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  1. Article ; Online: How is the COVID-19 pandemic impacting our life, mental health, and well-being? Design and preliminary findings of the pan-Canadian longitudinal COHESION study

    Stephan Gabet / Benoit Thierry / Rania Wasfi / Guido Simonelli / Catherine Hudon / Lily Lessard / Ève Dubé / Bouchra Nasri / Yan Kestens / Grégory Moullec

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    2023  Volume 20

    Abstract: Abstract Background With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian prospective COVID-19: ...

    Abstract Abstract Background With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian prospective COVID-19: HEalth and Social Inequities across Neighbourhoods (COHESION) cohort to provide a deeper understanding of how the COVID-19 pandemic context affects mental health and well-being, key determinants of health, and health inequities. Methods This paper presents the design of the two-phase COHESION Study, and descriptive results from the first phase conducted between May 2020 and September 2021. During that period, the COHESION research platform collected monthly data linked to COVID-19 such as infection and vaccination status, perceptions and attitudes regarding pandemic-related measures, and information on participants’ physical and mental health, well-being, sleep, loneliness, resilience, substances use, living conditions, social interactions, activities, and mobility. Results The 1,268 people enrolled in the Phase 1 COHESION Study are for the most part from Ontario (47%) and Quebec (33%), aged 48 ± 16 years [mean ± standard deviation (SD)], and mainly women (78%), White (85%), with a university degree (63%), and living in large urban centers (70%). According to the 298 ± 68 (mean ± SD) prospective questionnaires completed each month on average, the first year of follow-up reveals significant temporal variations in standardized indexes of well-being, loneliness, anxiety, depression, and psychological distress. Conclusions The COHESION Study will allow identifying trajectories of mental health and well-being while investigating their determinants and how these may vary by subgroup, over time, and across different provinces in Canada, in varying context including the pandemic recovery period. Our findings will contribute valuable insights to the urban health field and inform future public health interventions.
    Keywords COVID-19 ; Mental health ; Prospective cohort ; Social interactions ; Study design ; Well-being ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Breast cancer risk in relation to ambient concentrations of nitrogen dioxide and particulate matter

    Clémentine Lemarchand / Stephan Gabet / Sylvie Cénée / Nastassia Tvardik / Rémy Slama / Pascal Guénel

    Environment International, Vol 155, Iss , Pp 106604- (2021)

    results of a population-based case-control study corrected for potential selection bias (the CECILE study)

    2021  

    Abstract: Background: There is only scant evidence that air pollution increases the risk of breast cancer. Objectives: We investigated this relationship for three air pollutants: nitrogen dioxide (NO2) and particulate matter with an aerodynamical diameter below 10 ...

    Abstract Background: There is only scant evidence that air pollution increases the risk of breast cancer. Objectives: We investigated this relationship for three air pollutants: nitrogen dioxide (NO2) and particulate matter with an aerodynamical diameter below 10 µm (PM10) and 2.5 µm (PM2.5). Methods: We conducted a population-based case-control study on breast cancer in two French départements, including 1,229 women diagnosed with breast cancer in 2005–2007 and 1,316 control women frequency-matched on age. Concentrations of NO2, PM10 and PM2.5 at participants’ addresses occupied during the last 10 years were assessed using a chemistry transport model. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using multivariable logistic regression models where each woman was assigned a weight depending on her probability of selection into the study. Results: The OR for breast cancer per 10-µg/m3 increase in NO2 was 1.11 (95% CI, 0.98, 1.26), and 1.41 (95% CI 1.07, 1.86) in the highest exposure quintile (Q5), compared to the first. The ORs per 10-µg/m3 NO2 did not markedly differ between pre- (OR 1.09, 95% CI 0.89, 1.35)) and post-menopausal women (OR 1.14, 95% CI 0.97, 1.33)), but the OR was substantially higher for hormone-receptor positive (ER+/PR+) breast tumor subtypes (OR 1.15, 95% CI 1.00, 1.31) than for ER–/PR– tumors (OR 0.95, 95% CI 0.72, 1.26). Breast cancer risk was not associated with either PM10 (OR per 1 µg/m3 1.01, 95% CI, 0.96, 1.06) or PM2.5 (OR per 1 µg/m3 1.02, 95% CI 0.95, 1.08), regardless of the menopausal status or of the breast tumor subtype. Discussion: Our study provides evidence that NO2 exposure, a marker of traffic-related air pollutants, may be associated with an increased risk of breast cancer, particularly ER+/PR+ tumors.
    Keywords Air pollution ; Breast cancer ; Menopausal status ; Breast cancer subtypes ; Case-control study ; Environmental sciences ; GE1-350
    Subject code 616
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Which decreases in air pollution should be targeted to bring health and economic benefits and improve environmental justice?

