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Article: History and current trends in the treatment of idiopathic overactive bladder.

Habeš, Dominik / Leško, Daniel / Štěpán, Martin / Špaček, Jiří / Kestřánek, Jan

2021 Volume 86, Issue 4, Page(s) 284–290

Abstract: Objective: Historical and current view on the therapy of overactive bladder.: Methods: This review summarizes the historical approach and current therapy of overactive bladder. The articles were gathered from Pubmed and Scopus databases. Studies ... ...

Title translation	Historie a současné trendy v léčbě idiopatického hyperaktivního měchýře.
Abstract	Objective: Historical and current view on the therapy of overactive bladder. Methods: This review summarizes the historical approach and current therapy of overactive bladder. The articles were gathered from Pubmed and Scopus databases. Studies published before December 2020 were used for the review. Results and conclusion: Overactive bladder is a condition that quite a lot reduces the quality of life of our patients. Our therapeutic approach starts with non-pharmacological treatment, such as pelvic floor exercises. The next step is a pharmacological approach. The entry level drug is trospium. If the effect is not sufficient, propiverine, solifenacin, fesoterodine, darifenacin or mirabegron are used. Electrostimulation or botulinum toxin A application is an option only in cases that didnt respond to pharmacological treatment. It is safe to say, that in the end, there is a way of reducing the severity of overactive bladder symptoms for every patient.
MeSH term(s)	Benzhydryl Compounds ; Humans ; Muscarinic Antagonists/therapeutic use ; Quality of Life ; Solifenacin Succinate ; Treatment Outcome ; Urinary Bladder, Overactive/therapy
Chemical Substances	Benzhydryl Compounds ; Muscarinic Antagonists ; Solifenacin Succinate (KKA5DLD701)
Language	English
Publishing date	2021-09-07
Publishing country	Czech Republic
Document type	Journal Article ; Review
ZDB-ID	1187094-1
ISSN	1805-4455 ; 1210-7832 ; 0374-6852
ISSN (online)	1805-4455
ISSN	1210-7832 ; 0374-6852
DOI	10.48095/cccg2021284
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Article ; Online: Dynamics of the vitamin D C3-epimer levels in preterm infants.

Matejek, Tomas / Zapletalova, Bara / Stepan, Martin / Malakova, Jana / Palicka, Vladimir

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 6, Page(s) 1084–1094

Abstract: Objectives: The primary objective was to determine levels of C3-epi-25(OH)D in very low birth weight infants. The secondary objective was to evaluate the possible influence of preterm birth, intrauterine growth restriction (IUGR), and season of birth on ...

Abstract	Objectives: The primary objective was to determine levels of C3-epi-25(OH)D in very low birth weight infants. The secondary objective was to evaluate the possible influence of preterm birth, intrauterine growth restriction (IUGR), and season of birth on the production of C3-epimers. Methods: A total of 127 infants with birth weight less than 1,500 g met the inclusion criteria of the study. We examined 25-hydroxyvitamin-D [25(OH)D] levels and C3-epi-25(OH)D in maternal serum before labor, and in cord blood and infants' serum on days 14 and 28, and at discharge. Results: The mean levels (±SD) of C3-epi-25(OH)D of the cord, on day 14, on day 28, and at discharge were 2.2 (2.9), 7.7 (5.5), 11.7 (7.6) and 14.9 (11.7) nmol/L respectively. The proportion of total 25(OH)D as the C3-epimer was 6.9% (cord), 16.3% (day 14), 22.4% (day 28) and 23.3% (discharge). A statistically significant correlation between 25(OH)D and C3-epi-25(OH)D can be demonstrated from birth. The severity of immaturity and IUGR did not affect the production of C3-epimers. In summer/autumn vs. winter/spring, the mean (SD) percentage of total 25(OH)D as the C3-epimer significantly differs only in maternal serum samples and umbilical cord samples (p value <0.001). Conclusions: The production of C3-epi-25(OH)D is functional even in the most immature newborns, has fetal origins, and is largely dependent on circulating 25(OH)D. At the end of the first month of life, C3-epimers make up more than 20% of 25(OH)D.
MeSH term(s)	Infant ; Female ; Infant, Newborn ; Humans ; Infant, Premature ; Premature Birth ; Vitamin D ; Vitamins ; Calcifediol ; Vitamin D Deficiency ; Infant, Very Low Birth Weight
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2023-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-1128
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Article: Treatment options for locally recurrent vulvar cancer.

