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Article ; Online: Increased accuracy of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy using iterative reconstruction of images

Stević Miloš / Vlajković Marina

Vojnosanitetski Pregled, Vol 73, Iss 5, Pp 469-

2016 Volume 471

Abstract: Background/Aim. Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI) studies. There are artifacts in FBP which can cause falsepositive results. Iterative reconstruction (IR) is developed to reduce false positive ...

Abstract	Background/Aim. Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI) studies. There are artifacts in FBP which can cause falsepositive results. Iterative reconstruction (IR) is developed to reduce false positive findings in MPI studies. The aim of this study was to evaluate the difference in the number of false positive findings in MPI studies, between FBP and IR processing. Methods. We examined 107 patients with angina pectoris with MPI and coronary angiography (CAG), 77 man and 30 woman, aged 32−82. MPI studies were processed with FBP and with IR. Positive finding at MPI was visualization of the perfusion defect. Positive finding at CAG was stenosis of coronary artery. Perfusion defect at MPI without coronary artery stenosis at CAG was considered like false positive. The results were statistically analyzed with bivariate correlation, and with one sample t-test. Results. There were 20.6% normal, and 79.4% pathologic findings at FBP, 30.8% normal and 69.2% pathologic with IR and 37.4% normal and 62.6% pathologic at CAG. FBP produced 19 false-positive findings, at IR 11 false positive findings. The correlation between FBP and CAG was 0.658 (p < 0.01) and between IR and CAG 0.784 (p < 0.01). The number of false positive findings at MPI with IR was significantly lower than at FBP (p < 0.01). Conclusion. Our study shows that IR processing MPI scintigraphy has less number of false positive findings, therefore it is our choice for processing MPI studies.
Keywords	angina pectoris ; diagnosis ; scintigraphy ; coronary angiography ; technology ; medical ; methods ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Military Health Department, Ministry of Defance, Serbia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Increased accuracy of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy using iterative reconstruction of images.

Stević, Miloš / Vlajković, Marina

Vojnosanitetski pregled

2016 Volume 73, Issue 5, Page(s) 469–471

Abstract: Background/aim: Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI)studies. There are artifacts in FBP which can cause false-positive results. Iterative reconstruction (IR) is developed to reduce false ... ...

Abstract	Background/aim: Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI)studies. There are artifacts in FBP which can cause false-positive results. Iterative reconstruction (IR) is developed to reduce false positive findings in MPI studies. The aim of this study was to evaluate the difference in the number of false-positive findings in MPI studies, between FBP and IR processing. Methods: We examined 107 patients with angina pectoris with MPI and coronary angiography (CAG), 77 man and 30 woman, aged 32-82. MPI studies were processed with FBP and with IR. Positive finding at MPI was visualization of the perfusion defect. Positive finding at CAG was stenosis of coronary artery. Perfusion defect at MPI without coronary artery stenosis at CAG was considered like false positive. The results were statistically analyzed with bivariate correlation, and with one sample t-test. Results: There were 20.6% normal, and 79.4% pathologic findings at FBP, 30.8% normal and 69.2% pathologic with IR and 37.4% normal and 62.6% pathologic at CAG. FBP produced 19 false positive findings, at IR 11 false positive findings. The correlation between FBP and CAG was 0.658 (P < 0.01) and between IR and CAG 0.784 (P < 0.01). The number of false positive findings at MPI with IR was significantly lower than at FBP (p < 0.01). Conclusion: Our study shows that IR processing MPI scintigraphy has less number of false positive findings, therefore it is our choice for processing MPI studies.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Angina Pectoris/diagnostic imaging ; Coronary Angiography ; Coronary Stenosis/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Male ; Middle Aged ; Myocardial Perfusion Imaging/methods ; Tomography, Emission-Computed, Single-Photon/methods
Language	English
Publishing date	2016-07-18
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	123795-0
ISSN	0042-8450
ISSN	0042-8450
DOI	10.2298/vsp141104035s
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Article ; Online: Quality of sleep and fatigue in patients with the relapsing-remitting multiple sclerosis during the coronavirus disease-2019 pandemic.

Stojanov, Aleksandar / Vojinovic, Slobodan / Stojanov, Jelena / Malobabic, Marina / Stevic, Milos / Milosevic, Vuk / Stanojevic, Goran

Clinical neurology and neurosurgery

2021 Volume 205, Page(s) 106640

Abstract: ОBJECTIVE: Sleep disturbances and fatigue are frequent symptoms in multiple sclerosis patients. The aim was to assess the quality of sleep (QoS) and fatigue in patients with the relapsing-remitting multiple sclerosis (RRMS), during the coronavirus ... ...

