Article ; Online: Amniotic fluid-derived extracellular vesicles: characterization and therapeutic efficacy in an experimental model of bronchopulmonary dysplasia.
2021 Volume 23, Issue 12, Page(s) 1097–1107
Abstract: Background aims: Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use ... ...
| Abstract | Background aims: Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use in regenerative medicine, yet AF-EV characterization has not been fully explored. Methods: Here the authors demonstrate AF as a rich source of EVs and identify the microRNA and proteomic cargo. Bioinformatics analysis of this cargo revealed multiple pathway targets, including immunomodulatory, anti-inflammatory and free radical scavenging networks. The authors further demonstrated the therapeutic potential of this EV product as a novel preventative agent for bronchopulmonary dysplasia (BPD). Results: Intra-tracheal administration of AF-EVs preserved alveolar development, attenuated vascular remodeling and pulmonary hypertension, decreased lung pro-inflammatory cytokine expression and reduced macrophage infiltration in an experimental BPD model. Conclusions: The authors' results suggest that AF is a viable biological fluid for EV harvest and that AF-EVs have strong therapeutic potential for pulmonary diseases, such as BPD, warranting further development to transition this novel EV product into the clinic. |
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| MeSH term(s) | Amniotic Fluid ; Animals ; Bronchopulmonary Dysplasia/therapy ; Disease Models, Animal ; Extracellular Vesicles ; Humans ; Infant, Newborn ; Models, Theoretical ; Proteomics ; Rats, Sprague-Dawley ; Rats |
| Language | English |
| Publishing date | 2021-09-17 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2039821-9 |
| ISSN | 1477-2566 ; 1465-3249 |
| ISSN (online) | 1477-2566 |
| ISSN | 1465-3249 |
| DOI | 10.1016/j.jcyt.2021.07.011 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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