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Article ; Online: Soluble human leucocyte antigen-G and interleukin-10 levels in isocyanate-induced asthma.

Mapp, C E / Ferrazzoni, S / Rizzo, R / Miotto, D / Stignani, M / Boschetto, P / Maestrelli, P / Baricordi, O R

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2009 Volume 39, Issue 6, Page(s) 812–819

Abstract: Background: We previously reported that in moderate-to-severe asthma there is a deficit of IL-10 secretion that could prevent the production of soluble HLA-G (sHLA-G), a non-classical human leucocyte antigen class I molecule with tissue-protective ... ...

Abstract	Background: We previously reported that in moderate-to-severe asthma there is a deficit of IL-10 secretion that could prevent the production of soluble HLA-G (sHLA-G), a non-classical human leucocyte antigen class I molecule with tissue-protective properties in inflammatory responses. Objective: Our objective was to investigate the production of sHLA-G and the secretion of IL-10 by peripheral blood mononuclear cells (PBMCs) in asthma induced by isocyanates and to compare the results with those obtained in non-occupational allergic asthma. Method: sHLA-G and IL-10 were measured by ELISA in the culture supernatants of unstimulated or lipopolysaccharide (LPS)-stimulated PBMCs obtained from 20 subjects with isocyanate asthma, 16 asymptomatic subjects exposed to isocyanates, 18 subjects with non-occupational allergic asthma, and 26 healthy control subjects. Results: Occupational exposure to isocyanates was associated with high baseline levels of secretion of IL-10 by PBMCs, whether or not the exposed subjects had asthmatic symptoms. However, spontaneous production of sHLA-G by PBMC was significantly higher in subjects with isocyanate asthma compared with asymptomatic-exposed controls. In contrast, PBMCs from subjects with non-occupational allergic asthma produced sHLA-G only after LPS stimulation. Conclusions: sHLA-G production and IL-10 secretion are influenced by workplace exposure to isocyanates and by development of asthma. The different behaviour of both sHLA-G and IL-10 in asthma induced by isocyanates compared with non-occupational allergic asthma suggests a heterogeneous biological role for HLA-G molecules and for IL-10, a key cytokine of immune and inflammatory responses.
MeSH term(s)	Adult ; Asthma/immunology ; Cells, Cultured ; Female ; HLA Antigens/biosynthesis ; HLA Antigens/immunology ; HLA-G Antigens ; Histocompatibility Antigens Class I/biosynthesis ; Histocompatibility Antigens Class I/immunology ; Humans ; Interleukin-10/biosynthesis ; Interleukin-10/immunology ; Isocyanates/adverse effects ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Lipopolysaccharides/immunology ; Male ; Middle Aged ; Occupational Diseases/immunology
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Isocyanates ; Lipopolysaccharides ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2009-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/j.1365-2222.2009.03215.x
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Zs.A 767: Show issues

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Article ; Online: Possible role of human leukocyte antigen-G molecules in human oocyte/embryo secretome.

Rizzo, Roberta / Stignani, Marina / Melchiorri, Loredana / Baricordi, Olavio R

Human immunology

2009 Volume 70, Issue 12, Page(s) 970–975

Abstract: Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule observed for the first time in human cytotrophoblast. Several investigations have demonstrated the presence of soluble HLA-G in oocyte/embryo secretome. A focus on the possible role ...

Abstract	Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule observed for the first time in human cytotrophoblast. Several investigations have demonstrated the presence of soluble HLA-G in oocyte/embryo secretome. A focus on the possible role of HLA-G in oocyte/embryo context will be developed in this review. In addition, the possible use of HLA-G in assisted reproductive technology will be treated.
MeSH term(s)	Embryo, Mammalian/immunology ; Embryo, Mammalian/metabolism ; Female ; Follicular Fluid/immunology ; Follicular Fluid/metabolism ; HLA Antigens/immunology ; HLA Antigens/metabolism ; HLA-G Antigens ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Maternal-Fetal Relations ; Oocytes/immunology ; Oocytes/metabolism ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Receptors, KIR2DL5
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Receptors, Immunologic ; Receptors, KIR2DL5
Language	English
Publishing date	2009-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2009.07.020
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Zs.A 1597: Show issues

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Article ; Online: Comment on "Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: generation of IL-10 and induction of regulatory T cells".

Rizzo, Roberta / Stignani, Marina / Melchiorri, Loredana / Baricordi, Olavio R

Journal of immunology (Baltimore, Md. : 1950)

2009 Volume 182, Issue 8, Page(s) 4497

MeSH term(s)	Dermatitis, Contact/immunology ; Humans ; Interleukin-10/biosynthesis ; Interleukin-10/immunology ; Photopheresis ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2009-04-15
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0990025
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: HLA-G and inflammatory diseases.

