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  1. Article ; Online: Pulmonary valve infective endocarditis in an adult patient with atrial septal defect presenting with multiple pulmonary emboli - A case report.

    Ignatius, Remil / Stephen, Thomas / Varun, Cheruparambath

    Journal of cardiology cases

    2023  Volume 28, Issue 3, Page(s) 109–112

    Abstract: Isolated pulmonary valve (PV) infective endocarditis (IE) is a rare entity accounting for <2 % of all cases of IE. Risk of PV IE in patients with atrial septal defect (ASD) is considered negligible and there have only been a few cases reported to date. ... ...

    Abstract Isolated pulmonary valve (PV) infective endocarditis (IE) is a rare entity accounting for <2 % of all cases of IE. Risk of PV IE in patients with atrial septal defect (ASD) is considered negligible and there have only been a few cases reported to date. We describe a case of a 51-year-old woman with an ostium secundum ASD with associated PV endocarditis, who presented with multiple pulmonary septic emboli. Initially we tried antibiotic therapy and later she underwent successful surgery with ASD closure, vegetectomy, and PV repair. We want to draw attention to the possibility of IE of PV in a patient with ASD and report successful management with surgery and good recovery following treatment.
    Learning objective: In this study, we highlight the importance of keeping a strong clinical suspicion of infective endocarditis (IE) in patients presenting with fever and a pulmonary focus, especially in the setting of congenital heart disease (including even atrial septal defect). We also discuss the possible indications for surgical management in patients with pulmonary valve IE.
    Language English
    Publishing date 2023-05-06
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2023.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hospital-treated serious and invasive aspergillosis and candidiasis infections during the COVID-19 pandemic

    Matthew Smith / Stephen Thomas / Anita H Sung / Gillian Kiely / Jyotika K Singh / Jemma Lough

    BMJ Open, Vol 13, Iss

    a retrospective analysis of Hospital Episode Statistics data from England

    2023  Volume 5

    Abstract: Objectives To investigate the impact of COVID-19 on the burden of hospital-treated Aspergillus and Candida infections in England.Design A retrospective study using Hospital Episodes Statistics data to estimate the burden of serious and invasive fungal ... ...

    Abstract Objectives To investigate the impact of COVID-19 on the burden of hospital-treated Aspergillus and Candida infections in England.Design A retrospective study using Hospital Episodes Statistics data to estimate the burden of serious and invasive fungal infections (SIFIs) in all patients admitted in England during March 2018–February 2020 (pre-COVID-19) and during March 2020–October 2021 (the COVID-19 period).Setting Hospitals in England.Population All patients with codes corresponding to serious and invasive aspergillosis and candidiasis in any diagnosis position during their admission pre-COVID-19 and during the COVID-19 period.Outcome measures Age, spells, patient counts, mean length of stay, admission to critical care unit (CCU), length of stay in CCU, 30-day readmissions, failed discharges (readmission within 7 days) and comorbidities.Results During the COVID-19 period, hospitalisation spells with an invasive candidiasis code fell by 3.2% and spells with an aspergillosis code by 24.8%. Mean length of stay was higher for patients with aspergillosis with or without COVID-19 and candidiasis with or without COVID-19 during the pandemic than before the pandemic. During the pandemic, mean length of stay was higher for patients with aspergillosis with COVID-19 than those with aspergillosis alone but slightly lower for patients with candidiasis with COVID-19 than for those with candidiasis alone. Of patients with a diagnosis of COVID-19, 52.5% with aspergillosis and 60.0% with candidiasis were treated in CCU compared with 13.2% and 37.1%, respectively, without a COVID-19 diagnosis. The percentage of 30-day readmissions and failed discharges for patients with SIFI was higher for those with COVID-19 than for those without.Conclusions The burden of aspergillosis and candidiasis has been affected by COVID-19. Aspergillosis diagnoses fell among hospitalised patients during the pandemic, while candidiasis continued to fluctuate in patterns similar to pre-COVID-19. A higher burden for patients with SIFI was observed, ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: COVID-19, politics, economics and how the future pans out are inseparable.

    Green, Stephen Thomas / Cladi, Lorenzo

    Journal of the Royal Society of Medicine

    2020  Volume 114, Issue 2, Page(s) 60–62

    MeSH term(s) COVID-19 ; Humans ; Politics ; SARS-CoV-2
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/0141076820974999
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  4. Article ; Online: Science-based taxonomy still needs better governance

    Stephen Thomas Garnett / Les Christidis

    PLoS Biology, Vol 16, Iss 3, p e

    Response to Thomson et al.

    2018  Volume 2005249

    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Assessing unused residual Pfizer-BioNTech Covid-19 vaccine: a community observational study

    Hubbard, Stephen Thomas / Bais, Rajlaxmi

    medRxiv

    Abstract: Summary: Worldwide morbidity and mortality associated with Covid-19 are severe and ongoing. The Pfizer-BioNTech vaccine is said to be up to 95% effective against severe disease or death. We were able to demonstrate that an additional 9.8% of COVID-19 ... ...

