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  1. Book ; Thesis: Dendritische Zellen als Vermittler der schwangerschaftserhaltenden Wirkung von humanem Choriongonadotropin in einem Mausmodell

    Dauven, Dominique / Schüler, Thomas / Stephan, Holger

    2019  

    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details vorgelegt von Dominique Dauven aus Burg bei Magdeburg ; Gutachter: Thomas Schüler ; Holger Stephan
    Keywords Dendritische Zelle ; Choriongonadotropin ; Trächtigkeit
    Subject Tragzeit ; Schwangerschaft ; Gravidität ; HCG ; Gonadotrophinum chorionicum
    Language German
    Size 86 Blätter, Illustrationen, Diagramme
    Publisher Otto-von-Guericke-Universität Magdeburg
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Magdeburg, 2019
    HBZ-ID HT020208516
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Short all-out isokinetic cycling exercises of 90 and 15 s unlock exercise-induced hypoalgesia.

    Tomschi, Fabian / Schulz, Jana / Stephan, Holger / Hilberg, Thomas

    European journal of pain (London, England)

    2024  

    Abstract: Background: Acute physical activity leads to exercise-induced hypoalgesia (EIH). However, to what degree it can be induced by very short but highly intensive exercise is largely unknown. This study aims to investigate the effects of two different short ... ...

    Abstract Background: Acute physical activity leads to exercise-induced hypoalgesia (EIH). However, to what degree it can be induced by very short but highly intensive exercise is largely unknown. This study aims to investigate the effects of two different short all-out isokinetic exercise sessions on EIH.
    Methods: Twenty young male participants underwent three different interventions (90, 15 s all-out isokinetic cycling, respectively, and control) after an individualized low-intensity warm-up in a randomized-controlled-crossover design. Before (pre), after warm-up (post 1) as well as immediately post-intervention (post 2) pain sensitivity was measured employing pressure pain thresholds (PPT; in N) at the elbow, knee and ankle joints as well as the sternum and forehead. Performance parameters (e.g. lactate, perceived exertion, heart rate) were documented.
    Results: A 'time' × 'intervention' × 'body site' interaction effect (p < 0.001, η
    Conclusion: Global EIH assessed immediately after exercise can be induced by short highly intensive exercises. The effects are greater when the subjective and the objective exertion are higher as induced by the 90 s intervention.
    Significance statement: This study investigates the potential for brief, highly intensive exercise sessions to induce exercise-induced hypoalgesia (EIH). The research demonstrates that EIH can indeed be triggered by such short workouts, with greater effects observed during a 90 s session compared to a 15 s one, most likely due to higher subjective and objective exertion. These findings offer insights into the potential for extremely brief but intense exercises to alleviate pain, impacting exercise recommendations and pain management strategies.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.2276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Aufschlussreich und spannend; Präeklampsie – Diagnostik und klinisches Management : Fachbücher und Ratgeber

    Spahn, Annika / Stephan, Holger / Verlohren, Stefan

    Hebammenforum: Das Magazin des Bundes Deutscher Hebammen

    2023  Volume 24, Issue 4

    Keywords Präeklampsie ; Taunusstein
    Language German
    Size 24(2023), H. 4, S. 44-44
    Document type Article
    ZDB-ID 2104441-7
    ISSN 1611-4566
    ISSN 1611-4566
    Database bibnet.org

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  4. Article: Calculation of Oxygen Uptake during Ambulatory Cardiac Rehabilitation.

    Stephan, Holger / Klophaus, Nils / Wehmeier, Udo F / Tomschi, Fabian / Hilberg, Thomas

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Expression von Adhäsionsmolekülen der Leucam-Gruppe auf Monozyten und Alveolarmakrophagen bei Lungenfibrose und Sarkoidose

    Stephan, Holger

    1994  

    Author's details vorgelegt von Holger Stephan
    Language German
    Size 152 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT006873572
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Online: Reverse inequalities for slowly increasing sequences and functions

    Stephan, Holger

    (Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik ; 1972)

    2014  

    Abstract: We consider sharp inequalities involving slowly increasing sequences and functions, i.e., functions f(t) with f'(t) ≤1 and sequences (ai) with ai+1 - ai ≤ 1. The inequalities are reverse to mean inequalities, for example. In the continuous case, ... ...

