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Article ; Online: Adenosine in Intestinal Epithelial Barrier Function.

Stepanova, Mariya / Aherne, Carol M

2024 Volume 13, Issue 5

Abstract: At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier. In intestinal disorders, such ... ...

Abstract	At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier. In intestinal disorders, such as inflammatory bowel disease (IBD), barrier function is compromised, which results in rampant inflammation and tissue injury. In response to the destruction, the intestinal epithelium releases adenosine, a small but powerful nucleoside that functions as an alarm signal. Amidst the chaos of inflammation, adenosine aims to restore order. Within the scope of its effects is the ability to regulate intestinal epithelial barrier integrity. This review aims to define the contributions of adenosine to mucus production, microbiome-dependent barrier protection, tight junction dynamics, chloride secretion and acid-base balance to reinforce its importance in the intestinal epithelial barrier.
MeSH term(s)	Humans ; Adenosine ; Inflammatory Bowel Diseases ; Inflammation ; Intestinal Mucosa
Chemical Substances	Adenosine (K72T3FS567)
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13050381
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Article ; Online: Editorial: optimal combination of non-invasive tests to determine significant fibrosis in non-alcoholic fatty liver disease-authors' reply.

Stepanova, Maria / Younossi, Zobair

Alimentary pharmacology & therapeutics

2023 Volume 57, Issue 12, Page(s) 1463–1464

MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Fibrosis ; Liver Cirrhosis/diagnosis
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17517
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Conference proceedings ; Online: Turbulent transport and balance between plasma and magnetic pressures as key factors for the geomagnetic tail and inner magnetosphere interactions

Stepanova, M. / Antonova, E. / Espinoza, C.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Significant accumulated evidence indicates that the magnetosphere can be considered as a turbulent wake formed by the solar wind behind the Earth. The presence of turbulence observed in many regions constrains the repertoire of methods to describe such ... ...

Abstract	Significant accumulated evidence indicates that the magnetosphere can be considered as a turbulent wake formed by the solar wind behind the Earth. The presence of turbulence observed in many regions constrains the repertoire of methods to describe such plasmas, leaving the balance of total - plasma, magnetic, and dynamic - pressure at large scales as one of the most important conditions for the correct description of magnetospheric dynamics. Any local violation of the conservation of total pressure would alter plasma transport and lead to an increase in geomagnetic activity. Despite turbulence, the plasma in the inner magnetosphere is in magnetostatic equilibrium, and plasma pressure gradients determine the configuration of currents. In turn, the close Region 1 field-aligned currents generates the dawn-dusk electric field, which defines the largest scale of magnetospheric turbulence. Therefore, both plasma pressure and turbulence should be studied in a self-consistent way. Data from the THEMIS and CLUSTER satellites and the SuperDarn network were used to study the plasma sheet stability during quiet and disturbed geomagnetic conditions. It was found that the dawn-dusk electric field potential is the key parameter for the development of large- and medium- scale turbulence. The presence of turbulence and the ratio between the Alfvén and plasma velocities are also important for the evaluation of the applicability of a hydrodynamic approach to the analysis of large-scale magnetospheric dynamics, the mechanisms leading to the stochastization and unmagnetization of the particle motion in the turbulent plasmas, and formation of energetic tails in the particle distribution functions.
Subject code	532
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings ; Online: Self-consistent solution of geomagnetic field disturbances and plasma pressure distribution for strong geomagnetic storms

Espinoza, J. / Stepanova, M. / López, R. / Antonova, E.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The maintenance of magnetostatic equilibrium is the first problem that should be solved while we are analyzing any plasma configuration. It is not yet fully understood how the magnetosphere reaches magnetostatic equilibrium and what specific conditions ... ...

