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  1. Article: Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review.

    Bellini, Alice / Mazzarra, Sara / Sterrantino, Sara / Argnani, Desideria / Stella, Franco

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients ... ...

    Abstract Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the macroscopic complete resection, obtained by either extrapleural pneumonectomy or pleurectomy/decortication. Failure, in local and/or distant sites, is one of the major concerns; in fact, there has been no established treatment for the recurrence of MPM after the multimodal approach, and the role of surgery in this context is still controversial. By using electronic databases, studies that included recurrent MPM patients who underwent a second surgery were identified. The endpoints included were: a pattern of recurrence, post-recurrence survival (PRS), and the type of second surgery. When available, factors predicting better PRS and perioperative mortality and morbidity were collected. This systematic review offers an overview of the results that are currently obtained in patients undergoing a second surgery for relapsed MPM, with the aim to provide a comprehensive view on this subject that explores if a second surgery leads to an improvement in survival.
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Tracheal reconstruction: mini-review and anatomical study on the use of antero lateral thigh fascial flap for heterotopical transplantation.

    Sgarzani, Rossella / Meccariello, Giuseppe / Iannella, Giannicola / Stella, Franco / Negosanti, Luca

    Indian journal of thoracic and cardiovascular surgery

    2022  Volume 38, Issue 5, Page(s) 506–510

    Abstract: Background: The reconstructive tracheal options for extensive lesions still remain limited and although a valid substitute is required unfortunately, the biomechanical tracheal characteristics do not allow an easy replacement. In this study we reviewed ... ...

    Abstract Background: The reconstructive tracheal options for extensive lesions still remain limited and although a valid substitute is required unfortunately, the biomechanical tracheal characteristics do not allow an easy replacement. In this study we reviewed the described options and investigated, in human cadaver model, whether thigh fascia can be used, as an alternative to forearm fascia, as recipient site for trachea graft heterotopical allotransplantation.
    Anatomical study: In three fresh cadavers, 3 tracheal graft, 6 radial forearm (RF) fascial flaps and 6 antero-lateral thigh (ALT) fascial flaps were harvested. For each flap we simulated the heteretopical transplantation of the trachea in each fascial flap, and the harvesting of the composite graft as a free flap. The composite graft was finally decomposed at bench and the pedicle was injected to confirm fascial vascularization. The main measured outcomes were: flap fascia vascularization after pedicle injection, average time of flap harvesting, number of perforators included in ALT fascial flap and diameter of the vessels for anastomosis. Difficulties were noted, in order to compare RF flap and ALT flap.
    Results: Fascia vascularization was confirmed in all cases by pedicle injection. The main difficulty with radial flap was to harvest the fascial layer due to its thinness and its strong adherence to palmaris longus tendon, while the main difficulty with ALT flap was to prevent any traction on the perforators. The average time of flap harvesting and graft inset (by a junior plastic surgeon) was 1 h and 30 min for radial forearm flap and 2 h and 10 min for ALT flap.
    Conclusion: Despite many different techniques proposed in the literature, tracheal heterotopical allotransplantation still seemed the most promising, and ALT flap promised be a feasible alternative for heterotopical transplantation of trachea.
    Language English
    Publishing date 2022-04-04
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-022-01354-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Right upper video-assisted thoracoscopic lobectomy in partial anomalous pulmonary venous return.

    Caroli, Guido / Davoli, Fabio / Campisi, Alessio / Stella, Franco

    Interactive cardiovascular and thoracic surgery

    2021  

    Language English
    Publishing date 2021-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivab050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Three-chamber chest drain system in the COVID-19 era: is there a risk of further transmission?

    Davoli, Fabio / Poletti, Venerino / Stella, Franco

    Advances in respiratory medicine

    2020  Volume 88, Issue 4, Page(s) 366–368

    Abstract: We discuss the hypothesis that common Chest Drain Systems collected to a COVID-19 patient, could be a possible source of contamination for health care staff in a Thoracic Surgery ward and we propose an alternative way to minimize this further risk of ... ...

