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  1. Article ; Online: Surface Topography, Microbial Adhesion, and Immune Responses in Silicone Mammary Implant-Associated Capsular Fibrosis.

    Schoberleitner, Ines / Baier, Leoni / Lackner, Michaela / Zenz, Lisa-Maria / Coraça-Huber, Débora C / Ullmer, Wendy / Damerum, Annabelle / Faserl, Klaus / Sigl, Stephan / Steinkellner, Theresia / Winkelmann, Selina / Sarg, Bettina / Egle, Daniel / Brunner, Christine / Wolfram, Dolores

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Breast cancer is the most common cancer in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role in breast reconstruction, yet their interaction with the host immune ... ...

    Abstract Breast cancer is the most common cancer in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role in breast reconstruction, yet their interaction with the host immune system and microbiome remains poorly understood. This study investigates the impact of SMI surface topography on host antimicrobial responses, wound proteome dynamics, and microbial colonization. Biological samples were collected from ten human patients undergoing breast reconstruction with SMIs. Mass spectrometry profiles were analyzed for acute and chronic wound proteomes, revealing a nuanced interplay between topography and antimicrobial response proteins.
    MeSH term(s) Humans ; Female ; Silicones ; Breast Implants/adverse effects ; Breast Neoplasms/surgery ; Proteome ; RNA, Ribosomal, 16S/genetics ; Mastectomy ; Anti-Infective Agents ; Fibrosis
    Chemical Substances Silicones ; Proteome ; RNA, Ribosomal, 16S ; Anti-Infective Agents
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis.

    Schoberleitner, Ines / Faserl, Klaus / Tripp, Christoph H / Pechriggl, Elisabeth Judith / Sigl, Stephan / Brunner, Andrea / Zelger, Bettina / Hermann-Kleiter, Natascha / Baier, Leoni / Steinkellner, Theresia / Sarg, Bettina / Egle, Daniel / Brunner, Christine / Wolfram, Dolores

    Frontiers in immunology

    2024  Volume 15, Page(s) 1342895

    Abstract: Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study with 10 ... ...

    Abstract Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study with 10 patients investigated intra- and inter-individually, reduced surface roughness effects on disease progression, wound responses, chronic inflammation, and capsular composition. The results illuminate the significant impact of surface roughness on acute inflammatory responses, fibrinogen accumulation, and the subsequent fibrotic cascade. The reduction of surface roughness to an average roughness of 4 μm emerges as a promising approach for mitigating detrimental immune reactions, promoting healthy wound healing, and curbing excessive fibrosis. The identified proteins adhering to rougher surfaces shed light on potential mediators of pro-inflammatory and pro-fibrotic processes, further emphasizing the need for meticulous consideration of surface design. The composition of the implant capsule and the discovery of intracapsular HSP60 expression highlight the intricate web of stress responses and immune activation that can impact long-term tissue outcomes.
    MeSH term(s) Humans ; Prostheses and Implants ; Inflammation ; Silicones ; Fibrosis ; Wound Healing
    Chemical Substances Silicones
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1342895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The use of semi-compliant versus non-compliant balloon systems for predilatation during the implantation of self-expandable transcatheter aortic valves: Data from the VIenna CardioThOracic Aortic Valve RegistrY (VICTORY).

    Mach, Markus / Szalkiewicz, Philipp / Poschner, Thomas / Hasan, Waseem / Andreas, Martin / Winkler, Bernhard / Hasimbegovic, Ena / Steinkellner, Theresia / Strouhal, Andreas / Adlbrecht, Christopher / Delle-Karth, Georg / Grabenwöger, Martin

    European journal of clinical investigation

    2021  Volume 51, Issue 9, Page(s) e13570

    Abstract: Background: This study aimed to evaluate the differences in outcome arising from the use of semi-compliant (SCB) versus non-compliant balloon (NCB) systems for predilatation during self-expanding transcatheter aortic valve replacement (TAVR).: Methods! ...

    Abstract Background: This study aimed to evaluate the differences in outcome arising from the use of semi-compliant (SCB) versus non-compliant balloon (NCB) systems for predilatation during self-expanding transcatheter aortic valve replacement (TAVR).
    Methods: 251 TAVR procedures with the implantation of self-expanding valves after predilatation were analyzed. SCB systems were used in 166 and NCB systems in 85 patients. The primary endpoint was defined as device success, a composite endpoint comprising the absence of procedural mortality, correct valve positioning, adequate valve performance and the absence of more than a mild paravalvular leak. The secondary endpoints were chosen in accordance with the valve academic research consortium (VARC-2) endpoint definitions.
    Results: No significant differences were observed with regard to procedural device success between the SCB- and NCB cohort (SCB: 142 [85.5%%] vs. NCB: 77 [90.6%]; P = .257). There was a notable difference between the rates of conversion to open surgery and the postdilatation rate, both of which were higher for the NCB group (SCB: 1 [0.6%] vs. NCB: 4 [5.1%]; P = .042; SCB: 30 [18.1%] vs. NCB: 34 [40%]; P < .001). In a multivariate logistic regression analysis, the use of semi-compliant balloon systems for predilatation was associated with a lower risk for postdilatation (OR: 0.296; 95% CI: 0.149-0.588) and conversion to open surgery (OR: 0.205; 95% CI: 0.085-0.493; P = .001) but not for device success.
    Conclusion: While the balloon compliance did not affect the procedural mortality, device success or the rate of paravalvular leakage, the use of semi-compliant balloons for predilatation during TAVR should be investigated in larger randomized trials in the light of the lower rates of postdilatation and conversion to open surgery compared to their non-compliant counterparts.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Aged ; Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Atrioventricular Block/epidemiology ; Balloon Valvuloplasty/instrumentation ; Balloon Valvuloplasty/methods ; Bundle-Branch Block/epidemiology ; Cause of Death ; Conversion to Open Surgery/statistics & numerical data ; Female ; Humans ; Male ; Mortality ; Postoperative Complications/epidemiology ; Registries ; Transcatheter Aortic Valve Replacement/instrumentation ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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