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Article ; Online: Later achievement of infant motor milestones is related to lower levels of physical activity during childhood: the GECKO Drenthe cohort.

Brouwer, Silvia I / Stolk, Ronald P / Corpeleijn, Eva

2019 Volume 19, Issue 1, Page(s) 388

Abstract: Background: The aim of this study is to investigate whether age of infant motor milestone achievement is related to levels of physical activity (PA), weight status and blood pressure at age 4-7 years of age.: Methods: In the Dutch GECKO (Groningen ... ...

Abstract	Background: The aim of this study is to investigate whether age of infant motor milestone achievement is related to levels of physical activity (PA), weight status and blood pressure at age 4-7 years of age. Methods: In the Dutch GECKO (Groningen Expert Center of Kids with Obesity) Drenthe cohort, the age of achieving the motor milestone 'walking without support' was reported by parents. Weight status and blood pressure were assessed by trained health nurses and PA was measured using the Actigraph GT3X between age 4 and 7 years. Results: Adjusted for children's age, sex and the mother's education level, infants who achieved walking without support at a later age, spent more time in sedentary behaviour during childhood and less time in moderate-to-vigorous PA. Later motor milestones achievement was not related to higher BMI Z-score, waist circumference Z-score, diastolic or systolic blood pressure. Conclusion: The results of this study indicate that a later age of achieving motor milestone within the normal range have a weak relation to lower PA levels at later age. It is not likely that this will have consequences for weight status or blood pressure at 4-7 years of age.
MeSH term(s)	Age Factors ; Blood Pressure ; Body Weight ; Child ; Child Development ; Child, Preschool ; Cohort Studies ; Exercise ; Female ; Humans ; Male ; Motor Skills
Language	English
Publishing date	2019-10-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-019-1784-0
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Article ; Online: Motives for withdrawal of participation in biobanking and participants' willingness to allow linkages of their data.

Broekstra, Reinder / Aris-Meijer, Judith L / Maeckelberghe, Els L M / Stolk, Ronald P / Otten, Sabine

European journal of human genetics : EJHG

2021 Volume 30, Issue 3, Page(s) 367–377

Abstract: Data repositories, like research biobanks, seek to optimise the number of responding participants while simultaneously attempting to increase the amount of data donated per participant. Such efforts aim to increase the repository's value for its uses in ... ...

Abstract	Data repositories, like research biobanks, seek to optimise the number of responding participants while simultaneously attempting to increase the amount of data donated per participant. Such efforts aim to increase the repository's value for its uses in medical research to contribute to improve health care, especially when data linkage is permitted by participants. We investigated individuals' motives for participating in such projects and potential reasons for their withdrawal from participation in a population-based biobank. In addition, we analysed how these motives were related to various characteristics of the participants and their willingness to permit data linkage to their personal data for research. These questions were explored using a sample of participants in the Dutch Lifelines biobank (n = 2615). Our results indicated that motives for participation and withdrawal were premised on benefits or harm to society and to the individuals themselves. Although general values and trust both played key roles in participation, potential withdrawal and willingness to permit data linkage, they were differentially associated with motives for participation and withdrawal. These findings support and nuance previous findings by highlighting the distinctiveness and complexity of decision making regarding participation in or withdrawal from data donation. We suggest some new directions for improving recruitment, retention and safeguarding strategies in biobanking. In addition, our data provide initial evidence regarding how factors may relate with the probability that individuals will agree to data linkages, when controlling for their unique effects. Future research should further investigate how perceptions of harm and benefits may influence decision making on withdrawal of participation.
MeSH term(s)	Biological Specimen Banks ; Biomedical Research ; Humans ; Motivation ; Trust
Language	English
Publishing date	2021-11-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-021-00997-5
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Zs.A 3589: Show issues

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Article ; Online: Screening for diabetes.

Stolk, Ronald P

BMJ (Clinical research ed.)

2007 Volume 335, Issue 7618, Page(s) 457–458

MeSH term(s)	Diabetes Mellitus/prevention & control ; Diabetes Mellitus/psychology ; Humans ; Mass Screening/methods ; Stress, Psychological/etiology
Language	English
Publishing date	2007-08-30
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.39323.395336.BE
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Article ; Online: Infant Motor Milestones and Childhood Overweight: Trends over Two Decades in A Large Twin Cohort.

