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  1. Book: Renewable Bioresources

    Stevens, Christian V.

    scope and modification for non-food applications

    2004  

    Author's details ed.: Christian V. Stevens
    Keywords Renewable natural resources ; Sustainable development ; Ökologische Chemie ; Erneuerbare Ressourcen ; Erneuerbare Energien ; Chemische Industrie ; Nachhaltigkeit ; Biopolymere ; Rohstoffbeschaffung
    Subject Rohstoff ; Biomakromolekül ; Biologisches Makromolekül ; Natürliche Polymere ; Nachhaltige Entwicklung ; Langfristige Entwicklung ; Sustainable Development ; Dauerhafte Entwicklung ; Zukunftsfähige Entwicklung ; Nicht erschöpfbare Ressourcen ; Regenerierbare Ressourcen ; Chemieindustrie ; Chemischer Betrieb ; Sanfte Energie ; Erneuerbare Energiequelle ; Regenerative Energiequelle ; Regenerative Energie ; Erneuerbare Energie ; Alternativenergie ; Alternativenergien ; Regenerative Energien ; Alternative Energiequelle ; Grüne Energie ; Green energy ; Umwelt ; Umweltchemie ; Ökochemie ; Umweltwissenschaften
    Subject code 333.95
    Language English
    Size XVII, 310 S. : graph. Darst.
    Publisher Wiley
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013890691
    ISBN 0-470-85446-4 ; 0-470-85447-2 ; 978-0-470-85446-4 ; 978-0-470-85447-1
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    048/141 available for loan (reading room) Freihandmagazin (U1)

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  2. Article: Rxn-INSIGHT: fast chemical reaction analysis using bond-electron matrices.

    Dobbelaere, Maarten R / Lengyel, István / Stevens, Christian V / Van Geem, Kevin M

    Journal of cheminformatics

    2024  Volume 16, Issue 1, Page(s) 37

    Abstract: The challenge of devising pathways for organic synthesis remains a central issue in the field of medicinal chemistry. Over the span of six decades, computer-aided synthesis planning has given rise to a plethora of potent tools for formulating synthetic ... ...

    Abstract The challenge of devising pathways for organic synthesis remains a central issue in the field of medicinal chemistry. Over the span of six decades, computer-aided synthesis planning has given rise to a plethora of potent tools for formulating synthetic routes. Nevertheless, a significant expert task still looms: determining the appropriate solvent, catalyst, and reagents when provided with a set of reactants to achieve and optimize the desired product for a specific step in the synthesis process. Typically, chemists identify key functional groups and rings that exert crucial influences at the reaction center, classify reactions into categories, and may assign them names. This research introduces Rxn-INSIGHT, an open-source algorithm based on the bond-electron matrix approach, with the purpose of automating this endeavor. Rxn-INSIGHT not only streamlines the process but also facilitates extensive querying of reaction databases, effectively replicating the thought processes of an organic chemist. The core functions of the algorithm encompass the classification and naming of reactions, extraction of functional groups, rings, and scaffolds from the involved chemical entities. The provision of reaction condition recommendations based on the similarity and prevalence of reactions eventually arises as a side application. The performance of our rule-based model has been rigorously assessed against a carefully curated benchmark dataset, exhibiting an accuracy rate exceeding 90% in reaction classification and surpassing 95% in reaction naming. Notably, it has been discerned that a pivotal factor in selecting analogous reactions lies in the analysis of ring structures participating in the reactions. An examination of ring structures within the USPTO chemical reaction database reveals that with just 35 unique rings, a remarkable 75% of all rings found in nearly 1 million products can be encompassed. Furthermore, Rxn-INSIGHT is proficient in suggesting appropriate choices for solvents, catalysts, and reagents in entirely novel reactions, all within the span of a second, utilizing nothing more than an everyday laptop.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2486539-4
    ISSN 1758-2946
    ISSN 1758-2946
    DOI 10.1186/s13321-024-00834-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Versatile Palladium-catalyzed intramolecular cyclization to access new luminescent azaphosphaphenalene motifs.

    Simoens, Andreas / Kaczmarek, Anna M / Machado, Ian P / Van Hecke, Kristof / Stevens, Christian V

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 19, Page(s) e202303072

    Abstract: Using a straightforward sequence of diphosphonylation and a Pd-catalysed concerted-metalation-deprotonation (CMD), a synthetic strategy towards polyaromatic phosphorus containing heterocycles was developed. Herein, we report the synthesis and ... ...

    Abstract Using a straightforward sequence of diphosphonylation and a Pd-catalysed concerted-metalation-deprotonation (CMD), a synthetic strategy towards polyaromatic phosphorus containing heterocycles was developed. Herein, we report the synthesis and characterization of new azaphosphaphenalenes, using easily accessible palladium catalysts and starting materials. The key tetrahydroquinoline intermediates of the reaction were synthesised via a fast and effective procedure and could be isolated as such, or further reacted towards the target polyaromatic structures. The obtained products showed interesting luminescent properties and their emission, excitation and quantum yields were evaluated.
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glioblastoma-Associated Mesenchymal Stem/Stromal Cells and Cancer-Associated Fibroblasts: Partners in Crime?