Abstract	The maintenance of magnetostatic equilibrium is the first problem that should be solved while we are analyzing any plasma configuration. It is not yet fully understood how the magnetosphere reaches magnetostatic equilibrium and what specific conditions are necessary to maintain it. Unraveling these processes requires knowledge about the 2-D distribution of plasma pressure for different geomagnetic conditions. In this work, we have obtained a self-consistent numerical solution for the dipole magnetic field disturbances caused by plasma pressure in the case of an azimuthally symmetric plasma distribution specified in the near Earth's magnetosphere. These results are complemented with the use of actual data measured by high-orbit satellite missions, such as THEMIS, RBSP or MMS. The main result is that we can recover the Earth's magnetic field depression due to a 2-D pressure profile in the presence of strong geomagnetic storms.
Subject code	550
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modification of Cellulose Micro- and Nanomaterials to Improve Properties of Aliphatic Polyesters/Cellulose Composites: A Review.

Stepanova, Mariia / Korzhikova-Vlakh, Evgenia

Polymers

2022 Volume 14, Issue 7

Abstract: Aliphatic polyesters/cellulose composites have attracted a lot attention due to the perspectives of their application in biomedicine and the production of disposable materials, food packaging, etc. Both aliphatic polyesters and cellulose are ... ...

Abstract	Aliphatic polyesters/cellulose composites have attracted a lot attention due to the perspectives of their application in biomedicine and the production of disposable materials, food packaging, etc. Both aliphatic polyesters and cellulose are biocompatible and biodegradable polymers, which makes them highly promising for the production of "green" composite materials. However, the main challenge in obtaining composites with favorable properties is the poor compatibility of these polymers. Unlike cellulose, which is very hydrophilic, aliphatic polyesters exhibit strong hydrophobic properties. In recent times, the modification of cellulose micro- and nanomaterials is widely considered as a tool to enhance interfacial biocompatibility with aliphatic polyesters and, consequently, improve the properties of composites. This review summarizes the main types and properties of cellulose micro- and nanomaterials as well as aliphatic polyesters used to produce composites with cellulose. In addition, the methods for noncovalent and covalent modification of cellulose materials with small molecules, polymers and nanoparticles have been comprehensively overviewed and discussed. Composite fabrication techniques, as well as the effect of cellulose modification on the mechanical and thermal properties, rate of degradation, and biological compatibility have been also analyzed.
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14071477
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Article ; Online: Can Frequent Toothbrushing Reduce the Risk of Cirrhosis among Patients with Nonalcoholic Fatty Liver Disease? Hints from a Registry-Based Study.

Keklikkiran, Caglayan / Stepanova, Maria / Younossi, Zobair / Yilmaz, Yusuf

Digestive diseases (Basel, Switzerland)

2023 Volume 41, Issue 6, Page(s) 932–937

Abstract: Introduction: While poor oral hygiene has been previously associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an ... ...

Abstract	Introduction: While poor oral hygiene has been previously associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), its association with hepatic fibrosis remains unclear. Here, we sought to analyze if toothbrushing frequency, an easy-to-assess indicator of oral health habits, would be associated with liver stiffness measurement (LSM) by transient elastography (TE) in patients with an established diagnosis of NAFLD. Methods: In this registry-based study, LSM was measured in 1,156 patients with NAFLD and analyzed in relation to the self-reported daily frequency of toothbrushing. LSM values ≥12 kPa were considered indicative of cirrhosis. Results: A trend toward a stepwise decrease (cross-sectional p = 0.13) in LSM was found in patients who reported having their teeth brushed more frequently: less than once a day (10.6 ± 8.6 kPa; 13% of the study sample), once a day (9.95 ± 8.40 kPa; 40%), twice a day (9.21 ± 7.63 kPa; 43%), and after every meal (8.91 ± 5.30 kPa; 4%). Patients who brushed their teeth less than once a day had a significantly higher prevalence of LSM values ≥12 kPa (p < 0.05). In multivariable logistic regression analysis, the association of LSM values ≥12 kPa with toothbrushing habits remained statistically significant for less than once a day (odds ratio = 1.69, 95% confidence interval = 1.07-2.66, p = 0.02) with reference to twice a day or after every meal. Conclusion: Among patients with NAFLD, there is an independent association between brushing teeth less than once a day and TE-established cirrhosis.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology ; Liver/pathology ; Toothbrushing/adverse effects ; Cross-Sectional Studies ; Liver Cirrhosis/complications ; Fibrosis ; Elasticity Imaging Techniques
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000531981
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Article ; Online: Economic Burden and Patient-Reported Outcomes of Nonalcoholic Fatty Liver Disease.

