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  1. Article ; Online: Systemic therapy of necrobiotic xanthogranuloma: a systematic review.

    Steinhelfer, Lisa / Kühnel, Thomas / Jägle, Herbert / Mayer, Stephanie / Karrer, Sigrid / Haubner, Frank / Schreml, Stephan

    Orphanet journal of rare diseases

    2022  Volume 17, Issue 1, Page(s) 132

    Abstract: Background: Even though a plethora of systemic therapies have been proposed for necrobiotic xanthogranuloma (NXG), there is no systematic review on this topic in literature.: Objective: To review all existing literature on the systemic therapy of NXG ...

    Abstract Background: Even though a plethora of systemic therapies have been proposed for necrobiotic xanthogranuloma (NXG), there is no systematic review on this topic in literature.
    Objective: To review all existing literature on the systemic therapy of NXG in order to identify the most effective therapies.
    Methods: All reported papers in the literature were screened for systemic treatments of NXG. Papers without proper description of the therapies, papers describing topical therapy, and articles without assessment of effectiveness were excluded. Subsequently, we analyzed 79 papers and a total of 175 cases.
    Results: The most effective treatments for NXG are intravenous immunoglobulins (IVIG), corticosteroids, and combination therapies including corticosteroids.
    Conclusions: Corticosteroids and IVIG should therefore be considered first-line treatments in patients with NXG.
    MeSH term(s) Humans ; Immunoglobulins, Intravenous/therapeutic use ; Necrobiotic Xanthogranuloma/drug therapy ; Treatment Outcome
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-022-02291-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Delayed Imaging Improves Lesion Detectability in [

    Berliner, Christoph / Steinhelfer, Lisa / Chantadisai, Maythinee / Kroenke, Markus / Koehler, Daniel / Pose, Randi / Bannas, Peter / Knipper, Sophie / Eiber, Matthias / Maurer, Tobias

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 7, Page(s) 1036–1042

    Abstract: Our objective was to compare the ability to detect histopathologically confirmed lymph node metastases by early and delayed [ ...

    Abstract Our objective was to compare the ability to detect histopathologically confirmed lymph node metastases by early and delayed [
    MeSH term(s) Male ; Humans ; Prostate/pathology ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Neoplasm Recurrence, Local ; Prostatic Neoplasms/pathology ; Single Photon Emission Computed Tomography Computed Tomography ; Gallium Radioisotopes
    Chemical Substances Gallium Radioisotopes
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Article ; Online: Prostate-specific Membrane Antigen-radioguided Surgery Facilitates Pelvic Lymph Node Dissection During Radical Prostatectomy for the Treatment of Locally Advanced Prostate Cancer with Regional Lymph Node Metastases.

    Lunger, Lukas / Steinhelfer, Lisa / Korn, Philipp / Eiber, Matthias / Maurer, Tobias / Büchler, Jakob / Horn, Thomas / Gschwend, Jürgen E / Heck, Matthias M

    European urology oncology

    2023  Volume 6, Issue 1, Page(s) 95–98

    Abstract: Lymph node metastases (LNMs) are common in intermediate- to high-risk prostate cancer (PC) and may be missed during extended pelvic lymph node dissection (ePLND). Here we report on the use of prostate-specific membrane antigen (PSMA)-radioguided surgery ( ...

