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  1. Book ; Online ; Thesis: Analyse von Frühveränderungen der Retina und ihre Assoziation zu diabetischen Veränderungen des kornealen Nervenfaserplexus bei Typ-2 Diabetes mellitus

    Steingrube, Nadine [Verfasser] / Guthoff, Rainer [Akademischer Betreuer] / Ringelstein, Marius [Gutachter]

    2024  

    Author's details Nadine Steingrube ; Gutachter: Marius Ringelstein ; Betreuer: Rainer Guthoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Immunoglobulin E-Selective Immunoadsorption Reduces Peripheral and Skin-Bound Immunoglobulin E and Modulates Cutaneous IL-13 Expression in Severe Atopic Dermatitis.

    Reich, Kristian / Hartjen, Anna / Reich, Jeremias / Schröder, Julie / Steingrube, Nadine / Bresch, Martina / Ertas, Beyhan / Falk, Thomas M / Blödorn-Schlicht, Norbert / Jäckle, Stefan / Meier, Markus

    The Journal of investigative dermatology

    2018  Volume 139, Issue 3, Page(s) 720–723

    MeSH term(s) Adult ; Aged ; Dermatitis, Atopic/therapy ; Disease Progression ; Female ; Humans ; Immunoglobulin E/immunology ; Immunoglobulin E/metabolism ; Immunomodulation ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Male ; Middle Aged ; Pilot Projects ; Plasmapheresis/methods ; Severity of Illness Index ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/metabolism ; Skin/immunology ; T-Lymphocytes/immunology
    Chemical Substances Interleukin-13 ; Single-Chain Antibodies ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2018.09.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: German Diabetes Study - Baseline data of retinal layer thickness measured by SD-OCT in early diabetes mellitus.

    Schröder, Katharina / Szendroedi, Julia / Benthin, Anna / Gontscharuk, Veronika / Ackermann, Philipp / Völker, Magdalena / Steingrube, Nadine / Nowotny, Bettina / Ziegler, Dan / Müssig, Karsten / Geerling, Gerd / Kuß, Oliver / Roden, Michael / Guthoff, Rainer

    Acta ophthalmologica

    2018  Volume 97, Issue 2, Page(s) e303–e307

    Abstract: Purpose: Recent studies highlighted that early diabetic neurodegeneration is present before microvascular changes are visible. Retinal neurodegeneration can decrease retinal layer thickness. We aimed to determine whether decreased retinal layer ... ...

    Abstract Purpose: Recent studies highlighted that early diabetic neurodegeneration is present before microvascular changes are visible. Retinal neurodegeneration can decrease retinal layer thickness. We aimed to determine whether decreased retinal layer thickness is present already in the early time course of disease.
    Methods: A cross-sectional analysis of patients and healthy adults from the German Diabetes Study (GDS, ClinicalTrials.gov Identifier number: CT01055093, https://clinicaltrials.gov/ct2/show/NCT01055093). Inclusion criteria were a diagnosis of diabetes mellitus (DM) within the last 12 months. Retinal layers thickness in the nasal pericentral segment was measured by spectral domain ocular coherence tomography (SD-OCT). For statistical analysis proc mixed (sas-version 9.4) was used.
    Results: One hundred and seventy-eight eyes of 89 patients with type 1 DM (58 males, age 36 ± 11 years, BMI 25.5 ± 4.2 kg/m²) and 242 eyes of 121 patients with type 2 DM (84 males, age 53 ± 10 years, BMI 31.9 ± 6.3 kg/m²) with a disease duration of less than 1 year were compared to 76 eyes of 38 controls (27 males, age 41 ± 16 years, BMI 27.3 ± 6.4 kg/m²). Analysis of retinal layer thickness and visual function did not reveal a significant difference between patients and controls.
    Conclusion: In the early course of DM potential, neurodegeneration does not relate to measureable changes of retinal layer thickness.
    MeSH term(s) Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/etiology ; Disease Progression ; Female ; Follow-Up Studies ; Germany/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Retinal Ganglion Cells/pathology ; Severity of Illness Index ; Time Factors ; Tomography, Optical Coherence/methods ; Visual Acuity ; Young Adult
    Language English
    Publishing date 2018-09-21
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.13851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.90: Show issues Location:
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