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  1. AU="Stoica, Maria"
  2. AU="Romina Valentini"
  3. AU="Bagó, György Attila"
  4. AU="Bahrar, Harsh"
  5. AU="Judd, Dallin"

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  1. Artikel ; Online: Potassium carbonate-mediated β-selective anomeric O-alkylation with primary electrophiles: Application to the synthesis of glycosphingolipids

    Lakshika Hettiarachchi, Ishani / Wu, Fenglang / Stoica, Maria / Li, Xiaohua / Zhu, Jianglong

    Tetrahedron Letters. 2023 Apr. 19, p.154511-

    2023  , Seite(n) 154511–

    Abstract: Stereoselective construction of a variety of β-glycosides can be achieved using abundant and inexpensive K₂CO₃-mediated stereoselective anomeric O-alkylation of sugar lactols with primary electrophiles. In addition, application of this methodology to the ...

    Abstract Stereoselective construction of a variety of β-glycosides can be achieved using abundant and inexpensive K₂CO₃-mediated stereoselective anomeric O-alkylation of sugar lactols with primary electrophiles. In addition, application of this methodology to the synthesis of various azido-modified glycosphingolipids has been accomplished in good yields and excellent anomeric selectivity using sphingosine-derived primary triflate.
    Schlagwörter Lewis acids ; alkylation ; glycosphingolipids ; potassium ; stereoselectivity ; sugars ; Anomeric O-alkylation ; Glycosylation ; Carbohydrates
    Sprache Englisch
    Erscheinungsverlauf 2023-0419
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2023.154511
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  2. Artikel: Potassium carbonate-mediated

    Lakshika Hettiarachchi, Ishani / Wu, Fenglang / Stoica, Maria / Li, Xiaohua / Zhu, Jianglong

    Tetrahedron letters

    2023  Band 122

    Abstract: Stereoselective construction of a variety of β-glycosides can be achieved using abundant and inexpensive ... ...

    Abstract Stereoselective construction of a variety of β-glycosides can be achieved using abundant and inexpensive K
    Sprache Englisch
    Erscheinungsdatum 2023-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2023.154511
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  3. Artikel: Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures.

    Novac, Marius Bogdan / Boldeanu, Lidia / Dijmărescu, Anda Lorena / Boldeanu, Mihail Virgil / Neamțu, Simona Daniela / Radu, Lucreţiu / Manolea, Maria Magdalena / Șerbănescu, Mircea-Sebastian / Stoica, Maria / Rotaru, Luciana Teodora / Văduva, Constantin-Cristian

    Diagnostics (Basel, Switzerland)

    2024  Band 14, Heft 9

    Abstract: A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to ... ...

    Abstract A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to significantly affect the immune system of the mother and the patients' general postoperative course. This prospective study compared the plasma levels of catecholamines and cytokines in healthy pregnant patients having cesarean sections under spinal anesthesia versus general anesthesia. A total of 30 pregnant women undergoing elective cesarean sections were divided into two groups: 15 who received general anesthesia (GA) and 15 who received spinal anesthesia (SA). Blood samples were collected from all subjects before anesthesia induction (pre-OP), 6 h postoperatively (6 h post-OP), and 12 h (12 h post-OP), to measure levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-8, IL-4, IL-10, norepinephrine (NE), and epinephrine (EPI). When we compared the two groups, we discovered that only IL-6 and IL-4 had significantly higher levels pre-OP, whereas all studied cytokines exhibited an increase in the GA versus SA group at 6 and 12 h post-OP. In the case of catecholamines, we discovered that serum levels are positively related with pro-inflammatory or anti-inflammatory cytokines, depending on the time of day and type of anesthetic drugs. Compared to SA, GA has a more consistent effect on the inflammatory response and catecholamine levels. The findings of this study confirm that the type of anesthesia can alter postoperative immunomodulation to various degrees via changes in cytokine and catecholamine production. SA could be a preferable choice for cesarean section because it is an anesthetic method that reduces perioperative stress and allows for less opioid administration, impacting cytokine production with proper immunomodulation.
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14090880
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  4. Artikel: Retrospective Study Over the Hypospadias Surgery in a Single Tertiary Center.

