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  1. Book ; Online: Spatial Practices : Medieval/Modern (Volume 6)

    Stock, Markus / Vöhringer, Nicola

    2014  

    Keywords Anthologies (non-poetry) ; Literary Collections
    Size 1 Online-Ressource
    Publisher V&R unipress
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047993
    ISBN 9783737000017 ; 3737000018
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Topographies of the Early Modern City

    Groos, Arthur / Schiewer, Hans-Jochen / Stock, Markus

    2008  

    Keywords Early modern history: c 1450/1500 to c 1700 ; History
    Size 1 Online-Ressource
    Publisher V&R unipress GmbH
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021027349
    ISBN 9783862345359 ; 3862345351
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: State-of-the-art and potential of experimental microdosimetry in ion-beam therapy.

    Magrin, Giulio / Palmans, Hugo / Stock, Markus / Georg, Dietmar

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2023  Volume 182, Page(s) 109586

    Abstract: In radiotherapy, radiation-quality should be an expression of the biological and physical characteristics of ionizing radiation such as spatial distribution of ionization or energy deposition. Linear energy transfer (LET) and lineal energy (y) are two ... ...

    Abstract In radiotherapy, radiation-quality should be an expression of the biological and physical characteristics of ionizing radiation such as spatial distribution of ionization or energy deposition. Linear energy transfer (LET) and lineal energy (y) are two descriptors used to quantify the radiation quality. These two quantities are connected and exhibit similar features. In ion-beam therapy (IBT), lineal energy can be measured with microdosimeters, which are specifically designed to cope with the high fluence of particles in clinical beams, while the quantification of LET is generally based on calculations. In pre-clinical studies, microdosimetric spectra are used for the indirect determination of relative biological effectiveness (RBE), e.g., using the microdosimetric kinetic model (MKM) or biophysical response functions. In this context it is important to consider saturation effects, which occur when the highest values of y become less biologically relevant compared to the relative contribution they make to the physical dose. Recent clinical data suggests that local tumor control and normal tissue effects can be linked to macroscopic and microscopic dosimetry parameters. In particular, positive clinical outcomes have been correlated to the highest LET values in the density distribution, and there is no evident link to the saturation discussed above. A systematic collection of microdosimetric information in combination with clinical data in retrospective studies may clarify the role of radiation quality at the highest LET. In the clinical setting, microdosimetry is not widely used yet, despite its potential to be linked with LET by experimentally-determined y values. Through this connection, both play an important role in complex therapy techniques such as intensity modulated particle therapy (IMPT), LET-painting and multi-ion optimization. This review summarizes the current state of microdosimetry for IBT and its potential, as well as research and development needed to make experimental microdosimetry a mature procedure in a clinical context.
    MeSH term(s) Humans ; Retrospective Studies ; Radiometry/methods ; Proton Therapy/methods ; Relative Biological Effectiveness ; Radiotherapy Dosage ; Monte Carlo Method
    Language English
    Publishing date 2023-02-25
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2023.109586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The sensitivity of radiobiological models in carbon ion radiotherapy (CIRT) and its consequences on the clinical treatment plan: Differences between LEM and MKM models.

    Góra, Joanna / Grosshagauer, Sarah / Fossati, Piero / Mumot, Marta / Stock, Markus / Schafasand, Mansure / Carlino, Antonio

    Journal of applied clinical medical physics

    2024  , Page(s) e14321

    Abstract: Purpose: Carbon ion radiotherapy (CIRT) relies on relative biological effectiveness (RBE)-weighted dose calculations. Japanese clinics predominantly use the microdosimetric kinetic model (MKM), while European centers utilize the local effect model (LEM). ...