Baricordi, Olavio R / Stignani, Marina / Melchiorri, Loredana / Rizzo, Roberta

Inflammation & allergy drug targets

2008 Volume 7, Issue 2, Page(s) 67–74

Abstract: HLA-G antigens are non classical HLA-class I molecules characterized by a low allelic polymorphism, a limited tissue distribution and the presence of membrane bound and soluble isoforms. The HLA-G antigens were firstly detected in cytotrophoblast cells ... ...

Abstract	HLA-G antigens are non classical HLA-class I molecules characterized by a low allelic polymorphism, a limited tissue distribution and the presence of membrane bound and soluble isoforms. The HLA-G antigens were firstly detected in cytotrophoblast cells at the feto-maternal interface where they maintain a tolerogenic status between the mother and the semiallogenic fetus. Recently a variable expression of HLA-G molecules has been documented in several autoimmune diseases, viral infections, cancer diseases and transplantation. Overall the presence of HLA-G molecules in both membranes bound and soluble isoforms was associated with tolerogenic functions against innate and adaptative cellular responses. HLA-G antigens are able to affect the cytotoxicity of natural killer and CD8+ T cells, CD4+ T lymphocyte functions and dendritic cell maturation. In addition to the allelic polymorphism the HLA-G gene shows a deletion/insertion polymorphism of a 14 base pairs sequence (14bp) in the exon 8 at the 3' untranslated region. Several reports have associated the presence of the 14bp insertion allele (+14bp) to an unstable mRNA and a lower sHLA-G protein production, suggesting a different ability to counteract inflammation between genotypes. We reviewed the literature on the expression of HLA-G antigens in autoimmune and allergic diseases and the possible functional role of these molecules in counteracting inflammation.
MeSH term(s)	Alleles ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Asthma/immunology ; Asthma/metabolism ; Central Nervous System/immunology ; Central Nervous System/metabolism ; Exons ; Gastrointestinal Diseases/immunology ; Gastrointestinal Diseases/metabolism ; HLA Antigens/blood ; HLA Antigens/genetics ; HLA Antigens/immunology ; HLA Antigens/metabolism ; HLA-G Antigens ; Histocompatibility Antigens Class I/blood ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immune Tolerance/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Protein Isoforms/immunology ; Protein Isoforms/metabolism ; RNA, Messenger/immunology ; RNA, Messenger/metabolism ; Skin/immunology ; Skin/metabolism ; Trophoblasts/immunology ; Trophoblasts/metabolism
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Protein Isoforms ; RNA, Messenger
Language	English
Publishing date	2008-08-08
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2215862-5
ISSN	2212-4055 ; 1871-5281
ISSN (online)	2212-4055
ISSN	1871-5281
DOI	10.2174/187152808785107615
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Zs.A 5890: Show issues

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Article ; Online: The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis.

Chiusolo, P / Bellesi, S / Piccirillo, N / Giammarco, S / Marietti, S / De Ritis, D / Metafuni, E / Stignani, M / Baricordi, O R / Sica, S / Leone, G / Rizzo, R

Bone marrow transplantation

2012 Volume 47, Issue 1, Page(s) 120–124

Abstract: HLA-G molecules are HLA class Ib antigens characterized by tolerogenic and immunoinhibitory functions. The HLA-G 14-bp insertion/deletion (ins/del) polymorphism controls protein expression and seems to be implicated in both MTX treatment response and SCT ...

