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Book ; Thesis: Group a streptococci and host immunity

Stjernquist-Desatnik, Anna

a clin. and experimental study

1987

Size	getr. Zählung : graph. Darst.
Publishing country	Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Lund, Univ., Diss., 1987
HBZ-ID	HT002931249
Database	Catalogue ZB MED Medicine, Health

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Article: Okad diagnostisk kompetens--recept mot onödig antibiotikabehandling.

Stjernquist-Desatnik, Anna / Hermansson, Ann

Lakartidningen

2009 Volume 106, Issue 13, Page(s) 949; author reply 949–50

Title translation	Increased diagnostic competence--a prescription against unnecessary antibiotic treatment.
MeSH term(s)	Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Child ; Clinical Competence ; Drug Prescriptions/statistics & numerical data ; Drug Resistance, Bacterial ; Humans ; Otitis Media/diagnosis ; Otitis Media/drug therapy ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/drug therapy ; Risk Factors
Chemical Substances	Anti-Bacterial Agents
Language	Swedish
Publishing date	2009-03
Publishing country	Sweden
Document type	Comment ; Letter
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: Pharyngotonsillitis.

Stjernquist-Desatnik, Anna / Orrling, Arne

Periodontology 2000

2009 Volume 49, Page(s) 140–150

MeSH term(s)	Adolescent ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Humans ; Pharyngitis/drug therapy ; Pharyngitis/microbiology ; Pharyngitis/virology ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus/pathogenicity ; Tonsillitis/drug therapy ; Tonsillitis/microbiology ; Tonsillitis/virology ; Virulence Factors
Chemical Substances	Anti-Bacterial Agents ; Virulence Factors
Keywords	covid19
Language	English
Publishing date	2009-01-19
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1200504-6
ISSN	1600-0757 ; 0906-6713
ISSN (online)	1600-0757
ISSN	0906-6713
DOI	10.1111/j.1600-0757.2008.00282.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stapes surgery in Sweden: evaluation of a national-based register.

Strömbäck, Karin / Lundman, Lars / Bjorsne, Andreas / Grendin, Joakim / Stjernquist-Desatnik, Anna / Dahlin-Redfors, Ylva

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2017 Volume 274, Issue 6, Page(s) 2421–2427

Abstract: The aim of the National Quality Registries is to monitor the outcome of healthcare given to patients. The Swedish Quality register for otosclerosis surgery is one of the nine official national registers for ear, nose and throat diseases in Sweden. Since ... ...

Abstract	The aim of the National Quality Registries is to monitor the outcome of healthcare given to patients. The Swedish Quality register for otosclerosis surgery is one of the nine official national registers for ear, nose and throat diseases in Sweden. Since 2004, surgical and audiological results and patient satisfaction scores have been systematically collected from a majority of the ear, nose and throat clinics performing stapes surgery in Sweden. The results of 1688 patients who underwent primary operations for otosclerosis were evaluated for 24 out of totally 26 clinics performing stapes surgery, between 2004 and 2010. The most common surgical technique reported was stapedotomy accomplished in an overnight stay. A majority of patients experienced improved hearing, and were satisfied with the preoperative counselling. Successful surgery, defined as an ABG closure ≤10 dB HL, was achieved in 69%, improvement in AC by ≥20 dB in 63% and BC not worsened by more than ≥5 dB in 93% of the patients. An overall low incidence of postoperative complications was reported. The outcome for ABG and BC was demonstrated to be independent of the number of operations performed by each clinic. An evaluation of the register and the results from the SQOS revealed that stapes surgery is a safe procedure with good hearing outcomes, low complication rates and a high rate of patient's satisfaction on a national level.
Language	English
Publishing date	2017-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-017-4510-2
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Article ; Online: Bells pares ger resttillstånd hos 30 procent av vuxna patienter--Tidig behandling med kortison ökar utläkningen.

Berg, Thomas / Stjernquist-Desatnik, Anna / Kanerva, Mervi / Hultcrantz, Malou / Engström, Mats / Jonsson, Lars

Lakartidningen

2015 Volume 112

Abstract: Bell's palsy is an acute unilateral weakness or paralysis of the face of unknown cause. The incidence of the disease is 30 individuals per 100,000 per year. It is a diagnosis of exclusion and other known causes for acute peripheral facial palsy must be ... ...