Stepanova, Maria / Henry, Linda / Younossi, Zobair M

Clinics in liver disease

2023 Volume 27, Issue 2, Page(s) 483–513

Abstract: In addition to adverse clinical outcomes such as liver-related morbidity and mortality, nonalcoholic fatty liver disease (NAFLD) is associated with a substantial public health and economic burden and could also potentially impair health-related quality ... ...

Abstract	In addition to adverse clinical outcomes such as liver-related morbidity and mortality, nonalcoholic fatty liver disease (NAFLD) is associated with a substantial public health and economic burden and could also potentially impair health-related quality of life and other patient-reported outcomes. The disease also affects multiple aspects of patients' quality of life which are the most pronounced in physical health-related and fatigue domains as well as work productivity, and get more severe in patients with advanced liver disease or with non-hepatic comorbidities. The economic burden of NAFLD is substantial and is increasing, with the highest costs in those with advanced disease.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/therapy ; Non-alcoholic Fatty Liver Disease/complications ; Quality of Life ; Financial Stress ; Patient Reported Outcome Measures
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1472315-3
ISSN	1557-8224 ; 1089-3261
ISSN (online)	1557-8224
ISSN	1089-3261
DOI	10.1016/j.cld.2023.01.007
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Article ; Online: Pedagogy of Exceptional Childhood by V.P. Kashchenko

Stepanova M.A.

Клиническая и специальная психология, Vol 7, Iss 3, Pp 1-

to the 110th Anniversary of the Sanatorium-school for Retarded Abnormal Children by Dr. V.P. Kashchenko

2018 Volume 23

Abstract: The article is dedicated to the 110th anniversary of one of the first Russian medical and educational institutions for children with developmental disorders - Sanatorium-school for retarded abnormal children, opened in Moscow by V.P. Kashchenko in 1908. ... ...

Abstract	The article is dedicated to the 110th anniversary of one of the first Russian medical and educational institutions for children with developmental disorders - Sanatorium-school for retarded abnormal children, opened in Moscow by V.P. Kashchenko in 1908. Published during the life of V.P. Kashchenko methodical, scientific and practical work, as well as memories of his daughter A.V. Kashchenko allow us to trace the history of the Sanatorium for two decades before the removal V.P. Kashchenko from the institution in 1926. A detailed description of Sanatorium children, the management of their life, instruction and upbringing is given in the book. Special attention is paid to the research work of V.P. Kashchenko, and in particular, to the creation of a unique Museum of Pedology and Pedagogy of exceptional childhood. On the basis of generalization of the experience of medical and pedagogical activity V.P. Kashchenko formulated the principles of correctional pedagogics called bases of practical work with the defective (exclusive) child. In conclusion, an attempt is made to identify the contribution of V.P. Kashchenko to the development of psychological and pedagogical science and practice of instruction and upbringing of children with developmental disorders.
Keywords	therapeutic (correctional) pedagogy ; defectology ; Sanatorium-school for retarded abnormal children by Dr. V.P. Kashchenko ; defective child ; exceptional children ; problem child ; medical and educational institutions for children with developmental disorders ; V.P. Kashchenko ; Medicine ; R
Subject code	370
Language	Russian
Publishing date	2018-10-01T00:00:00Z
Publisher	Moscow State University of Psychology and Education
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease.

