Article ; Online: The impact of spectral basis set composition on estimated levels of cingulate glutamate and its associations with different personality traits.
2024 Volume 24, Issue 1, Page(s) 320
Abstract: Background: 1: Methods: To ensure comparability, we utilized five different exemplar basis sets, used in research, and two different analysis tools, r-based spant applying the ABfit method and Osprey using the LCModel.: Results: Our findings ... ...
| Abstract | Background: 1 Methods: To ensure comparability, we utilized five different exemplar basis sets, used in research, and two different analysis tools, r-based spant applying the ABfit method and Osprey using the LCModel. Results: Our findings revealed that the types of metabolites included in the basis set significantly affected the glutamate concentration. We observed that three basis sets led to more consistent results across different concentration types (i.e., absolute Glu in mol/kg, Glx (glutamate + glutamine), Glu/tCr), spectral fit and quality measurements. Interestingly, all three basis sets included phosphocreatine. Importantly, our findings also revealed that glutamate levels were differently associated with both schizotypal and autistic traits depending on basis set configuration and analysis tool, with the same three basis sets showing more consistent results. Conclusions: Our study highlights that scientific results may be significantly altered depending on the choices of metabolites included in the basis set, and with that emphasizes the importance of carefully selecting the configuration of the basis set to ensure accurate and consistent results, when using MR spectroscopy. Overall, our study points out the need for standardized analysis pipelines and reporting. |
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| MeSH term(s) | Humans ; Gyrus Cinguli/metabolism ; Glutamic Acid/metabolism ; Male ; Adult ; Female ; Proton Magnetic Resonance Spectroscopy/methods ; Young Adult ; Personality/physiology ; Psychotic Disorders/metabolism ; Magnetic Resonance Spectroscopy/methods ; Glutamine/metabolism |
| Chemical Substances | Glutamic Acid (3KX376GY7L) ; Glutamine (0RH81L854J) |
| Language | English |
| Publishing date | 2024-04-25 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2050438-X |
| ISSN | 1471-244X ; 1471-244X |
| ISSN (online) | 1471-244X |
| ISSN | 1471-244X |
| DOI | 10.1186/s12888-024-05646-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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