    Fruntelată, Radu / Stoica, George Alin / Ciobanu, Mircea Ovidiu / Ciurea, Marius Eugen / Nica, Oliviu / Stoica, Maria

    Current health sciences journal

    2021  Band 47, Heft 2, Seite(n) 177–183

    Abstract: Hypospadias surgery is a common activity in every department for pediatric surgery, increased incidence of this condition contributing this aspect. For this purpose permanent review of the data of cases is probably necessary, in order to promptly ... ...

    Abstract Hypospadias surgery is a common activity in every department for pediatric surgery, increased incidence of this condition contributing this aspect. For this purpose permanent review of the data of cases is probably necessary, in order to promptly evaluate short and long term results.
    Material and methods: The authors are presenting this retrospective clinical and statistical study, enrolling 149 patients, hospitalized and operated in the Department of Pediatric Surgery and Orthopedics, between 2009 and 2018. several parameters were taken into consideration: moment of conception, type of hypospadias, associated malformations, use of meatoplasty, age at meatoplasty, age at urethroplasty, type of urethroplasty, postoperative incidents and complications.
    Results: Most of the patients included in the study were classified as anterior type of hypospadias, associated malformations were present in 20,13% of the patients, and 80% of the associated malformations belonged to the urogenital system. Over 60% of the cases underwent meatoplasty as a tactical procedure. Mathieu was the most appreciated procedure (74,5%) for urethroplasty and over a half of the patients were operated after the age of 3 years. Early and late postoperative fistula formation was noted in 18,12% of cases.
    Conclusions: Better parameters to assess the exact type of hypospadias are needed to be introduced. Also, clear protocols for preoperative work-up in detection of other abnormalities, especially genito-urinary. Meatoplasty as a tactical procedure is having unclear influence for urethroplasty. Decreasing the age at urethroplasty should be the next goal. Some surgeons should really get overspecialized for this type of surgery.
    Sprache Englisch
    Erscheinungsdatum 2021-06-30
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.47.02.05
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  5. Artikel: Retrospective Study of a Patient with Multiple de Novo Skin Tumor Formations.

    Fruntealată, Radu-Florin / Balseanu, Tudor Adrian / Nica, Oliviu / Negrila, Alina Andreea / Petrovici, Ilaria Lorena / Marinescu, Elena Alexandra / Stoica, George-Alin / Stoica, Maria / Ciurea, Ana-Maria / Ciurea, Marius-Eugen

    Current health sciences journal

    2023  Band 49, Heft 3, Seite(n) 434–437

    Abstract: In Romania, the incidence of malignant melanocytic tumors is continuously increasing. According to the World Health Organization, the incidence of melanocytic and non-melanocytic skin neoplasms has increased considerably and globally, in the last decade. ...

    Abstract In Romania, the incidence of malignant melanocytic tumors is continuously increasing. According to the World Health Organization, the incidence of melanocytic and non-melanocytic skin neoplasms has increased considerably and globally, in the last decade. We present the case of a 49-year-old patient who, over the course of 7 years, came in the Plastic Surgery Clinic of the Emergency County Hospital of Craiova for the excision of a number of 25 skin tumor formations, located on the face, cervical region, trunk and upper limbs. Treatment included complete microsurgical excision and supervision. In the end, the patient's treatment compliance decreased significantly.
    Sprache Englisch
    Erscheinungsdatum 2023-09-30
    Erscheinungsland Romania
    Dokumenttyp Case Reports
    ZDB-ID 2708703-7
    ISSN 2069-4032 ; 2067-0656
    ISSN (online) 2069-4032
    ISSN 2067-0656
    DOI 10.12865/CHSJ.49.03.18
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  6. Buch ; Online: The I-ADOPT Interoperability Framework for FAIRer data descriptions of biodiversity

    Magagna, Barbara / Rosati, Ilaria / Stoica, Maria / Schindler, Sirko / Moncoiffe, Gwenaelle / Devaraju, Anusuriya / Peterseil, Johannes / Huber, Robert

    2021  

    Abstract: Biodiversity, the variation within and between species and ecosystems, is essential for human well-being and the equilibrium of the planet. It is critical for the sustainable development of human society and is an important global challenge. Biodiversity ...