Younossi, Zobair M / Paik, James M / Stepanova, Maria / Ong, Janus / Alqahtani, Saleh / Henry, Linda

Journal of hepatology

2024 Volume 80, Issue 5, Page(s) 694–701

Abstract: Background & aims: Recently, the term metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). Concern remains regarding whether the evidence generated under the NAFLD definition can be ... ...

Abstract	Background & aims: Recently, the term metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). Concern remains regarding whether the evidence generated under the NAFLD definition can be used for MASLD. We compared the clinical profile and outcomes of NAFLD to MASLD using tertiary care- and population-based data. Methods: Comparison data were obtained from our NAFLD database and the National Health and Nutrition Examination Survey (NHANES III). Clinical profiles and non-invasive tests (enhanced liver fibrosis [ELF] score, fibrosis-4 index [FIB-4] and vibration-controlled transient elastography) were compared. Mortality data were obtained from NHANES-National Death Index. All-cause mortality was assessed by Cox proportional hazards regression models and cause-specific mortality by competing risk analysis. Results: There were 6,429 patients in the NAFLD database (age: 54 ± 12 years, 42% male, BMI 35.4 ± 8.3, waist circumference 112 ± 17 cm, 52% type 2 diabetes). Average scores for ELF, FIB-4 and liver stiffness were 9.6 ± 1.2, 1.69 ± 1.24,14.0 ± 11.8 kPa, respectively; 99% met MASLD criteria; 95% met MASLD on BMI only. Predictive accuracy of ELF and FIB-4 were identical between MASLD and NAFLD. We included 12,519 eligible participants from NHANES (age 43.00 years, 47.38% male, 22.70% obese, 7.28% type 2 diabetes, 82.51% ≥1 cardiometabolic criteria). Among the NHANES study population, there was excellent concordance between MASLD and NAFLD diagnoses: Cohen's kappa coefficient: 0.968 (95% CI 0.962-0.973) with 5.29% of NAFLD cases not meeting MASLD criteria. After a median follow-up of 22.83 years, there were no mortality differences between MASLD and NAFLD diagnoses (p values ≥0.05). Conclusions: NAFLD and MASLD are similar except individuals with MASLD seem to be older with slightly higher mortality risk, likely owing to cardiometabolic risk factors. Clinical profiles and non-invasive test thresholds were also identical. These data provide evidence that NAFLD and MASLD terminologies can be used interchangeably. For the small proportion of patients with NAFLD who do not meet MASLD criteria, further consideration is needed. Impact and implications: In June 2023, new terminology (MASLD) was adopted to replace the term NAFLD as a means to better describe what the liver disease is rather than what it is not, as well as to potentially reduce stigma. Given that MASLD requires at least one cardiometabolic risk factor, questions were raised as to whether this change in the definition would nullify the similarities between NAFLD and MASLD and require new evidence to be generated for MASLD. We used our NAFLD database and a US population-based database to show that the vast majority of patients with NAFLD fulfill criteria for MASLD. Non-invasive tests performed similarly in both groups. Mortality risk was slightly higher in those with MASLD, which is attributed to the presence of cardiometabolic risks. These results provide evidence that data generated in the past three decades for NAFLD can be used interchangeably for MASLD.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Non-alcoholic Fatty Liver Disease/complications ; Nutrition Surveys ; Diabetes Mellitus, Type 2 ; Metabolic Diseases ; Cardiovascular Diseases ; Carboplatin/analogs & derivatives
Chemical Substances	NK 121 (110172-45-7) ; Carboplatin (BG3F62OND5)
Language	English
Publishing date	2024-01-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2024.01.014
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Article: Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery.

Stepanova, Mariia / Nikiforov, Alexey / Tennikova, Tatiana / Korzhikova-Vlakh, Evgenia

Pharmaceutics

2023 Volume 15, Issue 11

Abstract: Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and ... ...

Abstract	Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized.
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15112641
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