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  1. Book: Campylobacter jejuni

    Butcher, James / Stintzi, Alain

    methods and protocols

    (Methods in molecular biology ; 1512 ; Springer protocols)

    2017  

    Author's details edited by James Butcher, Alain Stintzi
    Series title Methods in molecular biology ; 1512
    Springer protocols
    Collection
    Keywords Campylobacter ; Campylobacter-host interactions ; Campylobacter-specific bacteriophages ; crystalize Campylobacter proteins ; gene mutants ; in vitro organ culture
    Language English
    Size xi, 274 Seiten, Illustrationen, 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019124548
    ISBN 978-1-4939-6534-2 ; 1-4939-6534-4 ; 978-1-4939-8229-5 ; 9781493965366 ; 1-4939-8229-X ; 1493965360
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1512- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Resistant starch, microbiome, and precision modulation.

    Dobranowski, Peter A / Stintzi, Alain

    Gut microbes

    2021  Volume 13, Issue 1, Page(s) 1926842

    Abstract: Resistant starch, microbiome, and precision modulation. Mounting evidence has positioned the gut microbiome as a nexus of health. Modulating its phylogenetic composition and function has become an attractive therapeutic prospect. Resistant starches ( ... ...

    Abstract Resistant starch, microbiome, and precision modulation. Mounting evidence has positioned the gut microbiome as a nexus of health. Modulating its phylogenetic composition and function has become an attractive therapeutic prospect. Resistant starches (granular amylase-resistant α-glycans) are available as physicochemically and morphologically distinguishable products. Attempts to leverage resistant starch as microbiome-modifying interventions in clinical studies have yielded remarkable inter-individual variation. Consequently, their utility as a potential therapy likely depends predominantly on the selected resistant starch and the subject's baseline microbiome. The purpose of this review is to detail i) the heterogeneity of resistant starches, ii) how resistant starch is sequentially degraded and fermented by specialized gut microbes, and iii) how resistant starch interventions yield variable effects on the gut microbiome.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/metabolism ; Gastrointestinal Microbiome ; Humans ; Resistant Starch/metabolism
    Chemical Substances Resistant Starch
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2021.1926842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Campylobacter jejuni

    Butcher, James / Stintzi, Alain

    methods and protocols

    (Methods in molecular biology, ; 1512 ; Springer protocols)

    2017  

    Author's details edited by James Butcher and Alain Stintzi
    Series title Methods in molecular biology, ; 1512
    Springer protocols
    MeSH term(s) Campylobacter jejuni
    Language English
    Size xi, 274 pages :, illustrations (some color) ;, 27 cm.
    Document type Book
    ISBN 9781493965342 ; 1493965344 ; 9781493965366 ; 1493965360
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: Multiomic spatial analysis reveals a distinct mucosa-associated virome.

    Yan, Austin / Butcher, James / Schramm, Laetitia / Mack, David R / Stintzi, Alain

    Gut microbes

    2023  Volume 15, Issue 1, Page(s) 2177488

    Abstract: The human gut virome has been increasingly explored in recent years. However, nearly all virome-sequencing efforts rely solely on fecal samples and few studies leverage multiomic approaches to investigate phage-host relationships. Here, we combine ... ...

    Abstract The human gut virome has been increasingly explored in recent years. However, nearly all virome-sequencing efforts rely solely on fecal samples and few studies leverage multiomic approaches to investigate phage-host relationships. Here, we combine metagenomics, metaviromics, and metatranscriptomics to study virome-bacteriome interactions at the colonic mucosal-luminal interface in a cohort of three individuals with inflammatory bowel disease; non-IBD controls were not included in this study. We show that the mucosal viral population is distinct from the stool virome and houses abundant crAss-like phages that are undetectable by fecal sampling. Through viral protein prediction and metatranscriptomic analysis, we explore viral gene transcription, prophage activation, and the relationship between the presence of integrase and temperate phages in IBD subjects. We also show the impact of deep sequencing on virus recovery and offer guidelines for selecting optimal sequencing depths in future metaviromic studies. Systems biology approaches such as those presented in this report will enhance our understanding of the human virome and its interactions with our microbiome and our health.
    MeSH term(s) Humans ; Virome ; Multiomics ; Gastrointestinal Microbiome/genetics ; Bacteriophages/genetics ; Metagenomics ; Intestinal Mucosa ; Spatial Analysis
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2023.2177488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The microbiome of two strategies for ammonia removal with the sequencing batch moving bed biofilm reactor treating cheese production wastewater.

    Tsitouras, Alexandra / Al-Ghussain, Nour / Butcher, James / Stintzi, Alain / Delatolla, Robert

    Applied and environmental microbiology

    2023  Volume 89, Issue 12, Page(s) e0150723

    Abstract: Importance: Cheese production facilities must abide by sewage discharge bylaws that prevent overloading municipal water resource recovery facilities, eutrophication, and toxicity to aquatic life. Compact treatment systems can permit on-site treatment of ...