Brouwer, Silvia I / Stolk, Ronald P / Bartels, Meike / van Beijsterveld, Toos C E M / Boomsma, Dorret I / Corpeleijn, Eva

International journal of environmental research and public health

2020 Volume 17, Issue 7

Abstract: Background: Poor motor skill competence may influence energy balance with childhood overweight as a result. Our aim was to investigate whether the age of motor milestone achievement has changed over the past decades and whether this change may ... ...

Abstract	Background: Poor motor skill competence may influence energy balance with childhood overweight as a result. Our aim was to investigate whether the age of motor milestone achievement has changed over the past decades and whether this change may contribute to the increasing trend observed in childhood overweight. Methods: Motor skill competence was assessed in children from the Young Netherlands Twin Register born between 1987 and 2007. Follow-up ranged from 4 up to 10 years. Weight and height were assessed at birth, 6 months, 14 months, and 2, 4, 7, and 10 years. Results: Babies born in later cohorts achieved their motor milestones 'crawling', 'standing', and 'walking unassisted' later compared to babies born in earlier cohorts (N = 18,514, p < 0.001). The prevalence of overweight at age 10 was higher in later cohorts (p = 0.033). The increase in overweight at age 10 was not explained by achieving motor milestones at a later age and this persisted after adjusting for gestational age, sex, and socioeconomic status. Conclusion: Comparing children born in 1987 to those born in 2007, we conclude that children nowadays achieve their motor milestones at a later age. This does not however, explain the increasing trend in childhood overweight.
MeSH term(s)	Body Mass Index ; Child ; Child Development ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Motor Skills ; Netherlands ; Overweight ; Pediatric Obesity ; Pregnancy
Language	English
Publishing date	2020-03-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph17072366
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Article ; Online: Identification of relevant biomarkers for type 2 diabetes.

Abbasi, Ali / Stolk, Ronald P / Bakker, Stephan Jl

The lancet. Diabetes & endocrinology

2014 Volume 2, Issue 2, Page(s) 106–107

MeSH term(s)	Biomarkers/metabolism ; Diabetes Mellitus, Type 2/diagnosis ; Humans ; Insulin Resistance
Chemical Substances	Biomarkers
Language	English
Publishing date	2014-02-03
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(14)70005-1
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Article ; Online: Comment on Vassy et al. polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes 2014;63:2172-2182.

Abbasi, Ali / Stolk, Ronald P / Bakker, Stephan J L

Diabetes

2014 Volume 63, Issue 7, Page(s) e11–2

MeSH term(s)	African Americans/genetics ; Diabetes Mellitus, Type 2/genetics ; Female ; Genotype ; Humans ; Insulin Resistance/genetics ; Male ; Obesity/complications ; Polymorphism, Single Nucleotide ; Whites/genetics
Language	English
Publishing date	2014-06-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db14-0271
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Article ; Online: (Un)Healthy in the City: Respiratory, Cardiometabolic and Mental Health Associated with Urbanity.

Zijlema, Wilma L / Klijs, Bart / Stolk, Ronald P / Rosmalen, Judith G M

PloS one

2015 Volume 10, Issue 12, Page(s) e0143910

Abstract: Background: Research has shown that health differences exist between urban and rural areas. Most studies conducted, however, have focused on single health outcomes and have not assessed to what extent the association of urbanity with health is explained ...

Abstract	Background: Research has shown that health differences exist between urban and rural areas. Most studies conducted, however, have focused on single health outcomes and have not assessed to what extent the association of urbanity with health is explained by population composition or socioeconomic status of the area. Our aim is to investigate associations of urbanity with four different health outcomes (i.e. lung function, metabolic syndrome, depression and anxiety) and to assess whether these associations are independent of residents' characteristics and area socioeconomic status. Methods: Our study population consisted of 74,733 individuals (42% males, mean age 43.8) who were part of the baseline sample of the LifeLines Cohort Study. Health outcomes were objectively measured with spirometry, a physical examination, laboratory blood analyses, and a psychiatric interview. Using multilevel linear and logistic regression models, associations of urbanity with lung function, and prevalence of metabolic syndrome, major depressive disorder and generalized anxiety disorder were assessed. All models were sequentially adjusted for age, sex, highest education, household equivalent income, smoking, physical activity, and mean neighborhood income. Results: As compared with individuals living in rural areas, those in semi-urban or urban areas had a poorer lung function (β -1.62, 95% CI -2.07;-1.16), and higher prevalence of major depressive disorder (OR 1.65, 95% CI 1.35;2.00), and generalized anxiety disorder (OR 1.58, 95% CI 1.35;1.84). Prevalence of metabolic syndrome, however, was lower in urban areas (OR 0.51, 95% CI 0.44;0.59). These associations were only partly explained by differences in residents' demographic, socioeconomic and lifestyle characteristics and socioeconomic status of the areas. Conclusions: Our results suggest a differential health impact of urbanity according to type of disease. Living in an urban environment appears to be beneficial for cardiometabolic health but to have a detrimental impact on respiratory function and mental health. Future research should investigate which underlying mechanisms explain the differential health impact of urbanity.
MeSH term(s)	Adult ; Environmental Exposure ; Female ; Health Status Indicators ; Humans ; Male ; Mental Disorders/physiopathology ; Metabolic Syndrome/physiopathology ; Middle Aged ; Prospective Studies ; Respiratory System/physiopathology ; Urban Population
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0143910
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Article ; Online: Combining informal care and paid work: The use of work arrangements by working adult-child caregivers in the Netherlands.

