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  1. Book: Enhancing cognitive fitness in adults

    Hartman-Stein, Paula E. / La Rue, Asenath

    a guide to the use and development of community-based programs

    2011  

    Author's details Paula E. Hartman-Stein ; Asenath la Rue ed
    Keywords Erwachsener ; Denktraining ; Mnemotechnik
    Subject Erwachsenenalter ; Erwachsener ; Erwachsene ; Ars memorativa ; Gedächtnismethode ; Gedächtnisschulung ; Gedächtnistraining ; Mnemonik ; Ars Memoriae ; Ars Memorie ; Mnemologie ; Denken ; Gehirn ; Gehirntraining ; Hirnleistungstraining ; Gehirn-Jogging
    Language English
    Size XXII, 499 S. : Ill., graph. Darst., Notenbeisp.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016958175
    ISBN 978-1-4419-0635-9 ; 9781441906366 ; 1-4419-0635-5 ; 1441906363
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 5202 order for loan Magazin

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  2. Book: Innovative behavioral healthcare for older adults

    Hartman-Stein, Paula E.

    a guidebook for changing times

    1998  

    Author's details ed. Paula E. Hartman-Stein
    Keywords Mental Health Services ; Aged ; United States
    Language English
    Size XX, 248 S.
    Publisher Jossey-Bass
    Publishing place San Francisco
    Publishing country United States
    Document type Book
    HBZ-ID HT013460342
    ISBN 0-7879-0963-7 ; 978-0-7879-0963-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 5464 order for loan Magazin

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  3. Article ; Online: James (Jim) Georgoulakis (1948-2017).

    Hartman-Stein, Paula E

    The American psychologist

    2018  Volume 73, Issue 5, Page(s) 699

    Abstract: Presents an obituary for James (Jim) Georgoulakis (1948-2017). Georgoulakis was a psychologist, soldier, and scholar. An international consultant, leader, and well-respected advocate, he fought behind the scenes for decades, particularly on issues ... ...

    Abstract Presents an obituary for James (Jim) Georgoulakis (1948-2017). Georgoulakis was a psychologist, soldier, and scholar. An international consultant, leader, and well-respected advocate, he fought behind the scenes for decades, particularly on issues related to psychology and Medicare. He held several leadership positions with the U.S. Army, including director of the largest outpatient mental health program in the Department of Defense and Director of ambulatory care research for six military facilities. Jim's most substantial contribution to the profession of psychology was representing the American Psychological Association (APA) on the AMA's Relative Update Committee (RUC) for 20 years. Among his many awards, Jim was inducted into the MBA National Business Honor Society and named a distinguished scholar in law school. In 2005, he was honored with an APA Presidential Citation for contributions to psychology. He was laid to rest with full military honors at Fort Sam Houston. (PsycINFO Database Record
    Language English
    Publishing date 2018-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209464-2
    ISSN 1935-990X ; 0003-066X
    ISSN (online) 1935-990X
    ISSN 0003-066X
    DOI 10.1037/amp0000306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.

    Savy, Virginia / Stein, Paula / Shi, Min / Williams, Carmen J

    Biology of reproduction

    2022  Volume 107, Issue 6, Page(s) 1439–1451

    Abstract: Egg activation in mammals is triggered by oscillations in egg intracellular calcium (Ca2+) level. Ca2+ oscillation patterns can be modified in vitro by changing the ionic composition of culture media or in vivo by conditions affecting mitochondrial ... ...

    Abstract Egg activation in mammals is triggered by oscillations in egg intracellular calcium (Ca2+) level. Ca2+ oscillation patterns can be modified in vitro by changing the ionic composition of culture media or in vivo by conditions affecting mitochondrial function, such as obesity and inflammation. In mice, disruption of Ca2+ oscillations in vitro impacts embryo development and offspring growth. Here we tested the hypothesis that, even without in vitro manipulation, abnormal Ca2+ signaling following fertilization impacts offspring growth. Plasma membrane Ca2+ ATPases (PMCA) extrude cytosolic Ca2+ to restore Ca2+ homeostasis. To disrupt Ca2+ signaling in vivo, we conditionally deleted PMCA1 (cKO) in oocytes. As anticipated, in vitro fertilized cKO eggs had increased Ca2+ exposure relative to controls. To assess the impact on offspring growth, cKO females were mated to wild type males to generate pups that had high Ca2+ exposure at fertilization. Because these offspring would be heterozygous, we also tested the impact of global PMCA1 heterozygosity on offspring growth. Control heterozygous pups that had normal Ca2+ at fertilization were generated by mating wild type females to heterozygous males; these control offspring weighed significantly less than their wild type siblings. However, heterozygous offspring from cKO eggs (and high Ca2+ exposure) were larger than heterozygous controls at 12 week-of-age and males had altered body composition. Our results show that global PMCA1 haploinsufficiency impacts growth and support that abnormal Ca2+ signaling after fertilization in vivo has a long-term impact on offspring weight. These findings are relevant for environmental and medical conditions affecting Ca2+ handling and for design of culture conditions and procedures for domestic animal and human assisted reproduction.
    MeSH term(s) Male ; Female ; Mice ; Humans ; Animals ; Calcium Signaling/physiology ; Calcium/metabolism ; Fertilization/physiology ; Zygote/metabolism ; Oocytes/metabolism ; Mammals/metabolism
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioac180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Superovulation Does Not Alter Calcium Oscillations Following Fertilization.

