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Article ; Online: Quantified mitral regurgitation and left atrial function in heart failure with reduced ejection fraction: interplay and outcome implications.

Malagoli, Alessandro / Rossi, Luca / Zanni, Alessia / Sticozzi, Concetta / Piepoli, Massimo F / Benfari, Giovanni

2022 Volume 24, Issue 4, Page(s) 694–702

Abstract: Aims: The clinical and prognostic importance of functional mitral regurgitation (FMR) in heart failure patients with reduced ejection fraction (HFrEF) has been highly debated. This study aims to define FMR linkage to cardiovascular (CV) outcomes and the ...

Abstract	Aims: The clinical and prognostic importance of functional mitral regurgitation (FMR) in heart failure patients with reduced ejection fraction (HFrEF) has been highly debated. This study aims to define FMR linkage to cardiovascular (CV) outcomes and the interplay with left atrial (LA) function in a prospective cohort of consecutive HFrEF outpatients. Methods and results: Overall, 286 consecutive outpatients with chronic HFrEF were prospectively enrolled. FMR was quantified by effective regurgitant orifice area (EROA). Global peak atrial longitudinal strain (PALS) was measured by speckle tracking echocardiography. The primary endpoint was a composite of congestive heart failure hospitalization or CV death. During a mean follow-up of 4.1 ± 1.5 years, the primary endpoint occurred in 99 patients (35%). The spline modelling of the risk by FMR severity showed an excess event risk starting at about the EROA value of 0.1 cm Conclusions: Our results refine the independent association between FMR and CV outcome among HFrEF outpatients. Within a moderate EROA range, LA function mitigates the clinical consequences of mitral regurgitation, providing measurable proof of the interplay between regurgitation and LA compliance.
MeSH term(s)	Atrial Function, Left ; Heart Atria/diagnostic imaging ; Heart Failure/epidemiology ; Humans ; Mitral Valve Insufficiency/epidemiology ; Prospective Studies ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2429
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Article ; Online: Refining the Role of Left Atrial Strain in Heart Failure with Reduced Ejection Fraction.

Malagoli, Alessandro / Rossi, Luca / Zanni, Alessia / Sticozzi, Concetta / Piepoli, Massimo Francesco / Benfari, Giovanni

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2021 Volume 34, Issue 7, Page(s) 804–805

MeSH term(s)	Atrial Appendage ; Heart Atria/diagnostic imaging ; Heart Failure/diagnostic imaging ; Humans ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Letter
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2021.02.010
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Article ; Online: Air pollution and out-of-hospital cardiac arrest risk: a 7-year study from a highly polluted area.

Moderato, Luca / Aschieri, Daniela / Lazzeroni, Davide / Rossi, Luca / Biagi, Andrea / Binno, Simone Maurizio / Monello, Alberto / Pelizzoni, Valentina / Sticozzi, Concetta / Zanni, Alessia / Capucci, Alessandro / Nani, Stefano / Ardissino, Diego / Nicolini, Francesco / Niccoli, Giampaolo

European heart journal. Acute cardiovascular care

2023 Volume 12, Issue 12, Page(s) 810–817

Abstract: Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. ...

Abstract	Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. The aim of the study was to evaluate the association between air pollution (short-, mid-, and long-term exposures) and OHCA risk, during a 7-year period in a highly polluted urban area in northern Italy, with a high density of automated external defibrillators (AEDs). Methods and results: Out-of-hospital cardiac arrests were prospectively collected from the 'Progetto Vita Database' between 1 January 2010 and 31 December 2017; day-by-day air pollution levels were extracted from the Environmental Protection Agency stations. Electrocardiograms of OHCA interventions were collected from the AED data cards. Day-by-day particulate matter (PM) 2.5 and 10, ozone (O3), carbon monoxide (CO), and nitrogen dioxide (NO2) levels were measured. A total of 880 OHCAs occurred in 748 days. A significant increase in OHCA risk with a progressive increase in PM2.5, PM10, CO, and NO2 levels was found. After adjustment for temperature and seasons, a 9% and 12% increase in OHCA risk for each 10 μg/m3 increase in PM10 (P < 0.0001) and PM2.5 (P < 0.0001) levels was found. Air pollutant levels were associated with both asystole and shockable rhythm risk, while no correlation was found with pulseless electrical activity. Conclusion: Short- and mid-term exposures to PM2.5 and PM10 are independently associated with the risk of OHCA due to asystole or shockable rhythm.
MeSH term(s)	United States ; Humans ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/etiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/adverse effects ; Air Pollutants/analysis
Chemical Substances	Particulate Matter ; Nitrogen Dioxide (S7G510RUBH) ; Air Pollutants
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1093/ehjacc/zuad105
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Article ; Online: Clinical and epidemiological characteristics of 320 deceased patients with COVID-19 in an Italian Province: A retrospective observational study.