    Xavier Morelli / Stephan Gabet / Camille Rieux / Hélène Bouscasse / Sandrine Mathy / Rémy Slama

    Environment International, Vol 129, Iss , Pp 538-

    2019  Volume 550

    Abstract: Background: Fine particulate matter (PM2.5) exposure entails large health effects in many urban areas. Public measures aiming at decreasing air pollution are often designed without targeting an explicit health benefit. Our objective was to investigate ... ...

    Abstract Background: Fine particulate matter (PM2.5) exposure entails large health effects in many urban areas. Public measures aiming at decreasing air pollution are often designed without targeting an explicit health benefit. Our objective was to investigate the health and economic benefits and the social inequalities in exposure resulting from several scenarios of reduction of PM2.5 exposure, in order to support decisions about urban policies. Material and methods: In the French conurbations of Grenoble and Lyon (0.4 and 1.4 million inhabitants, respectively), PM2.5 yearly average exposure was estimated on a 10-m grid by coupling a PM2.5 dispersion model to population density. Changes in death cases, life expectancy, lung cancer and term low birth weight incident cases as well as associated health economic costs were estimated for ten PM2.5 reduction scenarios differing in terms of amplitude of reduction and spatial extent. Changes in social differences in PM2.5 exposure were also assessed. Results: During the 2015–2017 period, PM2.5 average exposure was 13.9 μg/m3 in Grenoble and 15.3 μg/m3 in Lyon conurbations. Exposure to PM2.5 led to an estimated 145 (95% Confidence Interval, CI, 90–199) and 531 (95% CI, 330–729) premature deaths, 16 (95% CI, 8–24) and 65 (95% CI, 30–96) incident lung cancers, and 49 (95% CI, 19–76) and 193 (95% CI, 76–295) term low birth weight cases each year in Grenoble and Lyon conurbations, respectively, compared to a situation without PM2.5 anthropogenic sources, i.e. a PM2.5 concentration of 4.9 μg/m3. The associated costs amounted to 495 (Grenoble) and 1767 (Lyon) M€/year for the intangible costs related to all-cause non-accidental mortality and 27 and 105 M€ for the tangible and intangible costs induced by lung cancer. A PM2.5 exposure reduction down to the WHO air quality guideline (10 μg/m3) would reduce anthropogenic PM2.5-attributable mortality by half while decreases by 2.9 μg/m3 (Grenoble) and 3.3 μg/m3 (Lyon) were required to reduce it by a third. Scenarios focusing only on the ...
    Keywords Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Designing local air pollution policies focusing on mobility and heating to avoid a targeted number of pollution-related deaths

    Hélène Bouscasse / Stephan Gabet / Glen Kerneis / Ariane Provent / Camille Rieux / Nabil Ben Salem / Harry Dupont / Florence Troude / Sandrine Mathy / Rémy Slama

    Environment International, Vol 159, Iss , Pp 107030- (2022)

    Forward and backward approaches combining air pollution modeling, health impact assessment and cost-benefit analysis

    2022  

    Abstract: Context: Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM2.5) are often designed without targeting an explicit health benefit nor carrying out cost-benefit analyses. Methods: We developed a transdisciplinary backward and ... ...

    Abstract Context: Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM2.5) are often designed without targeting an explicit health benefit nor carrying out cost-benefit analyses. Methods: We developed a transdisciplinary backward and forward approach at the conurbation level: from health objectives set by local decision-makers, we estimated which reductions in PM2.5 exposures and emissions would allow to reach them, and identified urban policies leading to these reductions (backward approach). We finally conducted health impact and cost-benefit analyses of these policies (forward approach). The policies were related to the most emitting sectors in the considered area (Grenoble, France), wood heating and transport sectors. The forward approach also considered the health impact and co-benefits of these policies related to changes in physical activity and CO2 emissions. Findings: Decision-makers set three health targets, corresponding to decreases by 33% to 67% in PM2.5-attributable mortality in 2030, compared to 2016. A decrease by 42% in PM2.5 exposure (from 13.9 µg/m3) was required to reach the decrease by 67% in PM2.5-attributable mortality. For each Euro invested, the total benefit was about 30€ for policies focusing on wood heating, and 1 to 68€ for traffic policies. Acting on a single sector was not enough to attain a 67% decrease in PM2.5-attributable mortality. This target could be achieved by replacing all inefficient wood heating equipment by low-emission pellet stoves and reducing by 36% the traffic of private motorized vehicles. This would require to increase the share of active modes (walking, biking…), inducing increases in physical activity and additional health benefits beyond the initial target. Annual net benefits were between €484 and €629 per capita for policies with report on active modes, compared to between €162 and €270 without. Conclusions: Urban policies strongly reducing air pollution-attributable mortality can be identified by our approach. Such policies can be ...
    Keywords Dispersion model ; Economic analysis ; Fine particulate matter (PM2.5) ; Health impact assessment ; Transportation modal shift ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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