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  1. Book: Law and development

    Stephen, Frank H

    an institutional critique

    (Advances in new institutional analysis)

    2018  

    Abstract: This book draws on the analytical framework of New Institutional Economics (NIE) to critically examine the role which law and the legal system play in economic development. Analytical concepts from NIE are used to assess policies which have been ... ...

    Author's details Frank H. Stephen (Emeritus Professor of Regulation, School of Law, University of Manchester, UK)
    Series title Advances in new institutional analysis
    Abstract This book draws on the analytical framework of New Institutional Economics (NIE) to critically examine the role which law and the legal system play in economic development. Analytical concepts from NIE are used to assess policies which have been supported by multilateral development organisations including securing private property rights, reform of the legal system and financial development. The importance of culture in shaping the legal environment, which in turn influences financial sector development, is also assessed using Oliver Williamson's 'levels of social analysis' framework
    Keywords Economic development/Government policy ; Institutional economics ; Law and economic development ; Wirtschaftspolitik ; Marktwirtschaft ; Regulierung ; Rechtswissenschaft ; Neue Institutionenökonomik
    Language English
    Size ix, 187 Seiten, Illustrationen
    Document type Book
    ISBN 9781784718206 ; 9781784718213 ; 1784718203 ; 1784718211
    Database ECONomics Information System

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  2. Article: Withdrawal of routine brucellosis testing in beef herds.

    Stephen, Frank

    The Veterinary record

    2007  Volume 160, Issue 17, Page(s) 599

    MeSH term(s) Animals ; Brucellosis, Bovine/diagnosis ; Cattle ; Legislation, Veterinary ; Reagent Kits, Diagnostic/veterinary ; United Kingdom ; Veterinary Medicine/economics ; Veterinary Medicine/methods
    Chemical Substances Reagent Kits, Diagnostic
    Language English
    Publishing date 2007-03-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1136/vr.160.17.599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Lawyers, markets and regulation

    Stephen, Frank H

    2013  

    Abstract: The question of how we can best regulate the all-important markets for legal services is rarely investigated with the benefit of good empirical evidence about what's wrong and what works. The challenge of doing empirical work in this area is steep, ... ...

    Institution Europäische Union
    Author's details Frank H. Stephen, professor of regulation, School of Law, University of Manchester, UK
    Abstract 'The question of how we can best regulate the all-important markets for legal services is rarely investigated with the benefit of good empirical evidence about what's wrong and what works. The challenge of doing empirical work in this area is steep, given a lack of data and the complexity of comparing across very different jurisdictions and legal environments. In this much-needed contribution, Frank Stephen usefully brings together a set of empirical studies and an overview of the recent regulatory reforms that have been pursued in the UK and other European jurisdictions in the past two decades. The result will help policymakers make further progress in the increasingly urgent effort to establish efficient and accessible markets for legal services worldwide.' (Gillian K. Hadfield, USC Gould School of Law, US). -- 'Frank Stephen draws on thirty years' experience of working on the regulation of the legal professions, and on several empirical studies, to provide a fascinating account of the evolving attempts to introduce competition into the supply of legal services and how such attempts have sometimes been thwarted. It also makes a major contribution to the theoretical debate on the justifications, modes and likely impacts of regulation.' (Anthony Ogus, University of Manchester, UK and University of Rotterdam, The Netherlands). -- 'Professor Stephen's book provides a wonderfully concise, accessible and insightful review of both the theory and the empirical evidence (much of it his) on regulatory restrictions on the provision of legal services and challenges traditional arguments for the self-regulation of the legal profession. His economic/consumer welfare perspective provides a stimulating reference point in ongoing debates on the appropriate regulation of the market for legal services and the case for self-regulation, which (unlike the UK) is still very strongly espoused in North America, but under increasing scrutiny. Professor Stephen's book will intensify this scrutiny.' (Michael Trebilcock, University of Toronto, Canada).
    Keywords Lawyers/Discipline ; Lawyers/Marketing ; Legal ethics ; Practice of law ; Practice of law/Deregulation ; Practice of law/Economic aspects ; Deregulierung ; Regulierung ; Rechtsanwalt ; Rechtsberufe ; Großbritannien ; EU-Staaten
    Language English
    Size 1 Online-Ressource (ix, 181 pages)
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781781002674 ; 9781781002681 ; 9781783471133 ; 1781002673 ; 1781002681 ; 1783471131
    Database ECONomics Information System