Ndukwe, Munachiso Onyedikachi / Práznovec, Ivan / Štěpán, Martin / Sirák, Igor / Fibír, Aleš / Špaček, Jiří

Ceska gynekologie

2021 Volume 86, Issue 4, Page(s) 246–248

Abstract: Objective: Summarizing of treatment options for locally recurrent vulvar cancer in patients after previous complex oncological treatment and presenting a case report from our department.: Methods: Presenting a case report of a patient after previous ... ...

Title translation	Možnosti léčby lokálně recidivujícího karcinomu vulvy.
Abstract	Objective: Summarizing of treatment options for locally recurrent vulvar cancer in patients after previous complex oncological treatment and presenting a case report from our department. Methods: Presenting a case report of a patient after previous complex oncological treatment for spinocellular cancer of the vulva who presented with a locally recurrent tumor. The patient was treated with a wide radical local excision of the tumor followed by a posterior thigh flap graft. Conclusion: Surgical intervention is the primary mode of treatment in locally recurrent cancers of the vulva. Wide radical local excision as a mode of treatment can be optimized by the use of grafts aiding in wound healing.
MeSH term(s)	Carcinoma, Squamous Cell ; Female ; Humans ; Neoplasm Recurrence, Local/surgery ; Vulvar Neoplasms/surgery
Language	English
Publishing date	2021-09-07
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	1187094-1
ISSN	1805-4455 ; 1210-7832 ; 0374-6852
ISSN (online)	1805-4455
ISSN	1210-7832 ; 0374-6852
DOI	10.48095/cccg2021246
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Article: Treatment of Vulvovaginal Laxity by Electroporation: The Jett Plasma Medical for Her II Study.

Fait, Tomas / Baltazár, Tivadar / Bubenickova, Leona / Kestranek, Jan / Stepan, Martin / Muller, Miroslav / Turcan, Pavel

Journal of clinical medicine

2023 Volume 12, Issue 19

Abstract: Introduction: Vaginal laxity is a widespread and undertreated medical condition associated especially with vaginal parity.: Aim: To evaluate the efficacy and safety of electroporation therapy treatment of vulvovaginal laxity by the Jett Plasma for ... ...

Abstract	Introduction: Vaginal laxity is a widespread and undertreated medical condition associated especially with vaginal parity. Aim: To evaluate the efficacy and safety of electroporation therapy treatment of vulvovaginal laxity by the Jett Plasma for Her II device. Methods: The Jett Plasma for Her II Study is a multicentric, prospective, randomized, single-blinded, and controlled study. Women presenting with vaginal laxity were randomized to receive electroporation therapy delivered to the vaginal tissue (active-82 patients) vs. therapy with zero intensity (placebo-9 patients). Results: A total of 91 subjects whose average age was 48.69 ± 10.89 were included. Due to the results of a one-way analysis of variance, it may be concluded that in the case of the vaginal laxity questionnaire (VLQ), there is a statistically significant difference between actively treated patients and the placebo group (F Conclusions: Treatments of vulvovaginal laxity by electroporation therapy achieved significant and sustainable 12-month effectiveness. Responses to the questionnaires also suggest subjective improvement in self-reported sexual function, incontinence, sexual satisfaction, and urogenital distress.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196234
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Article: Statement of the Expert Discussion Panel of the 1st Expert Conference on Point‑of‑Care ultrasound.

Škulec, Roman / Balík, Martin / Černý, Vladimír / Doležal, David / Halata, David / Monhart, Zdeněk / Štěpán, Martin

Vnitrni lekarstvi

2023 Volume 69, Issue 4, Page(s) 242–243

Abstract: The document summarizes the statement of the expert discussion panel of the 1st Point- of-Care Ultrasonography, which took place on 14 November 2022 in Prague and which led to the foundation of the Czech Multidisciplinary Task Force Group for standards, ... ...