    Abstract Purpose: Carbon ion radiotherapy (CIRT) relies on relative biological effectiveness (RBE)-weighted dose calculations. Japanese clinics predominantly use the microdosimetric kinetic model (MKM), while European centers utilize the local effect model (LEM). Despite both models estimating RBE-distributions in tissue, their physical and mathematical assumptions differ, leading to significant disparities in RBE-weighted doses. Several European clinics adopted Japanese treatment schedules, necessitating adjustments in dose prescriptions and organ at risk (OAR) constraints. In the context of these two clinically used standards for RBE-weighted dose estimation, the objective of this study was to highlight specific scenarios for which the translations between models diverge, as shortcomings between them can influence clinical decisions.
    Methods: Our aim was to discuss planning strategies minimizing those discrepancies, ultimately striving for more accurate and robust treatments. Evaluations were conducted in a virtual water phantom and patient CT-geometry, optimizing LEM RBE-weighted dose first and recomputing MKM thereafter. Dose-averaged linear energy transfer (LETd) distributions were also assessed.
    Results: Results demonstrate how various parameters influence LEM/MKM translation. Similar LEM-dose distributions lead to markedly different MKM-dose distributions and variations in LETd. Generally, a homogeneous LEM RBE-weighted dose aligns with lower MKM values in most of the target volume. Nevertheless, paradoxical MKM hotspots may emerge (at the end of the range), potentially influencing clinical outcomes. Therefore, translation between models requires great caution.
    Conclusions: Understanding the relationship between these two clinical standards enables combining European and Japanese based experiences. The implementation of optimal planning strategies ensures the safety and acceptability of the clinical plan for both models and therefore enhances plan robustness from the RBE-weighted dose and LETd distribution point of view. This study emphasizes the importance of optimal planning strategies and the need for comprehensive CIRT plan quality assessment tools. In situations where simultaneous LEM and MKM computation capabilities are lacking, it can provide guidance in plan design, ultimately contributing to enhanced CIRT outcomes.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.14321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Influence of Motion on the Delivery Accuracy When Comparing Actively Scanned Carbon Ions versus Protons at a Synchrotron-Based Radiotherapy Facility.

    Lebbink, Franciska / Stock, Markus / Georg, Dietmar / Knäusl, Barbara

    Cancers

    2022  Volume 14, Issue 7

    Abstract: Motion amplitudes, in need of mitigation for moving targets irradiated with pulsed carbon ions and protons, were identified to guide the decision on treatment and motion mitigation strategy. Measurements with PinPoint ionisation chambers positioned in an ...

    Abstract Motion amplitudes, in need of mitigation for moving targets irradiated with pulsed carbon ions and protons, were identified to guide the decision on treatment and motion mitigation strategy. Measurements with PinPoint ionisation chambers positioned in an anthropomorphic breathing phantom were acquired to investigate different tumour motion scenarios, including rib and lung movements. The effect of beam delivery dynamics and spot characteristics was considered. The dose in the tumour centre was deteriorated up to 10% for carbon ions but only up to 5% for protons. Dose deviations in the penumbra increased by a factor of two when comparing carbon ions to protons, ranging from 2 to 30% for an increasing motion amplitude that was strongly dependent on the beam intensity. Layer rescanning was able to diminish the dose distortion caused by tumour motion, but an increase in spot size could reduce it even further to 5% within the target and 10% at the penumbra. An increased need for motion mitigation of carbon ions compared to protons was identified to assure target coverage and sparing of adjacent organs at risk in the penumbra region and outside the target. For the clinical implementation of moving target treatments at a synchrotron-based particle facility complex, time dependencies needed to be considered.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy.

    Nachankar, Ankita / Schafasand, Mansure / Hug, Eugen / Martino, Giovanna / Góra, Joanna / Carlino, Antonio / Stock, Markus / Fossati, Piero

    Cancers

    2024  Volume 16, Issue 7

    Abstract: To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM- ... ...

    Abstract To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM-I), prescribed D
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Parameter based 4D dose calculations for proton therapy.

    Lebbink, Franciska / Stocchiero, Silvia / Fossati, Piero / Engwall, Erik / Georg, Dietmar / Stock, Markus / Knäusl, Barbara

    Physics and imaging in radiation oncology

    2023  Volume 27, Page(s) 100473

    Abstract: Background and ... ...

    Abstract Background and purpose
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-6316
    ISSN (online) 2405-6316
    DOI 10.1016/j.phro.2023.100473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Planning Strategy to Optimize the Dose-Averaged LET Distribution in Large Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy.