Abstract	HLA-G molecules are HLA class Ib antigens characterized by tolerogenic and immunoinhibitory functions. The HLA-G 14-bp insertion/deletion (ins/del) polymorphism controls protein expression and seems to be implicated in both MTX treatment response and SCT outcome. The aim of our study is to evaluate the role of HLA-G 14 bp polymorphism in subjects affected by hematological malignancies undergoing allo-SCT and receiving MTX therapy for GvHD prophylaxis. We performed a retrospective analysis of HLA-G 14 bp polymorphism using a specific PCR in 47 recipients and in their respective donors, and evaluated the correlation with the incidence of aGvHD, OS and disease-free survival (DFS) after allo-SCT. We did not observe any correlation between this polymorphism and the risk of aGvHD occurrence. On the contrary, we found that the recipients with a 14 bp ins/14 bp ins genotype were characterized by a lower OS and DFS in univariate and multivariate analysis (OS=OR: 3.235; DFS=OR: 3.302). These data indicate a role for recipient HLA-G 14 bp polymorphism in allo-SCT immunotolerance status and follow-up.
MeSH term(s)	Adolescent ; Adult ; Child ; Disease-Free Survival ; Female ; Follow-Up Studies ; Graft vs Host Disease/genetics ; Graft vs Host Disease/mortality ; Graft vs Host Disease/prevention & control ; HLA-G Antigens/genetics ; Hematopoietic Stem Cell Transplantation ; Humans ; INDEL Mutation ; Immunosuppressive Agents/administration & dosage ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Male ; Methotrexate/administration & dosage ; Middle Aged ; Polymorphism, Genetic ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Retrospective Studies ; Survival Rate ; Time Factors ; Transplantation, Homologous
Chemical Substances	HLA-G Antigens ; Immunosuppressive Agents ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2012-01
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2011.40
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Zs.A 2168: Show issues

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Article ; Online: Soluble human leukocyte antigen-g and its insertion/deletion polymorphism in papillary thyroid carcinoma: novel potential biomarkers of disease?

Dardano, A / Rizzo, R / Polini, A / Stignani, M / Tognini, S / Pasqualetti, G / Ursino, S / Colato, C / Ferdeghini, M / Baricordi, O R / Monzani, F

The Journal of clinical endocrinology and metabolism

2012 Volume 97, Issue 11, Page(s) 4080–4086

Abstract: Introduction: Human leukocyte antigen-G (HLA-G), a nonclassical major histocompatibility complex class I antigen, plays a pivotal role in immune tolerance and a paradoxical role in cancers.: Aims: Our aims were to evaluate plasma soluble HLA-G (sHLA- ... ...

Abstract	Introduction: Human leukocyte antigen-G (HLA-G), a nonclassical major histocompatibility complex class I antigen, plays a pivotal role in immune tolerance and a paradoxical role in cancers. Aims: Our aims were to evaluate plasma soluble HLA-G (sHLA-G) concentrations and the 14-bp insertion/deletion polymorphism of the HLA-G gene in patients with papillary thyroid carcinoma (PTC) or Hashimoto's thyroiditis (HT) and to assess the possible association of these parameters with PTC aggressiveness. Methods: Samples for the analysis of sHLA-G and +14/-14-bp HLA-G polymorphism were obtained from 121 patients with HT and 183 with PTC; 245 gender- and age-matched healthy subjects served as controls. PTC histopathological aggressiveness was defined according to the last American Thyroid Association guidelines. Results: Positive serum antithyroid antibody titers were observed in 22% of PTC patients and lymphocyte infiltration of thyroid parenchyma at histological examination in 21%, whereas both circulating and histological autoimmunity was detectable in 12% of PTC patients. No differences in the +14/-14-bp polymorphism frequencies were observed between the study groups. The prevalence of detectable sHLA-G was lower in healthy controls (52%) as compared with both HT (57%) and PTC (62%) patients. By stratifying the study groups according to sHLA-G level of positive subjects, significantly higher plasma sHLA-G values in PTC (42.9 ± 3.3 ng/ml; P = 0.002) and HT patients (49.1 ± 2.6 ng/ml; P < 0.002) as compared with healthy controls (8.5 ± 1.8 ng/ml) were obtained. Moreover, PTC patients with detectable plasma sHLA-G levels showed a higher aggressive behavior (P < 0.04) than those without. Conclusions: Although confirming the frequent association between PTC and chronic autoimmune thyroiditis, these data suggest that elevated circulating sHLA-G levels, besides an important signal of alterations of immune homeostasis, may be considered a potential, novel marker of PTC histopathological aggressiveness at diagnosis. Additional studies are needed to confirm the actual role and clinical relevance of the HLA-G complex in PTC development and progression.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/pathology ; Child ; Female ; HLA-G Antigens/blood ; HLA-G Antigens/genetics ; Humans ; INDEL Mutation ; Male ; Middle Aged ; Polymorphism, Genetic ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Thyroiditis, Autoimmune/blood ; Thyroiditis, Autoimmune/genetics ; Thyroiditis, Autoimmune/pathology
Chemical Substances	Biomarkers, Tumor ; HLA-G Antigens
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2012-2231
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Article: HLA-G expression is a fundamental prerequisite to pregnancy.