Abstract	ОBJECTIVE: Sleep disturbances and fatigue are frequent symptoms in multiple sclerosis patients. The aim was to assess the quality of sleep (QoS) and fatigue in patients with the relapsing-remitting multiple sclerosis (RRMS), during the coronavirus disease-2019 (COVID-19) pandemic. Methods: The study included 67 patients with RRMS and 85 healthy control subjects. RRMS patients, who were tested in first half of 2019, were retested in April and May 2020, during the COVID-19 pandemic. We collected sociodemographic and clinical data, and also used the following questionnaires: Pittsburgh sleep quality index (PSQI), Fatigue Severity Scale (FSS), and Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54). Results: The FSS score and PSQI global score were significantly higher in patients with RRMS than in the control group (p < 0.01). We noticed a statistically significant difference between the results obtained a year ago and the results during the COVID-19 pandemic in PSQI global score (p < 0.01) and all subscores. Higher disability status was an independent predictor of the worse PSQI scores. Conclusion: During the COVID-19 outbreak worse QoS were noticed in RRMS patients than in healthy individuals. Also, QoS of RRMS patients is more affected during the COVID-19 pandemic than in regular circumstances. High levels of sleep disturbance and fatigue in RRMS patients correlates with worse life quality, female gender, lower educational level and partner status. The results of the present study provide evidence in support of regular screening and monitoring of fatigue and QoS in this patient population, especially during the pandemic states.
Language	English
Publishing date	2021-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2021.106640
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Article: The Impact of the Coronavirus Disease-2019 Pandemic on the Psychological Status and Quality of Life of Myasthenia Gravis Patients.

Stojanov, Aleksandar / Stojanov, Jelena / Milosevic, Vuk / Malobabic, Marina / Stanojevic, Goran / Stevic, Milos / Djordjevic, Gordana

Annals of Indian Academy of Neurology

2020 Volume 23, Issue 4, Page(s) 510–514

Abstract: Objectives: The coronavirus disease 2019 (COVID-19) is the largest pandemic of our times. We wanted to investigate the impact of COVID-19 pandemic on the psychological status, quality of life (QoL) and quality of sleep (QoS) of myasthenia gravis (MG) ... ...

Abstract	Objectives: The coronavirus disease 2019 (COVID-19) is the largest pandemic of our times. We wanted to investigate the impact of COVID-19 pandemic on the psychological status, quality of life (QoL) and quality of sleep (QoS) of myasthenia gravis (MG) patients. Methods: Data on the epidemiological and clinical characteristics of MG were collected. We used a self-designed questionnaire (consisting of 12 questions), a revised 15-item Myasthenia Gravis Quality of Life Questionnaire (MGQOL15r), a 36-item health survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh sleep quality index (PSQI), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAMD) were used. We reassessed patients who were tested three years ago using the same questionnaires. Results: The study included 64 MG patients. We noticed a statistically significant difference between the results obtained three years ago and the results from April 2020 in PSQI scores ( Conclusions: There is a significant impact of the COVID-19 epidemic on the psychological status and especially on the quality of sleep of MG patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
Keywords	covid19
Language	English
Publishing date	2020-05-08
Publishing country	India
Document type	Journal Article
ZDB-ID	2240174-X
ISSN	1998-3549 ; 0972-2327
ISSN (online)	1998-3549
ISSN	0972-2327
DOI	10.4103/aian.AIAN_551_20
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Article ; Online: Quality of sleep and health-related quality of life among health care professionals treating patients with coronavirus disease-19.

Stojanov, Jelena / Malobabic, Marina / Stanojevic, Goran / Stevic, Milos / Milosevic, Vuk / Stojanov, Aleksandar

The International journal of social psychiatry

2020 Volume 67, Issue 2, Page(s) 175–181

Abstract: Background: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress.: Aim: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care ... ...