    Abstract We discuss the hypothesis that common Chest Drain Systems collected to a COVID-19 patient, could be a possible source of contamination for health care staff in a Thoracic Surgery ward and we propose an alternative way to minimize this further risk of transmission.
    MeSH term(s) COVID-19 ; Chest Tubes/adverse effects ; Clinical Competence ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Drainage/adverse effects ; Humans ; Pandemics/prevention & control ; Patient Care Management/methods ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Risk Assessment ; Thoracic Surgical Procedures/methods ; Thoracostomy/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.a2020.0100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Histologic Confounding Findings in Coronavirus disease 2019 (COVID-19) Pathology.

    Rossi, Giulio / Caruso, Dora / Stella, Franco / Davoli, Fabio

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2020  Volume 15, Issue 12, Page(s) e192–e193

    MeSH term(s) COVID-19 ; China ; Humans ; Lung ; Lung Neoplasms ; Pandemics ; Perioperative Period ; SARS-CoV-2 ; Thoracic Surgery
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2020.06.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 652: Show issues

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  6. Article ; Online: Pseudocarcinomatous Mesothelioma: A Hitherto Unreported Presentation closely simulating primary lung cancer.

    Rossi, Giulio / Caroli, Guido / Caruso, Dora / Stella, Franco / Davoli, Fabio

    International journal of surgical pathology

    2021  Volume 29, Issue 7, Page(s) 775–779

    Abstract: Malignant mesothelioma (MM) has a wide range of clinical, radiologic, and pathologic presentations, mimicking lung cancer or interstitial lung diseases when predominantly involving the lung parenchyma. The case herein refers to a 79-year-old man, active ... ...

    Abstract Malignant mesothelioma (MM) has a wide range of clinical, radiologic, and pathologic presentations, mimicking lung cancer or interstitial lung diseases when predominantly involving the lung parenchyma. The case herein refers to a 79-year-old man, active smoker without asbestos exposure, incidentally discovered to have a pulmonary nodule in the right upper lobe (1.5 cm). The lesion was misinterpreted as primary lung adenocarcinoma at the frozen section in light of the predominant lepidic growth pattern. Definitive examination confirmed neoplastic proliferation along alveolar structures. However, the unusual globous shape of tumor cells along the alveoli abruptly merging with normal pneumocytes prompted us to perform some immunostains that surprisingly revealed a mesothelial differentiation (positive staining with calretinin, cytokeratins (CK5/6), D2-40, and negativity with BRCA-associated protein 1 (BAP1), Thyroid Transcription Factor 1 [TTF-1], claudin-4, carcinoembryonic antigen [CEA], and napsin). MM represents the pathologic counterpart of so-called pseudomesotheliomatous carcinoma, since it appears as a localized pulmonary neoplastic nodule displaying a predominant lepidic growth pattern (pseudocarcinomatous mesothelioma). The challenging diagnostic features of this unique case and a review of similar cases in the literature are discussed.
    MeSH term(s) Adenocarcinoma of Lung/diagnosis ; Aged ; Diagnosis, Differential ; Humans ; Lung/diagnostic imaging ; Lung Neoplasms/diagnosis ; Male ; Mesothelioma, Malignant/diagnosis ; Mesothelioma, Malignant/pathology ; Pleura/diagnostic imaging ; Pleura/pathology ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/pathology
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896921997559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Franco Stella

    Stella, Franco

    2010  

    Title variant Stella
    Language German ; Italian
    Size 29 cm
    Publisher DOM Publ
    Publishing place Berlin
    Document type Book
    Accompanying material Schuber
    ISBN 3938666641 ; 9783938666647
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article: Cancer Stem Cells (CSCs), Circulating Tumor Cells (CTCs) and Their Interplay with Cancer Associated Fibroblasts (CAFs): A New World of Targets and Treatments.

