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  1. Article: Immunoexpression of Claudin 4 in Gastric Adenocarcinomas.

    Crețu, Oana Iulia / Stepan, Mioara Desdemona / Florescu, Mirela Marinela / Stepan, Alex Emilian

    Current health sciences journal

    2022  Volume 48, Issue 4, Page(s) 373–378

    Abstract: Disturbance of the intercellular adhesion system represents a basic biomolecular mechanism in gastric carcinogenesis. Claudin 4 is member of a protein family involved in maintaining homeostasis and epithelial integrity. In this study, we analyzed the ... ...

    Abstract Disturbance of the intercellular adhesion system represents a basic biomolecular mechanism in gastric carcinogenesis. Claudin 4 is member of a protein family involved in maintaining homeostasis and epithelial integrity. In this study, we analyzed the immunoexpression of Claudin 4 in 58 cases of gastric adenocarcinomas, in relation to the main histopathological parameters of aggressiveness, the reactions obtained being evaluated through the intensity of the reactions and the number of positive cells. Positive membranous reactions of Claudin 4 were observed in all cases, in tumor cells and some stromal elements, but in some high grade gastric adenocarcinomas also cytoplasmic immunostaining was present. Claudin 4 high scores were associated with tubular, tubulopapillary and hepatoid adenocarcinomas, of low grade and in early stages, aspects that suggest the usefulness of the marker in evaluating the aggressiveness of gastric epithelial tumors.
    Language English
    Publishing date 2022-12-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.04.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters.

    Ciuciulete, Alexandra-Roxana / Stepan, Alex Emilian / Andreiana, Bianca Cătălina / Simionescu, Cristiana Eugenia

    Current health sciences journal

    2022  Volume 48, Issue 1, Page(s) 110–115

    Abstract: Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of ... ...

    Abstract Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of NMSC, respectively 70% and 25% of total cases. The present retrospective study was conducted over a one-year period and included 439 cases of NMSC, of which 336 BCC and 103 SCC. We analyzed a series of clinical parameters: gender, age, tumor size and tumor topography. The statistical analysis of the investigated parameters indicated gender-age associations for BCC, and topography-gender, as well as topography-age for SCC.
    Language English
    Publishing date 2022-03-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.01.16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: VEGF Immunoexpression in Prostate Adenocarcinoma.

    Pănuş, Andrei / Simionescu, Cristiana Eugenia / Drăgoescu, Petru Octavian / Stepan, Alex Emilian

    Current health sciences journal

    2021  Volume 47, Issue 1, Page(s) 89–95

    Abstract: Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas ...

    Abstract Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.
    Language English
    Publishing date 2021-03-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.47.01.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinicopathological Correlations in Cutaneous Squamous Cell Carcinomas.

    Ciuciulete, Alexandra-Roxana / Stepan, Alex Emilian / Andreiana, Bianca-Cătălina / Simionescu, Cristiana Eugenia

    Current health sciences journal

    2021  Volume 47, Issue 1, Page(s) 61–67

    Abstract: Squamous cell carcinomas (SCC) represent 20% of all nonmelanoma skin cancers, most tumors responding favorably to the conventional therapy. Incisional or excisional biopsy is essential for diagnosis and prognosis evaluation. The study included 103 cases ... ...

    Abstract Squamous cell carcinomas (SCC) represent 20% of all nonmelanoma skin cancers, most tumors responding favorably to the conventional therapy. Incisional or excisional biopsy is essential for diagnosis and prognosis evaluation. The study included 103 cases of SCC, following the assessment of some clinical and histopathological aggressivity factors, which were digitally stored and statistically analyzed using comparison tests. The tumor grade was significantly associated with the histological variant, the maximum tumor size, the perineural and lymphovascular invasion, the depth of the invasion and the status of resection limits. The pT category was significantly associated with the location and maximum tumor size, perineural invasion, depth of invasion and status of resection limits. It was observed a significant association of tumor grade and pT category. The evaluation of the clinical and histological characteristics of SCC is an important step in obtaining relevant prognostic information and applying appropriate therapy.
    Language English
    Publishing date 2021-03-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.47.01.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ezrin Immunoexpression in Prostate Adenocarcinomas.