Abstract	Background: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. Aim: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals treating patients with COVID-19, as well as quantifying the magnitude of symptoms of depression and levels of anxiety. Methods: We included 201 health care professionals in a cross-sectional, web-based study by applying 7-item Generalized Anxiety Disorder (GAD-7) Scale, Zung Self-rating Depression Scale, 36-item Health Survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh Sleep Quality Index (PSQI) and additional survey constructed for the purpose of the study. Results: Health care workers who treated COVID-19 patients were more afraid of becoming infected or of transmitting the infection to a family member with a significantly low self-assessment of their mental status. Poor QoS and HRQoL correlated with high health anxiety and severe depressive symptoms and several demographic characteristics. Multiple linear regression analysis showed that higher scores on GAD-7 (beta = .71, Conclusion: The major MH burden of health care professionals treating infected patients during the COVID-19 pandemic indicates that they need psychological support.
MeSH term(s)	Adult ; Anxiety/epidemiology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Female ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Health Surveys ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Quality of Life ; Serbia/epidemiology ; Sleep Wake Disorders/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/0020764020942800
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Article: A case of jejunal neurofibroma in von Recklinghausen's disease with active hemorrhage, detected and located with gastrointestinal bleeding scintigraphy: A case report with literature review.

Stević, Miloš / Vlajković, Marina / Veličković, Filip / Stanojević, Goran / Nestorović, Milica / Petrović, Filip

Hellenic journal of nuclear medicine

2020 Volume 23, Issue 1, Page(s) 81–85

Abstract: A 69 year old patient was admitted to hospital with massive gastrointestinal hemorrhage. The clinical presentation of the patient, except for bleeding, was dominated by the presence of neurofibromatosis type 1 - Von Recklinghausen disease. The patient ... ...

Abstract	A 69 year old patient was admitted to hospital with massive gastrointestinal hemorrhage. The clinical presentation of the patient, except for bleeding, was dominated by the presence of neurofibromatosis type 1 - Von Recklinghausen disease. The patient was referred to multislice computed tomography (CT) angiography, magnetic resonance imaging (MRI), esophagogastroduodenoscopy and colonoscopy, which were performed without successful detection of the bleeding site. The MRI examination showed the existence of a tumor located in the small pelvis. After that, gastrointestinal bleeding scintigraphy (GIBS) with technetium-99m (
MeSH term(s)	Computed Tomography Angiography ; Female ; Gastrointestinal Hemorrhage/complications ; Humans ; Jejunal Neoplasms/complications ; Jejunal Neoplasms/diagnostic imaging ; Neurofibroma/complications ; Neurofibroma/diagnostic imaging ; Neurofibromatosis 1/complications ; Radionuclide Imaging
Language	English
Publishing date	2020-03-31
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
DOI	10.1967/s002449912008
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Article ; Online: Psychological status of patients with relapsing-remitting multiple sclerosis during coronavirus disease-2019 outbreak.

Stojanov, Aleksandar / Malobabic, Marina / Milosevic, Vuk / Stojanov, Jelena / Vojinovic, Slobodan / Stanojevic, Goran / Stevic, Milos

Multiple sclerosis and related disorders

2020 Volume 45, Page(s) 102407

Abstract: Background: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS).: Methods: Data on ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS). Methods: Data on the socio-demographic and clinical characteristics of 95 RRMS patients were collected. We used a self-designed questionnaire, the Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAM-D). Patients who were tested one year ago were reassessed using the same questionnaires during the COVID-19 outbreak. Group of 99 healthy individuals (HC) were tested, using the same questionnaires. Results: The main concerns in RRMS patients were that someone that they know could be infected with COVID-19 (78.5%), or could die due to the infection (33.8%), and the lack of specific treatment options (25.8%). The main concerns about the RRMS status were that their disease would be worse if they get infected with COVID-19 (36.4%), that they would experience some difficulties in drug availability (43.6%), that they could not go to the hospital as usual (72.4%). Results on all questionnaires were worse in RRMS patients than in HC (p<0.01). We noticed a statistically significant difference between the results obtained a year ago and the results from April 2020 in HAM-A (p<0.05). Conclusions: There is an impact of the COVID-19 pandemic on the psychological status of RRMS patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
MeSH term(s)	Adult ; Anxiety/epidemiology ; Anxiety/etiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/psychology ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/psychology ; Pandemics ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Surveys and Questionnaires
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2020.102407
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Article: Psychological status of patients with relapsing-remitting multiple sclerosis during coronavirus disease-2019 outbreak

Stojanov, Aleksandar / Malobabic, Marina / Milosevic, Vuk / Stojanov, Jelena / Vojinovic, Slobodan / Stanojevic, Goran / Stevic, Milos

Mult Scler Relat Disord

Abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Data on the ... ...

