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  1. Book ; Online: Advances in the treatment of renal cell carcinoma

    Reynolds, Paul / Stewart, Grant D.

    2022  

    Author's details editor
    Language English
    Size 1 Online-Ressource (vii, 212 Seiten), Illustrationen, Diagramme
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note reprint of the special issue "Advances in the treatment of renal cell carcinoma" published in "Cancers" ; Open Access
    HBZ-ID HT021332565
    ISBN 978-3-0365-2934-9 ; 9783036529356 ; 3-0365-2934-9 ; 3036529357
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Advances in the Treatment of Renal Cell Carcinoma

    Reynolds, Paul / Stewart, Grant D

    2022  

    Keywords Medicine ; renal cell carcinoma ; autophagy ; hydroxychloroquine ; chloroquine ; ROC-325 ; cysteine cathepsins ; cysteine cathepsin inhibitors ; lysosome ; renal cancer ; metastatic renal cell carcinoma ; immune-based combination therapies ; network meta-analysis ; PD-L1 ; predictive ; biomarker ; treatment ; TKIs ; mRCC ; biomarkers ; soluble factors ; immunotherapy ; renal cell carcinoma (RCC) ; sunitib resistance ; artesunate (ART) ; Traditional Chinese Medicine (TCM) ; growth inhibition ; ferroptosis ; reactive oxygen species (ROS) ; clear cell renal cell carcinoma ; ccRCC ; RCC ; kidney cancer ; evolution ; evolutionary trajectory ; metastatic ; second line therapy ; renal cell cancer ; immune checkpoint inhibitors ; tyrosine kinase inhibitors ; individualization ; genomic signature ; transcriptomic analysis
    Language 0|e
    Size 1 electronic resource (221 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021611220
    ISBN 9783036529349 ; 3036529349
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The burden of performing minimal access surgery: ergonomics survey results from 462 surgeons across Germany, the UK and the USA.

    Morton, Jonathan / Stewart, Grant D

    Journal of robotic surgery

    2022  Volume 16, Issue 6, Page(s) 1347–1354

    Abstract: This international study aimed to understand, from the perspective of surgeons, their experience of performing minimal access surgery (MAS), to explore causes of discomfort while operating and the impact of poor ergonomics on surgeon welfare and career ... ...

    Abstract This international study aimed to understand, from the perspective of surgeons, their experience of performing minimal access surgery (MAS), to explore causes of discomfort while operating and the impact of poor ergonomics on surgeon welfare and career longevity across different specialties and techniques. A quantitative online survey was conducted in Germany, the UK and the USA from March to April 2019. The survey comprised 17 questions across four categories: demographics, intraoperative discomfort, effects on performance and anticipated consequences. In total, 462 surgeons completed the survey. Overall, 402 (87.0%) surgeons reported experiencing discomfort while operating at least 'sometimes'. The peak professional performance age was perceived to be 45-49 years by 30.7% of surgeons, 50-54 by 26.4% and older than 55 by 10.1%. 86 (18.6%) surgeons felt it likely they would consider early retirement, of whom 83 were experiencing discomfort. Our findings highlight the continued unmet needs of surgeons performing MAS, with the overwhelming majority experiencing discomfort, frequently in the back, neck and shoulders, and many likely to consider early retirement consequently. Innovative solutions are needed to alleviate this physical burden and, in turn, prevent economic and societal impacts on healthcare systems resulting from MAS limiting surgeon longevity.
    MeSH term(s) Humans ; Middle Aged ; Occupational Diseases/etiology ; Robotic Surgical Procedures/methods ; Ergonomics ; Surgeons ; Surveys and Questionnaires ; Germany ; United Kingdom
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-021-01358-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Re: Clinical Validation of a Targeted Methylation-based Multi-cancer Early Detection Test Using an Independent Validation Set.

    Rossi, Sabrina H / Stewart, Grant D

    European urology

    2022  Volume 82, Issue 4, Page(s) 442–443

    MeSH term(s) Biomarkers, Tumor/genetics ; DNA Methylation ; Early Detection of Cancer ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 294: Show issues

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  5. Article ; Online: Defining an evidence-based strategy for streamlining cancer multidisciplinary team meetings.

