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  1. Book ; Online ; E-Book: A guide to mechanical circulatory support

    Stewart, Scott / Blood, Peggy

    a primer for ventricular assist device (VAD) clinicians

    2023  

    Author's details edited by Scott Stewart, Peggy Blood
    MeSH term(s) Heart-Assist Devices. ; Assisted Circulation.
    Keywords Cardiovascular instruments, Implanted ; Blood/Circulation, Artificial
    Subject code 296
    Language English
    Dates of publication 2023-2023
    Size 1 online resource (290 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-05713-9 ; 9783031057120 ; 978-3-031-05713-7 ; 3031057120
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Strengthening Molecular Glues: Design Strategies for Improving Thalidomide Analogs as Cereblon Effectors and Anticancer Agents.

    Nutt, Michael J / Stewart, Scott G

    Drug discovery today

    2024  Volume 29, Issue 6, Page(s) 104010

    Abstract: In the two decades since a novel thalidomide analog was last approved, many promising drug candidates have emerged with remarkable potency as targeted protein degraders. Likewise, the advent of PROTACs for suppressing 'undruggable' protein targets ... ...

    Abstract In the two decades since a novel thalidomide analog was last approved, many promising drug candidates have emerged with remarkable potency as targeted protein degraders. Likewise, the advent of PROTACs for suppressing 'undruggable' protein targets reinforces the need for new analogs with improved cereblon affinity, target selectivity and drug-like properties. However, thalidomide and its approved derivatives remain plagued by several shortcomings, such as structural instability and poor solubility. Herein, we present a review of strategies for mitigating these shortcomings and highlight contemporary drug discovery approaches that have generated novel thalidomide analogs with enhanced efficacy as cereblon effectors and/or anticancer agents.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.104010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4725: Show issues Location:
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  3. Article ; Online: Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins.

    Stewart, Scott / Stankunas, Kryn

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2707, Page(s) 235–254

    Abstract: Adult zebrafish fins fully regenerate after resection, providing a highly accessible and remarkable vertebrate model of organ regeneration. Fin injury triggers wound epidermis formation and the dedifferentiation of injury-adjacent mature cells to ... ...

    Abstract Adult zebrafish fins fully regenerate after resection, providing a highly accessible and remarkable vertebrate model of organ regeneration. Fin injury triggers wound epidermis formation and the dedifferentiation of injury-adjacent mature cells to establish an organized blastema of progenitor cells. Balanced cell proliferation and redifferentiation along with cell movements then progressively reestablish patterned tissues and restore the fin to its original size and shape. A mechanistic understanding of these coordinated cell behaviors and transitions requires direct knowledge of proteins in their physiological context, including expression, subcellular localization, and activity. Antibody-based staining of sectioned fins facilitates such high-resolution analyses of specific, native proteins. Therefore, such methods are mainstays of comprehensive, hypothesis-driven fin regeneration studies. However, section immunostaining requires labor-intensive, empirical optimization. Here, we present detailed, multistep procedures for antibody staining and co-detecting proliferating cells using paraffin and frozen fin sections. We include suggestions to avoid common pitfalls and to streamline the development of optimized, validated protocols for new and challenging antibodies.
    MeSH term(s) Animals ; Zebrafish ; Cell Proliferation ; Antibodies ; Animal Fins ; Regeneration
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3401-1_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cover crop termination timings and methods effect on cotton (Gossypium hirsutum L.) development and yield

    Denton, Savana / Raper, Tyson / Stewart, Scott / Dodds, Darrin

    Crop, Forage & Turfgrass Management. 2023 June, v. 9, no. 1 p.e20206-

    2023  

    Abstract: Cover crops have been promoted for use in agricultural systems due to both environmental and economic opportunities. Cotton (Gossypium hirsutum L.) growers in West Tennessee faced challenges in 2015 and 2016 with cover crop termination management which ... ...

