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  1. Book: Tree Rings and natural hazards

    Stoffel, Markus

    a state-of-the-art

    (Advances in Global Change Research ; 41)

    2010  

    Author's details Markus Stoffel ... eds
    Series title Advances in Global Change Research ; 41
    Advances in global change research
    Collection Advances in global change research
    Keywords Naturkatastrophe ; Dendrochronologie
    Subject Jahresringchronologie ; Baumringchronologie ; Jahresringanalyse ; Naturkatastrophen
    Language English
    Size XV, 505 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    Note Erscheinungsjahr in Vorlageform: 2010
    HBZ-ID HT016329572
    ISBN 978-90-481-8735-5 ; 9789048187362 ; 90-481-8735-4 ; 9048187362
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    118/168 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Grosslawinen

    Stoffel, Markus

    Cratschla : Informationen aus dem Schweizerischen Nationalpark ; 915558-2 ; 1021-9706 ; - ; 2022 ; 1 ; 6

    2022  

    Publisher Eidgenössische Nationalparkkommission
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Murgänge in der Val Mingèr . und der Val da Stabelchod

    Stoffel, Markus

    Cratschla : Informationen aus dem Schweizerischen Nationalpark ; 915558-2 ; 1021-9706 ; - ; 2022 ; 1 ; 8

    2022  

    Publisher Eidgenössische Nationalparkkommission
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Extremereignisse im Schweizerischen Nationalpark

    Stoffel, Markus

    Cratschla : Informationen aus dem Schweizerischen Nationalpark ; 915558-2 ; 1021-9706 ; - ; 2022 ; 1 ; 4

    2022  

    Publisher Eidgenössische Nationalparkkommission
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Therapeutic RNA-silencing oligonucleotides in metabolic diseases.

    Goga, Algera / Stoffel, Markus

    Nature reviews. Drug discovery

    2022  Volume 21, Issue 6, Page(s) 417–439

    Abstract: Recent years have seen unprecedented activity in the development of RNA-silencing oligonucleotide therapeutics for metabolic diseases. Improved oligonucleotide design and optimization of synthetic nucleic acid chemistry, in combination with the ... ...

    Abstract Recent years have seen unprecedented activity in the development of RNA-silencing oligonucleotide therapeutics for metabolic diseases. Improved oligonucleotide design and optimization of synthetic nucleic acid chemistry, in combination with the development of highly selective and efficient conjugate delivery technology platforms, have established and validated oligonucleotides as a new class of drugs. To date, there are five marketed oligonucleotide therapies, with many more in clinical studies, for both rare and common liver-driven metabolic diseases. Here, we provide an overview of recent developments in the field of oligonucleotide therapeutics in metabolism, review past and current clinical trials, and discuss ongoing challenges and possible future developments.
    MeSH term(s) Humans ; Metabolic Diseases/drug therapy ; Metabolic Diseases/genetics ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/therapeutic use ; RNA ; RNA Interference
    Chemical Substances Oligonucleotides ; Oligonucleotides, Antisense ; RNA (63231-63-0)
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-022-00407-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 334: Show issues
    Zs.MG 63: Show issues

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  6. Article: Landslide-induced changes in tree-ring anatomy: A new dendrogeomorphic avenue?

    Šilhán, Karel / Stoffel, Markus

    Catena. 2022 June, v. 213

    2022  

    Abstract: The dendrogeomorphic dating of past landslides can be limited by the speed or magnitude of movements, as they are sometimes too small to induce growth responses in trees standing on unstable slopes. As a result, movements of low magnitude are generally ... ...

    Abstract The dendrogeomorphic dating of past landslides can be limited by the speed or magnitude of movements, as they are sometimes too small to induce growth responses in trees standing on unstable slopes. As a result, movements of low magnitude are generally assumed to remain undetectable in standard macroscopic analysis of growth disturbances in tree-ring series. To close this gap and to enlarge the suite of approaches available for the dendrogeomorphic detection of landslide activity in growth-ring records of trees, this study focuses on the detection of wood-anatomical growth responses in trees following low-magnitude landslides. Anatomical growth responses of five individuals of common spruce (Picea abies (L.) Karst.) growing on a monitored landslide have been analyzed in this study on a total of 200 tree rings from 40 increment cores extracted at two vertical levels of tree stems. Analysis included seven anatomical parameters commonly used in quantitative wood anatomy, with a focus on the year 2017 year during which the landslide body moved by 8 mm (prior to the start of the growing season) according to extensometer records. We report that mean tracheid lumen area (TLA) decreased significantly due to landsliding, whereas the mean number of traumatic resin ducts (TRD) and rays increased significantly after the occurrence of the landslide. By contrast, the intensity of stem tilting was visibly too small to induce the formation of compression wood but strong enough to induce larger number of rays, which are known to enhance stability as well. We also realize that the low intensity of the landslide movement also resulted in rather localized anatomical anomalies along the stem, with detected responses decreasing in intensity with increasing distance from the ground. We conclude that anatomical responses of P. abies trees can be used to detect past activity in low-magnitude landsliding and that this new proxy can thus extend the applicability of tree-ring approaches to landslide research and to the detection of events that have hitherto remained unidentified in reconstructions.
    Keywords Picea abies ; catenas ; compression wood ; growth rings ; landslides ; tracheids
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 519608-5
    ISSN 1872-6887 ; 0008-7769 ; 0341-8162
    ISSN (online) 1872-6887 ; 0008-7769
    ISSN 0341-8162
    DOI 10.1016/j.catena.2022.106144
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3389: Show issues

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  7. Article ; Online: FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress.