    Soukup, Tayana / Stewart, Grant D / Lamb, Benjamin W

    The Lancet. Oncology

    2023  Volume 24, Issue 10, Page(s) 1061–1063

    MeSH term(s) Humans ; Neoplasms/diagnosis ; Neoplasms/therapy ; Patient Care Team
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00440-0
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    Zs.A 5696: Show issues Location:
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  6. Article ; Online: Re: Germline Variants Associated with Toxicity to Immune Checkpoint Blockade.

    Jones, James O / Mitchell, Thomas J / Stewart, Grant D

    European urology

    2023  Volume 84, Issue 6, Page(s) 597

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal ; Immunotherapy ; Germ-Line Mutation ; Germ Cells
    Chemical Substances Immune Checkpoint Inhibitors ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.03.008
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    Zs.MO 294: Show issues

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  7. Article ; Online: Patient experience of follow-up after surgery for kidney cancer: a focus group study.

    Harrison, Hannah / Stewart, Grant D / Usher-Smith, Juliet A

    BJU international

    2023  Volume 132, Issue 1, Page(s) 47–55

    Abstract: Objective: To explore patient experience of follow-up care after kidney cancer surgery and to develop recommendations for best practice.: Methods: We conducted two focus groups, including 14 participants with experience of kidney cancer follow-up ... ...

    Abstract Objective: To explore patient experience of follow-up care after kidney cancer surgery and to develop recommendations for best practice.
    Methods: We conducted two focus groups, including 14 participants with experience of kidney cancer follow-up after surgery, to elicit patient views on current follow-up care. Thematic analysis was used to identify unifying themes to describe the patient experience of follow-up, and the results were then used to develop a set of recommendations for best practice.
    Results: We identified six themes (feelings of abandonment; uncertainty about the plan; anxiety about appointments; variation in care; a need for information; and a need for emotional support) that described current patient experience and areas in which current care could be improved. In particular, while most of the participants felt that their physical needs had been met, many had struggled with unmet emotional needs and a lack of information and resources. This was especially noted in the period immediately following surgery, when feelings of abandonment were common, and around follow-up scans and routine appointments, which were a source of anxiety. Our participants also described concerns about the lack of consistency between different hospitals and centres around the United Kingdom, with differences in the content and quality of follow-up care. Based on the results, we developed a list of recommendations to address some of the challenges described through relatively minor changes to the care pathway.
    Conclusions: We identified gaps and variability in current follow-up care after kidney cancer surgery, and have developed a set of recommendations that, if implemented, would improve the follow-up care experience for these patients.
    MeSH term(s) Humans ; Focus Groups ; Follow-Up Studies ; Carcinoma, Renal Cell ; Kidney Neoplasms/surgery ; Patient Outcome Assessment
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15982
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    Ui VI Zs.107: Show issues Location:
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  8. Article ; Online: Predicting cancer outcomes after resection of high-risk RCC.

    Usher-Smith, Juliet A / Stewart, Grant D

    Nature reviews. Urology

    2022  Volume 19, Issue 5, Page(s) 257–258

    MeSH term(s) Carcinoma, Renal Cell/surgery ; Female ; Humans ; Kidney Neoplasms/surgery ; Male ; Prognosis
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-022-00568-3
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  9. Article: Partial nephrectomy versus thermal ablation for clinical T1 renal tumours.

    Klatte, Tobias / Stewart, Grant D

    Annals of translational medicine

    2020  Volume 7, Issue Suppl 8, Page(s) S363

    Language English
    Publishing date 2020-01-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.09.12
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  10. Article ; Online: Re: Transcriptomic Signatures Related to the Obesity Paradox in Patients with Clear Cell Renal Cell Carcinoma: A Cohort Study.

    Yong, Cissy / Stewart, Grant D

    European urology

    2020  Volume 77, Issue 5, Page(s) 656–657

    MeSH term(s) Carcinoma, Renal Cell/genetics ; Cohort Studies ; Humans ; Kidney Neoplasms/genetics ; Obesity/complications ; Obesity/epidemiology ; Obesity/genetics ; Transcriptome
    Language English
    Publishing date 2020-02-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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