Biagi, Andrea / Rossi, Luca / Malagoli, Alessandro / Zanni, Alessia / Sticozzi, Concetta / Comastri, Greta / Gandolfi, Stefano / Villani, Giovanni Quinto

Journal of medical virology

2020 Volume 92, Issue 11, Page(s) 2718–2724

Abstract: Studies have described clinical features of patients with coronavirus disease (COVID-19). However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological ... ...

Abstract	Studies have described clinical features of patients with coronavirus disease (COVID-19). However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological characteristics of 320 deceased from the Italian experience. We retrospectively collected all consecutive non-survivor patients with laboratory-confirmed COVID-19 infection admitted to the Emergency Rooms (ERs) Piacenza Hospital Network during the first month of COVID-19 pandemic in Italy. Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient. A total of 1050 patients with confirmed COVID-19 pneumonia were admitted to the ERs between 24 February and 22 March 2020. Three hundred and twenty (30.5%) patients died with a median age of 78.0 years, 205 (64%) non-survivors were above 65 years old, 230 (71.9%) were male. Non-survivor patients showed frequently several coexisting medical conditions, with hypertension being the most common comorbidity (235 patients, 73.4%). The in-hospital mortality did not change during the progression of the pandemic. In this retrospective Italian study, most of COVID-19 deceased patients were elderly male aged over than 65 years. Hypertension was the most common coexisting disease. In-hospital mortality was high and showed no variation during the first month of the COVID-19 italian epidemic.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/mortality ; Comorbidity ; Female ; Geography ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Italy/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26147
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Zs.A 1320: Show issues

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Article ; Online: Mobile health and implantable cardiac devices: Patients' expectations.

Villani, Giovanni Q / Villani, Andrea / Zanni, Alessia / Sticozzi, Concetta / Maceda, Diego Penela / Rossi, Luca / Pisati, Maria Sole / Piepoli, Massimo F

European journal of preventive cardiology

2019 Volume 26, Issue 9, Page(s) 920–927

Abstract: Background: Mobile computing and communication technologies in health services and information (so-called mHealth) have modified the traditional approach in the follow-up of patients with implantable cardiac devices, increased patient engagement and ... ...

Abstract	Background: Mobile computing and communication technologies in health services and information (so-called mHealth) have modified the traditional approach in the follow-up of patients with implantable cardiac devices, increased patient engagement and empowerment, reduced healthcare costs and improved patients' outcome. Recent developments in mobile technology, with the introduction of smartphone-compatible devices that can measure various health parameters and transfer automatically generated data, have increased the potential application of remote monitoring and the interest towards mHealth. However, little is known about the patients' interest and expectations of this new technology. Objective: The patients' interest in the possibility of receiving data from their implantable cardiac device, clinical and health advice via remote monitoring on their smartphones were investigated. Methods: A questionnaire entitled 'Expectations for future possibility of self-management of device data' (Likert scale scored) was submitted to 300 consecutive implantable cardiac device outpatients. The questionnaire was focused on collecting patients' expectations in receiving direct information regarding their implantable cardiac device status (item 1, five questions), their own clinical status (item 2, seven questions) and advice on healthy lifestyle promotion (item 3, nine questions). Patient characteristics associated with greater interest towards mHealth were also investigated. Results: Questionnaires were completed by 268 patients (221 men, aged 69 ± 14 years). The Cronbach test reported an alpha value of 0.98 for item 1, 0.94 for item 2 and 0.97 for item 3. Patients declared to be mainly interested in the device interventions (62%) and in severe arrhythmia occurrence (61%), followed by data on heart failure severity (54%) and their performed physical activity (48%). Patients showed very little interest in ECG tracing (37%), but the lowest interest was expressed towards healthy lifestyle promotion advice (<40%). A higher education degree and the presence of the caregiver positively affected the interest towards remote monitoring information ( P < 0.001). Conclusions: The patients' interests were mainly directed at receiving information related to technical data of the implantable cardiac device and not to the overall management of the disease, underlying the insufficient awareness of patients towards the key role of self-control health status and the promotion of a healthy lifestyle.
MeSH term(s)	Aged ; Aged, 80 and over ; Defibrillators, Implantable ; Electric Countershock/instrumentation ; Female ; Health Knowledge, Attitudes, Practice ; Health Promotion ; Health Status ; Healthy Lifestyle ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Failure/psychology ; Heart Failure/therapy ; Humans ; Male ; Middle Aged ; Patient Participation ; Patient Satisfaction ; Predictive Value of Tests ; Remote Sensing Technology ; Risk Reduction Behavior ; Surveys and Questionnaires ; Telemedicine ; Treatment Outcome
Language	English
Publishing date	2019-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487319830531
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Zs.A 4686: Show issues