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  4. Book: Lawyers, markets and regulation

    Stephen, Frank H

    2013  

    Institution Europäische Union
    Author's details Frank H. Stephen
    Keywords Practice of law/Deregulation ; Practice of law/Economic aspects ; Deregulierung ; Regulierung ; Rechtsanwalt ; Rechtsberufe ; Großbritannien ; EU-Staaten
    Language English
    Size IX, 181 S.
    Publisher Elgar
    Publishing place Cheltenham u.a.
    Document type Book
    Note Hier auch später erschienene, unveränderte Nachdrucke
    ISBN 9781781002674 ; 9781781002681 ; 9781783471133 ; 1781002673 ; 1781002681 ; 1783471131
    Database ECONomics Information System

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  5. Article: A phase Ib trial of combined PKC and MEK inhibition with sotrastaurin and binimetinib in patients with metastatic uveal melanoma.

    Bauer, Sebastian / Larkin, James / Hodi, F Stephen / Stephen, Frank / Kapiteijn, Ellen H W / Schwartz, Gary K / Calvo, Emilano / Yerramilli-Rao, Padmaja / Piperno-Neumann, Sophie / Carvajal, Richard D

    Frontiers in oncology

    2023  Volume 12, Page(s) 975642

    Abstract: Background: Uveal melanoma is a disease characterized by constitutive activation of the G alpha pathway and downstream signaling of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. While limited clinical activity has been ... ...

    Abstract Background: Uveal melanoma is a disease characterized by constitutive activation of the G alpha pathway and downstream signaling of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. While limited clinical activity has been observed in patients with metastatic disease with inhibition of PKC or MEK alone, preclinical data has demonstrated synergistic antitumor effects with concurrent inhibition of PKC and MEK.
    Method: We conducted a phase Ib study of the PKC inhibitor sotrastaurin in combination with the MEK inhibitor binimetinib in patients with metastatic uveal melanoma using a Bayesian logistic regression model guided by the escalation with overdose control principle (NCT01801358). Serial blood samples and paired tumor samples were collected for pharmacokinetic (PK) and pharmacodynamic analysis.
    Results: Thirty-eight patients were treated across six dose levels. Eleven patients experienced DLTs across the five highest dose levels tested, most commonly including vomiting (n=3), diarrhea (n=3), nausea (n=2), fatigue (n=2) and rash (n=2). Common treatment related adverse events included diarrhea (94.7%), nausea (78.9%), vomiting (71.1%), fatigue (52.6%), rash (39.5%), and elevated blood creating phosphokinase (36.8%). Two dose combinations satisfying criteria for the maximum tolerated dose (MTD) were identified: (1) sotrastaurin 300 mg and binimetinib 30 mg; and, (2) sotrastaurin 200 mg and binimetinib 45 mg. Exposure to both drugs in combination was consistent with single-agent data for either drug, indicating no PK interaction between sotrastaurin and binimetinib. Stable disease was observed in 60.5% of patients treated. No patient achieved a radiographic response per RECIST v1.1.
    Conclusions: Concurrent administration of sotrastaurin and binimetinib is feasible but associated with substantial gastrointestinal toxicity. Given the limited clinical activity achieved with this regimen, accrual to the phase II portion of the trial was not initiated.
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.975642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Corporate governance in developing and emerging markets

    Ngwu, Franklin N / Osuji, Onyeka / Stephen, Frank H

    2017  

    Abstract: Part A: introduction -- Introduction / Onyeka K. Osuji, Franklin N. Ngwu and Frank H. Stephen -- Part B: models of corporate governance -- Varieties of corporate governance models : a review and synthesis / Agyenim Boateng & Jia Lu -- Development of the ... ...

