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  1. Book: High-throughput screening methods in toxicity testing

    Steinberg, Pablo

    2013  

    Author's details ed. by Pablo Steinberg
    Keywords High throughput screening (Drug development) ; Toxicity testing
    Language English
    Size XV, 552 S., [8] Bl. : Ill., graph. Darst., 25 cm
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT017637076
    ISBN 978-1-118-06563-1 ; 1-118-06563-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 918 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Editorial Comment.

    Steinberg, Peter

    The Journal of urology

    2021  Volume 206, Issue 5, Page(s) 1239

    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001948.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
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    Zs.MO 331: Show issues

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  3. Article: Red Meat-Derived Nitroso Compounds, Lipid Peroxidation Products and Colorectal Cancer.

    Steinberg, Pablo

    Foods (Basel, Switzerland)

    2019  Volume 8, Issue 7

    Abstract: About 20 years ago, the research group of Sheila Anne Bingham in Cambridge, UK, showed for the first time that volunteers consuming large amounts of red meat excrete high amounts of nitroso compounds via feces. In the meantime, it has been demonstrated ... ...

    Abstract About 20 years ago, the research group of Sheila Anne Bingham in Cambridge, UK, showed for the first time that volunteers consuming large amounts of red meat excrete high amounts of nitroso compounds via feces. In the meantime, it has been demonstrated that heme leads to the enhanced formation of nitroso compounds in the gastrointestinal tract and that the main nitroso compounds formed in the gastrointestinal tract are
    Language English
    Publishing date 2019-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods8070252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In Vitro-In Vivo Carcinogenicity.

    Steinberg, Pablo

    Advances in biochemical engineering/biotechnology

    2017  Volume 157, Page(s) 81–96

    Abstract: The evaluation of the carcinogenic potential of chemicals constitutes an essential step in assessing the risk that the chemicals pose to human health. The "gold standard" method to evaluate the carcinogenic potential of chemicals is the carcinogenicity ... ...

    Abstract The evaluation of the carcinogenic potential of chemicals constitutes an essential step in assessing the risk that the chemicals pose to human health. The "gold standard" method to evaluate the carcinogenic potential of chemicals is the carcinogenicity test in laboratory animals. However, because carcinogenicity studies in vivo are extremely time-consuming, expensive, make use of a high number of animals, and cannot be used to screen a high number of compounds at the same time, various different in vitro cell transformation assays have been developed. In this report, procedures to test the carcinogenicity in vivo and in vitro are described, whereby in the latter case three extensively evaluated test systems (the BALB/c 3T3 cell transformation assay, the Bhas 42 cell transformation assay, and the Syrian hamster embryo assay) are presented. Their performance shows that they are a useful complement to in vitro genotoxicity test batteries, can be used to identify non-genotoxic carcinogens, and as screening assays may significantly limit the number of chemicals to undergo an in vivo carcinogenicity testing, thereby strongly reducing the number of laboratory animals to be used. In the future, the development of human cell line-based transformation assays may contribute to increase further their relevance and the willingness to incorporate them into existing in vitro toxicity test batteries.
    MeSH term(s) Animals ; Biological Assay/methods ; Carcinogenesis/chemically induced ; Carcinogenicity Tests/methods ; Carcinogens/toxicity ; Dose-Response Relationship, Drug ; Environmental Monitoring/methods ; Humans ; In Vitro Techniques ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/pathology ; Risk Assessment/methods ; Tumor Cells, Cultured
    Chemical Substances Carcinogens
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0724-6145
    ISSN 0724-6145
    DOI 10.1007/10_2015_5013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Red Meat-Derived Nitroso Compounds, Lipid Peroxidation Products and Colorectal Cancer

    Steinberg, Pablo

    Foods. 2019 July 11, v. 8, no. 7

    2019  

    Abstract: About 20 years ago, the research group of Sheila Anne Bingham in Cambridge, UK, showed for the first time that volunteers consuming large amounts of red meat excrete high amounts of nitroso compounds via feces. In the meantime, it has been demonstrated ... ...

