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  1. Article ; Online: Cd59 and inflammation regulate Schwann cell development.

    Wiltbank, Ashtyn T / Steinson, Emma R / Criswell, Stacey J / Piller, Melanie / Kucenas, Sarah

    eLife

    2022  Volume 11

    Abstract: Efficient neurotransmission is essential for organism survival and is enhanced by myelination. However, the genes that regulate myelin and myelinating glial cell development have not been fully characterized. Data from our lab and others demonstrates ... ...

    Abstract Efficient neurotransmission is essential for organism survival and is enhanced by myelination. However, the genes that regulate myelin and myelinating glial cell development have not been fully characterized. Data from our lab and others demonstrates that
    MeSH term(s) Animals ; CD59 Antigens/genetics ; Inflammation ; Myelin Sheath/genetics ; Oligodendroglia/physiology ; Schwann Cells/physiology ; Zebrafish
    Chemical Substances CD59 Antigens
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.76640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cell type-specific role of CBX2 and its disordered region in spermatogenesis.

    Kim, Jongmin J / Steinson, Emma R / Lau, Mei Sheng / de Rooij, Dirk G / Page, David C / Kingston, Robert E

    Genes & development

    2023  Volume 37, Issue 13-14, Page(s) 640–660

    Abstract: Polycomb group (PcG) proteins maintain the repressed state of lineage-inappropriate genes and are therefore essential for embryonic development and adult tissue homeostasis. One critical function of PcG complexes is modulating chromatin structure. ... ...

    Abstract Polycomb group (PcG) proteins maintain the repressed state of lineage-inappropriate genes and are therefore essential for embryonic development and adult tissue homeostasis. One critical function of PcG complexes is modulating chromatin structure. Canonical Polycomb repressive complex 1 (cPRC1), particularly its component CBX2, can compact chromatin and phase-separate in vitro. These activities are hypothesized to be critical for forming a repressed physical environment in cells. While much has been learned by studying these PcG activities in cell culture models, it is largely unexplored how cPRC1 regulates adult stem cells and their subsequent differentiation in living animals. Here, we show in vivo evidence of a critical nonenzymatic repressive function of cPRC1 component CBX2 in the male germline. CBX2 is up-regulated as spermatogonial stem cells differentiate and is required to repress genes that were active in stem cells. CBX2 forms condensates (similar to previously described Polycomb bodies) that colocalize with target genes bound by CBX2 in differentiating spermatogonia. Single-cell analyses of mosaic
    MeSH term(s) Animals ; Male ; Chromatin/metabolism ; Cell Nucleus/metabolism ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism ; Spermatogenesis/genetics
    Chemical Substances Chromatin ; Polycomb Repressive Complex 1 (EC 2.3.2.27) ; Polycomb-Group Proteins
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.350393.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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