Oldenkamp, Marloes / Bültmann, Ute / Wittek, Rafael P M / Stolk, Ronald P / Hagedoorn, Mariët / Smidt, Nynke

Health & social care in the community

2017 Volume 26, Issue 1, Page(s) e122–e131

Abstract: An increasing number of people combine paid work with the provision of informal care for a loved one. This combination of work and care may cause difficulties, necessitating adaptations at work, i.e. work arrangements. The present study explores what ... ...

Abstract	An increasing number of people combine paid work with the provision of informal care for a loved one. This combination of work and care may cause difficulties, necessitating adaptations at work, i.e. work arrangements. The present study explores what types of work arrangements are used by working caregivers, and which caregiver, care and work characteristics are associated with the use of these work arrangements. Within the Lifelines Informal Care Add-on Study (Lifelines ICAS), data on 965 Dutch informal caregivers in the North of the Netherlands were collected between May 2013 and July 2014 (response rate 48%), and data on 333 working adult-child caregivers (aged 26-68 years, 82% female) were used in this study. A small majority (56%) of the working caregivers used one or more work arrangement(s): taking time off (41%), individual agreements with supervisor (30%), formal care leave arrangement (13%), and reduction in paid work hours (6%). Logistic regression analyses showed that long working hours (OR 1.06, 95% CI 1.01-1.08), and the experience of more health problems (OR 2.54, 95% CI 1.56-4.05) or a disrupted schedule due to caregiving (OR 2.50, 95% CI 1.66-3.78) increased the chance to have used one or more work arrangements. Lower educated working caregivers were less likely to have used a formal care leave arrangement (tertiary vs. primary education OR 2.75, 95% CI 1.13-6.67; tertiary vs. secondary education OR 1.27, 95% CI 1.27-5.09). Policy makers should inform working caregivers about the availability of the different work arrangements, with specific attention for low educated working caregivers. Employers need to consider a more caregiver-friendly policy, as almost half of the working adult-child caregivers did not use any work arrangement.
MeSH term(s)	Adult ; Aged ; Caregivers/statistics & numerical data ; Child ; Employment/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Patient Care/statistics & numerical data ; Workload
Language	English
Publishing date	2017-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.12485
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Zs.A 3728: Show issues

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Article ; Online: WITHDRAWN: Interventions for treating obesity in children.

Oude Luttikhuis, Hiltje / Baur, Louise / Jansen, Hanneke / Shrewsbury, Vanessa A / O'Malley, Claire / Stolk, Ronald P / Summerbell, Carolyn D

The Cochrane database of systematic reviews

2019 Volume 3, Page(s) CD001872

Abstract: Background: Child and adolescent obesity is increasingly prevalent, and can be associated with significant short- and long-term health consequences.: Objectives: To assess the efficacy of lifestyle, drug and surgical interventions for treating ... ...