Title translation	Residual states in 30 percent of adult patients with Bell's palsy. Early treatment with cortisone improves the healing process.
Abstract	Bell's palsy is an acute unilateral weakness or paralysis of the face of unknown cause. The incidence of the disease is 30 individuals per 100,000 per year. It is a diagnosis of exclusion and other known causes for acute peripheral facial palsy must be ruled out. The prognosis is overall favorable and about 70% of the patients recover completely within 6 months without treatment. Recent randomized controlled Bell's palsy trials have shown that treatment with corticosteroids shortens time to recovery and improves recovery rates while antiviral treatment alone is not more effective than placebo. The combination of corticosteroids and antivirals has not been proven more effective than corticosteroids alone. We present an update of Bell's palsy in adults with focus on diagnosis, treatment and follow-up of these patients.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Antiviral Agents/therapeutic use ; Bell Palsy/complications ; Bell Palsy/diagnosis ; Bell Palsy/drug therapy ; Bell Palsy/etiology ; Cortisone/therapeutic use ; Early Medical Intervention ; Humans ; Prednisolone/therapeutic use ; Recovery of Function
Chemical Substances	Adrenal Cortex Hormones ; Antiviral Agents ; Prednisolone (9PHQ9Y1OLM) ; Cortisone (V27W9254FZ)
Language	Swedish
Publishing date	2015-01-06
Publishing country	Sweden
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article: Foreign body in the peripheral bronchus: extraction using an interventional radiologic method.

Stjernquist-Desatnik, Anna / Cwikiel, Wojciech

Acta oto-laryngologica

2002 Volume 122, Issue 3, Page(s) 311–313

MeSH term(s)	Bronchi ; Crowns ; Foreign Bodies/therapy ; Humans ; Intubation, Intratracheal ; Male ; Middle Aged ; Radiography, Interventional
Language	English
Publishing date	2002-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	0001-6489
ISSN	0001-6489
DOI	10.1080/000164802753648222
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Article: Detection of herpes simplex and varicella-zoster viruses in patients with Bell's palsy by the polymerase chain reaction technique.

Stjernquist-Desatnik, Anna / Skoog, Eva / Aurelius, Elisabeth

The Annals of otology, rhinology, and laryngology

2006 Volume 115, Issue 4, Page(s) 306–311

Abstract: Objectives: Infectious causes of peripheral facial paralysis are well known. Bell's palsy, however, is an idiopathic facial paralysis, and the genesis is still unknown. Herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) have been ... ...

Abstract	Objectives: Infectious causes of peripheral facial paralysis are well known. Bell's palsy, however, is an idiopathic facial paralysis, and the genesis is still unknown. Herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) have been suggested as etiologic agents. Methods: Twenty consecutive adult patients with Bell's palsy were included in the study. Ten adult patients operated on for chronic otitis served as controls. A biopsy specimen from the posterior auricular muscle was resected within 72 hours after the onset of Bell's palsy and was analyzed together with cerebrospinal fluid (CSF) by nested polymerase chain reaction for HSV-1 and VZV DNA. Serum samples were analyzed for antibodies to HSV-1 and VZV. Results: HSV-1 DNA was found in the muscle biopsy specimen from 1 of the 20 patients, but was not found in any of the CSF samples. VZV DNA was detected in the muscle biopsy as well as the CSF from 1 other patient. All controls were negative. Seventeen of 19 patients had stationary serum antibody concentrations to HSV-1, and none displayed an antibody titer rise. A significant antibody titer rise to VZV was found in 1 of 19 patients, whereas 17 of 19 had stationary antibody levels. Conclusions: HSV-1 or VZV DNA was detected in 10% of patients with Bell's palsy in the present study. Viral replication might already have declined in many cases at the onset of the palsy. Use of an HSV-1/VZV polymerase chain reaction on a muscle biopsy specimen or CSF does not seem to be the method of choice for rapid etiologic diagnosis in the acute phase of Bell's palsy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Bell Palsy/cerebrospinal fluid ; Bell Palsy/virology ; Biopsy ; Case-Control Studies ; DNA, Viral/analysis ; DNA, Viral/cerebrospinal fluid ; Facial Muscles/virology ; Facial Paralysis/virology ; Female ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/isolation & purification ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/immunology ; Herpesvirus 3, Human/isolation & purification ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Polymerase Chain Reaction/methods
Chemical Substances	Antibodies, Viral ; DNA, Viral ; Immunoglobulin G
Language	English
Publishing date	2006-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/000348940611500410
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Article: Penicillin V, loracarbef and clindamycin in tonsillar surface fluid during acute group A streptococcal pharyngotonsillitis.

