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  1. Article ; Online: Novel use of abatacept and ruxolitinib as salvage therapy in steroid-refractory immune checkpoint blockade-induced myocarditis with myasthenia and myositis overlap syndrome.

    Byer, Stefano H / Stewart, Colten / Mansour, Shareef / Grewal, Udhayvir S

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 202, Page(s) 114027

    MeSH term(s) Humans ; Abatacept/adverse effects ; Immune Checkpoint Inhibitors/adverse effects ; Myocarditis/chemically induced ; Myocarditis/drug therapy ; Salvage Therapy ; Myositis/chemically induced ; Myositis/drug therapy ; Muscle Weakness ; Steroids/therapeutic use ; Nitriles ; Pyrazoles ; Pyrimidines
    Chemical Substances Abatacept (7D0YB67S97) ; Immune Checkpoint Inhibitors ; ruxolitinib (82S8X8XX8H) ; Steroids ; Nitriles ; Pyrazoles ; Pyrimidines
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  2. Article ; Online: An 82-Year-Old Male with Syncope.

    Byer, Stefano Henry / Simonson, Tanner J / Stewart, Colten / Mansour, Shareef / Grewal, Udhayvir Singh

    The American journal of medicine

    2024  Volume 137, Issue 5, Page(s) e94–e95

    MeSH term(s) Humans ; Male ; Syncope/etiology ; Aged, 80 and over ; Electrocardiography
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2024.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Hospital Variation in Epinephrine Administration Before Defibrillation for Cardiac Arrest Due to Shockable Rhythm.

    Stewart, Colten / Chan, Paul S / Kennedy, Kevin / Swanson, Morgan B / Girotra, Saket

    Critical care medicine

    2024  Volume 52, Issue 6, Page(s) 878–886

    Abstract: Objectives: Contrary to advanced cardiac life support guidelines that recommend immediate defibrillation for shockable in-hospital cardiac arrest (IHCA), epinephrine administration before first defibrillation is common and associated with lower survival ...

    Abstract Objectives: Contrary to advanced cardiac life support guidelines that recommend immediate defibrillation for shockable in-hospital cardiac arrest (IHCA), epinephrine administration before first defibrillation is common and associated with lower survival at a "patient-level." Whether this practice varies across hospitals and its association with "hospital-level" IHCA survival remains unknown. The purpose of this study was to determine hospital variation in rates of epinephrine administration before defibrillation for shockable IHCA and its association with IHCA survival.
    Design: Observational cohort study.
    Setting: Five hundred thirteen hospitals participating in the Get With The Guidelines Resuscitation Registry.
    Patients: A total of 37,668 adult patients with IHCA due to an initial shockable rhythm from 2000 to 2019.
    Interventions: Epinephrine before first defibrillation.
    Measurements and main results: Using multivariable hierarchical regression, we examined hospital variation in epinephrine administration before first defibrillation and its association with hospital-level rates of risk-adjusted survival. The median hospital rate of epinephrine administration before defibrillation was 18.8%, with large variation across sites (range, 0-68.8%; median odds ratio: 1.54; 95% CI, 1.47-1.61). Major teaching status and annual IHCA volume were associated with hospital rate of epinephrine administration before defibrillation. Compared with hospitals with the lowest rate of epinephrine administration before defibrillation (Q1), there was a stepwise decline in risk-adjusted survival at hospitals with higher rates of epinephrine administration before defibrillation (Q1: 44.3%, Q2: 43.4%; Q3: 41.9%; Q4: 40.3%; p for trend < 0.001).
    Conclusions: Administration of epinephrine before defibrillation in shockable IHCA is common and varies markedly across U.S. hospitals. Hospital rates of epinephrine administration before defibrillation were associated with a significant stepwise decrease in hospital rates of risk-adjusted survival. Efforts to prioritize immediate defibrillation for patients with shockable IHCA and avoid early epinephrine administration are urgently needed.
    MeSH term(s) Epinephrine/administration & dosage ; Epinephrine/therapeutic use ; Humans ; Heart Arrest/therapy ; Heart Arrest/mortality ; Heart Arrest/drug therapy ; Female ; Male ; Aged ; Middle Aged ; Electric Countershock/statistics & numerical data ; Electric Countershock/methods ; Hospitals/statistics & numerical data ; Cohort Studies ; Vasoconstrictor Agents/administration & dosage ; Vasoconstrictor Agents/therapeutic use
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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