Rizzo, Roberta / Melchiorri, Loredana / Stignani, Marina / Baricordi, Olavio R

Human immunology

2007 Volume 68, Issue 4, Page(s) 244–250

Abstract: Human leukocyte antigen-G (HLA-G) is thought to play a key role in implantation by controlling trophoblast invasion and maintaining a local immunosuppressive state. The secretion of soluble HLA-G antigens (sHLA-G) by early embryos seems necessary for a ... ...

Abstract	Human leukocyte antigen-G (HLA-G) is thought to play a key role in implantation by controlling trophoblast invasion and maintaining a local immunosuppressive state. The secretion of soluble HLA-G antigens (sHLA-G) by early embryos seems necessary for a successful implantation and could be a marker of increased pregnancy rate following in vitro fertilization. We have reviewed the results obtained during the last years (from 1987 to 2005). They overall confirmed the predictive role of sHLA-G production in pregnancy outcome. Furthermore, we have examined the technical procedures utilized, with a particular attention to the monoclonal antibodies used in the enzyme-linked immunosorbent assay (ELISA) techniques. New functional roles for HLA-G molecules in pregnancy could be suggested by the relationship observed between the presence of sHLA-G antigens in follicular fluids and sHLA-G expression in the corresponding fertilized oocyte. Furthermore, since maternal mRNA is fundamental for protein production in early embryos, the biologic role of the HLA-G 14 base pair polymorphism could be explored.
MeSH term(s)	Female ; HLA Antigens/biosynthesis ; HLA Antigens/genetics ; HLA-G Antigens ; Histocompatibility Antigens Class I/biosynthesis ; Histocompatibility Antigens Class I/genetics ; Humans ; Pregnancy/immunology
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I
Language	English
Publishing date	2007-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2006.10.012
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Zs.A 1597: Show issues

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Article ; Online: Potential role of soluble human leukocyte antigen-G molecules in multiple sclerosis.

Fainardi, Enrico / Rizzo, Roberta / Castellazzi, Massimiliano / Stignani, Marina / Granieri, Enrico / Baricordi, Olavio Roberto

Human immunology

2009 Volume 70, Issue 12, Page(s) 981–987

Abstract: Nonclassical human leukocyte antigen (HLA)-G antigens in soluble form (sHLA-G) have recently been suggested to have a potential role as immunomodulatory factors in multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative ... ...

Abstract	Nonclassical human leukocyte antigen (HLA)-G antigens in soluble form (sHLA-G) have recently been suggested to have a potential role as immunomodulatory factors in multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system of unknown etiology and supposed autoimmune origin. In MS patients, sHLA-G levels were elevated in cerebrospinal fluid (CSF), intrathecally synthesized, predominantly represented by the HLA-G5 isoform and even more elevated in cases of inactive disease, as determined by magnetic resonance imaging. In MS, CSF sHLA-G concentrations were also related to the formation of an intrathecal anti-inflammatory microenvironment based on a positive correlation to CSF interleukin-10 titers and an inverse association to the levels of antiapoptotic sFas molecules in the CSF. Expression of HLA-G antigens was detected in microglia, macrophages, and endothelial cells within and around MS lesions and was enhanced in microglial cells by T-helper-1 proinflammatory cytokines. A novel subpopulation of naturally occurring CD4(+) and CD8(+) regulatory T cells expressing HLA-G1 and secreting HLA-G5 was identified in the CSF of MS patients. Taken together, these findings seem to indicate that sHLA-G antigens may be implicated in the termination of MS autoimmunity and associated with remission of the disease through their function as anti-inflammatory molecules. However, the mechanisms operating in the immunomodulatory circuit mediated by sHLA-G proteins remain to be clarified.
MeSH term(s)	Autoimmunity/immunology ; HLA Antigens/cerebrospinal fluid ; HLA Antigens/immunology ; HLA-G Antigens ; Histocompatibility Antigens Class I/cerebrospinal fluid ; Histocompatibility Antigens Class I/immunology ; Humans ; Interleukin-10/cerebrospinal fluid ; Multiple Sclerosis/immunology ; Multiple Sclerosis/physiopathology ; T-Lymphocyte Subsets/immunology ; fas Receptor/cerebrospinal fluid
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; fas Receptor ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2009-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2009.07.014
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Article: CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis.

Fainardi, E / Rizzo, R / Melchiorri, L / Stignani, M / Castellazzi, M / Tamborino, C / Paolino, E / Tola, M R / Granieri, E / Baricordi, O R

Multiple sclerosis (Houndmills, Basingstoke, England)

2008 Volume 14, Issue 4, Page(s) 446–454

Abstract: Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting (RR) MS ... ...

