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  1. Article ; Online: Potential and limitation of retrospective HRMS based data analysis

    Kaufmann, A. / Arrizabalaga-Larrañaga, A. / Blokland, M.H. / Sterk, S.S.

    Food Control

    “Have meat-producing animals been exposed to illegal growth promotors such as SARMs?”

    2023  Volume 147

    Abstract: Targeted strategies using gas or liquid chromatography coupled to triple quadrupole mass analyzers are mostly used in food safety control laboratories. However, when a new chemical hazard emerges, the target list needs to be updated and thus the should ... ...

    Abstract Targeted strategies using gas or liquid chromatography coupled to triple quadrupole mass analyzers are mostly used in food safety control laboratories. However, when a new chemical hazard emerges, the target list needs to be updated and thus the should be reanalyzed. Under this scenario, the constant emergence of compounds that can illegally be used as growth promotors in cattle, such as selective androgen receptor modulators (SARM), and the phasing out of older SARMs, would require routine control laboratories (RCL) to constantly re-develop and re-validate their once developed targeted methods. Nevertheless, high-resolution mass spectrometry (HRMS) is not limited to analyzing samples using only a predefined targeted list and therefore the implementation of untargeted HRMS methods in RCLs to detect SARMs would enhance the laboratories throughput. In this study, two HRMS profile databases of cattle urine samples gathered over the past years and collected by two independent laboratories, were retrospectively analyzed to find out if a new SARM has been used. This study assesses different retrospective screening approaches based on the Schymanski identification confidence levels. A screening purely based on identification confidence levels 4 and 5 does not permit reliable detection of any exogenous trace compound that does not belong to a certain food or environmental matrix sample due to the high number of false detects. Therefore, it is shown that the availability of a physical reference substance to increase the identification confidence up to level 1 is essential to discriminate a suspected detection between a false positive detection or a confirmed finding.
    Keywords Cattle ; Growth promotors ; High-resolution mass spectrometry ; Retrospective analysis ; Selective androgen receptor modulators
    Subject code 540
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 1027805-9
    ISSN 0956-7135
    ISSN 0956-7135
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Bonn / Germany

    Z 5255: Show issues

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  2. Book ; Online: Detection and quantification of IGF-1 and IGF-2 in bovine plasma by LC-MS/MS

    Barbu, I.M. / Wubs, K.L. / Sterk, S.S.

    2022  

    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Proficiency test for corticosteroids in bovine and porcine urine

    Elbers, I.J.W. / Sterk, S.S.

    2022  

    Abstract: A proficiency test for corticosteroids in bovine and porcine urine was organized by the European Union Reference Laboratory (EURL) for hormonal growth promoting compounds, sedatives and mycotoxins. This EURL function is carried out by Wageningen Food ... ...

    Abstract A proficiency test for corticosteroids in bovine and porcine urine was organized by the European Union Reference Laboratory (EURL) for hormonal growth promoting compounds, sedatives and mycotoxins. This EURL function is carried out by Wageningen Food Safety Research (WFSR), part of Wageningen University & Research.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: Residue control in the European Union, the present and future challenges. Experiences from the Netherlands

    Sterk, S.S.

    Procedia Food Science

    2015  Volume 5

    Abstract: Residue control in the European Union has the primary goal to protect consumers from intolerable health hazards which may be associated with residues of veterinary drugs or non-licensed or forbidden substances in animal products. The present situation ... ...

    Abstract Residue control in the European Union has the primary goal to protect consumers from intolerable health hazards which may be associated with residues of veterinary drugs or non-licensed or forbidden substances in animal products. The present situation regarding residue control in the EU is discussed. In the near future Directive 96/23 will be revised and residue monitoring will become more risk based, which will present challenges to laboratories. What are the new risks (compounds), and how can these be effectively identified and controlled? Techniques and matrices will change in the coming years to accommodate this new monitoring system.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 2211-601X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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  5. Book ; Online: Examples of the use of a true mobile mass spectrometer for on-site analysis

    Blokland, M.H. / Jager, J. / Arrizabalaga Larrañaga, A. / Zoontjes, P.W. / Sterk, S.S.

    2022  

    Abstract: Nowadays, we use optical sensors in our smartphones and smartwatches to measure all kind of mostly health-related parameters. Unfortunately, their application is limited. Imagine the possibilities if you could take high-end laboratory equipment to the ... ...