    Lootens, Thibault / Roman, Bart I / Stevens, Christian V / De Wever, Olivier / Raedt, Robrecht

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as attractive therapeutic targets in several cancer types, due to their ability to enhance tumor growth and angiogenesis and their contribution to an immunosuppressive tumor ... ...

    Abstract Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as attractive therapeutic targets in several cancer types, due to their ability to enhance tumor growth and angiogenesis and their contribution to an immunosuppressive tumor microenvironment (TME). In glioblastoma (GB), mesenchymal stem cells (MSCs) seem to be recruited to the tumor site, where they differentiate into glioblastoma-associated mesenchymal stem/stromal cells (GA-MSCs) under the influence of tumor cells and the TME. GA-MSCs are reported to exert important protumoral functions, such as promoting tumor growth and invasion, increasing angiogenesis, stimulating glioblastoma stem cell (GSC) proliferation and stemness, mediating resistance to therapy and contributing to an immunosuppressive TME. Moreover, they could act as precursor cells for cancer-associated fibroblasts (CAFs), which have recently been identified in GB. In this review, we provide an overview of the different functions exerted by GA-MSCs and CAFs and the current knowledge on the relationship between these cell types. Increasing our understanding of the interactions and signaling pathways in relevant models might contribute to future regimens targeting GA-MSCs and GB-associated CAFs to inhibit tumor growth and render the TME less immunosuppressive.
    MeSH term(s) Humans ; Glioblastoma/metabolism ; Cancer-Associated Fibroblasts ; Mesenchymal Stem Cells/metabolism ; Signal Transduction ; Crime ; Tumor Microenvironment ; Fibroblasts/pathology
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Application of Porous Organic Polymers as Metal Free Photocatalysts in Organic Synthesis.

    Debruyne, Maarten / Van Der Voort, Pascal / Van Speybroeck, Veronique / Stevens, Christian V

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e202400311

    Abstract: Concerns about increasing greenhouse gas emissions and their effect on our environment highlight the urgent need for new sustainable technologies. Visible light photocatalysis allows the clean and selective generation of reactive intermediates under mild ...

    Abstract Concerns about increasing greenhouse gas emissions and their effect on our environment highlight the urgent need for new sustainable technologies. Visible light photocatalysis allows the clean and selective generation of reactive intermediates under mild conditions. The more widespread adoption of the current generation of photocatalysts, particularly those using precious metals, is hampered by drawbacks such as their cost, toxicity, difficult separation, and limited recyclability. This is driving the search for alternatives, such as porous organic polymers (POPs). This new class of materials is made entirely from organic building blocks, can possess high surface area and stability, and has a controllable composition and functionality. This review focuses on the application of POPs as photocatalysts in organic synthesis. For each reaction type, a representative material is discussed, with special attention to the mechanism of the reaction. Additionally, an overview is given, comparing POPs with other classes of photocatalysts, and critical conclusions and future perspectives are provided on this important field.
    Language English
    Publishing date 2024-03-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tuning the antimicrobial activity of microbial glycolipid biosurfactants through chemical modification.

    Pala, Melike / Castelein, Martijn G / Dewaele, Camille / Roelants, Sophie L K W / Soetaert, Wim K / Stevens, Christian V

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1347185

    Abstract: Sophorolipids, glycolipid biosurfactants derived from microorganisms such ... ...

    Abstract Sophorolipids, glycolipid biosurfactants derived from microorganisms such as
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1347185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Evaluatie van omega-halogeeniminen als synthon in de organische chemie en toepassing ervan in de landbouwscheikunde

    Stevens, Christian V.

    1991  

    Author's details Christian Stevens
    Size 218 S. : graph. Darst.
    Publishing country Belgium
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Gent, Univ., Diss., 1991
    Note Zsfassung in engl. Sprache
    HBZ-ID HT004167643
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    AY 15782 order for loan Geschlossenes Magazin (U2)

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  8. Article ; Online: Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents.

    Seena, Sahadevan / Ferrão, Rafaela / Pala, Melike / Roelants, S L K W / Soetaert, Wim / Stevens, Christian V / Ferreira, Lino / Rai, Akhilesh

    Biomaterials advances

    2023  Volume 146, Page(s) 213299

    Abstract: Antimicrobial peptides (AMPs) are considered promising candidates to treat various infections in soft tissues and skin. However, no effective treatment based on AMPs has been reached to clinics due to their instability in serum and wounds. Biosurfactants ...