    Aramini, Beatrice / Masciale, Valentina / Arienti, Chiara / Dominici, Massimo / Stella, Franco / Martinelli, Giovanni / Fabbri, Francesco

    Cancers

    2022  Volume 14, Issue 10

    Abstract: The importance of defining new molecules to fight cancer is of significant interest to the scientific community. In particular, it has been shown that cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self- ... ...

    Abstract The importance of defining new molecules to fight cancer is of significant interest to the scientific community. In particular, it has been shown that cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity; on the other side, circulating tumor cells (CTCs) seem to split away from the primary tumor and appear in the circulatory system as singular units or clusters. It is becoming more and more important to discover new biomarkers related to these populations of cells in combination to define the network among them and the tumor microenvironment. In particular, cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment with different functions, including matrix deposition and remodeling, extensive reciprocal signaling interactions with cancer cells and crosstalk with immunity. The settings of new markers and the definition of the molecular connections may present new avenues, not only for fighting cancer but also for the definition of more tailored therapies.
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14102408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The role of Ivor Lewis esophagectomy in the treatment of achalasia with megaesophagus: A case report.

    Zini Radaelli, Lorenzo Federico / Aramini, Beatrice / Ciarrocchi, Angelo Paolo / Sanna, Stefano / Argnani, Desideria / Stella, Franco

    Annals of medicine and surgery (2012)

    2022  Volume 77, Page(s) 103630

    Abstract: Introduction: Achalasia with megaesophagus is a pathology characterized by widespread and irregular dilation of the esophageal lumen. In most cases, this dilation is caused by contraction and subsequent failed relaxation of the lower esophageal ... ...

    Abstract Introduction: Achalasia with megaesophagus is a pathology characterized by widespread and irregular dilation of the esophageal lumen. In most cases, this dilation is caused by contraction and subsequent failed relaxation of the lower esophageal sphincter (LES). It may be associated with a partial or complete slowing of the esophageal peristalsis.
    Case overview: We present the case of a 58-year-old woman who developed dysphagia, regurgitation, and substantial weight loss (11 kg) over a span of 1 year. Symptomatic achalasia with megaesophagus was diagnosed following chest and abdominal computed tomography (CT) with contrast and transit RX with gastrografin and esophageal manometry. The patient refuse all minimally endoscopic treatments and opted straightly for the treatment with esophagectomy sec. Ivor-Lewis. At the 6-month follow-up, the patient appeared in excellent general clinical condition and oral gastrografin radiography (OGR) showed good channeling.
    Discussion: Patients require medical attention when presenting with achalasia that has eroded the esophageal wall enough to form a megaesophagus. Early and minimally invasive treatments (i.e., medical therapy, endoscopic dilation, and myotomy) are insufficient at this stage, and thus esophageal surgery is required. Among the most common surgical approaches, we must mention esophagectomy sec. McKeown and esophagectomy with interposition of a colic loop sec. Wilkins; however, based on our experience, esophagectomy sec. Ivor-Lewis with intrathoracic anastomosis leads to excellent results and can therefore be considered a valid alternative for treating complex cases.
    Conclusions: Subtotal esophagectomy sec. Ivor-Lewis with intrathoracic anastomosis is effective in treating achalasia with megaesophagus.
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The sternum reconstruction: Present and future perspectives.

    Aramini, Beatrice / Masciale, Valentina / Radaelli, Lorenzo Federico Zini / Sgarzani, Rossella / Dominici, Massimo / Stella, Franco

    Frontiers in oncology

    2022  Volume 12, Page(s) 975603

    Abstract: Sternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum or treating infections. Moreover, the removal of the sternum involves the additional challenge of performing a functional reconstruction. Fortunately, various ... ...

    Abstract Sternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum or treating infections. Moreover, the removal of the sternum involves the additional challenge of performing a functional reconstruction. Fortunately, various approaches have been proposed for improving the operation and outcome of reconstruction, including allograft transplantation, using novel materials, and developing innovative surgical approaches, which promise to enhance the quality of life for the patient. This review will highlight the surgical approaches to sternum reconstruction and the new perspectives in the current literature.
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.975603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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