    Abstract Nowadays, we use optical sensors in our smartphones and smartwatches to measure all kind of mostly health-related parameters. Unfortunately, their application is limited. Imagine the possibilities if you could take high-end laboratory equipment to the field. Current mass spectrometers are, at best transportable, not truly portable. What if you could fit an MS in a small backpack or carry it in your hand? In recent years, we have invested in research, leading to effective on-site MS. A portable gas chromatography-mass spectrometer, Griffin 510 instrument (Flir, Wilsonville, OR, USA), has been used in this study. This Portable GC-MS is fully battery-operated, consisting of a split-splitless injector, a 15 m polysiloxane DB-5 column, an electron ionization (EI) source, and a single quadrupole mass analyzer. The high vacuum is obtained using a small turbopump. Besides a traditional liquid injection, a heated sample probe can be used, which sucks in vapors. These vapors can be analyzed directly via membrane introduction mass spectrometry (MIMS) or concentrated via an internal dual-bed pre-concentrator. The portable MS can run continuously for 4 hours without external power or helium supply using small helium bottles and a swappable battery.
    Keywords Life Science
    Subject code 621
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: Bovine Teeth

    Lasaroms, J.J.P. / van Dam, M.D. / Linders, R.F. / Sterk, S.S.

    A new Forensic Matrix for the detection of Regulated and Banned Substances

    2022  

    Abstract: To investigate illicit administration of regulated and banned substances used for growth-promoting purposes in cattle breeding, it is common to analyse the usual matrices like urine, feed, animal tissue, and hair samples nowadays.We wondered if there is ... ...

    Abstract To investigate illicit administration of regulated and banned substances used for growth-promoting purposes in cattle breeding, it is common to analyse the usual matrices like urine, feed, animal tissue, and hair samples nowadays.We wondered if there is a different type of sample material available that could overcome these disadvantages? A requirement is that the samples should be traceable to the animals and be easy to collect, for example, at slaughterhouses. Possible 'offal’? The question arised if bovine teeth could be the ‘new’ matrix.Therefore, we set to develop and validate a liquid chromatography tandem-mass spectrometry (UHPLC-MS/MS) method to detect different class of compounds (beta-agonists, NSAID’s and a selection of veterinary drugs (tetracyclines, quinolines, macrolides and sulfonamides) in bovine teeth.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: A new control strategy to detect thiouracil abuse

    Blokland, M.H. / van Tricht, E.F. / Thissen, M.A.T. / Groot, M.J. / Sterk, S.S.

    2022  

    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: 4-acetaminophen (Paracetamol) levels in treated and untreated veal calves, an update

    Groot, M.J. / van Dijk, A. / van Baak, M.J. / Boshuis, P. / van de Braak, A.E. / Zuidema, T. / Sterk, S.S.

    Food Control

    2023  Volume 147

    Abstract: Recently, residues of 4-acetaminophen (paracetamol) have been found in urine of slaughter animals. To investigate its possible origin, a 7 week animal experiment was performed with 5 groups of 4 calves fed different amounts of roughage, and treated or ... ...

    Abstract Recently, residues of 4-acetaminophen (paracetamol) have been found in urine of slaughter animals. To investigate its possible origin, a 7 week animal experiment was performed with 5 groups of 4 calves fed different amounts of roughage, and treated or not with 4-acetaminophen. Group 1 (control): new-born calves were fed, after the first days of colostrum, solely dairy based calf milk replacer (CMR). The animals from the other groups were 2–3 weeks of age at the start of the experiment and were fed the same CMR. Group 2 was administered oral Pracetam® 30 mg acetaminophen/kg Body Weight (BW) in the CMR, 5 days a week at alternate weeks, with maximum roughage. Group 3 was fed legal minimum roughage. Group 4 received the maximum roughage. Group 5 was administered human paracetamol pills 30 mg/kg BW once a week at weeks 2–6 with maximum roughage. The animals were housed in separate pens on slatted rubber floors without bedding. The controls were housed in a different room than the other animals. Urine was sampled once in the acclimatization period and for 5 days after treatment. At week 2, 4 and 6 at respectively 1, 2 and 3 days after treatment, one animal from groups 2 and 5 was sacrificed. An additional animal from group 4 was sacrificed at week 4, the rest of the animals at day 43. Urine, muscle, liver and kidney were analysed for residues of 4-acetaminophen and its metabolites. It appeared that controls and the low and high roughage animals had almost no 4-acetaminophen (<3 μg/L) in the urine and low levels of metabolites, whereas high roughage had at slaughter higher levels of metabolites than low roughage. Pracetam® treated animals showed high levels 4-acetaminophen (up to 130.000 μg/L) and metabolites during treatment, and lower levels (2800 μg/L) at slaughter. In the paracetamol treated animals 4-acetaminophen and metabolites were detectable during treatment (up to 130.000 μg/L) and until 7 days after treatment (110 μg/L). 4-Acetaminophen and metabolites were only present in tissues of treated animals, ...
    Keywords Life Science
    Subject code 630
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 1027805-9
    ISSN 0956-7135
    ISSN 0956-7135
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5255: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online: EURL Reflection paper 2.0