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Article ; Online: Role of comorbidities on the mortality in patients with SARS-CoV-2 infection: an Italian cohort study.

Vergara, Pasquale / Rossi, Luca / Biagi, Andrea / Falasconi, Giulio / Pannone, Luigi / Zanni, Alessia / Sticozzi, Concetta / Comastri, Greta / Gandolfi, Stefano / Godino, Cosmo / Malagoli, Alessandro / Villani, Giovanni Q

Minerva medica

2021 Volume 114, Issue 2, Page(s) 185–190

Abstract: Background: Cardiovascular comorbidities are a common cause of death in COVID-19 and the aim of this study is to evaluate the effect of comorbidities on mortality in COVID-19 patients.: Methods: In this retrospective observational study we enrolled ... ...

Abstract	Background: Cardiovascular comorbidities are a common cause of death in COVID-19 and the aim of this study is to evaluate the effect of comorbidities on mortality in COVID-19 patients. Methods: In this retrospective observational study we enrolled 1049 patients hospitalized with confirmed SARS-CoV-2 infection in a single Italian Center from 21 February to 20 March 2020 Evaluated risk factors (RFs) were: advanced age, gender, hypertension, diabetes, atrial fibrillation, hyperlipidemia, chronic kidney disease, thyroid disease, chronic obstructive pulmonary disease, malignancy, stroke, cardiovascular disease, and peripheral vascular disease. Endpoint of the study was death from any cause. A multivariate logistic regression model was built using covariates that showed as statistically significant at univariate regression analysis. Results: Median age at presentation was 71.1 years (IQR: 59.1-80.5); 244 (72.2%) were males. Primary outcome occurred in 338 patients (32.2%). In decedents, median survival from Hospitalization was 6 (IQR: 3-10) days. 264 decedents had 1 RF, 120 had 2 RFs and 39 had ≥3 RFs. At multivariate logistic regression model, variables associated with primary outcome were: age class (64-69 years) (OR 3.03, CI: 1.75-5.31, P<0.001), age class (70-88 years) (OR 10.08, CI: 6.67-15.72, P<0.001), age class (≥88 years) (OR 23.99, CI: 13.21-44.82, P<0.001), male gender (OR 1.88, CI: 1.36-2.62, P<0.001), diabetes (OR 1.56, CI: 1.07-2.26, P=0.02), stroke (OR 3.41, CI: 1.33-9.91, P=0.015). Conclusions: Age, male gender, presence of diabetes and stroke appeared as independent predictors of mortality in COVID-19 patients. A table for risk of 30 days-mortality in SARS-CoV-2 infection was built, based on odds ratios derived from multivariate regression analysis.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; COVID-19 ; Cohort Studies ; SARS-CoV-2 ; Comorbidity ; Risk Factors ; Diabetes Mellitus/epidemiology ; Retrospective Studies ; Hospitalization ; Stroke
Language	English
Publishing date	2021-04-29
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.21.07187-1
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Article ; Online: Left Atrial Function Predicts Cardiovascular Events in Patients With Chronic Heart Failure With Reduced Ejection Fraction.