    Abstract Cover crops have been promoted for use in agricultural systems due to both environmental and economic opportunities. Cotton (Gossypium hirsutum L.) growers in West Tennessee faced challenges in 2015 and 2016 with cover crop termination management which resulted in failed cotton stands. The objective of this experiment was to determine effects of cover crop termination timing and method on cotton emergence, development, and yield. Field experiments were conducted from 2018 to 2020 in both small plot and on‐farm scenarios across West Tennessee. Cover crop termination timings consisted of an at‐planting termination, 3 weeks prior to planting, and both a broadcast and furrow‐strip termination 6 weeks prior to planting. The cover crop termination methods consisted of chemical termination, mechanical termination, and chemical + mechanical termination. At‐planting termination reduced emergence by 25% and delayed maturity of 65% of the stand relative to a 6‐week broadcast termination. Mechanical termination reduced emergence by 26% and delayed maturity of 26% of the stand relative to the chemical and chemical plus mechanical termination treatments. Thrips injury ratings were greater in cotton following a chemical + mechanical termination of the cover crop. Damage from three‐cornered alfalfa hoppers (Sissistilus festinus) was less prevalent in cotton following cover crops terminated 6 weeks prior to planting in a broadcast method compared to other timings. While early season effects were observed, end‐of‐season yield differences were not noted. Still, producers in short season environments should be aware of the higher level of risk associated with at‐planting terminations or terminations.
    Keywords Gossypium hirsutum ; alfalfa ; cotton ; cover crop termination ; cover crops ; forage ; risk ; turf management ; Tennessee
    Language English
    Dates of publication 2023-06
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2374-3832
    DOI 10.1002/cft2.20206
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: VAD 911: Process Improvement for First Responders Treating Ventricular Assist Device Patients.

    Stewart, Scott M / Kim, Bernard

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2021  Volume 66, Issue 10, Page(s) 1120–1126

    Abstract: Ventricular assist devices (VAD) complications including stroke, device failure, gastrointestinal bleeding, and infection all can manifest in the outpatient environment. Often, first responders do not have the knowledge base to respond appropriately. ... ...

    Abstract Ventricular assist devices (VAD) complications including stroke, device failure, gastrointestinal bleeding, and infection all can manifest in the outpatient environment. Often, first responders do not have the knowledge base to respond appropriately. This study conducted an assessment of first responders generalized knowledge and self-reported competency regarding VAD use, provided an education course, and tested for improvement immediately after and 1 month postintervention. Two hundred thirty-six first responders participated from communities with known VAD patients. Responses indicated poor knowledge, experience, and competency. Twenty-one percent had seen a manufacturer training video, 26% had attended prior training, and 38% knew who to contact with a VAD emergency. Generalized knowledge of VAD therapy was poor with majority not understanding use of anticoagulation, when to initiate chest compressions and assessment variations. Self-reported competency was low with 80% of participants reporting unsafe to marginal about VAD awareness. Comparison of 1 month postintervention to preintervention, generalized knowledge improved by a minimum of 38% for each question and competency increased by over 50%. From this study comes the recommendation that VAD centers must include the community first responders as part of their discharge planning for the VAD patient and improve community outreach to ensure appropriate patient outcomes.
    MeSH term(s) Adult ; Education, Medical/methods ; Emergency Responders/education ; Female ; Health Knowledge, Attitudes, Practice ; Heart Failure/therapy ; Heart-Assist Devices ; Humans ; Male
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fever and Abdominal Pain in a 10-year-old with Autism.

    Dunn, Charles L / Wessler, Jacob M / Pragani, Jaisal K / Stewart, Scott E

    Pediatrics in review

    2022  Volume 42, Issue 12, Page(s) 706–711

    MeSH term(s) Abdominal Pain/etiology ; Autistic Disorder/complications ; Autistic Disorder/diagnosis ; Child ; Diagnosis, Differential ; Fever ; Humans
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2020-0100
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    Zs.B 2595: Show issues Location:
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  7. Article ; Online: Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review protocol.

    Wilkinson-Stokes, Matt / Colbeck, Marc / Stewart, Scott

    JBI evidence synthesis

    2021  Volume 19, Issue 9, Page(s) 2415–2422

    Abstract: Objective: This systematic review will aim to summarize and evaluate the literature describing the evidence regarding adverse events from the administration of nitrates during right ventricular myocardial infarction.: Introduction: Withholding ... ...

    Abstract Objective: This systematic review will aim to summarize and evaluate the literature describing the evidence regarding adverse events from the administration of nitrates during right ventricular myocardial infarction.
    Introduction: Withholding nitrates in the setting of right ventricular myocardial infarction is currently recommended by the American Heart Association, European Society of Cardiology, and in the Australian Journal of General Practice, due to the risk that decreasing preload in the setting of already compromised right ventricular ejection fraction may reduce cardiac output and precipitate hypotension or exacerbate cardiogenic shock. The original evidence from 1989 underpinning these recommendations displays methodological weaknesses including low sample size and confounding interventions. More recent and comprehensive research from 2014, 2016, 2018, and 2019 conflicts with the conclusions from the 1989 study, suggesting instead that nitrate administration during right ventricular myocardial infarction results in no significant difference in the rate of adverse events. The combination of recommended practice based on 30-year-old evidence and the emergence of recent challenging evidence suggest that this topic merits systematic review.
    Inclusion criteria: The study will include both experimental and observational (descriptive and analytical) study designs that discuss the occurrence of adverse events from the administration of nitrates during a known right ventricular myocardial infarction.
    Methods: Six databases will be systematically searched: the Cochrane CENTRAL Register, PubMed, Embase, MEDLINE Complete, CINAHL, and Google Scholar. Identified studies will be independently assessed for inclusion by two investigators using JBI critical appraisal tools. Data will be extracted for narrative and tabular synthesis.
    Systematic review registration number: PROSPERO CRD42020172839.
    MeSH term(s) Adult ; Australia ; Humans ; Myocardial Infarction/chemically induced ; Nitrates/adverse effects ; Stroke Volume ; Systematic Reviews as Topic ; United States ; Ventricular Function, Right
    Chemical Substances Nitrates
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article
    ISSN 2689-8381
    ISSN (online) 2689-8381
    DOI 10.11124/JBIES-20-00183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterning.