    Abstract Antimicrobial peptides (AMPs) are considered promising candidates to treat various infections in soft tissues and skin. However, no effective treatment based on AMPs has been reached to clinics due to their instability in serum and wounds. Biosurfactants such as acidic sophorolipids (ASLs) of very high concentrations (equal or above 5 mg/mL) have been demonstrated to be antimicrobial agents, however these concentrations might induce cytotoxic effects to human cells. Here, we have demonstrated the synergistic antimicrobial effect of ASL nanoparticles (NPs) and LL37 peptides (below their minimum inhibitory concentrations; MICs) to eradicate Gram-positive and Gram-negative bacteria in human serum (HS) and in the presence of trypsin. The formulations containing ASL NPs (500 μg/mL) and LL37 peptides (15-25 μg/mL) effectively kill wide strains of bacteria in 5 % HS and the presence of trypsin. Moreover, the combination of ASL NPs (500 μg/mL) and LL37 peptides (15 μg/mL) prevents the formation of S. aureus biofilm and eradicates the one-day old biofilm. Importantly, the combination of ASL NPs and LL37 peptides severely damages the cell membrane of Escherichia coli (E. coli) as shown by atomic force microscopy (AFM). The combination of ASL NPs and LL37 peptides rapidly damages the outer (OM) and inner membrane (IM) of E. coli, while ASL NPs (1000 μg/mL) alone slowly compromise the integrity of the bacterial membrane. Importantly, the combination of ASL NPs and LL37 peptides is biocompatible to human keratinocyte cells (HaCaTs) and human umbilical vein endothelial cells (HUVECs), and induces the expression of anti-inflammatory cytokine in macrophages. Overall, ASL NPs in combination with LL37 peptides might be developed as an effective topical formulation to prevent bacterial infections in the skin.
    MeSH term(s) Humans ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Antimicrobial Peptides ; Escherichia coli ; Staphylococcus aureus ; Trypsin/pharmacology ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Anti-Infective Agents/pharmacology ; Bacteria ; Human Umbilical Vein Endothelial Cells ; Biofilms
    Chemical Substances Antimicrobial Cationic Peptides ; Anti-Bacterial Agents ; sophorolipid ; Antimicrobial Peptides ; Trypsin (EC 3.4.21.4) ; Anti-Infective Agents
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Use of (modified) natural adsorbents for arsenic remediation: A review.

    Asere, Tsegaye Girma / Stevens, Christian V / Du Laing, Gijs

    The Science of the total environment

    2019  Volume 676, Page(s) 706–720

    Abstract: Arsenic (As) is a ubiquitous element found in the atmosphere, soils and rocks, natural waters and organisms. It is one of the most toxic elements and has been classified as a human carcinogen (group I). Arsenic contamination in the groundwater has been ... ...

    Abstract Arsenic (As) is a ubiquitous element found in the atmosphere, soils and rocks, natural waters and organisms. It is one of the most toxic elements and has been classified as a human carcinogen (group I). Arsenic contamination in the groundwater has been observed in >70 countries, like Bangladesh, India, West Bengal, Myanmar, Pakistan, Vietnam, Nepal, Cambodia, United States and China. About 200 million people are being exposed to excessive As through consumption of contaminated drinking water. Therefore, developing affordable and efficient techniques to remove As from drinking water is critical to protect human health. The currently available technologies include coagulation-flocculation, adsorption, ion exchange, electrochemical conversion and membrane technologies. However, most of the aforementioned treatment techniques require high initial and maintenance costs, and skilled manpower on top of that. Nowadays, adsorption has been accepted as a suitable removal technology, particularly for developing regions, because of its simple operation, potential for regeneration, and little toxic sludge generation. Processes based on the use of natural, locally available adsorbents are considered to be more accessible for developing countries, have a lower investment cost and a lower environmental impact (CO
    Language English
    Publishing date 2019-04-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.04.237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Porous organic polymers as metal free heterogeneous organocatalysts

    Debruyne, Maarten / Van Speybroeck, Veronique / Van Der Voort, Pascal / Stevens, Christian V.

    Green chemistry. 2021 Oct. 4, v. 23, no. 19

    2021  

    Abstract: Efficient catalysis is essential from a green chemistry perspective. Porous organic polymers (POPs) have recently emerged as highly effective materials for catalytic applications. POPs possess controllable compositions and functionalities, high surface ... ...

    Abstract Efficient catalysis is essential from a green chemistry perspective. Porous organic polymers (POPs) have recently emerged as highly effective materials for catalytic applications. POPs possess controllable compositions and functionalities, high surface areas and can be very stable. In this review we focus on the application of POPs as metal free heterogeneous organocatalysts, a booming field in green chemistry. Acid, base, combined acid–base and hydrogen bonding catalysis are addressed. In addition, chiral catalysis and CO₂ utilization with POPs are discussed. The aim is to provide a comprehensive overview of the field, exploring all different types of POPs as metal free catalysts. Special attention is given to the synthesis conditions to provide the reader with more insight into the construction of these types of materials.
    Keywords carbon dioxide ; catalytic activity ; green chemistry ; hydrogen ; organocatalysts
    Language English
    Dates of publication 2021-1004
    Size p. 7361-7434.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d1gc02319e
    Database NAL-Catalogue (AGRICOLA)

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