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  1. Article ; Online: Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone

    Urošević Jovica / Mitić Miroslav / Arsić Biljana / Stojanović Gordana

    Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1117-

    2022  Volume 1123

    Abstract: The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2- ... ...

    Abstract The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The optimal conditions for the investigated synthesis were temperature of 150 °C, reaction time 24 h, and the CH3COOH/pTsOH catalyst. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium.
    Keywords cyclic condensation ; gc-ms ; side reactions ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Serbian

    Ickovski, Jovana D / Cvetković, Vladimir J / Jovanović, Nikola M / Mitrović, Tatjana Lj / Stojanović, Gordana S

    Natural product research

    2024  , Page(s) 1–12

    Abstract: The chemical composition and biological activities of the essential oils obtained from ... ...

    Abstract The chemical composition and biological activities of the essential oils obtained from Serbian
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2334312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction of the paper published in Journal of the Serbian Chemical Society 76 (2011) 987

    Stojanović Gordana S.

    Journal of the Serbian Chemical Society, Vol 82, Iss 11, Pp 1333-

    2017  Volume 1333

    Abstract: Link to the corrected article 10.2298/ ... ...

    Abstract Link to the corrected article 10.2298/JSC101004087S
    Keywords nema ; Chemistry ; QD1-999
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
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  4. Article ; Online: Mineral, phenolic content and antioxidant activity of selected honey samples consumed in Serbia

    Velimirović, Dragan / Tošić, Snežana / Mitić, Snežana / Pavlović, Aleksandra / Rašić Mišić, Ivana / Stojanović, Gordana

    Journal of Apicultural Research 2023, v. 62, no. 4, p. 850-862

    2023  , Page(s) 850–862

    Abstract: Although present in very small quantities, metals are important constituents of honey, having a significant impact on vital functions in the human body. Moreover, honey can be a good source of natural antioxidants, which have an important role in ... ...

    Abstract Although present in very small quantities, metals are important constituents of honey, having a significant impact on vital functions in the human body. Moreover, honey can be a good source of natural antioxidants, which have an important role in reducing the negative effects of certain human diseases. The content of the determined macroelements in the analyzed samples of domestic honey turned out to be of the following descending order: Na > K>Ca > Mg, and Ca > Na > Mg > K for the commercial types of honey. Generally, the detected content of macroelements was higher in domestic honey compared to commercial honeys, as well as in the case of the content of microelements. In some types of honey, the toxic elements Pb and Cd were detected, which is an indicator of environmental pollution. The results of total phenols content and antioxidant activities have shown that the sample of domestic floral honey from the area of Vlasina has the largest total phenols content and very high antioxidant activities, as well as manuka in the group of the commercial types of honey. The contents of the detected macro and microelements have shown lot of variations which confirms that the geographical origin of honey has a very important influence on its final mineral composition. The detected contents of Pb and Cd, were low, but due to the cumulative and toxic effects of these metals, it is necessary to constantly monitor the content of these pollutants in honey.
    Keywords antioxidant activity ; antioxidants ; apiculture ; honey ; humans ; mineral content ; pollution ; provenance ; research ; toxicity ; Serbia ; minerals ; nutrients ; ICP-OES ; UV/Vis
    Language English
    Dates of publication 2023-0808
    Size p. 850-862
    Publishing place Taylor & Francis
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 281228-9
    ISSN 2078-6913 ; 0021-8839
    ISSN (online) 2078-6913
    ISSN 0021-8839
    DOI 10.1080/00218839.2021.1898783
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    In stock of ZB MED Bonn / Germany

    Z 2023: Show issues

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  5. Article ; Online: Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta.

    Petrović, Aleksandra / Madić, Višnja / Stojanović, Gordana / Zlatanović, Ivana / Zlatković, Bojan / Vasiljević, Perica / Đorđević, Ljubiša

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117032

    Abstract: Ethnopharmacological relevance: The polyherbal mixture made of Centaurium erythraea aerial parts and Cichorium intybus roots and Potentilla erecta rhizomes has been used for centuries to treat both the primary and secondary complications of diabetes.: ...