Title translation	Stanovisko expertního diskusního panelu I. odborné konference Point-of‑Care ultrasonografie.
Abstract	The document summarizes the statement of the expert discussion panel of the 1st Point- of-Care Ultrasonography, which took place on 14 November 2022 in Prague and which led to the foundation of the Czech Multidisciplinary Task Force Group for standards,education and research in Point-of-Care ultrasound (Czech POCUS group).
MeSH term(s)	Humans ; Point-of-Care Systems ; Ultrasonography
Language	English
Publishing date	2023-06-09
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article ; Online: Intra-amniotic infection and sterile intra-amniotic inflammation in women with preterm labor with intact membranes are associated with a higher rate of

Kacerovsky, Marian / Stranik, Jaroslav / Kukla, Rudolf / Bolehovska, Radka / Bostik, Pavel / Matulova, Jana / Stepan, Martin / Hladky, Jan / Jacobsson, Bo / Musilova, Ivana

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 7344–7352

Abstract: Objective: To determine the prevalence of : Methods: Overall, 115 women with singleton pregnancies complicated by PTL between gestational ages of 22 + 0 and 34 + 6 weeks were included in this study. Paired amniotic and cervical fluid samples were ... ...

Abstract	Objective: To determine the prevalence of Methods: Overall, 115 women with singleton pregnancies complicated by PTL between gestational ages of 22 + 0 and 34 + 6 weeks were included in this study. Paired amniotic and cervical fluid samples were collected at the time of admission via transabdominal amniocentesis using a Dacron polyester swab. Microbial invasion of the amniotic cavity was diagnosed based on a combination of culture and molecular biology methods. Intra-amniotic inflammation was determined based on the concentration of interleukin-6 in the amniotic fluid. Bacterial and Results: Intra-amniotic infection and sterile inflammation were identified in 14% (16/115) and 25% (29/115) of the women, respectively. Conclusions: In PTL , both forms of intra-amniotic inflammation were associated with a higher prevalence of
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Infant ; Ureaplasma ; Obstetric Labor, Premature/microbiology ; Amniotic Fluid/microbiology ; Inflammation ; DNA ; Chorioamnionitis/microbiology ; Fetal Membranes, Premature Rupture/microbiology
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2021-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1947231
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Article ; Online: Association between periodontal disease and preterm prelabour rupture of membranes.

Radochova, Vladimira / Stepan, Martin / Kacerovska Musilova, Ivana / Slezak, Radovan / Vescicik, Peter / Menon, Ramkumar / Jacobsson, Bo / Kacerovsky, Marian

Journal of clinical periodontology

2019 Volume 46, Issue 2, Page(s) 189–196

Abstract: Objective: Periodontal disease is a possible contributing factor to preterm delivery. The aim of this study was to compare the periodontal status of women with preterm prelabour rupture of membranes (PPROM) and women with uncomplicated singleton ... ...

Abstract	Objective: Periodontal disease is a possible contributing factor to preterm delivery. The aim of this study was to compare the periodontal status of women with preterm prelabour rupture of membranes (PPROM) and women with uncomplicated singleton pregnancies. Patients and methods: Seventy-eight women with PPROM at gestational ages between 24 + 0 and 36 + 6 weeks and 77 healthy women with uncomplicated pregnancies, matched for gestational age at sampling without preterm birth, were included in this study. All women underwent evaluation of periodontal and oral hygiene status. Results: Women with PPROM had higher gingival and plaque indexes in crude analysis (gingival index: median 0.80 versus 0.20; p < 0.0001; plaque index: median 0.80 versus 0.10; p < 0.0001), even after adjustment for smoking status (p < 0.0001 and p < 0.0001). Mean clinical attachment loss (CAL) and probing pocket depth (PPD) values were higher in women with PPROM in the crude analysis (CAL: median 2.3 mm versus 1.8 mm; p < 0.0001; PPD: median 2.3 mm versus 1.8; p < 0.0001), as well as after adjustment for smoking status (p < 0.0001 and p < 0.0001). Conclusions: Pregnant women with PPROM residing in central Europe had worse periodontal status than women with uncomplicated pregnancies.
MeSH term(s)	Adult ; Europe ; Female ; Fetal Membranes, Premature Rupture ; Gestational Age ; Humans ; Infant, Newborn ; Periodontal Diseases ; Pregnancy ; Premature Birth ; Young Adult
Language	English
Publishing date	2019-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13067
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Article ; Online: Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabor rupture of membranes.