    Popescu, Tudor Cristian Timotei / Stepan, Alex Emilian / Florescu, Mirela Marinela / Simionescu, Cristiana Eugenia

    Current health sciences journal

    2022  Volume 48, Issue 4, Page(s) 413–417

    Abstract: Ezrin is a component of cell surface structures, the most important member of the Ezrin/radixin/moesin family. In this study, we aimed to evaluate the expression of ezrin in 50 cases of prostate carcinoma (PA) in relation to the ISUP (International ... ...

    Abstract Ezrin is a component of cell surface structures, the most important member of the Ezrin/radixin/moesin family. In this study, we aimed to evaluate the expression of ezrin in 50 cases of prostate carcinoma (PA) in relation to the ISUP (International Society of Urological Pathology) groups. Ezrin expression analysis was identified in 78% of the PA cases investigated, with predominantly cytoplasmic staining pattern and variable intensity. Overall, we observed an increase in the intensity of the immunostaining progressively with the decrease in cell differentiation. Statistical analysis indicated the predominance of high FSS in the ISUP 4-5 groups and low FSS in the ISUP 1-2 groups, aspects that were statistically significant. Ezrin was expressed in the majority of PAs analyzed and its expression was associated with ISUP grades, an aspect that suggests involvement in PA progression.
    Language English
    Publishing date 2022-12-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.04.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Classification and Grading Systems in Gastric Adenocarcinomas.

    Crețu, Oana Iulia / Stepan, Alex Emilian / Simionescu, Cristiana Eugenia / Marinescu, Daniela / Stepan, Mioara Desdemona

    Current health sciences journal

    2022  Volume 48, Issue 3, Page(s) 284–291

    Abstract: Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of ... ...

    Abstract Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of increasing the diagnostic accuracy. In this study we statistically analyzed 112 cases of gastric adenocarcinomas in relation to different classification and grading systems, in order to identify their efficacy and concordance in the histopathological diagnosis. The results indicated a significant association of the Lauren and World Health Organization 2019 classifications and also between these and the three-tier and two-tier grading systems, which supports their practical utility in establishing the diagnosis and assessment of the tumor aggressiveness, for the differentiated therapy.
    Language English
    Publishing date 2022-09-30
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.03.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Histopathological Study of the Prostate Cancer Growth Patterns in Relation with the Grading Systems.

    Popescu, Tudor Cristian Timotei / Stepan, Alex Emilian / Florescu, Mirela Marinela / Simionescu, Cristiana Eugenia

    Current health sciences journal

    2022  Volume 48, Issue 1, Page(s) 95–101

    Abstract: Prostate adenocarcinomas are common lesions with a high incidence and variable prognosis, which can be assessed using tumor grading systems. In this study, we analyzed 329 prostate adenocarcinomas in relation to tumor variants, growth patterns, classical ...

    Abstract Prostate adenocarcinomas are common lesions with a high incidence and variable prognosis, which can be assessed using tumor grading systems. In this study, we analyzed 329 prostate adenocarcinomas in relation to tumor variants, growth patterns, classical and updated grading systems. The study indicated statistical associations of atrophic, pseudohyperplastic and microcystic variants with low grading scores, the associations of glomeruloid, cribriform with or without necrosis and signet ring-like cell variants with high grading scores, and also of single growth patterns with intermediate scores, which supports the accordance and usefulness of existing grading systems for the identification of aggressive prostate tumor lesions.
    Language English
    Publishing date 2022-03-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.01.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Clinicopathological Prognostic Parameters of Endometrioid Endometrial Carcinomas.

    Drocaş, Ileana / Crăiţoiu, Ştefania / Stepan, Alex Emilian / Drocaş, Ioan Andrei / Stepan, Mioara Desdemona

    Current health sciences journal

    2022  Volume 48, Issue 2, Page(s) 187–195

    Abstract: Endometrioid endometrial carcinomas (EEC) are common malignant lesions of the female genital tract, with incidence and risk factors that raise issues to improve histopathological prognostic factors. The study included 50 EEC cases, for which the ... ...