    Author's details edited by Franklin N. Ngwu, Onyeka K. Osuji and Frank H. Stephen
    Abstract Part A: introduction -- Introduction / Onyeka K. Osuji, Franklin N. Ngwu and Frank H. Stephen -- Part B: models of corporate governance -- Varieties of corporate governance models : a review and synthesis / Agyenim Boateng & Jia Lu -- Development of the Anglo-American model of corporate governance in developing and emerging markets / Franklin N. Ngwu -- New institutional economics, culture and corporate governance / Frank H. Stephen -- Corporate governance in the BRICS and mint countries -- Brazil : recent corporate governance advances and retreats / Ricardo P. C. Leal and Flávia S Maranho -- Corporate governance in Russia : law, instrumentality and political order / Rilka Dragneva -- Corporate governance in India : the potential for ghandism / Mia Mahmudur Rahim and Sanjaya Kuruppu -- Corporate governance in China : regulatory reforms and policies / Min (Ann) Du and Agyenim Boateng -- Institutions and corporate governance in South Africa / Thanti Mthanti and Kalu Ojah -- Corporate governance in Mexico / Eduardo Morales -- Corporate governance in Indonesia / Sylvia Veronica Siregar -- Institutional perspectives on corporate governance reforms in Nigeria / Olabisi Daodu, Franklin Nakpodia and Emmanuel Adegbite -- Corporate governance in Turkey / Gül Okutan Nilsson -- Critical issues for corporate governance in developing and emerging markets -- Corporate governance and state-owned firms : the case of Brazil / Alexandre Coelho -- Corporate governance under Islam : Islamic republic of Iran / Surendra Arjoon -- Shareholder value, emerging economies and the need to reconcile the corporate objective with sustainable and inclusive goals / Vincenzo Bavoso -- Improving corporate governance in developing and emerging markets : the politics, economics and law / Olawale Ajayi -- Share ownership in developing and emerging economies : legal institutions and determinants of effective corporate governance / Ngozi Okoye -- Director disqualification as a corporate governance tool in developing and emerging markets / Onyeka Osuji and Imogen Moore -- The market for corporate control and shareholder versus stakeholder models : whither developing and emerging market economies? / Kalu Ojah and Euphemia Godspower-Akpomiemie -- Part E: conclusion -- Corporate governance in developing and emerging markets : the way forward / Frank H. Stephen, Franklin N. Ngwu and Onyeka K. Osuji -- Index
    Keywords Business enterprises/Law and legislation ; Corporate governance ; Corporate Governance ; Entwicklungsländer ; Schwellenländer
    Language English
    Size xvii, 341 Seiten
    Publisher Routledge
    Publishing place London ; New York
    Document type Book
    Note Enthält 21 Beiträge ; Includes bibliographical references and index
    ISBN 9781138955851 ; 9781315666020 ; 113895585X ; 1315666022
    Database ECONomics Information System

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  7. Book ; Online: Corporate Governance in Developing and Emerging Markets

    Ngwu, Franklin N / Osuji, Onyeka K / Stephen, Frank H

    2016  

    Abstract: 20 The market for corporate control and shareholder versus stakeholder models: whither developing and emerging market economies? -- Part E Conclusion -- 21 Corporate governance in developing and emerging markets: the way forward -- Index ... Cover -- Title ...