    Abstract Biodiversity, the variation within and between species and ecosystems, is essential for human well-being and the equilibrium of the planet. It is critical for the sustainable development of human society and is an important global challenge. Biodiversity research has become increasingly data-intensive and it deals with heterogeneous and distributed data made available by global and regional initiatives, such as GBIF, ILTER, LifeWatch, BODC, PANGAEA, and TERN, that apply different data management practices. In particular, a variety of metadata and semantic resources have been produced by these initiatives to describe biodiversity observations, introducing interoperability issues across data management systems. To address these challenges, the InteroperAble Descriptions of Observable Property Terminology WG (I-ADOPT WG) was formed by a group of international terminology providers and data center managers in 2019 with the aim to build a common approach to describe what is observed, measured, calculated, or derived. Based on an extensive analysis of existing semantic representations of variables, the WG has recently published the I-ADOPT framework ontology to facilitate interoperability between existing semantic resources and support the provision of machine-readable variable descriptions whose components are mapped to FAIR vocabulary terms. The I-ADOPT framework ontology defines a set of high level semantic components that can be used to describe a variety of patterns commonly found in scientific observations. This contribution will focus on how the I-ADOPT framework can be applied to represent variables commonly used in the biodiversity domain.

    Comment: submitted to S4BioDiv 2021: 3rd International Workshop on Semantics for Biodiversity, September 15, 2021, Bozen, Italy
    Schlagwörter Computer Science - Artificial Intelligence
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2021-07-14
    Erscheinungsland us
    Dokumenttyp Buch ; Online
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  7. Artikel ; Online: OSA treatment with CPAP: Randomized crossover study comparing tolerance and efficacy with and without humidification by ThermoSmart.

    Boyer, Laurent / Philippe, Carole / Covali-Noroc, Ala / Dalloz, Marie-Amélie / Rouvel-Tallec, Anny / Maillard, Dominique / Stoica, Maria / d'Ortho, Marie-Pia

    The clinical respiratory journal

    2019  Band 13, Heft 6, Seite(n) 384–390

    Abstract: Objectives: Adherence to continuous positive airway pressure (CPAP) remains an issue, as adverse effects (AE) such as rhinitis, dry/congested nose, dry mouth or throat are commonly experienced. The aim of the study was to compare CPAP efficacy and ... ...

    Abstract Objectives: Adherence to continuous positive airway pressure (CPAP) remains an issue, as adverse effects (AE) such as rhinitis, dry/congested nose, dry mouth or throat are commonly experienced. The aim of the study was to compare CPAP efficacy and tolerance in severe obstructive sleep apnea (OSA) patients with or without (w/o) heated humidification using the ThermoSmart system.
    Methods: Multicenter RCT study in which CPAP-naive patients with severe OSA and meeting one or more of the following criteria: >65 years, using >1 drying medication, previous nasal symptoms or nasal surgery, were included. Patients were randomized to CPAP w/o heated humidification for 1 month and then crossed-over to the other treatment arm for another month. Naso-pharyngeal symptoms, Quality of life (FOSQ-10), sleepiness (ESS) and CPAP compliance and efficacy data were collected.
    Results: Forty patients were enrolled: age 62 ± 9 years, diagnostic AHI 46.7 ± 15.3/hour. About 70% were using >1 drying medication, mainly antihypertensives. Both treatment modalities were found to normalize AHI and decrease sleepiness with no differences between 2 modes, compliance (4.63 ± 0.39 vs 4.70 ± 0.36 h/night) or leaks (32.4 ± 2.0 versus 31.1 ± 1.7l/min). With heated humidification, there was a significant decrease in nasal symptoms such as dry/congested nose. At the study end, 26 patients preferred ThermoSmart ON, 3 did not have preference and 11 preferred ThermoSmart OFF.
    Conclusion: ThermoSmart helps to decrease nose and throat discomfort because of CPAP therapy, these effects did not translate to better compliance but patients had a preference for ThermoSmart.
    Mesh-Begriff(e) Aged ; Continuous Positive Airway Pressure/adverse effects ; Continuous Positive Airway Pressure/methods ; Cross-Over Studies ; Double-Blind Method ; Female ; France ; Hot Temperature ; Humans ; Humidifiers ; Male ; Nasal Obstruction/etiology ; Nasal Obstruction/prevention & control ; Patient Compliance ; Quality of Life ; Sleep Apnea, Obstructive/therapy ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13022
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  8. Artikel ; Online: Analysis of the relationship between placental histopathological aspects of preterm and term birth.