Malagoli, Alessandro / Rossi, Luca / Bursi, Francesca / Zanni, Alessia / Sticozzi, Concetta / Piepoli, Massimo Francesco / Villani, Giovanni Quinto

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2018 Volume 32, Issue 2, Page(s) 248–256

Abstract: Background: Heart failure (HF) is known to be the most widespread epidemic of cardiovascular disease. Among several factors with prognostic value for the clinical course of HF, left atrial (LA) function has not yet been fully examined. The aim of this ... ...

Abstract	Background: Heart failure (HF) is known to be the most widespread epidemic of cardiovascular disease. Among several factors with prognostic value for the clinical course of HF, left atrial (LA) function has not yet been fully examined. The aim of this prospective study was to evaluate LA function for the prediction of major cardiovascular outcomes in stable patients with chronic HF with reduced ejection fraction. Additionally, as secondary end points, cardiovascular mortality and atrial fibrillation were analyzed separately. Methods: The predictive value of LA function evaluated by speckle-tracking echocardiography was assessed in a population of 286 outpatients referred to the authors' institution for routine evaluation of chronic HF. Global peak atrial longitudinal strain was measured at the end of the reservoir phase and calculated by averaging in all LA segments. Results: During a median follow-up period of 48 ± 11 months, major adverse cardiac events occurred in 98 patients (34%). In a multivariate model, global peak atrial longitudinal strain (hazard ratio, 0.95; 95% CI, 0.94-0.96; P = .02), left ventricular ejection fraction (hazard ratio, 0.95; 95% CI, 0.93-0.97; P = .01), and renal failure (hazard ratio, 0.98; 95% CI, 0.97-0.99; P = .01) were independent predictors of an adverse outcome. Sixty-six patients (23%) died of cardiac causes. Fifty-four patients (19%) developed atrial fibrillation. Patients with lower global peak atrial longitudinal strain showed worse event-free survival and developed atrial fibrillation more frequently than those with higher levels. Conclusions: LA function assessed by speckle-tracking echocardiography is an independent prognostic marker in patients with HF with reduced ejection fraction.
MeSH term(s)	Aged ; Atrial Function, Left/physiology ; Echocardiography, Doppler/methods ; Feasibility Studies ; Female ; Follow-Up Studies ; Heart Atria/diagnostic imaging ; Heart Atria/physiopathology ; Heart Failure/diagnosis ; Heart Failure/mortality ; Heart Failure/physiopathology ; Humans ; Italy/epidemiology ; Male ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Stroke Volume/physiology ; Survival Rate/trends ; Ventricular Function, Left
Language	English
Publishing date	2018-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2018.08.012
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Renin-angiotensin system inhibitors and mortality in patients with COVID-19.

Rossi, Luca / Malagoli, Alessandro / Biagi, Andrea / Zanni, Alessia / Sticozzi, Concetta / Comastri, Greta / Pannone, Luigi / Gandolfi, Stefano / Vergara, Pasquale / Villani, Giovanni Quinto

Infection

2020 Volume 49, Issue 2, Page(s) 287–294

Abstract: Association of renin-angiotensin system inhibitors with risk of death in patients with hypertension (HTN) and coronavirus disease 2019 (COVID-19) is not well characterized. The aim of this study was to evaluate the outcomes of patients with HTN and COVID- ...

