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  1. Article ; Online: Breathing new life into the respiratory pump.

    Stickland, Michael K

    The Journal of physiology

    2022  Volume 600, Issue 18, Page(s) 4051–4052

    MeSH term(s) Humans ; Respiration ; Respiratory System ; Spinal Cord Injuries
    Language English
    Publishing date 2022-08-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Pulmonary Vasculature.

    Hopkins, Susan R / Stickland, Michael K

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 5, Page(s) 538–554

    Abstract: The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed enabling gas exchange. The distribution of pulmonary blood flow is ... ...

    Abstract The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed enabling gas exchange. The distribution of pulmonary blood flow is regulated by several factors including effects of vascular branching structure, large-scale forces related to gravity, and finer scale factors related to local control. Hypoxic pulmonary vasoconstriction is one such important regulatory mechanism. In the face of local hypoxia, vascular smooth muscle constriction of precapillary arterioles increases local resistance by up to 250%. This has the effect of diverting blood toward better oxygenated regions of the lung and optimizing ventilation-perfusion matching. However, in the face of global hypoxia, the net effect is an increase in pulmonary arterial pressure and vascular resistance. Pulmonary vascular resistance describes the flow-resistive properties of the pulmonary circulation and arises from both precapillary and postcapillary resistances. The pulmonary circulation is also distensible in response to an increase in transmural pressure and this distention, in addition to recruitment, moderates pulmonary arterial pressure and vascular resistance. This article reviews the physiology of the pulmonary vasculature and briefly discusses how this physiology is altered by common circumstances.
    MeSH term(s) Humans ; Vasoconstriction/physiology ; Vascular Resistance ; Lung ; Pulmonary Circulation/physiology ; Hypoxia ; Blood Pressure
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1770059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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  3. Article ; Online: Capillary Red Cell Transit-Time is an Important Contributor to Exercise-Induced Pulmonary Diffusion Limitation.

    Hopkins, Susan R / Dempsey, Jerome A / Stickland, Michael K

    Medicine and science in sports and exercise

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 869: Show issues Location:
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  4. Article ; Online: Capillary Red Cell Transit-Time is an Important Contributor to Exercise-Induced Pulmonary Diffusion Limitation: Response to Zavorsky.

    Hopkins, Susan R / Dempsey, Jerome A / Stickland, Michael K

    Medicine and science in sports and exercise

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 869: Show issues Location:
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  5. Article: Variations in COPD Health Care Access and Outcomes: A Rapid Review.

    Shatto, Julie A / Stickland, Michael K / Soril, Leslie J J

    Chronic obstructive pulmonary diseases (Miami, Fla.)

    2024  Volume 11, Issue 2, Page(s) 229–246

    Abstract: Background: Health inequities among individuals with chronic obstructive pulmonary disease (COPD) are often associated with differential access to health care and health outcomes. A greater understanding of the literature concerning such variation is ... ...

    Abstract Background: Health inequities among individuals with chronic obstructive pulmonary disease (COPD) are often associated with differential access to health care and health outcomes. A greater understanding of the literature concerning such variation is necessary to determine where gaps or inequities exist along the continuum of COPD care.
    Methods: A rapid review of the published and grey literature reporting variations in health care access and/or health outcomes for individuals with COPD was completed. Variation was defined as differential patterns in access indicators or outcome measures within sociodemographic categories, including age, ethnicity, geography, race, sex, and socioeconomic status. Emergent themes were identified from the included literature and synthesized narratively.
    Results: Thirty-five articles were included for final review; the majority were retrospective cohort studies. Twenty-five studies assessed variation in access to health care. Key indicators included: access to spirometry testing, medication adherence, participation in pulmonary rehabilitation, and contact with general practitioners and/or respiratory specialists. Twenty-one studies assessed variation in health outcomes in COPD and key metrics included: hospital-based resource utilization (length of stay and admissions/readmissions), COPD exacerbations, and mortality. Patients who live in rural environments and those of lower socioeconomic status had both poorer access to care and outcomes at the system and patient level. Other sociodemographic variables, including ethnicity, race, age, and sex were associated with variation in health care access and outcomes, although these findings were less consistent.
    Conclusion: The results of this rapid review suggest that substantial variation in access and outcomes exists for individuals with COPD, highlighting opportunities for targeted interventions and policies.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2771715-X
    ISSN 2372-952X
    ISSN 2372-952X
    DOI 10.15326/jcopdf.2023.0441
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  6. Article: The Pulmonary Vasculature

    Hopkins, Susan R. / Stickland, Michael K.

    Seminars in Respiratory and Critical Care Medicine

    (Pulmonary Physiology)

    2023  Volume 44, Issue 05, Page(s) 538–554

    Abstract: The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed enabling gas exchange. The distribution of pulmonary blood flow is ... ...