    Camen, Ioana Victoria / Istrate-Ofiţeru, Anca Maria / Novac, Liliana Victoria / Manolea, Maria Magdalena / Dijmărescu, Anda Lorena / Neamţu, Simona Daniela / Radu, Lucreţiu / Boldeanu, Mihail Virgil / Şerbănescu, Mircea Sebastian / Stoica, Maria / Motoc, Andrei Gheorghe Marius / Novac, Marius Bogdan / Bujorescu, Daniela Loredana

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2022  Band 63, Heft 2, Seite(n) 357–367

    Abstract: Objectives: This study aims to establish a correlation between placental histopathological and immunohistochemical (IHC) changes and preterm birth with fetal growth restriction (FGR, formerly called intrauterine growth restriction - IUGR).: Patients, ... ...

    Abstract Objectives: This study aims to establish a correlation between placental histopathological and immunohistochemical (IHC) changes and preterm birth with fetal growth restriction (FGR, formerly called intrauterine growth restriction - IUGR).
    Patients, materials, and methods: This prospective study was performed on a group of 30 parturients, with singleton gestation, of which 15 patients gave birth at term, and the other 15 patients gave birth prematurely. After the statistical correlation of the clinical and demographic data with premature birth (PB) and term birth (TB), we performed histological and IHC research on the respective placentae. To observe normal and pathological microscopic placental structures, we used the Hematoxylin-Eosin (HE) and Periodic Acid Schiff-Hematoxylin (PAS-H) classical stainings, but also special immunostaining with anti-cluster of differentiation 34 (CD34) and anti-vascular endothelial growth factor (VEGF) antibodies.
    Results: We found a statistically significant difference between the TB∕PB categories and the age of the patients, their antepartum weight, the weight of the newborns, and the placenta according to the sex of the newborn. Histological analysis revealed in the case of TB, small areas of perivillous amyloid deposition, with the significant extension of these areas both intravillous and perivillous in the case of PB. Massive intravillous calcifications, syncytial knots, and intravillous vascular thrombosis were also frequently present in PB. With PAS-H staining were highlighted the intra∕extravillous vascular basement membranes, but especially the massive fibrin deposits rich in glycosaminoglycans. By the IHC technique with the anti-CD34 antibody, we noticed the numerical vascular density, higher in the case of TB, but in the case of PB, there were large areas of placental infarction, with a lack of immunostaining in these areas. Through the anti-VEGF antibody, we observed the presence of signal proteins that determined and stimulated the formation of neoformation vessels in the areas affected by the lack of post-infarction placental vascularization. We observed a highly significant difference between placental vascular density between TB∕PB and newborn weight, sex, or placental weight.
    Conclusions: Any direct proportional link between the clinical maternal-fetal and histological elements yet studied must be considered. Thus, establishing an antepartum risk group can prevent a poor pregnancy outcome.
    Mesh-Begriff(e) Humans ; Infant, Newborn ; Pregnancy ; Female ; Placenta/pathology ; Premature Birth/metabolism ; Premature Birth/pathology ; Prospective Studies ; Hematoxylin/metabolism ; Term Birth ; Fetal Growth Retardation/pathology ; Pregnancy Complications/pathology ; Infarction/pathology
    Chemische Substanzen Hematoxylin (YKM8PY2Z55)
    Sprache Englisch
    Erscheinungsdatum 2022-09-08
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.63.2.07
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  9. Buch ; Online: Electrical transport properties of Co-based skutterudites filled with Ag and Au

    Stoica, Maria / Lo, Cynthia S.