    Abstract Lymph node metastases (LNMs) are common in intermediate- to high-risk prostate cancer (PC) and may be missed during extended pelvic lymph node dissection (ePLND). Here we report on the use of prostate-specific membrane antigen (PSMA)-radioguided surgery (RGS) during open radical prostatectomy (RP) with ePLND to resect locoregional LNMs identified on preoperative PSMA positron emission tomography (PET). Preoperative PSMA PET showed 78 LNMs in 35 patients undergoing RP with ePLND and RGS between January 2018 and June 2020. In 14 patients (40%), LNMs were located outside the ePLND template. RGS achieved resection of PSMA-positive LNMs in 33/35 patients (94%). On univariable analysis, lower metastatic burden with up to two PSMA-positive LNMs on preoperative PET was associated with better postoperative outcomes. Limitations include the retrospective analysis and the small sample size. RGS facilitates resection of PSMA-positive LNs in patients treated with RP. Our data indicate a favorable treatment outcome in patients with low metastatic LN burden on preoperative PSMA PET. PATIENT SUMMARY: We investigated the use of radioactive guidance to remove lymph nodes affected by prostate cancer during surgical removal of the prostate. This approach can help to identify cancerous lymph nodes that might otherwise be missed and could lead to better survival outcomes.
    MeSH term(s) Humans ; Male ; Lymph Node Excision/methods ; Lymphatic Metastasis/pathology ; Prostate/pathology ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Surgery, Computer-Assisted/methods
    Chemical Substances KLK3 protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2023-01-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2022.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Accelerated liver water T

    Huaroc Moquillaza, Elizabeth / Weiss, Kilian / Stelter, Jonathan / Steinhelfer, Lisa / Lee, Yoo Jin / Amthor, Thomas / Koken, Peter / Makowski, Marcus R / Braren, Rickmer / Doneva, Mariya / Karampinos, Dimitrios C

    NMR in biomedicine

    2024  Volume 37, Issue 5, Page(s) e5097

    Abstract: Purpose: Liver T: Methods: The proposed continuous inversion-recovery (IR) Look-Locker methodology combines a single-shot gradient echo spiral readout, Dixon processing and a dictionary-based analysis for liver wT: Results: The phantom results are ...

    Abstract Purpose: Liver T
    Methods: The proposed continuous inversion-recovery (IR) Look-Locker methodology combines a single-shot gradient echo spiral readout, Dixon processing and a dictionary-based analysis for liver wT
    Results: The phantom results are in good agreement with MRS. The proposed method encodes the IR-curve for the liver wT
    Conclusion: A single-shot spiral acquisition can be combined with a continuous IR Look-Locker method to perform rapid repeatable multi-slice liver water T
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Image Interpretation, Computer-Assisted/methods ; Liver/diagnostic imaging ; Abdomen ; Respiration ; Phantoms, Imaging ; Reproducibility of Results ; Heart
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.5097
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    Zs.A 2869: Show issues Location:
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  5. Article ; Online: Artificial intelligence support in MR imaging of incidental renal masses: an early health technology assessment.

    Marka, Alexander W / Luitjens, Johanna / Gassert, Florian T / Steinhelfer, Lisa / Burian, Egon / Rübenthaler, Johannes / Schwarze, Vincent / Froelich, Matthias F / Makowski, Marcus R / Gassert, Felix G

    European radiology

    2024  

    Abstract: Objective: This study analyzes the potential cost-effectiveness of integrating an artificial intelligence (AI)-assisted system into the differentiation of incidental renal lesions as benign or malignant on MR images during follow-up.: Materials and ... ...

    Abstract Objective: This study analyzes the potential cost-effectiveness of integrating an artificial intelligence (AI)-assisted system into the differentiation of incidental renal lesions as benign or malignant on MR images during follow-up.
    Materials and methods: For estimation of quality-adjusted life years (QALYs) and lifetime costs, a decision model was created, including the MRI strategy and MRI + AI strategy. Model input parameters were derived from recent literature. Willingness to pay (WTP) was set to $100,000/QALY. Costs of $0 for the AI were assumed in the base-case scenario. Model uncertainty and costs of the AI system were assessed using deterministic and probabilistic sensitivity analysis.
    Results: Average total costs were at $8054 for the MRI strategy and $7939 for additional use of an AI-based algorithm. The model yielded a cumulative effectiveness of 8.76 QALYs for the MRI strategy and of 8.77 for the MRI + AI strategy. The economically dominant strategy was MRI + AI. Deterministic and probabilistic sensitivity analysis showed high robustness of the model with the incremental cost-effectiveness ratio (ICER), which represents the incremental cost associated with one additional QALY gained, remaining below the WTP for variation of the input parameters. If increasing costs for the algorithm, the ICER of $0/QALY was exceeded at $115, and the defined WTP was exceeded at $667 for the use of the AI.
    Conclusions: This analysis, rooted in assumptions, suggests that the additional use of an AI-based algorithm may be a potentially cost-effective alternative in the differentiation of incidental renal lesions using MRI and needs to be confirmed in the future.
    Clinical relevance statement: These results hint at AI's the potential impact on diagnosing renal masses. While the current study urges careful interpretation, ongoing research is essential to confirm and seamlessly integrate AI into clinical practice, ensuring its efficacy in routine diagnostics.
    Key points: • This is a model-based study using data from literature where AI has been applied in the diagnostic workup of incidental renal lesions. • MRI + AI has the potential to be a cost-effective alternative in the differentiation of incidental renal lesions. • The additional use of AI can reduce costs in the diagnostic workup of incidental renal lesions.
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10643-5
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    Zs.A 3300: Show issues Location:
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  6. Article ; Online: Long-Term Nephrotoxicity of