    Abstract Importance: Cheese production facilities must abide by sewage discharge bylaws that prevent overloading municipal water resource recovery facilities, eutrophication, and toxicity to aquatic life. Compact treatment systems can permit on-site treatment of cheese production wastewater; however, competition between heterotrophs and nitrifiers impedes the implementation of the sequencing batch moving bed biofilm reactor (SB-MBBR) for nitrification from high-carbon wastewaters. This study demonstrates that a single SB-MBBR is not feasible for nitrification when operated with anerobic and aerobic cycling for carbon and phosphorous removal from cheese production wastewater, as nitrification does not occur in a single reactor. Thus, two reactors in series are recommended to achieve nitrification from cheese production wastewater in SB-MBBRs. These findings can be applied to pilot and full-scale SB-MBBR operations. By demonstrating the potential to implement partial nitrification in the SB-MBBR system, this study presents the possibility of implementing partial nitrification in the SB-MBBR, resulting in the potential for more sustainable treatment of nitrogen from cheese production wastewater.
    MeSH term(s) Wastewater ; Ammonia ; Biofilms ; Cheese ; Bioreactors ; Microbiota ; Nitrification ; Nitrogen/analysis ; Carbon ; Denitrification ; Waste Disposal, Fluid/methods
    Chemical Substances Wastewater ; Ammonia (7664-41-7) ; Nitrogen (N762921K75) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01507-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Biofilm morphology and microbiome of sequencing batch moving bed biofilm reactors treating cheese production wastewater

    Tsitouras, Alexandra / Butcher, James / Li, Jennifer / Stintzi, Alain / Delatolla, Robert

    Bioresource technology reports. 2022 Feb., v. 17

    2022  

    Abstract: Compact, on-site treatment of cheese production wastewater is required to meet increasing regulations. This study investigates the treatment of cheese production wastewater of a sequencing batch moving bed biofilm reactor (SB-MBBR); the effects of ... ...

    Abstract Compact, on-site treatment of cheese production wastewater is required to meet increasing regulations. This study investigates the treatment of cheese production wastewater of a sequencing batch moving bed biofilm reactor (SB-MBBR); the effects of anaerobic staging times and aeration rates on biofilm morphology, dry-mass, thickness, mean dry-density, biomass viability, and microbiome. Increasing anaerobic staging time from 72 to 168 min improved carbon removal rates from 24.8 ± 0.5 to 41.6 ± 1.3 g·m⁻² d⁻¹, likely due to a rougher biofilm morphology, lower mean dry-density and therefore enhanced biofilm mass transport. The microbiome community shifts from a population dominated by denitrifiers and possibly putative polyphosphate accumulating organisms, Brachymonas, Dechloromonas, and Rhodoferax, to a lower abundance of fermenting bacteria with increasing anaerobic staging time and lower aeration. This study provides new evidence of polyphosphate accumulating organisms in SB-MBBRs treating cheese production wastewater, supporting the feasibility of the SB-MBBR for on-site treatment of carbon, nitrogen and phosphorous.
    Keywords Brachymonas ; Dechloromonas ; Rhodoferax ; aeration ; biofilm ; biomass ; carbon ; cheesemaking ; denitrifying microorganisms ; mass transfer ; microbiome ; nitrogen ; phosphorus ; viability ; wastewater
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2589-014X
    DOI 10.1016/j.biteb.2021.100898
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Virome Sequencing of the Human Intestinal Mucosal-Luminal Interface.

    Yan, Austin / Butcher, James / Mack, David / Stintzi, Alain

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 582187

    Abstract: While the human gut virome has been increasingly explored in recent years, nearly all studies have been limited to fecal sampling. The mucosal-luminal interface has been established as a viable sample type for profiling the microbial biogeography of the ... ...

    Abstract While the human gut virome has been increasingly explored in recent years, nearly all studies have been limited to fecal sampling. The mucosal-luminal interface has been established as a viable sample type for profiling the microbial biogeography of the gastrointestinal tract. We have developed a protocol to extract nucleic acids from viruses at the mucosal-luminal interface of the proximal and distal colon. Colonic viromes from pediatric patients with Crohn's disease demonstrated high interpatient diversity and low but significant intrapatient variation between sites. Whole metagenomics was also performed to explore virome-bacteriome interactions and to compare the viral communities observed in virome and whole metagenomic sequencing. A site-specific study of the human gut virome is a necessary step to advance our understanding of virome-bacteriome-host interactions in human diseases.
    MeSH term(s) Child ; Feces ; Gastrointestinal Microbiome ; Humans ; Metagenome ; Metagenomics ; Virome ; Viruses/genetics
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.582187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluating live microbiota biobanking using an

    Zhang, Xu / Walker, Krystal / Mayne, Janice / Li, Leyuan / Ning, Zhibin / Stintzi, Alain / Figeys, Daniel

    Gut microbes

    2022  Volume 14, Issue 1, Page(s) 2035658

    Abstract: Biobanking of live microbiota is becoming indispensable for mechanistic and clinical investigations of drug-microbiome interactions and fecal microbiota transplantation. However, there is a lack of methods to rapidly and systematically evaluate whether ... ...