Abstract	Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting (RR) MS patients classified according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Sixty-four patients with other inflammatory neurological disorders (OIND) and 64 subjects with noninflammatory neurological disorders (NIND) served as controls. CSF concentrations were higher in RRMS and in OIND than in NIND patients for sHLA-I (P < 0.02), greater in RRMS than in OIND and in NIND for sHLA-G (P < 0.001 and P < 0.01, respectively) and lower in RRMS than in OIND and in NIND for sFas (P < 0.001 and P < 0.02, respectively). An increase in CSF levels was identified in MRI active RRMS for sHLA-I (P < 0.01) and in MRI stable RRMS for sHLA-G (P < 0.01), whereas CSF values of sFas were decreased in RRMS without Gd-enhancing lesions (P < 0.02). In MS patients with no evidence of MRI disease activity, a trend towards an inverse correlation was found between CSF concentrations of sHLA-G and sHLA-I and between CSF levels of sHLA-G and sFas. Our results indicate that enhanced CSF levels of sHLA-I antigens most likely represent an indirect manifestation of intrathecal immune activation taking place in neuroinflammation. Conversely, reciprocal fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in MS through Fas/FasL-mediated mechanisms.
MeSH term(s)	Adult ; Apoptosis/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; HLA Antigens/cerebrospinal fluid ; HLA-G Antigens ; Histocompatibility Antigens Class I/cerebrospinal fluid ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/cerebrospinal fluid ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Neuritis/cerebrospinal fluid ; Neuritis/pathology ; Severity of Illness Index ; fas Receptor/cerebrospinal fluid
Chemical Substances	HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; fas Receptor
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458507085137
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Zs.A 4428: Show issues

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Article ; Online: A functional role for soluble HLA-G antigens in immune modulation mediated by mesenchymal stromal cells.

Rizzo, R / Campioni, D / Stignani, M / Melchiorri, L / Bagnara, G P / Bonsi, L / Alviano, F / Lanzoni, G / Moretti, S / Cuneo, A / Lanza, F / Baricordi, O R

Cytotherapy

2008 Volume 10, Issue 4, Page(s) 364–375

Abstract: Background: It has been suggested that soluble factors produced by bone marrow (BM) mesenchymal stromal cells (MSC) play a fundamental role in mediating immune modulation. HLA-G antigens (Ag) are major histocompatibility complex (MHC) class Ib molecules ...

Abstract	Background: It has been suggested that soluble factors produced by bone marrow (BM) mesenchymal stromal cells (MSC) play a fundamental role in mediating immune modulation. HLA-G antigens (Ag) are major histocompatibility complex (MHC) class Ib molecules characterized by a limited polymorphism and a splicing mechanism that regulates the production of membrane-bound and soluble isoforms. Interleukin-10 (IL-10) cytokine is one of the main up-modulators of soluble HLA-G Ag (sHLA-G) production by CD14+ peripheral blood monocyte cells and increased IL-10 levels are reported to be associated with MSC immune modulation. Methods: We investigated, by specific enzyme-linked immunosorbent assay (ELISA), the possible role of sHLA-G molecules in the inhibition of the peripheral blood mononuclear cell (PBMC) response to phytohemagglutinin (PHA) mediated by MSC from different sources. Results: There was a significant correlation between the presence of increased levels of sHLA-G and IL-10 in the MSC/PBMC/PHA culture supernatants and lymphoproliferative inhibition. Neutralizing experiments performed with monoclonal Ab directed against HLA-G and IL-10 molecules confirmed the inhibitory ability of sHLA-G Ag. Furthermore, exogenous IL-10 induced sHLA-G molecule secretion by MSC alone in a polymorphic way, while a longitudinal analysis confirmed the loss of MSC inhibitory functions in relation to in vitro MSC aging. Discussion: Overall the results obtained suggest a functional role for sHLA-G molecules in inhibiting the PBMC response mediated by MSC. Moreover, the ability of IL-10 to induce sHLA-G Ag production by MSC alone could be proposed as a marker of MSC functional ability.
MeSH term(s)	Adult ; Animals ; Antibodies/immunology ; Antigens, CD/metabolism ; Biomarkers/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Cells, Cultured ; Coculture Techniques ; Female ; HLA Antigens/immunology ; HLA-G Antigens ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunity/physiology ; Immunophenotyping ; Interleukin-10/immunology ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; Mesoderm/cytology ; Middle Aged ; Stromal Cells/cytology ; Stromal Cells/immunology
Chemical Substances	Antibodies ; Antigens, CD ; Biomarkers ; HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2008
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1080/14653240802105299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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