Abstract	BACKGROUND: The coronavirus disease 2019 (COVID-19) is a global health emergency. The aim was to investigate the impact of COVID-19 pandemic on the psychological status of patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Data on the socio-demographic and clinical characteristics of 95 RRMS patients were collected. We used a self-designed questionnaire, the Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAM-D). Patients who were tested one year ago were reassessed using the same questionnaires during the COVID-19 outbreak. Group of 99 healthy individuals (HC) were tested, using the same questionnaires. RESULTS: The main concerns in RRMS patients were that someone that they know could be infected with COVID-19 (78.5%), or could die due to the infection (33.8%), and the lack of specific treatment options (25.8%). The main concerns about the RRMS status were that their disease would be worse if they get infected with COVID-19 (36.4%), that they would experience some difficulties in drug availability (43.6%), that they could not go to the hospital as usual (72.4%). Results on all questionnaires were worse in RRMS patients than in HC (p<0.01). We noticed a statistically significant difference between the results obtained a year ago and the results from April 2020 in HAM-A (p<0.05). CONCLUSIONS: There is an impact of the COVID-19 pandemic on the psychological status of RRMS patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #653798
Database	COVID19

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Article: Quality of sleep and health-related quality of life among health care professionals treating patients with coronavirus disease-19

Stojanov, Jelena / Malobabic, Marina / Stanojevic, Goran / Stevic, Milos / Milosevic, Vuk / Stojanov, Aleksandar

Int J Soc Psychiatry

Abstract: BACKGROUND: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. AIM: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals ... ...

Abstract	BACKGROUND: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. AIM: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals treating patients with COVID-19, as well as quantifying the magnitude of symptoms of depression and levels of anxiety. METHODS: We included 201 health care professionals in a cross-sectional, web-based study by applying 7-item Generalized Anxiety Disorder (GAD-7) Scale, Zung Self-rating Depression Scale, 36-item Health Survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh Sleep Quality Index (PSQI) and additional survey constructed for the purpose of the study. RESULTS: Health care workers who treated COVID-19 patients were more afraid of becoming infected or of transmitting the infection to a family member with a significantly low self-assessment of their mental status. Poor QoS and HRQoL correlated with high health anxiety and severe depressive symptoms and several demographic characteristics. Multiple linear regression analysis showed that higher scores on GAD-7 (beta = .71, p < .01) and lower scores on mental health (MH) subscale on SF36 questionnaire (beta = -.69; p < .01) were independent predictors of the higher PSQI score (adjusted R2 = .61, p < .01 for overall model). Higher scores on GAD-7 (beta = .68, p < .01) and worse self-perceived mental status (beta = .25; p < .05) were independent predictors of the lower SF36 scores (adjusted R2 = .73, p < .01 for overall model). CONCLUSION: The major MH burden of health care professionals treating infected patients during the COVID-19 pandemic indicates that they need psychological support.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #647491
Database	COVID19

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Article ; Online: Quality of sleep and health-related quality of life among health care professionals treating patients with coronavirus disease-19

Stojanov, Jelena / Malobabic, Marina / Stanojevic, Goran / Stevic, Milos / Milosevic, Vuk / Stojanov, Aleksandar

International Journal of Social Psychiatry

2020 , Page(s) 2076402094280

Abstract: Background: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. Aim: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals ... ...

Abstract	Background: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. Aim: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals treating patients with COVID-19, as well as quantifying the magnitude of symptoms of depression and levels of anxiety. Methods: We included 201 health care professionals in a cross-sectional, web-based study by applying 7-item Generalized Anxiety Disorder (GAD-7) Scale, Zung Self-rating Depression Scale, 36-item Health Survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh Sleep Quality Index (PSQI) and additional survey constructed for the purpose of the study. Results: Health care workers who treated COVID-19 patients were more afraid of becoming infected or of transmitting the infection to a family member with a significantly low self-assessment of their mental status. Poor QoS and HRQoL correlated with high health anxiety and severe depressive symptoms and several demographic characteristics. Multiple linear regression analysis showed that higher scores on GAD-7 (beta = .71, p < .01) and lower scores on mental health (MH) subscale on SF36 questionnaire (beta = –.69; p < .01) were independent predictors of the higher PSQI score (adjusted R 2 = .61, p < .01 for overall model). Higher scores on GAD-7 (beta = .68, p < .01) and worse self-perceived mental status (beta = .25; p < .05) were independent predictors of the lower SF36 scores (adjusted R 2 = .73, p < .01 for overall model). Conclusion: The major MH burden of health care professionals treating infected patients during the COVID-19 pandemic indicates that they need psychological support.
Keywords	Psychiatry and Mental health ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/0020764020942800
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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