    Arrizabalaga Larrañaga, A. / Groot, M.J. / Blokland, M.H. / Barbu, I.M. / Smits, N.G.E. / Sterk, S.S.

    Natural growth promoting substances in biological samples : Presence - and formation - of hormones and other growth promoting substances in food producing animals.

    2022  

    Abstract: From 29 November to 1 December 1995, Directorate-General VI, Agriculture, of the European Commission organised the “Scientific conference on growth promotion in meat production”1. During this conference, worldwide leading scientists discussed the ... ...

    Abstract From 29 November to 1 December 1995, Directorate-General VI, Agriculture, of the European Commission organised the “Scientific conference on growth promotion in meat production”1. During this conference, worldwide leading scientists discussed the existing and emerging growth-enhancing substances, the assessment of health risks, and the methods for detection and surveillance. One of the papers, presented by the group of Guy Maghuin-Rogister (University of Liège) was titled: “Methods of detection and surveillance of natural sex steroid hormones”. This paper assessed the possibilities of setting thresholds based on quantitative data obtained with immunoassays. For various situations, it was concluded that discrimination between untreated and treated animals should be possible but that further research would be needed to effectively enforce the ban on the use of hormones for growth promotion.Also during the Euroresidue conferences, held from 1990 until 2022, it has shown that even when some strategies are determined, for a number of naturally occurring compounds there is still need for an enforcement strategy.In 2014 we evaluated the status of natural occurring growth promoters in the EURL Reflection paper. We wanted to provide enforcement bodies with practical guidelines and to identify the remaining research needs.Now, eight years later, we updated the EURL Reflection paper. Literature of the past 8 years is incorporated, and we give an update on research and strategies, and new endogenous compounds that are identified.We expect that with this 2.0 version, we will provide updated information to enforcement agencies and laboratories and channel our research activities for the coming years to solve the blind spots addressed in this Reflection paper.
    Keywords Life Science
    Subject code 306
    Language English
    Publisher Wageningen Food Safety Research
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Liquid chromatography-isotope ratio mass spectrometry in food residue control

    Jager, J. / Blokland, M.H. / Zoontjes, P.W. / van Asseldonk, L.L.M. / Roelofs, G. / Sterk, S.S. / Bovee, T.F.H.

    2022  

    Abstract: Residues that can also have an endogenous origin, need confirmative testing by carbon isotope ratio analysis. For this, gas chromatography-combustion-isotope ratio mass spectrometry (GC-c-IRMS) was traditionally used within Wageningen Food Safety ... ...

    Abstract Residues that can also have an endogenous origin, need confirmative testing by carbon isotope ratio analysis. For this, gas chromatography-combustion-isotope ratio mass spectrometry (GC-c-IRMS) was traditionally used within Wageningen Food Safety Research (WFSR). However, GC-c-IRMS is often not applicable for nonvolatile’s or require derivatisation. To overcome this limitation for non-volatile’s, liquid chromatographyisotope ratio mass spectrometry (LC-IRMS) can be used. This is a challenge, as the interface design between LC and IRMS requires the need for carbon-free eluents, thereby limiting usable LC separation techniques. Here we present preliminary results using LC-IRMS as a confirmatory technique for endogenous and/or exogenous steroids, antipyretics and thyreostats.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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