    Abstract Biobanking of live microbiota is becoming indispensable for mechanistic and clinical investigations of drug-microbiome interactions and fecal microbiota transplantation. However, there is a lack of methods to rapidly and systematically evaluate whether the biobanked microbiota maintains their cultivability and functional activity. In this study, we use a rapid
    MeSH term(s) Bacteria/chemistry ; Bacteria/growth & development ; Bacteria/metabolism ; Biological Specimen Banks ; Feces/microbiology ; Gastrointestinal Microbiome ; Humans ; Microbial Viability ; Prebiotics/analysis ; Preservation, Biological/methods ; Proteomics/methods
    Chemical Substances Prebiotics
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1949-0984
    ISSN (online) 1949-0984
    DOI 10.1080/19490976.2022.2035658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Using Galleria mellonella as an Infection Model for Campylobacter jejuni Pathogenesis.

    Askoura, Momen / Stintzi, Alain

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1512, Page(s) 163–169

    Abstract: Nonmammalian model systems of infection have been employed recently to study bacterial virulence. For instance, Galleria mellonella (the greater wax moth) has been shown to be susceptible to infection by many bacterial pathogens including the enteric ... ...

    Abstract Nonmammalian model systems of infection have been employed recently to study bacterial virulence. For instance, Galleria mellonella (the greater wax moth) has been shown to be susceptible to infection by many bacterial pathogens including the enteric pathogen Campylobacter jejuni. In contrast to the traditional animal models for C. jejuni such as the chick colonization model and ferret diarrheal model, the Galleria mellonella infection model has the advantages of lower cost, ease of use and no animal breeding is required. However, injecting the larvae with bacteria requires care to avoid killing of larvae, which could lead to misleading results. Here, we describe the infection of G. mellonella larvae by C. jejuni and how to record/interpret results.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6536-6_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of pair-housing pubertal and adult male and female mice on LPS-induced age-dependent immune responses: A potential role for the gut microbiota.

    Murray, Emma / Butcher, James / May Kearns, Madeleine / Lamba, Sanjeevani / Liang, Jacky / Stintzi, Alain / Ismail, Nafissa

    Brain, behavior, and immunity

    2023  Volume 110, Page(s) 297–309

    Abstract: Puberty is a critical period of development that is marked by the maturation of the stress and immune systems. There are marked age and sex differences in peripheral and central inflammatory responses to an immune challenge between pubertal and adult ... ...

    Abstract Puberty is a critical period of development that is marked by the maturation of the stress and immune systems. There are marked age and sex differences in peripheral and central inflammatory responses to an immune challenge between pubertal and adult mice. Given the strong link between the gut microbiome and immune system, it is possible that the age and sex differences in immune responses are mediated by age and sex differences in gut microbial composition. The current study investigated whether cohousing adult and pubertal CD1 mice through three weeks of pair-housing, with the potential for microbiome exchange via coprophagy and other close contact, could mitigate age-dependent immune responses. Cytokine concentrations in the blood and cytokine mRNA expression in the brain were assessed following exposure to the immune challenge lipopolysaccharide (LPS). The results show that all mice displayed increased cytokine concentrations in serum and central cytokine mRNA expression in the hippocampus, hypothalamus and prefrontal cortex (PFC) at eight hours following LPS treatment. Pubertal male and female mice, that were pair-housed with a pubertal counterpart, displayed lower cytokine concentrations in serum and lower cytokine mRNA expression in the brain compared to adult mice that were pair-housed with an adult counterpart. However, when adult and pubertal mice were pair-housed, the age differences in both peripheral cytokine concentrations and central cytokine mRNA expression were mitigated. We also found that pair-housing adult and pubertal mice eliminated the age difference in gut bacterial diversity. These results suggest that microbial composition could be involved in modulating these age-associated immune responses and thus may represent a potential therapeutic target.
    MeSH term(s) Mice ; Female ; Male ; Animals ; Gastrointestinal Microbiome ; Lipopolysaccharides/pharmacology ; Housing ; Immunity ; Cytokines/metabolism ; RNA, Messenger
    Chemical Substances Lipopolysaccharides ; Cytokines ; RNA, Messenger
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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