    Abstract About 20 years ago, the research group of Sheila Anne Bingham in Cambridge, UK, showed for the first time that volunteers consuming large amounts of red meat excrete high amounts of nitroso compounds via feces. In the meantime, it has been demonstrated that heme leads to the enhanced formation of nitroso compounds in the gastrointestinal tract and that the main nitroso compounds formed in the gastrointestinal tract are S-nitrosothiols and the nitrosyl heme. Moreover, it has been postulated that these endogenously formed nitroso compounds may alkylate guanine at the O6-position, resulting in the formation of the promutagenic DNA lesions O6-methylguanine and O6-carboxymethylguanine, which, if not repaired (in time), could lead to gene mutations and, subsequently to the development of colorectal cancer. Alternatively, it has been postulated that heme iron could contribute to colorectal carcinogenesis by inducing lipid peroxidation. In the present review, the evidence supporting the above-mentioned hypotheses will be presented.
    Keywords DNA damage ; carcinogenesis ; colorectal neoplasms ; feces ; gastrointestinal system ; genes ; guanine ; heme ; heme iron ; lipid peroxidation ; mutation ; nitroso compounds ; red meat ; thiols ; volunteers ; United Kingdom
    Language English
    Dates of publication 2019-0711
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods8070252
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Red Meat-Derived Nitroso Compounds, Lipid Peroxidation Products and Colorectal Cancer

    Steinberg, Pablo

    2019  

    Keywords Text ; ddc:610 ; colon cancer -- endogenously formed nitroso compounds -- lipid peroxidation products -- red meat
    Language English
    Publishing date 2019-07-11
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Book ; Audio / Video ; Online: Red meat-derived endogenously formed N-nitroso compounds and colon cancer

    Steinberg, Pablo

    2019  

    Keywords Text ; ddc:610
    Language English
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article: The psychiatry of family practice: personality disorders part 2: interviewing the patient.

    Steinberg, P

    Canadian family physician Medecin de famille canadien

    2011  Volume 29, Page(s) 1953–1957

    Abstract: Part 1 of this article, published on page 1942, encourages family doctors to consider their patients' personalities in clinical assessment and management. This section discusses patient interviewing, demonstrating how family physicians can listen for ` ... ...

    Abstract Part 1 of this article, published on page 1942, encourages family doctors to consider their patients' personalities in clinical assessment and management. This section discusses patient interviewing, demonstrating how family physicians can listen for `themes' in a patient's conversation that may hold clues to what is bothering him. It is also best to avoid giving a patient too much support in an attempt `to make him feel better' because such support may also prevent him from making mature decisions. It is equally important generally to avoid giving specific advice, because it may prevent patients from taking responsibility for their own actions. The clinician can use his own feelings and reactions to the patient to better understand the patient's personality and problems. Consultation with a psychiatrist can help clarify the family physician's role in assisting a particular patient. Balint groups are recommended for family doctors who are interested in further developing their interviewing skills.
    Language English
    Publishing date 2011-02-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2236: Show issues Location:
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    Zs.MG 5: Show issues

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  9. Article: The psychiatry of family practice: personality disorders part 1: the problem patient.

    Steinberg, P

    Canadian family physician Medecin de famille canadien

    2011  Volume 29, Page(s) 1942–1947

    Abstract: Part 1 of this two part article on personality disorders follows Voineskos et al's suggestion that "in the psychiatric training of medical students the focus should be primarily on teaching `psychiatry of medicla practice' and much less on teaching ` ... ...

    Abstract Part 1 of this two part article on personality disorders follows Voineskos et al's suggestion that "in the psychiatric training of medical students the focus should be primarily on teaching `psychiatry of medicla practice' and much less on teaching `specialty psychiatry'."(1) It is not a comprehensive phenomenological presentation of the subject, but an attempt to stimulate clinicians to consider aspects of the personalities of their patients-`psychiatric' or otherwise-in clinical assessment and management. It also attempts to integrate historically `psychiatric' skills and concepts into family practice. Case histories are discussed with particular reference to the work of Michael Balint.(2).
    Language English
    Publishing date 2011-02-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Book ; Thesis: Tumorvorläuferzellen in der Leber

    Steinberg, Pablo

    Untersuchungen zur Rolle von ovalen Zellen in der Entstehung epithelialer Lebertumoren

    1993  

    Author's details von Pablo Steinberg
    Language German
    Size 96 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Habil.-Schr., 1993
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT006545659
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 MB 534 order for loan Magazin

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