Article ; Online: Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.
The Journal of infectious diseases
2011 Volume 203, Issue 5, Page(s) 595–601
Abstract: Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV- ... ...
| Abstract | Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; CD4 Lymphocyte Count ; Case-Control Studies ; Female ; Genotype ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/genetics ; Hepacivirus/genetics ; Hepatitis C/genetics ; Hepatitis C/virology ; Humans ; Interferons ; Interleukins/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; RNA, Viral/analysis ; Regression Analysis ; Treatment Outcome | ||||||||||
| Chemical Substances | interferon-lambda, human ; Interleukins ; RNA, Viral ; Interferons (9008-11-1) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2011-01-21 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/jiq098 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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