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  1. Article ; Online: COVID-19 associated Kikuchi-Fujimoto disease.

    Stimson, Laura / Stitson, Richard / Bahhadi-Hardo, Maria / Renaudon-Smith, Edward

    British journal of haematology

    2021  Volume 192, Issue 5, Page(s) e124–e126

    MeSH term(s) Adolescent ; Anosmia/etiology ; Antigens, CD/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Bacterial Infections/diagnosis ; Biopsy ; COVID-19/complications ; COVID-19/diagnosis ; Causality ; Delayed Diagnosis ; Histiocytes/enzymology ; Histiocytes/ultrastructure ; Histiocytic Necrotizing Lymphadenitis/diagnosis ; Histiocytic Necrotizing Lymphadenitis/etiology ; Histiocytic Necrotizing Lymphadenitis/pathology ; Humans ; Lung/diagnostic imaging ; Lymph Nodes/pathology ; Male ; Peroxidase/analysis ; SARS-CoV-2/isolation & purification ; Symptom Assessment
    Chemical Substances Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD68 antigen, human ; MPO protein, human (EC 1.11.1.7) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2021-02-07
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Asynchronous bilateral leiomyomata of tunica vaginalis: A case report.

    Varma, Raghav / Stitson, Richard / Malki, Manar

    Urology case reports

    2019  Volume 28, Page(s) 101067

    Abstract: Leiomyomata are smooth muscle tumours that are slow growing and benign. We report a case of bilateral leiomyomata arising from tunica vaginalis. A 65 year old presented with a 5-year history of a slow growing left testicular mass and underwent radical ... ...

    Abstract Leiomyomata are smooth muscle tumours that are slow growing and benign. We report a case of bilateral leiomyomata arising from tunica vaginalis. A 65 year old presented with a 5-year history of a slow growing left testicular mass and underwent radical orchidectomy. He presented again 18 months later with a slow growing right testicular mass and underwent local surgical resection. In both the cases the diagnosis of tunica vaginalis leiomyoma was determined through subsequent histopathological analysis. We hope to inform urologists to be aware of this benign rare entity as it can be cured through a simple, organ preserving surgical excision.
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2019.101067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Myeloid sarcoma: extramedullary manifestation of myeloid disorders.

    Campidelli, Cristina / Agostinelli, Claudio / Stitson, Richard / Pileri, Stefano A

    American journal of clinical pathology

    2009  Volume 132, Issue 3, Page(s) 426–437

    Abstract: Myeloid sarcoma (MS), also termed extramedullary acute myeloid leukemia, extramedullary myeloid tumor, and granulocytic sarcoma or chloroma, is a rare manifestation that is characterized by the occurrence of 1 or more tumor myeloid masses occurring at an ...

    Abstract Myeloid sarcoma (MS), also termed extramedullary acute myeloid leukemia, extramedullary myeloid tumor, and granulocytic sarcoma or chloroma, is a rare manifestation that is characterized by the occurrence of 1 or more tumor myeloid masses occurring at an extramedullary site. The wide spectrum of this disorder and the conditions that it overlaps diagnostically were well reflected in the 25 cases submitted to the Society for Hematopathology/European Association for Haematopathology Workshop held in Indianapolis, IN, in November 2007. This review, on the one hand, focuses on the definition and most recent achievements on the pathobiology of MS, and on the other, also in the light of the revised World Health Organization classification, summarizes the main features of a representative series of this condition aiming to provide readers a useful document for daily practice.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Child, Preschool ; Congresses as Topic ; Female ; Humans ; Infant ; Male ; Middle Aged ; Sarcoma, Myeloid/classification ; Sarcoma, Myeloid/pathology ; Sarcoma, Myeloid/physiopathology
    Language English
    Publishing date 2009-09
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/AJCP1ZA7HYZKAZHS
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis.

    Dogan, Ahmet / Burke, Jerome S / Goteri, Gaia / Stitson, Richard N M / Wotherspoon, Andrew C / Isaacson, Peter G

    The American journal of surgical pathology

    2003  Volume 27, Issue 7, Page(s) 903–911

    Abstract: Occasionally, primary large B-cell lymphomas (LBLs) arising in the spleen present with a micronodular pattern involving the splenic white pulp but sparing the red pulp. Histologically, the nodules contain scattered large B cells in a background of ... ...

    Abstract Occasionally, primary large B-cell lymphomas (LBLs) arising in the spleen present with a micronodular pattern involving the splenic white pulp but sparing the red pulp. Histologically, the nodules contain scattered large B cells in a background of numerous T cells and histiocytes. They can cause substantial difficulty in histologic diagnosis as the morphology can mimic reactive and inflammatory lesions as well as other lymphoid neoplasms. In this study, we examined the histology and immunophenotype of the micronodular T-cell/histiocyte-rich LBL (MTLBL) of the spleen with a view to establish the characteristics that may be helpful in diagnosis. Paraffin-embedded material from 17 cases of MTLBL was studied. Clinical features and histology were reviewed and immunohistochemistry was performed for immunoglobulins, CD20, CD79a, CD3, CD68, CD10, BCL6, BCL2, OCT-2, epithelial membrane antigen, CD30, CD138, and EBV markers. The median age of presentation was 56 years, and the most frequent presenting features were anemia and B symptoms. All cases showed a micronodular pattern of involvement. The tumor nodules comprised a mixture of numerous CD3+ T cells and CD68+ histiocytes and scattered large CD20+ B cells with immunoglobulin light chain restriction. They were positive for BCL6 and OCT2 but negative for CD10, CD138, and EBV markers. There was variable expression of epithelial membrane antigen, Bcl-2, and CD30. No follicle dendritic cell meshwork infrastructure underlying the nodules could be demonstrated by staining for CD21 or CD35 antigens. The prognosis was poor; seven of the 12 cases with follow-up were dead within 2 years. MTLBL is unique variant of T-cell/histiocyte-rich diffuse LBL, characterized by primary splenic presentation and a micronodular architecture. The main differential diagnoses include granulomatous inflammation, Hodgkin's lymphoma, follicular lymphoma, and peripheral T-cell lymphomas.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; DNA, Neoplasm/analysis ; Female ; Histiocytes/chemistry ; Histiocytes/immunology ; Histiocytes/pathology ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization ; Lymphoma, B-Cell/chemistry ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/pathology ; Lymphoma, Large B-Cell, Diffuse/chemistry ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; RNA-Binding Proteins/analysis ; Ribosomal Proteins ; Splenic Neoplasms/chemistry ; Splenic Neoplasms/immunology ; Splenic Neoplasms/pathology ; T-Lymphocytes/chemistry ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
    Chemical Substances Biomarkers, Tumor ; DNA, Neoplasm ; RNA-Binding Proteins ; Ribosomal Proteins ; RPL22 protein, human (135844-68-7)
    Language English
    Publishing date 2003-06-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/00000478-200307000-00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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