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  1. Book: Modulation of presynaptic calcium channels

    Stephens, Gary / Mochida, Sumiko

    2013  

    Author's details Gary Stephens ; Sumiko Mochida ed
    Language English
    Size XII, 365 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017640565
    ISBN 978-94-007-6333-3 ; 9789400763340 ; 94-007-6333-6 ; 9400763344
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 980 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Targeting the cell's gatekeepers for novel drug discovery.

    Stephens, Gary J / Shukla, Arun K

    British journal of pharmacology

    2022  Volume 179, Issue 14, Page(s) 3485–3486

    MeSH term(s) Drug Discovery
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15831
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: An Introduction to Patch Clamp Recording.

    Hill, Charlotte L / Stephens, Gary J

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2188, Page(s) 1–19

    Abstract: Electrophysiology is an essential tool aiding the study of the functions and dysfunctions of electrically excitable cells and their networks. The patch clamp method is a refined electrophysiological technique that can directly measure the membrane ... ...

    Abstract Electrophysiology is an essential tool aiding the study of the functions and dysfunctions of electrically excitable cells and their networks. The patch clamp method is a refined electrophysiological technique that can directly measure the membrane potential and/or the amount of current passing across the cell membrane. The patch clamp technique is also incredibly versatile and can be used in a variety of different configurations to study a range of properties, from spontaneous cell firing activity in native tissue to the activation and/or deactivation kinetics of individual channels expressed in recombinant cell lines. In this chapter we give an overview of patch clamping and how the different configurations can be set up and applied to electrophysiological research.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Electrophysiological Phenomena ; Equipment Design ; Humans ; Ion Channels/metabolism ; Patch-Clamp Techniques/instrumentation ; Patch-Clamp Techniques/methods
    Chemical Substances Ion Channels
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0818-0_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of cannabidiol as a treatment for severe childhood epilepsies.

    Williams, Claire M / Stephens, Gary J

    British journal of pharmacology

    2020  Volume 177, Issue 24, Page(s) 5509–5517

    Abstract: In recent years, there has been a growing appreciation by regulatory authorities that cannabis-based medicines can play a useful role in disease therapy. Although often conflagrated by proponents of recreational use, the legislative rescheduling of ... ...

    Abstract In recent years, there has been a growing appreciation by regulatory authorities that cannabis-based medicines can play a useful role in disease therapy. Although often conflagrated by proponents of recreational use, the legislative rescheduling of cannabis-derived compounds, such as cannabidiol (CBD), has been associated with the steady increase in the pursuit of use of medicinal cannabis. One key driver in this interest has been the scientific demonstration of efficacy and safety of CBD in randomised, placebo-controlled clinical trials in children and young adults with difficult-to-treat epilepsies, which has encouraged increasing numbers of human trials of CBD for other indications and in other populations. The introduction of CBD as the medicine Epidiolex in the United States (in 2018) and as Epidyolex in the European Union (in 2019) as the first cannabis-derived therapeutic for the treatment of seizures was underpinned by preclinical research performed at the University of Reading. This work was awarded the British Pharmacological Society Sir James Black Award for Contributions to Drug Discovery 2019 and is discussed in the following review article.
    MeSH term(s) Anticonvulsants/therapeutic use ; Cannabidiol/therapeutic use ; Child ; Epilepsies, Myoclonic/drug therapy ; Epilepsy/drug therapy ; Humans ; Lennox Gastaut Syndrome/drug therapy ; Young Adult
    Chemical Substances Anticonvulsants ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15274
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Protofibrillar Amyloid Beta Modulation of Recombinant hCaV2.2 (N-Type) Voltage-Gated Channels.

    Kaisis, Eleni / Thei, Laura J / Stephens, Gary J / Dallas, Mark L

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 12

    Abstract: Cav2.2 channels are key regulators of presynaptic ... ...

    Abstract Cav2.2 channels are key regulators of presynaptic Ca
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15121459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CACHD1: A new activity-modifying protein for voltage-gated calcium channels.