    Author's details Holger Stephan
    Series title Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik ; 1972
    Abstract We consider sharp inequalities involving slowly increasing sequences and functions, i.e., functions f(t) with f'(t) ≤1 and sequences (ai) with ai+1 - ai ≤ 1. The inequalities are reverse to mean inequalities, for example. In the continuous case, integrals of powers are estimated by powers of integrals, whereas in the discrete case powers of sums are estimated by sums of powers of sums. The problem is connected with interpolation theory in Banach spaces, one of them W1, ∞.
    Language English
    Size Online-Ressource (PDF-Datei: 12 S., 176 KB)
    Publisher Techn. Informationsbibl. und Univ.-Bibl ; Weierstraß-Inst. für Angewandte Analysis und Stochastik Leibniz-Inst. im Forschungsverbund Berlin e.V
    Publishing place Hannover ; Berlin
    Document type Book ; Online
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article: Additional Active Movements Are Not Required for Strength Gains in the Untrained during Short-Term Whole-Body Electromyostimulation Training.

    Stephan, Holger / Wehmeier, Udo Frank / Förster, Tim / Tomschi, Fabian / Hilberg, Thomas

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 5

    Abstract: Recommendations for conventional strength training are well described, and the volume of research on whole-body electromyostimulation training (WB-EMS) is growing. The aim of the present study was to investigate whether active exercise movements during ... ...

    Abstract Recommendations for conventional strength training are well described, and the volume of research on whole-body electromyostimulation training (WB-EMS) is growing. The aim of the present study was to investigate whether active exercise movements during stimulation have a positive effect on strength gains. A total of 30 inactive subjects (28 completed the study) were randomly allocated into two training groups, the upper body group (UBG) and the lower body group (LBG). In the UBG (
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11050741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Contemporary Synthesis of Ultrasmall (sub-10 nm) Upconverting Nanomaterials.

    Joshi, Tanmaya / Mamat, Constantin / Stephan, Holger

    ChemistryOpen

    2020  Volume 9, Issue 6, Page(s) 703–712

    Abstract: Due to their unique photophysical properties, upconverting nanoparticles (UCNPs), i. e. particles capable of converting near-infrared (NIR) photons into tunable emissions in the range of ultraviolet (UV) to NIR, have great potential for use in various ... ...

    Abstract Due to their unique photophysical properties, upconverting nanoparticles (UCNPs), i. e. particles capable of converting near-infrared (NIR) photons into tunable emissions in the range of ultraviolet (UV) to NIR, have great potential for use in various biomedical fields such as bioimaging, photodynamic therapy and bioanalytical applications. As far as biomedical applications are concerned, these materials have a number of advantageous properties such as brilliant luminescence and exceptional photostability. Very small "stealth" particles (sub-10 nm), which can circulate in the body largely undetected by the immune system, are particularly important for in vivo use. The fabrication of such particles, which simultaneously have a defined (ultrasmall) size and the required optical properties, is a great challenge and an area that is in its infancy. This minireview provides a concise overview of recent developments on appropriate synthetic methodologies to produce such UCNPs. Particular attention was given to the influence of both surfactants and dopants used to precisely adjust size, crystalline phase and optical properties of UCNPs.
    Language English
    Publishing date 2020-06-12
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655605-4
    ISSN 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202000073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Significance of Comparative Genomics in Modern Evolutionary Venomics

    Stephan Holger Drukewitz / Björn Marcus von Reumont

    Frontiers in Ecology and Evolution, Vol

    2019  Volume 7

    Abstract: Venoms evolved convergently in diverse animal lineages as key adaptations that increase the evolutionary fitness of species which are manifold employed for defense, predation, and competition. They constitute complex cocktails of various toxins that ... ...