    Steinhelfer, Lisa / Lunger, Lukas / Cala, Lisena / Pfob, Christian H / Lapa, Constantin / Hartrampf, Philipp E / Buck, Andreas K / Schäfer, Hannah / Schmaderer, Christoph / Tauber, Robert / Brosch-Lenz, Julia / Haller, Bernhard / Meissner, Valentin H / Knorr, Karina / Weber, Wolfgang A / Eiber, Matthias

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  Volume 65, Issue 1, Page(s) 79–84

    Abstract: ... β- ... ...

    Abstract β-emitting
    MeSH term(s) Male ; Humans ; Retrospective Studies ; Treatment Outcome ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostate-Specific Antigen ; Dipeptides/adverse effects ; Lutetium/adverse effects ; Heterocyclic Compounds, 1-Ring/adverse effects
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Dipeptides ; Lutetium (5H0DOZ21UJ) ; Heterocyclic Compounds, 1-Ring
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.265986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  7. Article ; Online: Extensive

    Schäfer, Hannah / Mayr, Sarah / Büttner-Herold, Maike / Knorr, Karina / Steinhelfer, Lisa / Böger, Carsten A / Gschwend, Jürgen E / Heemann, Uwe / Eiber, Matthias / Schmaderer, Christoph / Tauber, Robert

    European urology

    2022  Volume 83, Issue 5, Page(s) 385–390

    Abstract: Lutetium-177 prostate-specific membrane antigen ( ...

    Abstract Lutetium-177 prostate-specific membrane antigen (
    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Dipeptides ; Kidney/pathology ; Lutetium/therapeutic use ; Thrombotic Microangiopathies ; Treatment Outcome
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Dipeptides ; Lutetium (5H0DOZ21UJ)
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.05.025
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  8. Article ; Online: Pretherapeutic Comparative Dosimetry of

    Feuerecker, Benedikt / Chantadisai, Maythinee / Allmann, Anne / Tauber, Robert / Allmann, Jakob / Steinhelfer, Lisa / Rauscher, Isabel / Wurzer, Alexander / Wester, Hans-Jürgen / Weber, Wolfgang A / d'Alessandria, Calogero / Eiber, Matthias

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 63, Issue 6, Page(s) 833–839

    Abstract: Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands allow for labeling ... ...

    Abstract Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands allow for labeling with
    MeSH term(s) Dipeptides/therapeutic use ; Heterocyclic Compounds, 1-Ring/therapeutic use ; Humans ; Ligands ; Lutetium/therapeutic use ; Male ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/pathology ; Radiopharmaceuticals/adverse effects ; Retrospective Studies ; Tomography, X-Ray Computed ; Urea/analogs & derivatives
    Chemical Substances Dipeptides ; Heterocyclic Compounds, 1-Ring ; Ligands ; PSMA I&T ; Radiopharmaceuticals ; Lutetium (5H0DOZ21UJ) ; Urea (8W8T17847W) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.262671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 328: Show issues

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