    2012  

    Abstract: This work presents theoretical calculations of the electrical transport properties of the Ag, Au, and La fractionally filled bulk skutterudites: CoSb3, CoAs3, and CoP3. Density functional theory (DFT), along with projector augmented wave (PAW) potentials, ...

    Abstract This work presents theoretical calculations of the electrical transport properties of the Ag, Au, and La fractionally filled bulk skutterudites: CoSb3, CoAs3, and CoP3. Density functional theory (DFT), along with projector augmented wave (PAW) potentials, was used to calculate bulk band structures and partial density of states. The Seebeck coefficient (S), electrical conductivity (s), and power factor (S2 s) were calculated as a function of temperature and filling fraction using the momentum matrix method along the entire first Brillouin zone. Calculated trends in the electrical transport properties agree with previously published experimental measurements for p-type unfilled and La filled CoSb3. The calculated S and s values for the Ag and Au filled compounds indicates that the most promising electronic properties are exhibited by p-type Au0.125(CoSb3)4, Au0.25(CoSb3)4, and Au(CoSb3)4. Au is therefore recommended as a promising filler for improved thermoelectric properties in cobalt antimonides. Ag is also a good filler for cobalt phosphides; the creation of a negative indirect band gap is observed in Ag(CoP3)4, which indicates semimetallic behavior, so this compound may possibly exhibit lower thermal conductivity than metallic CoP3. Finally, we recommend future directions for improving the thermoelectric figure of merit of these materials.

    Comment: http://prb.aps.org/accepted/47079O4aCda1d715a93277f09887a733b255818bc
    Schlagwörter Condensed Matter - Materials Science ; 81
    Thema/Rubrik (Code) 621
    Erscheinungsdatum 2012-09-14
    Erscheinungsland us
    Dokumenttyp Buch ; Online
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  10. Artikel ; Online: Site-specific protein labelling and immobilization mediated by microbial transglutaminase.

    Oteng-Pabi, Samuel K / Pardin, Christophe / Stoica, Maria / Keillor, Jeffrey W

    Chemical communications (Cambridge, England)

    2014  Band 50, Heft 50, Seite(n) 6604–6606

    Abstract: Microbial transglutaminase (mTG) shows broad substrate specificity that is amenable to in vitro bio-conjugation applications. Herein, test proteins were genetically fused with peptide tags, followed by mTG-mediated propargylation of their reactive Gln ... ...

    Abstract Microbial transglutaminase (mTG) shows broad substrate specificity that is amenable to in vitro bio-conjugation applications. Herein, test proteins were genetically fused with peptide tags, followed by mTG-mediated propargylation of their reactive Gln residues. The propargylated proteins were subjected to copper-assisted azide-alkyne cycloaddition to demonstrate either fluorescent labelling or immobilization.
    Mesh-Begriff(e) Alkynes/chemistry ; Azides/chemistry ; Catalysis ; Copper/chemistry ; Cycloaddition Reaction ; Enzymes, Immobilized/chemistry ; Enzymes, Immobilized/metabolism ; Glutamine/chemistry ; Glutamine/metabolism ; Oligopeptides/chemistry ; Pargyline/analogs & derivatives ; Pargyline/chemistry ; Pargyline/metabolism ; Propylamines/chemistry ; Propylamines/metabolism ; Proteins/chemistry ; Proteins/metabolism ; Streptomycetaceae/enzymology ; Substrate Specificity ; Transglutaminases/metabolism
    Chemische Substanzen Alkynes ; Azides ; Enzymes, Immobilized ; Oligopeptides ; Propylamines ; Proteins ; Glutamine (0RH81L854J) ; propargylamine (2450-71-7) ; tyrosyl-alanyl-glycine (69537-64-0) ; Copper (789U1901C5) ; Pargyline (9MV14S8G3E) ; Transglutaminases (EC 2.3.2.13)
    Sprache Englisch
    Erscheinungsdatum 2014-06-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c4cc00994k
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