    Stephens, Gary J / Cottrell, Graeme S

    Channels (Austin, Tex.)

    2019  Volume 13, Issue 1, Page(s) 120–123

    MeSH term(s) Calcium Channels/metabolism ; Humans ; Ion Channel Gating ; Membrane Proteins/metabolism ; Receptor Activity-Modifying Proteins/metabolism
    Chemical Substances CACHD1 protein, human ; Calcium Channels ; Membrane Proteins ; Receptor Activity-Modifying Proteins
    Language English
    Publishing date 2019-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2262854-X
    ISSN 1933-6969 ; 1933-6950
    ISSN (online) 1933-6969
    ISSN 1933-6950
    DOI 10.1080/19336950.2019.1600968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Recent advances in targeting ion channels to treat chronic pain.

    Stevens, Edward B / Stephens, Gary J

    British journal of pharmacology

    2018  Volume 175, Issue 12, Page(s) 2133–2137

    Abstract: Linked articles: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc. ...

    Abstract Linked articles: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc.
    MeSH term(s) Analgesics/pharmacology ; Animals ; Chronic Pain/drug therapy ; Chronic Pain/metabolism ; Humans ; Ion Channels/antagonists & inhibitors ; Ion Channels/metabolism
    Chemical Substances Analgesics ; Ion Channels
    Language English
    Publishing date 2018-06-01
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Anti-AMPA Receptor Autoantibodies Reduce Excitatory Currents in Rat Hippocampal Neurons.

    Day, Charlotte / Silva, John-Paul / Munro, Rebecca / Baker, Terry S / Wolff, Christian / Bithell, Angela / Stephens, Gary J

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 1

    Abstract: The GluR3 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) has been identified as a target for autoantibodies (Aabs) in autoimmune encephalopathy and other diseases. Recent studies have proposed mechanisms by which these ...

    Abstract The GluR3 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) has been identified as a target for autoantibodies (Aabs) in autoimmune encephalopathy and other diseases. Recent studies have proposed mechanisms by which these Aabs act, but their exact role in neuronal excitability is yet to be established. Patient Aabs have been shown to bind to specific regions within the GluR3 subunit. GLUR3B peptides were designed based on described (ELISA) immunogenic epitopes for Aabs and an immunisation strategy was used to generate novel anti-AMPAR Aabs. Target-specific binding and specificity of affinity-purified anti-AMPAR Aabs was confirmed using enzyme-linked immunosorbent assay, immunocytochemistry and Western blot. Functional anti-AMPAR Aab effects were determined on excitatory postsynaptic currents (EPSCs) from primary hippocampal neurons using whole-cell patch-clamp electrophysiology. Acute (10 or 30 min) or longer-term (24 h) application of anti-AMPAR Aabs caused a significant reduction in the mean frequency of spontaneous and miniature EPSCs in hippocampal neurons. Our data demonstrate that anti-AMPAR Aabs targeting peptides linked to auto-immune diseases mediate inhibitory effects on neuronal excitability at the synaptic level, such effects may lead to disruption of the excitatory/inhibitory balance at a network level.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16010077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Modulation of presynaptic calcium channels

    Stephens, Gary / Mochida, Sumiko

    2013  

    Author's details Gary Stephens, Sumiko Mochida, editors
    MeSH term(s) Calcium Channels/metabolism ; Neuronal Plasticity/physiology ; Presynaptic Terminals/metabolism ; Synapses/physiology ; Synaptic Transmission/physiology
    Language English
    Size xii, 365 pages :, illustrations
    Document type Book
    ISBN 9789400763333 ; 9789400763340 ; 9400763336 ; 9400763344
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: α

    Ablinger, Cornelia / Eibl, Clarissa / Geisler, Stefanie M / Campiglio, Marta / Stephens, Gary J / Missler, Markus / Obermair, Gerald J

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: ... The ... ...

    Abstract The α
    MeSH term(s) Calcium Channels/metabolism ; Hippocampus/metabolism ; Neurogenesis ; Neurons/metabolism ; Synapses/metabolism
    Chemical Substances Calcium Channels
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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