirus species isolated from horse plasma. The identification was based on a straightforward HTS approach. Following enrichment in cell culture, RNA was extracted from the growth medium and rapid library preparation, HTS and primary bioinformatic analyses were performed in less than 12 hours. Taxonomical profiling of the sequencing reads did not reveal sequence similarities to any known virus. Subsequent application of de novo assembly tools to the sequencing reads produced contigs, of which three showed some similarity to the L, M, and S segments of viruses belonging to the Orthobunyavirus genus. Further refinement of these contigs resulted in high-quality, full-length genomic sequences of the three genomic segments (L, M and S) of a novel Orthobunyavirus. Characterization of the genomic sequence, including the prediction of open reading frames and the inspection of consensus genomic termini and phylogenetic analysis, further confirmed that the novel virus is indeed a new species, which we named Ness Ziona virus.
    MeSH term(s) Genome, Viral/genetics ; High-Throughput Nucleotide Sequencing/methods ; Open Reading Frames/genetics ; Orthobunyavirus/genetics ; Phylogeny ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-40036-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The coding capacity of SARS-CoV-2.

    Finkel, Yaara / Mizrahi, Orel / Nachshon, Aharon / Weingarten-Gabbay, Shira / Morgenstern, David / Yahalom-Ronen, Yfat / Tamir, Hadas / Achdout, Hagit / Stein, Dana / Israeli, Ofir / Beth-Din, Adi / Melamed, Sharon / Weiss, Shay / Israely, Tomer / Paran, Nir / Schwartz, Michal / Stern-Ginossar, Noam

    Nature

    2020  Volume 589, Issue 7840, Page(s) 125–130

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic
    MeSH term(s) Animals ; Cell Line ; Gene Expression Profiling ; Genome, Viral/genetics ; Humans ; Molecular Sequence Annotation ; Open Reading Frames/genetics ; Peptides/genetics ; Peptides/metabolism ; Protein Biosynthesis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Ribosomes/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Viral Proteins/biosynthesis ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances Peptides ; RNA, Messenger ; RNA, Viral ; Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2739-1
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