    Series title Pulmonary Physiology
    Abstract The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed enabling gas exchange. The distribution of pulmonary blood flow is regulated by several factors including effects of vascular branching structure, large-scale forces related to gravity, and finer scale factors related to local control. Hypoxic pulmonary vasoconstriction is one such important regulatory mechanism. In the face of local hypoxia, vascular smooth muscle constriction of precapillary arterioles increases local resistance by up to 250%. This has the effect of diverting blood toward better oxygenated regions of the lung and optimizing ventilation–perfusion matching. However, in the face of global hypoxia, the net effect is an increase in pulmonary arterial pressure and vascular resistance. Pulmonary vascular resistance describes the flow-resistive properties of the pulmonary circulation and arises from both precapillary and postcapillary resistances. The pulmonary circulation is also distensible in response to an increase in transmural pressure and this distention, in addition to recruitment, moderates pulmonary arterial pressure and vascular resistance. This article reviews the physiology of the pulmonary vasculature and briefly discusses how this physiology is altered by common circumstances.
    Keywords gravity ; Zone model ; fractal ; hypoxic pulmonary vasoconstriction ; pulmonary vascular resistance
    Language English
    Publishing date 2023-10-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1770059
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Getting to the heart of the matter: understanding cardiovascular limitations at high altitude.

    Stickland, Michael K

    The Journal of physiology

    2018  Volume 597, Issue 4, Page(s) 987

    MeSH term(s) Altitude ; Exercise Tolerance ; Humans ; Hypovolemia ; Vasoconstriction ; Ventricular Function
    Language English
    Publishing date 2018-05-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP276345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.65: Show issues Location:
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  8. Article ; Online: In chronic obstructive pulmonary disease, home-based maintenance telerehabilitation reduced the risk of exacerbations, hospitalisations and emergency visits [commentary].

    Stickland, Michael K

    Journal of physiotherapy

    2017  Volume 64, Issue 1, Page(s) 56

    MeSH term(s) Emergency Service, Hospital ; Hospitalization ; Humans ; Pulmonary Disease, Chronic Obstructive ; Telerehabilitation
    Language English
    Publishing date 2017-12-27
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2543915-7
    ISSN 1836-9561 ; 1836-9553 ; 0004-9514
    ISSN (online) 1836-9561
    ISSN 1836-9553 ; 0004-9514
    DOI 10.1016/j.jphys.2017.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2001: Show issues Location:
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  9. Article: Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.

    Davies, Rachelle / Wiebe, Natasha / Brotto, Andrew / Stickland, Michael K / Braam, Branko / Thompson, Stephanie

    Canadian journal of kidney health and disease

    2023  Volume 10, Page(s) 20543581231213798

    Abstract: Background: Autonomic nervous system (ANS) dysfunction and vascular stiffness increase cardiovascular risk in people with chronic kidney disease (CKD). Chronic elevations in sympathetic activity can lead to increased arterial stiffness; however, the ... ...

    Abstract Background: Autonomic nervous system (ANS) dysfunction and vascular stiffness increase cardiovascular risk in people with chronic kidney disease (CKD). Chronic elevations in sympathetic activity can lead to increased arterial stiffness; however, the relationship between these variables is unknown in CKD.
    Objective: To explore the association between measures of autonomic function and arterial stiffness in patients with moderate-to-severe CKD.
    Methods: This study was a prespecified secondary analysis of a randomized controlled trial. This included the following measures: 24-hour ambulatory blood pressure (BP), carotid-femoral and carotid-radial pulse wave velocity (PWV), and postexercise heart rate recovery (HRR). We used mixed effect linear regression models with Bayesian information criteria (BIC) to assess the contribution of ANS measurements.
    Results: Forty-four patients were included in the analysis. Mean carotid-femoral and carotid-radial PWV were 7.12 m/s (95% CI 6.13, 8.12) and 8.51 m/s (7.90, 9.11), respectively. Mean systolic dipping, calculated as percentage change in mean systolic readings from day to night, was 10.0% (95% CI 7.79, 12.18). Systolic dipping was independently associated with carotid-radial PWV, MD -0.09 m/s (95% CI -0.15, -0.02) and had the lowest BIC.
    Conclusions: Systolic dipping was associated with carotid-radial PWV in people with moderate-to-severe CKD; however, there was no association with carotid-femoral PWV. Systolic dipping may be a feasible surrogate of ANS function, as the association with carotid-radial PWV was consistent with the minimal clinically important difference (MCID). Future studies are needed to define the relationship between ANS function, arterial stiffness, and CV events over time in people with CKD.
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2765462-X
    ISSN 2054-3581
    ISSN 2054-3581
    DOI 10.1177/20543581231213798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Respiratory Health Strategic Clinical Network: Five years of innovation in respiratory care.

    Stickland, Michael K / Sharpe, Heather

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2019  Volume 191, Issue Suppl, Page(s) S30–S32

    MeSH term(s) Community Networks/trends ; Diffusion of Innovation ; Humans ; Respiratory Physiological Phenomena
    Language English
    Publishing date 2019-12-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.190582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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