    Kobiita, Ahmad / Silva, Pamuditha N / Schmid, Marc W / Stoffel, Markus

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112986

    Abstract: Pancreatic β cells display functional and transcriptional heterogeneity in health and disease. The sequence of events leading to β cell heterogeneity during metabolic stress is poorly understood. Here, we characterize β cell responses to early metabolic ... ...

    Abstract Pancreatic β cells display functional and transcriptional heterogeneity in health and disease. The sequence of events leading to β cell heterogeneity during metabolic stress is poorly understood. Here, we characterize β cell responses to early metabolic stress in vivo by employing RNA sequencing (RNA-seq), assay for transposase-accessible chromatin with sequencing (ATAC-seq), single-cell RNA-seq (scRNA-seq), chromatin immunoprecipitation sequencing (ChIP-seq), and real-time imaging to decipher temporal events of chromatin remodeling and gene expression regulating the unfolded protein response (UPR), protein synthesis, mitochondrial function, and cell-cycle progression. We demonstrate that a subpopulation of β cells with active UPR, decreased protein synthesis, and insulin secretary capacities is more susceptible to proliferation after insulin depletion. Alleviation of endoplasmic reticulum (ER) stress precedes the progression of the cell cycle and mitosis and ensures appropriate insulin synthesis. Furthermore, metabolic stress rapidly activates key transcription factors including FoxM1, which impacts on proliferative and quiescent β cells by regulating protein synthesis, ER stress, and mitochondrial activity via direct repression of mitochondrial-encoded genes.
    MeSH term(s) Insulin-Secreting Cells ; Cell Cycle ; Mitosis ; Insulin ; Mitochondria
    Chemical Substances Insulin
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Infektiöse, rekombinante Vaccinia-Virus-Vektoren

    Stoffel, Markus

    Konstruktion, Charakterisierung und Expression der Gene eines neuen humanen Cytomegalovirus-Glykoproteins und zweier chimärer Proteine

    1991  

    Author's details vorgelegt von Markus Stoffel
    Size 88 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1991
    HBZ-ID HT003782017
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    91 D 3806 order for loan Magazin

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  9. Article: Vessels in a

    Piccinelli, Silvia / Francon, Loïc / Corona, Christophe / Stoffel, Markus / Slamova, Lenka / Cannone, Nicoletta

    Frontiers in plant science

    2023  Volume 13, Page(s) 1023384

    Abstract: Introduction: Mean xylem vessel or tracheid area have been demonstrated to represent powerful proxies to better understand the response of woody plants to changing climatic conditions. Yet, to date, this approach has rarely been applied to shrubs.: ... ...

    Abstract Introduction: Mean xylem vessel or tracheid area have been demonstrated to represent powerful proxies to better understand the response of woody plants to changing climatic conditions. Yet, to date, this approach has rarely been applied to shrubs.
    Methods: Here, we developed a multidecadal, annually-resolved chronology of vessel sizes for Rhododendron ferrugineum shrubs sampled at the upper shrubline (2,550 m asl) on a north-facing, inactive rock glacier in the Italian Alps.
    Results and discussion: Over the 1960-1989 period, the vessel size chronology shares 64% of common variability with summer temperatures, thus confirming the potential of wood anatomical analyses on shrubs to track past climate variability in alpine environments above treeline. The strong winter precipitation signal recorded in the chronology also confirms the negative effect of long-lasting snow cover on shrub growth. By contrast, the loss of a climate-growth relation signal since the 1990s for both temperature and precipitation, significantly stronger than the one found in radial growth, contrasts with findings in other QWA studies according to which stable correlations between series of anatomical features and climatic parameters have been reported. In a context of global warming, we hypothesize that this signal loss might be induced by winter droughts, late frost, or complex relations between increasing air temperatures, permafrost degradation, and its impacts on shrub growth. We recommend future studies to validate these hypotheses on monitored rock glaciers.
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1023384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators.

    Nikolaou, Kostas C / Godbersen, Svenja / Manoharan, Muthiah / Wieland, Stefan / Heim, Markus H / Stoffel, Markus

    JCI insight

    2023  Volume 8, Issue 21

    Abstract: Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3 ubiquitin ... ...

    Abstract Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3 ubiquitin ligase is induced by the synergistic actions of proinflammatory TNF-α and fatty acids in livers of humans and mice with NASH. TRIM21 ubiquitinates and degrades ChREBP, SREBP1, ACC1, and FASN, key regulators of de novo lipogenesis, and A1CF, an alternative splicing regulator of the high-activity ketohexokinase-C (KHK-C) isoform and rate-limiting enzyme of fructose metabolism. TRIM21-mediated degradation of these lipogenic activators improved steatosis and hyperglycemia as well as fructose and glucose tolerance. Our study identifies TRIM21 as a negative regulator of liver steatosis in NASH and provides mechanistic insights into an immunometabolic crosstalk that limits fatty acid synthesis and fructose metabolism during metabolic stress. Thus, enhancing this natural counteracting force of steatosis through inhibition of key lipogenic activators via TRIM21-mediated ubiquitination may provide a therapeutic opportunity to treat NASH.
    MeSH term(s) Animals ; Humans ; Mice ; Fructose/metabolism ; Inflammation ; Lipogenesis ; Non-alcoholic Fatty Liver Disease ; Ubiquitination
    Chemical Substances Fructose (30237-26-4) ; SS-A antigen
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.164694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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