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  1. Book: Zipes and Jalife's cardiac electrophysiology

    Jalife, José / Stevenson, William G. / Zipes, Douglas P.

    from cell to bedside

    2022  

    Title variant Cardiac electrophysiology
    Author's details José Jalife, William G. Stevenson
    Keywords Arrhythmias, Cardiac ; Heart / physiology ; Electrophysiologic Techniques, Cardiac ; Cardiac Electrophysiology / methods
    Language English
    Size xxv, 1669 Seiten, Illustrationen, Diagramme
    Edition Eight edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu Enhanced Digital Version über Code
    HBZ-ID HT021293321
    ISBN 978-0-323-75745-4 ; 0-323-75745-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 460 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügber

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  2. Article ; Online: The Continuing Saga of Tissue Inhibitor of Metalloproteinase 2: Emerging Roles in Tissue Homeostasis and Cancer Progression.

    Stetler-Stevenson, William G

    The American journal of pathology

    2023  Volume 193, Issue 10, Page(s) 1336–1352

    Abstract: Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were originally identified as cytokine-like erythroid growth factors. Subsequently, TIMPs were characterized as endogenous inhibitors of matrixin proteinases. These ... ...

    Abstract Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were originally identified as cytokine-like erythroid growth factors. Subsequently, TIMPs were characterized as endogenous inhibitors of matrixin proteinases. These proteinases are the primary mediators of extracellular matrix turnover in pathologic conditions, such as cancer invasion and metastasis. Thus, TIMPs were immediately recognized as important regulators of tissue homeostasis. However, TIMPs also demonstrate unique biological activities that are independent of metalloproteinase regulation. Although often overlooked, these non-protease-mediated TIMP functions demonstrate a variety of direct cellular effects of potential therapeutic value. TIMP2 is the most abundantly expressed TIMP family member, and ongoing studies show that its tumor suppressor activity extends beyond protease inhibition to include direct modulation of tumor, endothelial, and fibroblast cellular responses in the tumor microenvironment. Recent data suggest that TIMP2 can suppress both primary tumor growth and metastatic niche formation. TIMP2 directly interacts with cellular receptors and matrisome elements to modulate cell signaling pathways that result in reduced proliferation and migration of neoplastic, endothelial, and fibroblast cell populations. These effects result in enhanced cell adhesion and focal contact formation while reducing tumor and endothelial proliferation, migration, and epithelial-to-mesenchymal transitions. These findings are consistent with TIMP2 homeostatic functions beyond simple inhibition of metalloprotease activity. This review examines the ongoing evolution of TIMP2 function, future perspectives in TIMP research, and the therapeutic potential of TIMP2.
    MeSH term(s) Humans ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Neoplasms/metabolism ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Proteolysis ; Homeostasis ; Peptide Hydrolases/metabolism ; Tissue Inhibitor of Metalloproteinases/metabolism ; Tissue Inhibitor of Metalloproteinase-3/metabolism ; Tumor Microenvironment
    Chemical Substances Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Tissue Inhibitor of Metalloproteinase-1 ; Peptide Hydrolases (EC 3.4.-) ; Tissue Inhibitor of Metalloproteinases ; Tissue Inhibitor of Metalloproteinase-3
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2023.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.76: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: EP Corner: Oscillations.

    Stevenson, William G / Richardson, Travis D

    Heart rhythm

    2024  

    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.02.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
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  4. Book: Cardiac electrophysiology

    Zipes, Douglas P. / Jalife, José / Stevenson, William G.

    from cell to bedside

    (ExpertConsult.com)

    2018  

    Author's details Douglas P. Zipes, MD, José Jalife, MD, William G. Stevenson, MD
    Series title ExpertConsult.com
    Keywords Arrhythmias, Cardiac ; Heart / physiology ; Electrophysiologic Techniques, Cardiac ; Cardiac Electrophysiology / methods
    Language English
    Size xxxi, 1389 Seiten, Illustrationen, Diagramme
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index, Zugang zu Online-Ausgabe über Code und QR-Code
    HBZ-ID HT019842198
    ISBN 978-0-323-44733-1 ; 9780323448888 ; 0-323-44733-3 ; 0323448887
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1716 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code und QR-Code aus lizenzrechtlichen Gründen nicht verfügbar

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  5. Article ; Online: Concerning High Rates of Cerebral Embolic Events in STROKE-VT.

