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Article: Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Gojkovic-Bukarica, Lj., University of Belgrade, Belgrade (Serbia). Faculty of Medicine / Stojnic, N., University of Belgrade, Belgrade (Serbia). Faculty of Medicine / Peric, M., Institute for Cardiovascular Diseases Dedinje, Belgrade (Serbia) / Cvejic, J., University of Novi Sad, Novi Sad (Serbia). Faculty of Medicine / Bumbasirevic, M., Clinical Center of Serbia, Belgrade (Serbia). Institute of Orthopedics and Traumatology / Lesic, A., Clinical Center of Serbia, Belgrade (Serbia). Institute of Orthopedics and Traumatology / Cupic, V., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine / Milosevic, I., Clinical Center of Serbia, Belgrade (Serbia). Institute of Orthopedics and Traumatology / Kanjuh, V., Serbian Academy of Sciences and Arts, Belgrade (Serbia)

Acta Veterinaria (Serbia)

(2010)  Volume v. 60, Issue (2-3), Page(s) p. 145–154

Abstract: Pinacidil, a previously studied potassium channel opener (PCO), is a potent antihypertensive agent in animals and humans. Its mechanism of action is not completly defined. The aim of our study was to investigate the antivasoconstricting effect of ... ...

Abstract Pinacidil, a previously studied potassium channel opener (PCO), is a potent antihypertensive agent in animals and humans. Its mechanism of action is not completly defined. The aim of our study was to investigate the antivasoconstricting effect of pinacidil on the isolated RA and to study whether this effect is endothelium-dependent. Contractions of isolated RA rings intact endothelium were provoked by electrical field stimulation (EFS, 20Hz) or exogenously applied noradrenaline (NA, 10 microM). Pinacidil (10 nM-0.1 mM) produced a concentration-dependent inhibition of both EFS- and NA-evoked contractions (P is greater than 0.05). NO synthesis inhibitor, L-NAME (10 microM) and the guanylate cyclase inhibitor, methylene blue (10 microM) did partly antagonize NA-evoked contractions and were without effect on EFS-induced contractions. Thus, the antivasoconstrictor effect of pinacidil on RA is partly endothelium-dependent and probably mediated via cGMP-dependent NO-pathway.
Keywords ANIMALS ; MANKIND ; ARTERIES ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR AGENTS ; ANIMAL ; GENRE HUMAIN ; ARTERE ; MALADIE CARDIOVASCULAIRE ; MODIFICATEUR CARDIOVASCULAIRE ; ANIMALES ; GENERO HUMANO ; ARTERIAS ; ENFERMEDADES CARDIOVASCULARES ; MEDICAMENTOS CARDIOVASCULARES ; http://www.fao.org/aos/agrovoc#c_444 ; http://www.fao.org/aos/agrovoc#c_4586 ; http://www.fao.org/aos/agrovoc#c_8948 ; http://www.fao.org/aos/agrovoc#c_34231 ; http://www.fao.org/aos/agrovoc#c_1316
Language English
Document type Article
ISSN 0567-8315
Database AGRIS - International Information System for the Agricultural Sciences and Technology

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