    Abstract Ethnopharmacological relevance: The polyherbal mixture made of Centaurium erythraea aerial parts and Cichorium intybus roots and Potentilla erecta rhizomes has been used for centuries to treat both the primary and secondary complications of diabetes.
    Aim of the study: As a continuation of our search for the most effective herbal mixture used as an ethnopharmacological remedy for diabetes, this study aimed to compare the in vitro biological activities of this polyherbal mixture and its individual ingredients, and, most importantly, to validate the ethnopharmacological value of the herbal mixture through evaluation of its phytochemical composition, its potential in vivo toxicity and its effect on diabetes complications.
    Materials and methods: Phytochemical analysis was performed using HPLC-UV. Antioxidant activity was estimated via the DPPH test. Potential cytotoxicity/anticytotoxicity was assessed using an in vitro RBCs antihemolytic assay and an in vivo sub-chronic oral toxicity method. Antidiabetic activity was evaluated using an in vitro α-amylase inhibition assay and in vivo using a chemically induced diabetic rat model.
    Results: The HPLC-UV analysis revealed the presence of p-hydroxybenzoic acid, p-hydroxybenzoic acid derivative, catechin, five catechin derivatives, epicatechin, isoquercetin, hyperoside, rutin, four quercetin derivatives, caffeic acid, and four caffeic acid derivatives in the polyherbal mixture decoction. Treatment with the decoction has shown no toxic effects. The antioxidant and cytoprotective activities of the polyherbal mixture were higher than the reference's ones. Its antidiabetic activity was high in both in vitro and in vivo studies. Fourteen days of treatment with the decoction (15 g/kg) completely normalized blood glucose levels of diabetic animals, while treatments with insulin and glimepiride only slightly lowered glycemic values. In addition, lipid status of treated animals as well as levels of serum AST, ALT, ALP, creatinine, urea and MDA were completely normalized. In addition, the polyherbal mixture completely restored the histopathological changes of the liver, kidneys and all four Cornu ammonis regions of the hippocampus.
    Conclusions: The polyherbal mixture was effective in the prevention of both primary and secondary diabetic complications such as hyperlipidemia, increased lipid peroxidation, non-alcoholic fatty liver disease, nephropathy and neurodegeneration.
    MeSH term(s) Rats ; Animals ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Centaurium ; Cichorium intybus ; Potentilla ; Catechin ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Blood Glucose
    Chemical Substances Hypoglycemic Agents ; caffeic acid (U2S3A33KVM) ; Plant Extracts ; Catechin (8R1V1STN48) ; phenolic acid (I3P9R8317T) ; Antioxidants ; Phytochemicals ; Blood Glucose
    Language English
    Publishing date 2023-08-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Elemental composition of selected lichen species growing on the Balkan Peninsula

    Tošić Snežana / Pavlović Aleksandra / Dimitrijević Ivana / Zlatanović Ivana / Mitić Violeta / Stojanović Gordana

    Journal of the Serbian Chemical Society, Vol 87, Iss 11, Pp 1313-

    2022  Volume 1325

    Abstract: The amount of nineteen elements in eleven different lichen species, six fruticose (Bryoria capillaris, Bryoria fuscescens, Cladonia rangiformis, Ramalina capitata, Usnea chaetophora and Evernia prunastri) and five foliose (Hypogymnia tubulosa, Lobaria ... ...

    Abstract The amount of nineteen elements in eleven different lichen species, six fruticose (Bryoria capillaris, Bryoria fuscescens, Cladonia rangiformis, Ramalina capitata, Usnea chaetophora and Evernia prunastri) and five foliose (Hypogymnia tubulosa, Lobaria pulmonaria, Peltigera horizontalis, Umbilicaria cylindrica and Umbilicaria crustulosa) from five natural areas of the Balkan Peninsula (Serbia and Bulgaria) were determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). Among macronutrients, the highest content was observed for Ca and K, while Mg and Na were represented in the smallest amount. Fe, Mn, Zn and Ba were the most abundant trace elements in contrast to Cd and Co, whose concentrationс wеre the lowest.
    Keywords heavy metals ; icp-oes determination ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
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  7. Article ; Online: The effects of

    Stanković, Miroslava / Ickovski, Jovana D / Ljupković, Radomir B / Stojanović, Gordana S

    Natural product research

    2021  Volume 36, Issue 17, Page(s) 4536–4539

    Abstract: Methanol extracts ... ...

    Abstract Methanol extracts of
    MeSH term(s) Artemisia ; Cinnamates ; Coumaric Acids ; Depsides ; Humans ; Lymphocytes ; Methanol ; Plant Extracts/pharmacology ; Quercetin/pharmacology ; Rutin/pharmacology ; Rosmarinic Acid
    Chemical Substances Cinnamates ; Coumaric Acids ; Depsides ; Plant Extracts ; Rutin (5G06TVY3R7) ; Quercetin (9IKM0I5T1E) ; ferulic acid (AVM951ZWST) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2021-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1990918
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  8. Article: Volatile Organic Compound Composition and Glandular Trichome Characteristics of In Vitro Propagated Clinopodium pulegium (Rochel) Bräuchler: Effect of Carbon Source

    Stojičić, Dragana / Tošić, Svetlana / Stojanović, Gordana / Zlatković, Bojan / Jovanović, Snežana / Budimir, Snežana / Uzelac, Branka

    Plants. 2022 Jan. 13, v. 11, no. 2

    2022  

    Abstract: Clinopodium pulegium (Rochel) Bräuchler (Lamiaceae) is an endangered species endemic to the Southern Carpathians. It is characterized by the production of high amounts of essential oils, which emit volatile organic compounds (VOCs) that have an essential ...