    Richardson, Travis D / Stevenson, William G

    JACC. Clinical electrophysiology

    2022  Volume 8, Issue 2, Page(s) 257

    MeSH term(s) Humans ; Intracranial Embolism/epidemiology ; Intracranial Embolism/etiology ; Stroke/epidemiology ; Stroke/etiology
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2021.11.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High-density pace-mapping for scar-related ventricular tachycardia ablation.

    Richardson, Travis D / Stevenson, William G

    Journal of cardiovascular electrophysiology

    2022  Volume 33, Issue 8, Page(s) 1810–1812

    MeSH term(s) Catheter Ablation/adverse effects ; Cicatrix/etiology ; Cicatrix/surgery ; Electrocardiography ; Humans ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/surgery
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15585
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2863: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Shape of Ventricular Tachycardia.

    Stevenson, William G / Tandri, Harikrishna / Roden, Dan M

    Circulation

    2023  Volume 148, Issue 18, Page(s) 1368–1370

    MeSH term(s) Humans ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/therapy ; Arrhythmias, Cardiac ; Electrocardiography
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.066574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Atrial Fibrillation Related Mortality: Another Curve to Bend.

    Kanagasundram, Arvindh / Stevenson, William G

    Journal of the American Heart Association

    2021  Volume 10, Issue 15, Page(s) e022555

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Atrial Fibrillation/drug therapy ; Humans ; Hypertension/drug therapy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.022555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Newer Methods for Ventricular Tachycardia Ablation and When to Use Them.

    Stevenson, William G / Sapp, John L

    The Canadian journal of cardiology

    2021  Volume 38, Issue 4, Page(s) 502–514

    Abstract: Radiofrequency (RF) catheter ablation has long been an important therapy for ventricular tachycardia and frequent symptomatic premature ventricular beats and nonsustained arrhythmias when antiarrhythmic drugs fail to suppress the arrhythmias. It is ... ...

    Abstract Radiofrequency (RF) catheter ablation has long been an important therapy for ventricular tachycardia and frequent symptomatic premature ventricular beats and nonsustained arrhythmias when antiarrhythmic drugs fail to suppress the arrhythmias. It is increasingly used in preference to antiarrhythmic drugs, sparing the patient adverse effects of drugs. Success of ablation varies with the underlying heart disease and type of arrhythmia: very effective for patients without structural heart disease, less effective in structural heart disease. Failure occurs when a target for ablation cannot be identified or ablation lesions fail to reach and abolish the arrhythmia substrate that may be extensive, intramural, or subepicardial in location. Approaches to improving ablation lesion creation are modifications to RF ablation and emerging investigational techniques. Easily- implemented modifications to RF methods include manipulating the size and location of the cutaneous dispersive electrode, increasing duration of RF delivery, and use of lower-tonicity catheter irrigation (usually 0.45% saline). When catheters can be placed on either side of culprit substrate, RF can be delivered in a bipolar or simultaneous unipolar configuration that can be successful. Catheters with extendable and retractable irrigated needles for delivery of RF are under investigation in clinical trials. Cryoablation is potentially useful with specific situations in which maintaining contact is difficult. Transvascular ethanol ablation and stereotactic radioablation have both shown promise for arrhythmias that fail other ablation strategies. Although substantial clinical progress has been achieved, further improvement is clearly needed. With ability to increase ablation lesion size, continued careful evaluation of safety, which has been excellent for standard RF ablation, remains important.
    MeSH term(s) Catheter Ablation/methods ; Cryosurgery ; Humans ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/surgery ; Ventricular Premature Complexes/etiology
    Language English
    Publishing date 2021-12-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
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  10. Article ; Online: Atrial Fibrillation. Reply.

    Michaud, Gregory F / Stevenson, William G

    The New England journal of medicine

    2021  Volume 385, Issue 4, Page(s) 383–384

    MeSH term(s) Atrial Appendage ; Atrial Fibrillation/surgery ; Catheter Ablation ; Humans
    Language English
    Publishing date 2021-07-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2103291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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