    Robbins, Amy E / Horst, Samuel G / Lewis, Victor M / Stewart, Scott / Stankunas, Kryn

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Fraser Syndrome is a rare, multisystemic autosomal recessive disorder characterized by disrupted epithelial-mesenchymal associations upon loss of Fraser Complex genes. Disease manifestation and affected organs are highly variable. Digit malformations ... ...

    Abstract Fraser Syndrome is a rare, multisystemic autosomal recessive disorder characterized by disrupted epithelial-mesenchymal associations upon loss of Fraser Complex genes. Disease manifestation and affected organs are highly variable. Digit malformations such as syndactyly are common but of unclear developmental origins. We explored if zebrafish
    Language English
    Publishing date 2023-07-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.08.548238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pre-Employment physical capacity testing as a predictor of musculoskeletal injury in Victorian paramedics.

    Jenkins, Natasha / Smith, Gavin / Stewart, Scott / Kamphuis, Catherine

    Work (Reading, Mass.)

    2021  Volume 70, Issue 1, Page(s) 263–270

    Abstract: Background: Paramedic work has periods of intermittent high physical demand, a risk of workplace injury, may be confounded by inherent fitness of the paramedic.: Objective: This study aimed to identify the nature of workplace musculoskeletal injury, ... ...

    Abstract Background: Paramedic work has periods of intermittent high physical demand, a risk of workplace injury, may be confounded by inherent fitness of the paramedic.
    Objective: This study aimed to identify the nature of workplace musculoskeletal injury, and determine if there was a relationship between pre-employment physical capacity testing (PEPCT) scores and risk of workplace musculoskeletal injury within the paramedic industry.
    Methods: A retrospective case review using PEPCT scores and workplace injury (WI) manual handling data collected from 2008 to 2015 by an Australian pre-hospital emergency care provider (Ambulance Victoria), enabled comparison and analysis of two distinct data sets.
    Results: A total of 538 paramedics were included for analysis with 34 paramedics reporting a workplace musculoskeletal injury from manual handling. The mean time to injury from commencement of employment was 395.4 days (SD 516.2). Female paramedics represented 53.0%and male paramedics represented 47%of the sample. Mean total PEPCT score for the entire sample was 19.1 (SD 2.9) with a range from 16.2-22, while for those reporting injuries it was 18.3 (SD 2.6) with a range from 15.7-20.9.
    Conclusions: Musculoskeletal injury amongst Victorian paramedics is more prevalent where the paramedic is female, and/or within three years of commencement of employment. The PEPCT score did not differentiate those at risk of subsequent injury.
    MeSH term(s) Allied Health Personnel ; Australia/epidemiology ; Emergency Medical Technicians ; Employment ; Female ; Humans ; Male ; Retrospective Studies
    Language English
    Publishing date 2021-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-213570
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4810: Show issues Location:
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  10. Article ; Online: Reduced toxin binding associated with resistance to Vip3Aa in the corn earworm (

    Kerns, Dawson D / Yang, Fei / Kerns, David L / Stewart, Scott D / Jurat-Fuentes, Juan Luis

    Applied and environmental microbiology

    2023  Volume 89, Issue 12, Page(s) e0164423

    Abstract: Importance: Helicoverpa ... ...

    Abstract Importance: Helicoverpa zea
    MeSH term(s) Animals ; United States ; Zea mays/metabolism ; Endotoxins/metabolism ; Insecticide Resistance/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Plants, Genetically Modified/metabolism ; Hemolysin Proteins/genetics ; Moths/genetics ; Bacillus thuringiensis/genetics ; Larva/metabolism
    Chemical Substances Endotoxins ; Bacterial Proteins ; Hemolysin Proteins
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01644-23
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