    Abstract Endometrioid endometrial carcinomas (EEC) are common malignant lesions of the female genital tract, with incidence and risk factors that raise issues to improve histopathological prognostic factors. The study included 50 EEC cases, for which the clinicopathological parameters represented by age, risk factors, tumor grade, histological differences, invasion pattern, tumor stage and association of endometrial hyperplasia were analyzed statistically. The results indicated the predominance of EEC in the 7th decade of life, with associated risk factors (78%), more frequently well differentiated (52%), with no other specifications related to differentiation (NOS, 60%), with irregular invasion pattern (66%) in<50% of the myometrial wall (48%). Irregular pattern, microcystic, elongated, and fragmented (MELF) pattern and myoinvasion associated with vascular invasion (MVI) pattern were significantly associated with high grade and advanced stage tumors. With the exception of EEC-NOS and squamous differentiation, all other tumors were associated with low grade (G1). In this study there was a tendency to associate the age group of 60-69 years with the presence of endometrial hyperplasia and with high grade and advanced stage. Apart from the high grade and advanced stage, in the aggressive profile of the EEC can be included as the clinicopathological parameters the 7th decade of life and the irregular, MELF and MVI invasion patterns.
    Language English
    Publishing date 2022-06-30
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.02.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: VEGF Immunoexpression in Endometrioid Endometrial Carcinomas.

    Drocaş, Ileana / Crăiţoiu, Ştefania / Stepan, Alex Emilian / Simionescu, Cristiana Eugenia / Marinescu, Daniela

    Current health sciences journal

    2022  Volume 48, Issue 2, Page(s) 155–161

    Abstract: Vascular endothelial growth factor (VEGF) is the most important stimulator of endometrial tumor angiogenesis, a mechanism that may be a therapeutic target in the context of an incidence and persistent mortality of endometrial endometrial carcinomas (EEC). ...

    Abstract Vascular endothelial growth factor (VEGF) is the most important stimulator of endometrial tumor angiogenesis, a mechanism that may be a therapeutic target in the context of an incidence and persistent mortality of endometrial endometrial carcinomas (EEC). In this study, VEGF immunoexpression was analyzed for 50 cases of EEC in relation to the histopathological parameters of tumor aggressiveness. High VEGF scores have been associated with the high grade and advanced stage of EEC, but unrelated to the depth of myometrial invasion, the pattern of tumor invasion, or vascular invasion. VEGF may be useful for assessing EEC aggression, but also for tumor angiogenic potential, which recommends it as a possible mark for specific antitumor therapy.
    Language English
    Publishing date 2022-06-30
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.48.02.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunoexpression of Claudins -3, -4 and -7 in prostate adenocarcinomas.

    Popescu, Tudor Cristian Timotei / Stepan, Alex Emilian / Florescu, Mirela Marinela / Stepan, Mioara Desdemona / Simionescu, Cristiana Eugenia

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2022  Volume 64, Issue 2, Page(s) 165–171

    Abstract: Claudins are a family of essential tight junction proteins, abnormally expressed in human carcinomas. The studies that indicated the involvement of claudins in tumor biology and progression suggest the possibility of their utility as markers for ... ...

    Abstract Claudins are a family of essential tight junction proteins, abnormally expressed in human carcinomas. The studies that indicated the involvement of claudins in tumor biology and progression suggest the possibility of their utility as markers for diagnosis or prognosis, but also as possible targets for therapy. We investigated 50 prostate adenocarcinomas (PAs) for which we followed the expression of Claudins -3, -4 and -7 in relation to International Society of Urological Pathology (ISUP) grades. We observed the positivity for Claudin-3, Claudin-4, and Claudin-7 in 76%, 74% and 46% of cases. Analysis of the immunoexpression pattern revealed the cytoplasmic and nuclear translocation for Claudins -3 and -4, and only cytoplasmic for Claudin-7. For all claudins investigated, we noted a final staining score with significantly higher values or at the limit of statistical significance for PA belonging to ISUP groups 1-4. The internalization of Claudins -3, -4 and -7 expression, regardless of the degree of PA, indicates their involvement in prostate carcinogenesis. In addition, the similar immunoexpression patterns of the three investigated claudins and their positive linear correlation suggest a coordinated regulation and indicate the possibility of a targeted treatment strategy.
    MeSH term(s) Male ; Humans ; Claudin-3 ; Prostate/metabolism ; Prostate/pathology ; Claudins/metabolism ; Claudin-4 ; Prostatic Neoplasms/pathology ; Adenocarcinoma/pathology
    Chemical Substances Claudin-3 ; Claudins ; Claudin-4
    Language English
    Publishing date 2022-11-25
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.64.2.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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