Orrling, Arne / Kamme, Carl / Stjernquist-Desatnik, Anna

Scandinavian journal of infectious diseases

2005 Volume 37, Issue 6-7, Page(s) 429–435

Abstract: Patients with acute group A- strepotococcal pharyngotonsillitis were randomly assigned to treatment for 10 d with either phenoxymethylpenicillin (PcV), loracarbef or clindamycin. The concentrations of the drugs, respectively, were determined in tonsillar ...

Abstract	Patients with acute group A- strepotococcal pharyngotonsillitis were randomly assigned to treatment for 10 d with either phenoxymethylpenicillin (PcV), loracarbef or clindamycin. The concentrations of the drugs, respectively, were determined in tonsillar surface fluid (TSF), serum and the saliva in each patient on altogether 5 occasions; before, during and 4 d after end of therapy. On the same occasions blood was drawn for analysis of C-reactive protein (CRP) and orosomucoid. On the last d of treatment PcV could be detected in TSF in 1 of 6 patients only. Loracarbef had a slower decrease in TSF during therapy and measurable levels did occur 2 d after end of therapy corresponding to MIC 100 for GAS. This may be related to the somewhat better clinical results of the cephalosporins than of PcV, and possibly indicates that an extended therapy with these drugs in primary GAS pharyngotonsillitis for more than the arbitrarily chosen 10 d could reduce the number of recurrent episodes. PcV and loracarbef were not detected in serum after the end of treatment. The concentration of clindamycin in both TSF and the saliva was fairly longstanding during therapy and reached levels exceeding MIC 100 for GAS, in both TSF and serum 2 d after the end of treatment. Several investigations have shown that GAS, especially in the stationary phase may invade respiratory epithelial cells and are present intracellularly in patients with acute pharyngotonsillitis as well as in asymptomatic carriers. The same T-type, identical DNA fingerprints and arbitrarily primed patterns are found in GAS before and after treatment failure indicating that the primary episode and the failures are caused by the same strain. The longstanding concentrations of clindamycin in TSF, roughly independent of the degree of the local inflammation combined with its intracellular accumulation and activity against resting GAS seem to explain the efficiency of the drug in recurrent GAS pharyngotonsillitis. CRP and orosomucoid were of limited value in differing between bacterial and viral pharyngtonsillitis and a correlation between antibiotic concentration and CRP/orosomucoid levels was not found.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; C-Reactive Protein ; Cephalosporins/pharmacokinetics ; Cephalosporins/therapeutic use ; Clindamycin/pharmacokinetics ; Clindamycin/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Orosomucoid ; Palatine Tonsil/metabolism ; Penicillin V/pharmacokinetics ; Penicillin V/therapeutic use ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus pyogenes ; Tissue Distribution ; Tonsillitis/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins ; Orosomucoid ; Clindamycin (3U02EL437C) ; loracarbef (3X11EVM5SU) ; C-Reactive Protein (9007-41-4) ; Penicillin V (Z61I075U2W)
Language	English
Publishing date	2005
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	390956-6
ISSN	1651-1980 ; 0036-5548
ISSN (online)	1651-1980
ISSN	0036-5548
DOI	10.1080/00365540410020947
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Article: Outcome of treatment with valacyclovir and prednisone in patients with Bell's palsy.

Axelsson, Sara / Lindberg, Sven / Stjernquist-Desatnik, Anna

The Annals of otology, rhinology, and laryngology

2003 Volume 112, Issue 3, Page(s) 197–201

Abstract: Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent microorganism such as herpes simplex type I as a causative agent. Thirty percent of patients with Bell's palsy given no treatment will ... ...