    Nachankar, Ankita / Schafasand, Mansure / Carlino, Antonio / Hug, Eugen / Stock, Markus / Góra, Joanna / Fossati, Piero

    Cancers

    2023  Volume 15, Issue 19

    Abstract: To improve outcomes in large sarcomas/chordomas treated with CIRT, there has been recent interest in LET optimization. We evaluated 22 pelvic sarcoma/chordoma patients treated with CIRT [large: HD-CTV ≥ 250 ... ...

    Abstract To improve outcomes in large sarcomas/chordomas treated with CIRT, there has been recent interest in LET optimization. We evaluated 22 pelvic sarcoma/chordoma patients treated with CIRT [large: HD-CTV ≥ 250 cm
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15194903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Patient Breathing Motion and Delivery Specifics Influencing the Robustness of a Proton Pancreas Irradiation.

    Knäusl, Barbara / Lebbink, Franciska / Fossati, Piero / Engwall, Erik / Georg, Dietmar / Stock, Markus

    Cancers

    2023  Volume 15, Issue 9

    Abstract: Motion compensation strategies in particle therapy depend on the anatomy, motion amplitude and underlying beam delivery technology. This retrospective study on pancreas patients with small moving tumours analysed existing treatment concepts and serves as ...

    Abstract Motion compensation strategies in particle therapy depend on the anatomy, motion amplitude and underlying beam delivery technology. This retrospective study on pancreas patients with small moving tumours analysed existing treatment concepts and serves as a basis for future treatment strategies for patients with larger motion amplitudes as well as the transition towards carbon ion treatments. The dose distributions of 17 hypofractionated proton treatment plans were analysed using 4D dose tracking (4DDT). The recalculation of clinical treatment plans employing robust optimisation for mitigating different organ fillings was performed on phased-based 4D computed tomography (4DCT) data considering the accelerator (pulsed scanned pencil beams delivered by a synchrotron) and the breathing-time structure. The analysis confirmed the robustness of the included treatment plans concerning the interplay of beam and organ motion. The median deterioration of
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Spatial Practices

    Stock, Markus / Vöhringer, Nicola

    Medieval/Modern

    (Transatlantische Studien zu Mittelalter und Früher Neuzeit – Transatlantic Studies on Medieval and Early Modern Literature and Culture (TRAST) ; Band 006)

    2014  

    Abstract: In recent decades, the conceptualization of space and place as social constructs, rather than static settings has received significant attention and has been re-evaluated with an emphasis on the cultural, social, and political practice. This shift moves ... ...

    Series title Transatlantische Studien zu Mittelalter und Früher Neuzeit – Transatlantic Studies on Medieval and Early Modern Literature and Culture (TRAST) ; Band 006
    Abstract In recent decades, the conceptualization of space and place as social constructs, rather than static settings has received significant attention and has been re-evaluated with an emphasis on the cultural, social, and political practice. This shift moves away from regarding space as fixed, unchanging container towards a realization that space is always inextricably linked with social practice and cultural signification. Thus, the study of spatial practices interrogates human action in different spaces, human agency in the production of space, and space in its capacity to prompt human action. By focusing on human action in manipulating and subverting space, and thereby creating multiple coexisting and overlapping spatialities, the interest also shifts from semiotic correlations in cultural expressions to events, practices, material and medial embodiment of culture. This collection of essays approaches the study of space and place from a historically inclusive perspective; it gives new insights into historical shifts and changes in the construction and perception of space as well as historical developments and diachonicity of literary, social, and architectural sites and places. It aims to gather a number of case studies in order to collect historically concrete evidence of such spatial practices as reflected in literature and art as well as in sources pertaining to the social and political life of premodern, early modern, and modern era. Prof. Dr. Markus Stock is an Associate Professor of German and Medieval Studies at the University of Toronto. Nicola Vöhringer studied at the University of Tübingen, Strasbourg and Nebraska.
    Keywords Kultur Literatur Sprache
    Language German
    Size Online-Ressource
    Edition 1. Aufl.
    Publisher V&R Unipress
    Publishing place Göttingen
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783847100010 ; 3847100017
    DOI 10.14220/9783737000017
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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