    Savy, Virginia / Stein, Paula / Shi, Min / Williams, Carmen J

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 762057

    Abstract: Superovulation is a common approach to maximize the number of eggs available for either clinical assisted reproductive technologies or experimental animal studies. This procedure provides supraphysiological amounts of gonadotropins to promote continued ... ...

    Abstract Superovulation is a common approach to maximize the number of eggs available for either clinical assisted reproductive technologies or experimental animal studies. This procedure provides supraphysiological amounts of gonadotropins to promote continued growth and maturation of ovarian follicles that otherwise would undergo atresia. There is evidence in mice, cows, sheep, and humans that superovulation has a detrimental impact on the quality of the resulting ovulated eggs or embryos. Here we tested the hypothesis that eggs derived from superovulation have a reduced capacity to support calcium oscillations, which are a critical factor in the success of embryo development. Eggs were obtained from mice that were either naturally cycling or underwent a standard superovulation protocol. The eggs were either parthenogenetically activated using strontium or fertilized
    Language English
    Publishing date 2021-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.762057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microinjection of dsRNA into fully-grown mouse oocytes.

    Stein, Paula

    Cold Spring Harbor protocols

    2009  Volume 2009, Issue 1, Page(s) pdb.prot5132

    Abstract: RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a double-stranded RNA (dsRNA) of choice into fully-grown, germinal vesicle- ... ...

    Abstract RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a double-stranded RNA (dsRNA) of choice into fully-grown, germinal vesicle-intact (GV) mouse oocytes by microinjection. Microinjected oocytes can be cultured for up to 2 d or they can be matured to metaphase II. The metaphase II eggs can be fertilized in vitro and cultured up to the blastocyst stage. The efficiency of knockdown by RNAi can be assayed by quantitative reverse transcriptase (RT)-PCR (qPCR).
    MeSH term(s) Animals ; Culture Media/metabolism ; Female ; Metaphase ; Mice ; Microinjections/methods ; Oocytes/cytology ; Oocytes/metabolism ; Phenotype ; Polymerase Chain Reaction ; RNA Interference ; RNA, Double-Stranded/genetics ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors
    Chemical Substances Culture Media ; RNA, Double-Stranded ; RNA, Messenger
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot5132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microinjection of plasmids into meiotically incompetent mouse oocytes.

    Stein, Paula

    Cold Spring Harbor protocols

    2009  Volume 2009, Issue 1, Page(s) pdb.prot5135

    Abstract: RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a mammalian double-stranded RNA (dsRNA) expression vector into meiotically ... ...

    Abstract RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a mammalian double-stranded RNA (dsRNA) expression vector into meiotically incompetent mouse oocytes by microinjection. During mouse oocyte growth, there is a progressive decline in transcriptional activity, such that the fully-grown oocyte is transcriptionally quiescent. For this reason, the microinjection of plasmids should be performed in growing oocytes, obtained from 12- to 13-d-old females. Microinjected oocytes can be cultured for up to 2 d. The efficiency of knockdown by RNAi can be assayed by quantitative reverse transcriptase (RT)-PCR (qPCR).
    MeSH term(s) Animals ; Female ; Genetic Vectors ; Meiosis ; Mice ; Mice, Transgenic ; Microinjections/methods ; Oocytes/cytology ; Oocytes/metabolism ; Plasmids/metabolism ; RNA Interference ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transgenes
    Chemical Substances RNA, Double-Stranded
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot5135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microinjection of dsRNA into mouse one-cell embryos.

    Stein, Paula

    Cold Spring Harbor protocols

    2009  Volume 2009, Issue 1, Page(s) pdb.prot5133

    Abstract: RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a double-stranded RNA (dsRNA) of choice into mouse one-cell embryos by ... ...

    Abstract RNA interference (RNAi) is a suitable method for sequence-specific post-transcriptional gene silencing in a number of model systems. The following protocol describes delivery of a double-stranded RNA (dsRNA) of choice into mouse one-cell embryos by microinjection. Microinjected embryos can be cultured for up to 4 d, i.e., to the blastocyst stage. The efficiency of knockdown by RNAi can be assayed by quantitative reverse transcriptase (RT)-PCR (qPCR).
    MeSH term(s) Animals ; Blastocyst/cytology ; Embryo, Mammalian/cytology ; Female ; Gene Silencing ; Genetic Techniques ; Male ; Mice ; Microinjections/methods ; RNA Interference ; RNA, Double-Stranded/genetics ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances RNA, Double-Stranded
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.prot5133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Modulators of calcium signalling at fertilization.

    Stein, Paula / Savy, Virginia / Williams, Audrey M / Williams, Carmen J

    Open biology

    2020  Volume 10, Issue 7, Page(s) 200118

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Calcium/metabolism ; Calcium Release Activated Calcium Channels/genetics ; Calcium Signaling/genetics ; Endoplasmic Reticulum/genetics ; Fertilization/genetics ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics
    Chemical Substances Calcium Release Activated Calcium Channels ; Inositol 1,4,5-Trisphosphate Receptors ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.200118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The United State of Medicine: Healing Identity Confusion.

    Stein, Paula N / Smoller PhD, Andreas H

    The American journal of medicine

    2018  Volume 131, Issue 10, Page(s) 1141–1142

    MeSH term(s) American Medical Association ; Humans ; Osteopathic Medicine/education ; Osteopathic Medicine/methods ; Osteopathic Physicians ; United States
    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2018.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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