Abstract	Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent microorganism such as herpes simplex type I as a causative agent. Thirty percent of patients with Bell's palsy given no treatment will not recover completely, and 5% will have severe sequelae. The aim of this study was to find out whether treatment with an antiviral drug in combination with corticosteroids is more effective than no medical treatment at all in patients with Bell's palsy. Fifty-six consecutive adult patients attending the otorhinolaryngology department of the University Hospital of Lund from 1997 to 1999 were treated with 1 g of valacyclovir hydrochloride 3 times per day for 7 days and 50 mg of prednisone daily for 5 days, with the dose being reduced by 10 mg daily for the next 5 days. Fifty-six adult patients with Bell's palsy attending the same department between 1995 and 1996 who were given no medical treatment were studied retrospectively and used as the control group. Forty-nine patients (87.5%) in the treatment group recovered completely, as compared with 38 patients (68%) in the control group (p < .05). One patient (1.8%) in the treatment group displayed severe sequelae, defined as a House-Brackmann score of IV or worse, as compared with 10 of 56 patients (18%) in the control group (p < .01). Among patients over 60 years old, 10 of 10 in the treatment group had complete recovery, as compared with 5 of 12 patients in the control group (p < .01). The present study showed a significantly better outcome in patients with Bell's palsy treated with valacyclovir and prednisone as compared with patients given no medical treatment. This difference in outcome was especially pronounced among elderly patients.
MeSH term(s)	Acyclovir/administration & dosage ; Acyclovir/analogs & derivatives ; Acyclovir/therapeutic use ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Bell Palsy/drug therapy ; Bell Palsy/virology ; Case-Control Studies ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Herpesvirus 1, Human/physiology ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; Prednisone/therapeutic use ; Treatment Outcome ; Valine/administration & dosage ; Valine/analogs & derivatives ; Valine/therapeutic use ; Virus Activation
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Valine (HG18B9YRS7) ; valacyclovir (MZ1IW7Q79D) ; Prednisone (VB0R961HZT) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2003-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/000348940311200301
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Article ; Online: Prednisolone in Bell's palsy related to treatment start and age.

Axelsson, Sara / Berg, Thomas / Jonsson, Lars / Engström, Mats / Kanerva, Mervi / Pitkäranta, Anne / Stjernquist-Desatnik, Anna

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2011 Volume 32, Issue 1, Page(s) 141–146

Abstract: Objective: To evaluate if treatment start and age are related to the outcome in Bell's palsy patients treated with prednisolone.: Study design: Prospective, randomized, double-blind, placebo-controlled, multicenter trial.: Setting: Sixteen ... ...

Abstract	Objective: To evaluate if treatment start and age are related to the outcome in Bell's palsy patients treated with prednisolone. Study design: Prospective, randomized, double-blind, placebo-controlled, multicenter trial. Setting: Sixteen otorhinolaryngologic centers in Sweden and 1 in Finland. Patients: Data were collected from the Scandinavian Bell's palsy study. A total of 829 patients were treated within 72 hours of onset of palsy. Follow-up was 12 months. Intervention: Patients were randomly assigned to treatment with placebo plus placebo (n = 206), prednisolone plus placebo (n = 210), valacyclovir plus placebo (n = 207), or prednisolone plus valacyclovir (n = 206). Main outcome measures: Facial function was assessed with the Sunnybrook grading system, and complete recovery was defined as Sunnybrook = 100. Time from onset of palsy to treatment start was registered. Results: Patients treated with prednisolone within 24 hours and 25 to 48 hours had significantly higher complete recovery rates, 66% (103/156) and 76% (128/168), than patients given no prednisolone, 51% (77/152) and 58% (102/177) (p = 0.008 and p = 0.0003, respectively). For patients treated within 49 to 72 hours of palsy onset, there were no significant differences. Patients aged 40 years or older had significantly higher complete recovery rates if treated with prednisolone, whereas patients aged younger than 40 years did not differ with respect to prednisolone treatment. However, synkinesis was significantly less in patients younger than 40 years given prednisolone (p = 0.002). Conclusion: Treatment with prednisolone within 48 hours of onset of palsy resulted in significantly higher complete recovery rates and less synkinesis compared with no prednisolone.
MeSH term(s)	Acyclovir/administration & dosage ; Acyclovir/analogs & derivatives ; Acyclovir/therapeutic use ; Adolescent ; Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Bell Palsy/drug therapy ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Finland ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Intention to Treat Analysis ; Male ; Middle Aged ; Prednisolone/administration & dosage ; Prednisolone/therapeutic use ; Prospective Studies ; Recovery of Function ; Sweden ; Time Factors ; Treatment Outcome ; Valine/administration & dosage ; Valine/analogs & derivatives ; Valine/therapeutic use
Chemical Substances	Antiviral Agents ; Glucocorticoids ; Prednisolone (9PHQ9Y1OLM) ; Valine (HG18B9YRS7) ; valacyclovir (MZ1IW7Q79D) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2011-01
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0b013e3182009f35
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