    Abstract 20 The market for corporate control and shareholder versus stakeholder models: whither developing and emerging market economies? -- Part E Conclusion -- 21 Corporate governance in developing and emerging markets: the way forward -- Index

    Cover -- Title -- Copyright -- Contents -- List of figures and tables -- About the contributors -- Part A Introduction -- 1 Introduction: corporate governance in developing and emerging markets -- Part B Models of corporate governance -- 2 Varieties of corporate governance models: a review and synthesis -- 3 Development of the Anglo-American model of corporate governance in developing and emerging markets -- 4 New Institutional Economics, culture and corporate governance -- Part C Corporate governance in the BRICS and MINT countries -- 5 Brazil: recent corporate governance advances and retreats -- 6 Corporate governance in Russia: law, instrumentality and political order -- 7 Corporate governance in India: the potential for Ghandism -- 8 Corporate governance in China: regulatory reforms and policies -- 9 Institutions and corporate governance in South Africa -- 10 Corporate governance in Mexico: regulatory and institutional perspectives -- 11 Corporate governance in Indonesia -- 12 Institutional perspectives on corporate governance reforms in Nigeria -- 13 Corporate governance in Turkey -- Part D Critical issues for corporate governance in developing and emerging markets -- 14 Corporate governance and state-owned firms: the case of Brazil -- 15 Corporate governance under Islam: Islamic Republic of Iran -- 16 Shareholder value, emerging economies and the need to reconcile the corporate objective with sustainable and inclusive goals -- 17 Improving corporate governance in developing and emerging markets: the politics, economics and law -- 18 Share ownership in developing and emerging economies: legal institutions and determinants of effective corporate governance -- 19 Director disqualification as a corporate governance tool in developing and emerging markets
    Language English
    Size 1 Online-Ressource (360 pages)
    Document type Book ; Online
    ISBN 9781138955851 ; 9781317353874 ; 9781138955851 ; 113895585X ; 1317353870 ; 113895585X
    Database ECONomics Information System

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  8. Article: Partial blindness and alternative insights in the ascription of negligence liability

    Murphy, John / Stephen, Frank H

    Essays in the law and economics of regulation , p. 239-252

    2008  , Page(s) 239–252

    Author's details John Murphy and Frank H. Stephen
    Language English
    Publisher Intersentia [u.a.]
    Publishing place Antwerpen [u.a.]
    Document type Article
    Database ECONomics Information System

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  9. Book ; Online: The Beginnings of Political Economy

    Stephen, Frank / Backhaus, Jürgen Georg

    (The European Heritage in Economics and the Social Sciences, 7 ; v.No. 7)

    2008  

    Abstract: Contains eleven essays on Johann Heinrich Gottlob von Justi's concepts of the modern economy that show both Justi's life and professional work, focusing on his ideas on economics and social sciences. This book presents the aspects of his biography that ... ...

    Series title The European Heritage in Economics and the Social Sciences, 7 ; v.No. 7
    Abstract Contains eleven essays on Johann Heinrich Gottlob von Justi's concepts of the modern economy that show both Justi's life and professional work, focusing on his ideas on economics and social sciences. This book presents the aspects of his biography that gave rise to the development of his economic thought
    Language English
    Size Online-Ressource (207 p)
    Publisher Springer
    Publishing place Dordrecht
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780387097787 ; 0387097783
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Online: The Beginnings of Political Economy

    Backhaus, Jürgen Georg / Stephen, Frank

    Johann Heinrich Gottlob von Justi

    (The European Heritage in Economics and the Social Sciences ; 7)

    2009  

    Author's details edited by Jürgen Georg Backhaus, Frank Stephen, Jürgen Georg Backhaus
    Series title The European Heritage in Economics and the Social Sciences ; 7
    Keywords Economics ; Economics/Methodology ; Political science ; Social sciences/Methodology ; Sociology
    Language English
    Size Online-Ressource, v.: digital
    Publisher Springer US
    Publishing place Boston, MA
    Document type Book ; Online
    ISBN 9780387097787 ; 9780387097794 ; 0387097783 ; 0387097791
    DOI 10.1007/978-0-387-09779-4
    Database Former special subject collection: coastal and deep sea fishing

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