Musilova, Ivana / Kacerovsky, Marian / Stepan, Martin / Bestvina, Tomas / Pliskova, Lenka / Zednikova, Barbora / Jacobsson, Bo

PloS one

2017 Volume 12, Issue 8, Page(s) e0182731

Abstract: Objective: To evaluate maternal serum C-reactive protein (CRP) concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) in relation to the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra- ... ...

Abstract	Objective: To evaluate maternal serum C-reactive protein (CRP) concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) in relation to the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI). Methods: Two hundred and eighty-seven women with singleton pregnancies complicated by PPROM between 2014 and 2016 were included in this study. Maternal blood and amniotic fluid samples were collected at the time of admission. Maternal serum CRP concentration was measured using a high-sensitivity immunoturbidimetric assay. Interleukin-6 (IL-6) concentration was measured using a point-of-care test. MIAC was diagnosed based on a positive polymerase chain reaction result for Ureaplasma species, Mycoplasma hominis, and/or Chlamydia trachomatis and for the 16S rRNA gene. IAI was characterized by an amniotic fluid IL-6 concentration of ≥ 745 pg/mL. Result: Women with MIAC and IAI had higher maternal serum CRP concentrations than did women without (with MIAC: median 6.9 mg/L vs. without MIAC: median 4.9 mg/L; p = 0.02; with IAI: median 8.6 mg/L vs. without IAI: median 4.7 mg/L; p < 0.0001). When women were split into four subgroups based on the presence of MIAC and/or IAI, women with the presence of both MIAC and IAI had higher maternal serum CRP than did women with IAI alone, with MIAC alone, and women without MIAC and IAI (both MIAC and IAI: median: 13.1 mg/L; IAI alone: 6.0 mg/L; MIAC alone: 3.9 mg/L; and without MIAC and IAI: median 4.8 mg/L; p < 0.0001). The maternal serum CRP cutoff value of 17.5 mg/L was the best level to identify the presence of both MIAC and IAI, with sensitivity of 47%, specificity of 96%, positive predictive value of 42%, negative predictive value of 96%, and the positive likelihood ratio of 10.9. Conclusion: The presence of both MIAC and IAI was associated with the highest maternal serum CRP concentrations. Maternal serum CRP concentration in women with PPROM at the time of admission can rule out the presence of the combined condition of both MIAC and IAI, therefore, it may serve as a non-invasive screening tool to distinguish between women with PPROM who are at high or at low risk for the presence of both MIAC and IAI.
MeSH term(s)	Adolescent ; Adult ; Amniotic Fluid/metabolism ; Amniotic Fluid/microbiology ; Biomarkers ; C-Reactive Protein ; Chorioamnionitis/blood ; Chorioamnionitis/diagnosis ; Chorioamnionitis/microbiology ; Delivery, Obstetric/methods ; Female ; Fetal Membranes, Premature Rupture/blood ; Fetal Membranes, Premature Rupture/diagnosis ; Fetal Membranes, Premature Rupture/etiology ; Gestational Age ; Humans ; Interleukin-6/metabolism ; Pregnancy ; Pregnancy Complications ; ROC Curve ; Young Adult
Chemical Substances	Biomarkers ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0182731
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Article ; Online: Transabdominal Amniocentesis Is a Feasible and Safe Procedure in Preterm Prelabor Rupture of Membranes.

Musilova, Ivana / Bestvina, Tomas / Stranik, Jaroslav / Stepan, Martin / Jacobsson, Bo / Kacerovsky, Marian

Fetal diagnosis and therapy

2017 Volume 42, Issue 4, Page(s) 257–261

Abstract: Objectives: To determine the feasibility and the complication rate of amniocentesis in a large cohort of women with preterm prelabor rupture of membranes (PPROM).: Methods: A retrospective cohort study was conducted in all women with singleton ... ...