    Abstract Clinopodium pulegium (Rochel) Bräuchler (Lamiaceae) is an endangered species endemic to the Southern Carpathians. It is characterized by the production of high amounts of essential oils, which emit volatile organic compounds (VOCs) that have an essential role in biotic and abiotic stress responses and in plant–plant and plant–insect interactions. The present study was initiated to phytochemically examine the influence of different carbon sources in the nutrition medium on VOC emissions of micropropagated C. pulegium plants, using gas chromatography–mass spectrometry analysis of headspace VOCs. The volatile profiles were subjected to multivariate analysis with respect to the presence, concentration and type of carbon source in the nutrient medium. In addition, the effect of different carbohydrates on the density and size of the leaf glandular trichomes, the main structures involved in the emission of VOCs, was determined. A total of 19 VOCs, primarily belonging to mono- and sesquiterpenes previously described in plants, were tentatively identified. Six VOCs were produced at levels higher than 2% of the total VOC emission, dominated by pulegone, ß-pinene and menthone. Inclusion of the carbohydrates in the culture media affected the production of the main leaf trichome-associated volatile allelochemicals although the qualitative composition of the volatiles changed only slightly. Multivariate analysis showed that the concentration, rather than the carbohydrate type, influenced the VOC profile.
    Keywords Clinopodium ; abiotic stress ; allelochemicals ; carbohydrates ; carbon ; endangered species ; gas chromatography-mass spectrometry ; headspace analysis ; leaves ; menthone ; micropropagation ; multivariate analysis ; nutrition ; sesquiterpenoids ; trichomes ; volatile organic compounds ; Carpathian region
    Language English
    Dates of publication 2022-0113
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11020198
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: The effects of Artemisia methanol extracts and ferulic acid, rutin, rosmarinic acid, and quercetin on micronucleus distribution on human lymphocytes

    Stanković, Miroslava / Ickovski, Jovana D. / Ljupković, Radomir B. / Stojanović, Gordana S.

    Natural product research. 2022 Sept. 1, v. 36, no. 17

    2022  

    Abstract: Methanol extracts of A. absinthium, A. annua, A vulgaris, A. scoparia, and A. alba from Serbia at concentrations of 1.00; 2.00 and 4.00 μg/ml, and as pure compounds identified in examined extracts (ferulic acid, rutin, rosmarinic acid, and quercetin) ... ...

    Abstract Methanol extracts of A. absinthium, A. annua, A vulgaris, A. scoparia, and A. alba from Serbia at concentrations of 1.00; 2.00 and 4.00 μg/ml, and as pure compounds identified in examined extracts (ferulic acid, rutin, rosmarinic acid, and quercetin) were examined for their effects on micronucleus distribution in human lymphocytes in vitro. All extracts greatly reduced the number of micronuclei in the concentration of 2.00 μg/ml comparing to the control, whereby A. alba extract exhibited the most prominent effect on decreasing frequency of micronucleus (45.2%), followed by extracts of A. vulgaris, A. absinthium, A. scoparia and A. annua. The same declining trend was observed for the extracts at concentrations of 4.00 µg/ml, and 1.00 µg/ml, respectively. Among pure compounds (concentration 2.00 μg/ml), rutin showed the most pronounced effect on decreasing frequency of micronucleus (41.7%), higher than ferulic acid, quercetin, and rosmarinic acid comparing to the control.
    Keywords Artemisia absinthium ; ferulic acid ; humans ; methanol ; quercetin ; research ; rosmarinic acid ; rutin ; Serbia
    Language English
    Dates of publication 2022-0901
    Size p. 4530-4533.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1990918
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  10. Article: Volatile Organic Compound Composition and Glandular Trichome Characteristics of In Vitro Propagated

    Stojičić, Dragana / Tošić, Svetlana / Stojanović, Gordana / Zlatković, Bojan / Jovanović, Snežana / Budimir, Snežana / Uzelac, Branka

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Clinopodium ... ...

    Abstract Clinopodium pulegium
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11020198
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