    Abstract Summary: Worldwide morbidity and mortality associated with Covid-19 are severe and ongoing. The Pfizer-BioNTech vaccine is said to be up to 95% effective against severe disease or death. We were able to demonstrate that an additional 9.8% of COVID-19 vaccine doses could theoretically be given if the residual vaccine within the reconstituted Pfizer vials after six doses are extracted were used. This could be achieved by aseptically combining this excess vaccine from multiple vials to achieve full 0.3ml doses. Methods: An observational study was conducted in April, 2021, at a mass vaccine site run by a community volunteer organization on Bainbridge Island, Washington. We measured the amount of Pfizer-BioNTech COVID-19 vaccine that was left in 172 vials after six doses had been withdrawn per Centers for Disease Control (CDC) protocol. Results: A total of 30.68 ml of leftover vaccine was measured and discarded as medical waste. 1,036 doses were given from these vials. An extra 102 doses theoretically could have been given using the residual vaccine in the vials. This would have resulted in 9.8% additional doses of COVID-19 vaccine without requiring new vials. Conclusion: The ability to combine solution from reconstituted Pfizer vaccine vials to minimize waste and obtain additional doses of vaccine could result in an increase in the number of individuals that could be vaccinated worldwide without additional cost. Further studies to validate our findings are warranted. Clinical trials to study the feasibility, safety and efficacy of protocols using this excess vaccine should be considered.
    Keywords covid19
    Language English
    Publishing date 2021-08-09
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.08.03.21261569
    Database COVID19

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  6. Article ; Online: Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.

    Figtree, Gemma Alexandra / Vernon, Stephen Thomas / Nicholls, Stephen James

    European journal of preventive cardiology

    2021  Volume 29, Issue 4, Page(s) 580–587

    Abstract: Coronary artery disease (CAD) remains the leading cause of death worldwide. The role of hypertension, cholesterol, diabetes mellitus, and smoking in driving disease has been well recognized at a population level and has been the target of primary ... ...

    Abstract Coronary artery disease (CAD) remains the leading cause of death worldwide. The role of hypertension, cholesterol, diabetes mellitus, and smoking in driving disease has been well recognized at a population level and has been the target of primary prevention strategies for over 50 years with substantial impact. However, in many cases, these factors alone do not provide enough precision at the individual level to allow physicians and patients to take appropriate preventive measures and many patients continue to suffer acute coronary syndromes in the absence of these risk factors. Recent advances in user-friendly chip designs, high speed throughput, and economic efficiency of genome-wide association studies complemented by advances in statistical analytical approaches have facilitated the rapid development of polygenic risk scores (PRSs). The latest PRSs combine data regarding hundreds of thousands of single-nucleotide polymorphisms to predict chronic diseases including CAD. Novel CAD PRSs are strong predictors of risk and may have application, in a complementary manner with existing risk prediction algorithms. However, there remain substantial controversies, and ultimately, we need to move forward from observational studies to prospectively and rigorously assess the potential impact if widespread implementation is to be aspired to. Consideration needs to be made of ethnicity, sex, as well as age, and risk estimate based on existing non-genomic algorithms. We provide an overview and commentary on the important advances in deriving and validating PRSs, as well as pragmatic considerations that will be required for implementation of the new knowledge into clinical practice.
    MeSH term(s) Coronary Artery Disease/diagnosis ; Coronary Artery Disease/genetics ; Coronary Artery Disease/prevention & control ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Primary Prevention ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwaa030
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    Zs.A 4686: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Response to 'Analysis of learning curves in gastroscopy training: the need for composite measures for defining competence' by Siau

    Ward, Stephen Thomas / Dunckley, Paul

    Gut

    2018  Volume 67, Issue 6, Page(s) 1198–1199

    MeSH term(s) Clinical Competence ; Gastroscopy ; Learning Curve
    Language English
    Publishing date 2018
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2017-315191
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    Zs.A 160: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Science-based taxonomy still needs better governance: Response to Thomson et al.

    Garnett, Stephen Thomas / Christidis, Les

    PLoS biology

    2018  Volume 16, Issue 3, Page(s) e2005249

    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.2005249
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    Zs.A 6193: Show issues Location:
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  9. Article: Statistical significance and scientific misconduct

    Ziliak, Stephen Thomas

    Review of social economy : publication of the Association for Social Economics volume LXXIV, number 1 (March 2016) Seite 83-97

    improving the style of the published research paper

    2016  

    Author's details Stephen T. Ziliak
    Keywords Research ethics ; econometrics ; Bayes factors ; human values ; statistical reporting
    Language English
    Publisher Routledge$h1944-
    Publishing place London [u.a.]
    Document type Article
    ZDB-ID 280967-9 ; 2007774-9
    ISSN 1470-1162 ; 0034-6764
    ISSN (online) 1470-1162
    ISSN 0034-6764
    Database ECONomics Information System

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  10. Article ; Online: Severe stridor and profound weakness after cerebral malaria.

    Fuller, Charlotte / Wooldridge, Gavin / Liomba, Alice / Ray, Stephen Thomas James

    BMJ case reports

    2021  Volume 14, Issue 4

    Abstract: Cerebral malaria (CM) is defined by WHO as coma (Blantyre Coma Score 2 or less) in a patient ... ...

    Abstract Cerebral malaria (CM) is defined by WHO as coma (Blantyre Coma Score 2 or less) in a patient with
    MeSH term(s) Child ; Coma ; Critical Care ; Humans ; Infant ; Malaria, Cerebral/complications ; Malaria, Cerebral/diagnosis ; Malaria, Falciparum ; Respiratory Sounds/etiology
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-237681
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