Abstract	Objectives: To determine the feasibility and the complication rate of amniocentesis in a large cohort of women with preterm prelabor rupture of membranes (PPROM). Methods: A retrospective cohort study was conducted in all women with singleton gestation complicated by PPROM at between 24+0 and 36+6 weeks admitted to the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Czech Republic between May 2008 and July 2016. Amniocentesis was offered as a part of a routine protocol of PPROM for the detection of microbial invasion of the amniotic cavity and intra-amniotic inflammation. Procedure was performed under ultrasound guidance. A successful procedure was defined as obtaining at least 0.5 mL of amniotic fluid. No more than 2 attempts were performed. Results: In total, 590 women with PPROM were included. Amniocentesis was successful in 96% (567/590). Two amniocentesis attempts were necessary in 9% (55/590) and the transplacental approach was used in 13% (76/590). No association between gestational age at sampling and the amniocentesis failure rate was found (Spearman rho -0.12; p = 0.71). The complication rate was 0.7% (4/590). Two umbilical cord punctures and 2 chorionic plate fetal vessel injuries occurred, without fetal morbidity. Conclusion: Based on our study population, so far the largest published, amniocentesis is a feasible and safe procedure carrying a very low risk of failure or complications in PPROM.
MeSH term(s)	Adult ; Amniocentesis/adverse effects ; Amniocentesis/statistics & numerical data ; Feasibility Studies ; Female ; Fetal Membranes, Premature Rupture ; Humans ; Pregnancy ; Retrospective Studies ; Tertiary Care Centers
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000457951
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Article ; Online: Preterm Prelabor Rupture of Membranes between 34 and 37 Weeks: A Point-of-Care Test of Vaginal Fluid Interleukin-6 Concentrations for a Noninvasive Detection of Intra-Amniotic Inflammation.

Kacerovsky, Marian / Musilova, Ivana / Bestvina, Tomas / Stepan, Martin / Cobo, Teresa / Jacobsson, Bo

Fetal diagnosis and therapy

2017 Volume 43, Issue 3, Page(s) 175–183

Abstract: Objective: The aim of this study was to investigate whether a previously reported vaginal fluid point-of-care interleukin (IL)-6 cut-off value of 2,500 pg/mL can be used for the identification intra-amniotic inflammation in women with preterm prelabor ... ...

Abstract	Objective: The aim of this study was to investigate whether a previously reported vaginal fluid point-of-care interleukin (IL)-6 cut-off value of 2,500 pg/mL can be used for the identification intra-amniotic inflammation in women with preterm prelabor rupture of membranes (PPROM) between 34 and 37 weeks. Material and methods: A prospective cohort study was conducted in women with singleton gestation complicated by PPROM between 34 + 0 and 36 + 6 weeks. Vaginal fluid was successfully obtained in 118 women from the posterior vaginal fornix via aspiration using a sterile urine sample tube with a suction tip. Amniotic fluid was obtained via transabdominal amniocentesis. IL-6 concentrations were assessed in both fluids immediately after sampling. Intra-amniotic inflammation was defined as an amniotic fluid point-of-care IL-6 concentration of ≥745 pg/mL. Results: The tested vaginal fluid IL-6 cut-off value had a sensitivity of 91%, specificity of 91%, positive predictive value of 50%, negative predictive value of 99%, positive likelihood ratio of 9.7, and negative likelihood ratio of 0.1 for the identification of intra-amniotic inflammation. Conclusion: The point-of-care vaginal fluid IL-6 test with a cut-off value of 2,500 pg/mL shows good sensitivity, specificity, and negative predictive value for the identification of intra-amniotic inflammation in PPROM between 34 and 37 weeks.
MeSH term(s)	Adult ; Female ; Fetal Membranes, Premature Rupture ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Infection/diagnosis ; Interleukin-6/analysis ; Point-of-Care Testing ; Pregnancy ; Prospective Studies ; Vagina/chemistry ; Young Adult
Chemical Substances	IL6 protein, human ; Interleukin-6
Language	English
Publishing date	2017-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000477617
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