Abstract	Association of renin-angiotensin system inhibitors with risk of death in patients with hypertension (HTN) and coronavirus disease 2019 (COVID-19) is not well characterized. The aim of this study was to evaluate the outcomes of patients with HTN and COVID-19 with respect to different chronic antihypertensive drug intake. We performed a retrospective, observational study from a large cohort of patients with HTN and with a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection admitted to the Emergency Rooms (ER) of the Piacenza Hospital network from February 21, 2020 to March 20, 2020. There were 1050 patients admitted to the ERs of the Piacenza Hospital network with COVID-19. HTN was present in 590 patients [median age, 76.2 years (IQR 68.2-82.6)]; 399 (66.1%) patients were male. Of them, 248 patients were chronically treated with ACEi, 181 with ARBs, and 161 with other drugs (O-drugs) including beta blockers, diuretics and calcium-channel inhibitors. With respect to the antihypertensive use, there was no difference between comorbid conditions. During a follow-up of 38 days (IQR 7.0-46.0), 256 patients (43.4%) died, without any difference stratifying for antihypertensive drugs. Of them, 107 (43.1%) were in ACEi group vs 67 (37%) in ARBs group vs 82 (50.7%) in O-drugs group, (log-rank test: p = 0.066). In patients with HTN and COVID-19, neither ACEi nor ARBs were independently associated with mortality. After adjusting for potential confounders in risk prediction, the rate of death was similar. Our data confirm Specialty Societal recommendations, suggesting that treatment with ACEIs or ARBs should not be discontinued because of COVID-19.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; COVID-19/mortality ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/mortality ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Survival Rate ; COVID-19 Drug Treatment
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
Language	English
Publishing date	2020-11-22
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01550-0
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Article: Clinical and epidemiological characteristics of 320 deceased Covid-19 patients in an Italian Province: a retrospective observational study

Biagi, Andrea / Rossi, Luca / Malagoli, Alessandro / Zanni, Alessia / Sticozzi, Concetta / Comastri, Greta / Gandolfi, Stefano / Villani, Giovanni Quinto

J. med. virol

Abstract: BACKGROUND: Studies have described clinical features of Covid-19 patients. However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological characteristics of 320 ... ...

Abstract	BACKGROUND: Studies have described clinical features of Covid-19 patients. However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological characteristics of 320 deceased from the Italian experience. METHODS: We retrospectively collected all consecutive non-survivor patients with laboratory-confirmed Covid-19 infection admitted to the Emergency Rooms (ER) Piacenza Hospital Network during the first month of Covid-19 pandemic in Italy. Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient. RESULTS: A total of 1050 patients with confirmed Covid-19 pneumonia were admitted to the ERs between 24 February,2020, and 22 March,2020. 320 (30.5%) patients died with a median age of 78.0 years, 205 (64%) non-survivors were above 65 years old, 230 (71.9 %) were male. Non-survivor patients showed frequently several coexisting medical conditions, with hypertension being the most common comorbidity (235 patients, 73.4%). The in-hospital mortality did not change during the progression of the pandemic. CONCLUSION: In this retrospective Italian study, most of Covid-19 deceased patients were elderly male aged over than 65 years. Hypertension was the most common coexisting disease. In-hospital mortality was high and showed no variation during the first month of the Covid-19 italian epidemic. This article is protected by copyright. All rights reserved.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #591695
Database	COVID19

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Article: Clinical and epidemiological characteristics of 320 deceased patients with COVID-19 in an Italian Province: A retrospective observational study

Biagi, Andrea / Rossi, Luca / Malagoli, Alessandro / Zanni, Alessia / Sticozzi, Concetta / Comastri, Greta / Gandolfi, Stefano / Villani, Giovanni Quinto

J. med. virol

Abstract	Studies have described clinical features of patients with coronavirus disease (COVID-19). However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological characteristics of 320 deceased from the Italian experience. We retrospectively collected all consecutive non-survivor patients with laboratory-confirmed COVID-19 infection admitted to the Emergency Rooms (ERs) Piacenza Hospital Network during the first month of COVID-19 pandemic in Italy. Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient. A total of 1050 patients with confirmed COVID-19 pneumonia were admitted to the ERs between 24 February and 22 March 2020. Three hundred and twenty (30.5%) patients died with a median age of 78.0 years, 205 (64%) non-survivors were above 65 years old, 230 (71.9%) were male. Non-survivor patients showed frequently several coexisting medical conditions, with hypertension being the most common comorbidity (235 patients, 73.4%). The in-hospital mortality did not change during the progression of the pandemic. In this retrospective Italian study, most of COVID-19 deceased patients were elderly male aged over than 65 years. Hypertension was the most common coexisting disease. In-hospital mortality was high and showed no variation during the first month of the COVID-19 italian epidemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #591695
Database	COVID19

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