Abstract	Background: Child and adolescent obesity is increasingly prevalent, and can be associated with significant short- and long-term health consequences. Objectives: To assess the efficacy of lifestyle, drug and surgical interventions for treating obesity in childhood. Search methods: We searched CENTRAL on The Cochrane Library Issue 2 2008, MEDLINE, EMBASE, CINAHL, PsycINFO, ISI Web of Science, DARE and NHS EED. Searches were undertaken from 1985 to May 2008. References were checked. No language restrictions were applied. Selection criteria: We selected randomised controlled trials (RCTs) of lifestyle (i.e. dietary, physical activity and/or behavioural therapy), drug and surgical interventions for treating obesity in children (mean age under 18 years) with or without the support of family members, with a minimum of six months follow up (three months for actual drug therapy). Interventions that specifically dealt with the treatment of eating disorders or type 2 diabetes, or included participants with a secondary or syndromic cause of obesity were excluded. Data collection and analysis: Two reviewers independently assessed trial quality and extracted data following the Cochrane Handbook. Where necessary authors were contacted for additional information. Main results: We included 64 RCTs (5230 participants). Lifestyle interventions focused on physical activity and sedentary behaviour in 12 studies, diet in 6 studies, and 36 concentrated on behaviorally orientated treatment programs. Three types of drug interventions (metformin, orlistat and sibutramine) were found in 10 studies. No surgical intervention was eligible for inclusion. The studies included varied greatly in intervention design, outcome measurements and methodological quality.Meta-analyses indicated a reduction in overweight at 6 and 12 months follow up in: i) lifestyle interventions involving children; and ii) lifestyle interventions in adolescents with or without the addition of orlistat or sibutramine. A range of adverse effects was noted in drug RCTs. Authors' conclusions: While there is limited quality data to recommend one treatment program to be favoured over another, this review shows that combined behavioural lifestyle interventions compared to standard care or self-help can produce a significant and clinically meaningful reduction in overweight in children and adolescents. In obese adolescents, consideration should be given to the use of either orlistat or sibutramine, as an adjunct to lifestyle interventions, although this approach needs to be carefully weighed up against the potential for adverse effects. Furthermore, high quality research that considers psychosocial determinants for behaviour change, strategies to improve clinician-family interaction, and cost-effective programs for primary and community care is required.
MeSH term(s)	Anti-Obesity Agents/therapeutic use ; Child ; Diet, Reducing ; Humans ; Life Style ; Motor Activity ; Pediatric Obesity/therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Anti-Obesity Agents
Language	English
Publishing date	2019-03-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD001872.pub3
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Article ; Online: Motorized transportation, social status, and adiposity: the China Health and Nutrition Survey.

Qin, Li / Stolk, Ronald P / Corpeleijn, Eva

American journal of preventive medicine

2012 Volume 43, Issue 1, Page(s) 1–10

Abstract: Background: Increased dependence on motorized transportation may contribute to obesity. Countries in rapid socioeconomic transitions, such as China, provide an opportunity to investigate such an association.: Purpose: The aim of the study was to ... ...

Abstract	Background: Increased dependence on motorized transportation may contribute to obesity. Countries in rapid socioeconomic transitions, such as China, provide an opportunity to investigate such an association. Purpose: The aim of the study was to examine the hypotheses that increased dependence on motorized transportation is related to adiposity and that this effect will be more pronounced in adults with high SES or those who live in urban regions. Methods: Data from the longitudinal China Health and Nutrition Survey conducted from 1997 to 2006 (n=3853, aged 18-55 years at baseline, 52% women, ~7.8 years' follow-up) were used to examine the association between motorized transportation (none, 1-5 years, >5 years) and changes in body weight and waist circumference (WC) by using multivariate regression. SES factors were obtained from questionnaires. Data were analyzed in 2010. Results: Use of motorized transportation for >5 years was related to ~1.2 kg greater weight gain (p=0.006) and ~1.0 cm larger WC gain (p=0.017) in men, when compared with the nonmotorized transportation group and adjusted for baseline age, anthropometry, dietary intake, and follow-up time. These changes were slightly more pronounced in men with higher income or from rural areas, but the difference was not significant. In women, the tendency to have motorized transportation with weight gain was less pronounced (+1.1 kg, p=0.008). Low education and high income were the most predominant factors. In 2006, motorized transportation was associated with a 1.3-fold higher OR for obesity (p(trend)=0.054) and abdominal obesity (p(trend)=0.047) in men, and a 2-fold higher OR of obesity in women (p(trend) <0.001). Conclusions: Motorized transportation was related to an increase in adiposity in the Chinese population, particularly in men.
MeSH term(s)	Adiposity/physiology ; Adolescent ; Adult ; Anthropometry ; Automobiles/statistics & numerical data ; China/epidemiology ; Economic Development ; Female ; Health Surveys ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Nutrition Surveys ; Obesity/epidemiology ; Obesity/etiology ; Ownership/statistics & numerical data ; Social Class ; Young Adult
Language	English
Publishing date	2012-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2012.03.022
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