    Abstract Venoms evolved convergently in diverse animal lineages as key adaptations that increase the evolutionary fitness of species which are manifold employed for defense, predation, and competition. They constitute complex cocktails of various toxins that feature a broad range of bioactivities. The majority of described venom proteins belong to protein families that are known to comprise housekeeping genes or harbor protein-domains, which are present in genes with non-venom related functions. However, the evolutionary processes and mechanisms that foster the origin of these venom proteins and triggered their recruitment into the venom delivery system are still critically discussed. In most instances single or combined proteomic and transcriptomic approaches are applied to describe venom compositions and the biological context of venoms. For neglected species these studies represent crucial contributions to improve our understanding of venom diversity on a broader scale. Nonetheless, the inference of the evolutionary origin of putative toxins in these studies could be misleading without appropriate coverage of gene populations from different tissue samples (gene completeness) or complementary genome data. Providing a valid backbone to correctly map transcriptome and proteome data, whole genome sequences facilitate a clear distinction between variability of venom proteins or toxins due to posttranslational modifications, alternative splicing, and false-positive matches that stem from sequencing or read processing and assembly errors. High-quality whole genome sequence data of venomous species are still sparse and unevenly distributed within taxon lineages. However, to reveal the evolutionary pattern of putative toxins in venomous lineages and to identify ancestral variants of venom proteins, the appropriate sampling of genomes from venomous and non-venomous species is crucial. Nevertheless, larger comparative studies based on multiple whole genome data sets are still sparse to uncover processes of venom evolution. Here, ...
    Keywords venom evolution ; gene duplication ; single gene co-option ; origin of toxins ; orphan genes ; whole genome sequences ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 612
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Acute Effect of Electromyostimulation Superimposed on Running on Maximal Velocity, Metabolism, and Perceived Exertion.

    Stephan, Holger / Hagedorn, Thorsten / Wehmeier, Udo Frank / Tomschi, Fabian / Hilberg, Thomas

    Biology

    2022  Volume 11, Issue 4

    Abstract: Electromyostimulation has been shown to intensify exercise when superimposed on cycling. However, little is known about the application during running, which might help to prevent injuries linked to high running volumes, as intensification of running ... ...

    Abstract Electromyostimulation has been shown to intensify exercise when superimposed on cycling. However, little is known about the application during running, which might help to prevent injuries linked to high running volumes, as intensification of running allows for a reduction in training volume. Therefore, the purpose of the study was to examine the effects of electromyostimulation superimposed on running. Men who were no younger than 18 and no older than 35 were eligible for inclusion in the study. Exclusion criteria were previous experience with electromyostimulation training, the presence of a contraindication according to the manufacturer, or a contraindication to physical activity. A sample of 22 healthy males with an ordinary performance capability accomplished three similar cardiopulmonary treadmill tests until exhaustion in a crossover study design that included lactate measurements and interrogations of perceived exertion. The first test was conducted without electromyostimulation and was followed in a randomized order by the second and the third test condition with 30 or 85 Hz stimulation, respectively, of the lower body. Superimposed electromyostimulation significantly reduced the maximal achieved velocity (control 15.6 ± 1.1 vs. 30 Hz 15.1 ± 1.2, p = 0.002; vs. 85 Hz 14.9 ± 1.1 km/h, p < 0.001), increased the perceived exertion at 10, 12 and 14 km/h (85 Hz + 0.7, p = 0.036; +0.9, p = 0.007; +1.3, p < 0.001; 30 Hz + 0.7, p = 0.025; +1.0, p = 0.002; +1.2, p < 0.001), and induced a significantly higher oxygen uptake at 8 km/h (85 Hz + 1.1, p = 0.006; 30 Hz + 0.9 mL·min−1·kg−1, p = 0.042), 10 km/h (30 Hz + 0.9 mL·min−1·kg−1, p = 0.032), and 14 km/h (85 Hz + 1.0 mL·min−1·kg−1, p = 0.011). Both electromyostimulation conditions significantly limited the maximal lactate level (30 Hz p = 0.046; 85 Hz p < 0.001) and 85 Hz also the recovery lactate level (p < 0.001). Superimposed electromyostimulation is feasible and intensifies running. Coaches and athletes could benefit from the increased training stimulus by reducing running velocity or volume, by combining endurance and strength training, and also by inducing better adaptations while maintaining the same velocity or volume. Therefore, electromyostimulation superimposed on running could be an interesting training tool for runners.
    Language English
    Publishing date 2022-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11040593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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